Abstract:
PURPOSE:The authors identify any diurnal intraocular pressure (IOP) variation in healthy Cayo Santiago macaques, as well as Cayo Santiago macaques with normotensive and hypertensive primary open-angle glaucoma (POAG), to further evaluate their potential value as a model for human POAG. METHODS:Twenty-four monkeys (eight animals each of the healthy control, normotensive glaucoma, and hypertensive glaucoma groups) were sedated with ketamine hydrochloride and the IOP measured hourly from 8:00 AM until 3:00 PM with a Tonopen XL applanation tonometer (Mentor, Norwell, MA, U.S.A.). Mean IOP time profiles, mean IOPs at each observation time, and linear trends in mean IOP over time were compared among groups. Intraocular pressure rate-of-change over time and residual variation about the regression line for each individual eye were analyzed. Cup/disc ratio (C/D) was compared with baseline IOP, IOP profile mean and slope, and IOP residual variation. RESULTS:A significant group and time effect on mean IOP (p = 0.0001 and 0.011, respectively), with highest values at 2:00 PM or 3:00 PM, and a significant increasing linear trend in mean IOP over time in the hypertensive group were observed (p = 0.012). Intermediate readings between control and hypertensive mean IOPs were identified for the normotensive glaucoma group. The biggest range of IOP variation was found in the hypertensive glaucoma monkeys. Higher variations in IOP did not lead to an increase in C/D. CONCLUSIONS:This study provides evidence that the Cayo Santiago macaques are a valuable model for human normotensive and hypertensive POAG.
journal_name
J Glaucomajournal_title
Journal of glaucomaauthors
Komaromy AM,Brooks DE,Kubilis PS,Dawson WW,Sapp HL Jr,Nelson G,Collins BR,Sherwood MBsubject
Has Abstractpub_date
1998-04-01 00:00:00pages
128-31issue
2eissn
1057-0829issn
1536-481Xjournal_volume
7pub_type
杂志文章abstract:PURPOSE:To investigate the efficacy of argon laser trabeculoplasty (ALT) for the treatment of primary open-angle glaucoma (POAG) and of glaucoma associated with exfoliation syndrome (EXF). METHODS:Review of > 200 charts from patients treated with ALT between 1981 and 1987 identified 66 POAG and 29 EXF eyes that underw...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:
更新日期:1996-10-01 00:00:00
abstract:INTRODUCTION:Glaucoma in patients with nonbullous congenital ichthyosiform erythroderma (NBCIE) is a rare entity that has not been described in a histologically confirmed case. We present a unique case of coexisting glaucoma, ichthyosis, and dwarfism that has not been previously described. METHODS:We present a case of...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0000000000001016
更新日期:2018-11-01 00:00:00
abstract:PURPOSE:To determine whether the multifocal visual evoked potential (mfVEP) technique can detect early functional damage in ocular hypertensive (OHT) and glaucoma suspect (GS) patients with normal standard achromatic automated perimetry (SAP) results. PATIENTS AND METHODS:Twenty-five GS patients (25 eyes), 25 patients...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/01.ijg.0000212237.26466.0e
更新日期:2006-08-01 00:00:00
abstract:PRECIS:The association between primary open-angle glaucoma (POAG) and subsequent development of chronic kidney disease (CKD) was investigated using a nationwide, population-based, retrospective cohort in South Korea. POAG increases the risk of subsequent CKD development. PURPOSE:The purpose of this study was to invest...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0000000000001390
更新日期:2019-12-01 00:00:00
abstract:PURPOSE:To compare the results of Ahmed glaucoma valve (AGV) implantation in eyes containing silicone oil to those without silicone oil. METHODS:This was a multicenter, retrospective, comparative study of 94 eyes in 94 patients with mean follow-up of 2 years, comparing surgical outcomes in eyes with silicone oil (N=47...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0b013e318182ede3
更新日期:2009-04-01 00:00:00
abstract:PURPOSE:To evaluate the relationship between time-domain and spectral domain-scanning laser ophthalmoscopy/optical coherence tomography (SD-SLO/OCT), and to compare the ability of these methods to detect glaucoma. METHODS:Forty-nine glaucoma and 43 healthy participants were imaged by SD-SLO/OCT and Stratus OCT. Bland-...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0b013e3181d1d332
更新日期:2011-01-01 00:00:00
abstract:PURPOSE:The goal of this study was to identify the early postoperative intraocular pressure (IOP) that predicts low pressure control after a trabeculectomy with mitomycin C. MATERIALS AND METHODS:This study retrospectively analyzed the medical records of the initial trabeculectomy with mitomycin C in patients with pri...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0b013e318285fd7d
更新日期:2014-08-01 00:00:00
abstract:PURPOSE:To determine the outcomes of inferonasal Baerveldt glaucoma implant (BGI) surgery. PATIENTS AND METHODS:A retrospective, non-comparative case series of 182 eyes of 182 patients who underwent inferonasal placement of a Baerveldt glaucoma implant. The main outcome measures included intraocular pressure, number o...
