Oxidative stress in primary open-angle glaucoma.

Abstract:

PURPOSE:To analyze oxidative stress in primary open-angle glaucoma (POAG). MATERIAL AND METHODS:A case-control study including 90 eyes of 90 patients who needed antiglaucomatous surgery in the course of POAG (glaucoma group, n=50) and from patients who were operated of nonpathologic cataracts (cataract group, n=40). Free radical formation via lipid peroxidation by malondialdehyde-thiobarbituric acid reactive substances (MDA-TBARS) test and total antioxidant status in the aqueous humor samples of both groups were determined. Statistical analyses were carried out in relation to MDA-TBARS and total antioxidant status and their correlations with glaucoma risk factors. RESULTS:Significantly higher MDA-TBARS were detected in the POAG with respect to the comparative group of cataract subjects (P<0.001). Antioxidant activity was significantly lower in the POAG than in the cataract group (P<0.001). CONCLUSIONS:Aqueous humor samples may be used for determining oxidative and antioxidant status in pathologic processes. Glaucomatous eyes had a significant increase in oxidative status and decreased antioxidant activity in the aqueous humor than the cataract eyes. Oxidative stress may play a pathogenical role in the POAG.

journal_name

J Glaucoma

journal_title

Journal of glaucoma

authors

Zanon-Moreno V,Marco-Ventura P,Lleo-Perez A,Pons-Vazquez S,Garcia-Medina JJ,Vinuesa-Silva I,Moreno-Nadal MA,Pinazo-Duran MD

doi

10.1097/IJG.0b013e31815c3a7f

subject

Has Abstract

pub_date

2008-06-01 00:00:00

pages

263-8

issue

4

eissn

1057-0829

issn

1536-481X

pii

00061198-200806000-00004

journal_volume

17

pub_type

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