journal_title:Journal of glaucoma
pub_type: 杂志文章,多中心研究
doi:10.1097/01.ijg.0000195597.30600.27
更新日期:2006-02-01 00:00:00
abstract:PURPOSE:Microvasculature dropout (MvD) is a novel finding seen in optical coherence tomography angiography (OCTA), which is characterized by a localized dehiscence of the choriocapillaris in the parapapillary atrophy area. Disc hemorrhage (DH) is an important factor often associated with the development and especially ...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0000000000001688
更新日期:2021-01-01 00:00:00
abstract:PURPOSE:To evaluate three new approaches for staging severity of glaucomatous visual field defects using frequency doubling technology. PATIENTS AND METHODS:One hundred and four patients with either ocular hypertension or chronic glaucoma were tested with both standard automated perimetry (SAP, 30-2 Humphrey threshold...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/00061198-200310000-00004
更新日期:2003-10-01 00:00:00
abstract:PURPOSE:To determine the clinical features of optic disc progression in patients with ocular hypertension and early glaucoma. PATIENTS:A total of 336 eyes of 168 patients with ocular hypertension or early glaucoma. METHODS:Two glaucoma specialists independently graded the baseline and most recent optic disc photograp...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0b013e31824c9251
更新日期:2013-06-01 00:00:00
abstract:PURPOSE:To measure the serum bile acids (SBA) in patients with primary open-angle glaucoma (POAG) and to compare with nonglaucomatous controls. PATIENTS AND METHODS:A hospital-based case control study of 90 patients above the age of 40 years was conducted. Patients with POAG formed the study group and individuals with...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0000000000000993
更新日期:2018-08-01 00:00:00
abstract::Many of these techniques have been adapted to investigate hemodynamic alterations, not only in glaucoma, but in diverse disorders such as diabetic retinopathy, macular degeneration, retinal dystrophies, and nonglaucomatous optic neuropathies. However, each of these techniques has limitations and there is not a single ...
journal_title:Journal of glaucoma
pub_type: 杂志文章,评审
doi:10.1097/00061198-200110001-00022
更新日期:2001-10-01 00:00:00
abstract:PURPOSE:Recent studies have found nocturnal reductions in systemic arterial blood pressure associated with progressive visual field loss in glaucoma. Although ocular ischemia has been hypothesized to link these two phenomena, it remains unknown if perfusion of the eye is reduced during the night in patients with glauco...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:
更新日期:1997-06-01 00:00:00
abstract:PURPOSE:We assessed vision-related quality of life (VR-QOL) in glaucoma patients and examined the relationship between VR-QOL and indices of visual function and subjective symptoms. PATIENTS AND METHODS:Four hundred seventy-two glaucoma patients completed a questionnaire concerning VR-QOL and subjective symptoms of gl...
journal_title:Journal of glaucoma
pub_type: 杂志文章,多中心研究
doi:10.1097/IJG.0000000000000221
更新日期:2016-03-01 00:00:00
abstract:PURPOSE:The aim of this study was to investigate the changes in longitudinal retinal nerve fiber layer thickness (RNFLT) as determined by spectral-domain optical coherence tomography (OCT) after optic disc hemorrhage (DH) in glaucomatous eyes. METHODS:A total of 65 eyes with unilateral DH and 65 contralateral eyes wit...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0000000000000083
更新日期:2014-10-01 00:00:00
abstract:PURPOSE:To study the additive effect of latanoprost 0.005% in patients who have uncontrolled intraocular pressure (IOP) using timolol 0.5% and dorzolamide 2%. METHODS:Fifty-two consecutive patients with open-angle glaucoma who were using timolol and dorzolamide and were considered to have IOP above their defined targe...
journal_title:Journal of glaucoma
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00061198-200004000-00010
更新日期:2000-04-01 00:00:00
abstract:PURPOSE:To evaluate the effectiveness of using a noncontact tonometer (NCT) versus a rebound tonometer (ICare) when measuring the intraocular pressure (IOP) in healthy children. DESIGN:Prospective observational study. METHODS:A total of 180 (96 males and 84 females) healthy children, aged 6 months to 15 years, were r...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0b013e3181d12dc4
更新日期:2011-01-01 00:00:00
abstract:PURPOSE:To evaluate the diagnostic ability of macular parameters and peripapillary retinal nerve fiber layer (RNFL) parameters for early glaucoma using spectral domain optical coherence tomography (SD-OCT). MATERIALS AND METHODS:One eye from 32 early glaucoma patients (including preperimetric glaucoma) and 32 normal p...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0b013e3181e079ed
更新日期:2011-04-01 00:00:00
abstract:PURPOSE:The author studied the effects of pupillary dilation on perimetry in a group of glaucomatous patients receiving timolol therapy. PATIENTS AND METHODS:A prospective study compared the visual fields of 23 patients with primary open-angle glaucoma of varying severity (mean defect: 3.84; short-term fluctuation: 1....
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:
更新日期:1997-08-01 00:00:00
abstract:PURPOSE:To examine intra- and interrater agreement when analyzing cumulative defect curves. Cumulative defect (Bebié) curves provide a graphical representation of the visual field and allow a subjective classification of diffuse and localized loss. METHODS:We used 75 Humphrey 30-2 visual field tests, randomly chosen f...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:
更新日期:1997-04-01 00:00:00
abstract:PRECIS:Chinese Glaucoma Study Consortium (CGSC) as the first nationwide glaucoma registry in China, we describe its design, rationale, the geographic distribution of the hospitals, and baseline patient characteristics. AIM:As a leading cause of blindness in China, glaucoma affects 2% to 4% of adults over the age of 40...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0000000000001378
更新日期:2019-11-01 00:00:00
abstract:OBJECTIVE:To describe reoperations in the operating room for complications encountered within 90 days after glaucoma surgery at a single institution over a 2-year period. DESIGN:Retrospective case series. SUBJECTS:Adult patients who have undergone glaucoma surgery including a tube shunt, trabeculectomy with mitomycin...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0000000000001484
更新日期:2020-05-01 00:00:00
abstract:PURPOSE:To report a simple technique for removal of malpositioned Ex-PRESS miniature glaucoma filtration device. PATIENT AND METHODS:A patient who underwent removal of a malpositioned Ex-PRESS shunt from the right eye with wound revision. RESULTS:Description of step-by-step technique for removal of the Ex-PRESS shunt...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0b013e31827b1540
更新日期:2014-09-01 00:00:00
abstract:PRECIS:Citicoline eyedrops in patients with progressing glaucoma. PURPOSE:This study aimed to test whether the additional therapy with citicoline eyedrops to intraocular pressure (IOP)-lowering treatment could slow glaucoma progression in patients with worsening of damage and IOP 18 mm Hg or less. DESIGN:This was a r...
journal_title:Journal of glaucoma
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1097/IJG.0000000000001565
更新日期:2020-07-01 00:00:00
abstract:PURPOSE:Impairment of the blood-aqueous barrier in unoperated eyes with pseudoexfoliation syndrome has been demonstrated by fluorescein angiography, fluorophotometry, measurement of aqueous flare, and determination of aqueous protein. We performed noninvasive quantification of aqueous flare using the laser flare-cell m...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:
更新日期:1999-02-01 00:00:00
abstract:PRCIS:Use of toric intraocular lenses is a reasonable option for better visual outcomes when a combined minimally invasive glaucoma surgery (MIGS) and cataract surgery is performed in eyes with corneal astigmatism. PURPOSE:To assess the efficacy of toric intraocular lenses (IOLs) in combined cataract and MIGS, visual ...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0000000000001705
更新日期:2021-01-01 00:00:00
abstract:PURPOSE:To evaluate the neuroprotective effect of rasagiline (N-propargyl-1 (R)-aminoindan), a selective monoamine oxidase inhibitor, on the survival of retinal ganglion cells (RGCs) in glaucomatous rat eyes. Rasagiline is an FDA approved anti-Parkinson disease drug with neuroprotective capabilities that were shown in ...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0b013e3181e3d101
更新日期:2011-06-01 00:00:00
abstract:PURPOSE:To investigate the efficacy and safety of a treatment strategy with latanoprost and dorzolamide in primary pediatric glaucoma patients partially responsive to surgery. PATIENTS AND METHODS:Children with primary pediatric glaucoma having postsurgical untreated intraocular pressure (IOP) between 22 and 26 mm Hg ...
journal_title:Journal of glaucoma
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1097/IJG.0000000000000773
更新日期:2017-11-01 00:00:00
abstract:PURPOSE:To evaluate aqueous levels of vascular endothelial growth factor (VEGF) and endothelin-1 (ET-1) in patients with branch retinal vein occlusion (BRVO) with and without normal tension glaucoma (NTG), and to assess the therapeutic efficacy of intravitreal bevacizumab (IVB) in these patients. METHODS:Sixteen eyes ...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0b013e3182312047
更新日期:2013-02-01 00:00:00