Abstract:
PURPOSE:To determine the clinical features of optic disc progression in patients with ocular hypertension and early glaucoma. PATIENTS:A total of 336 eyes of 168 patients with ocular hypertension or early glaucoma. METHODS:Two glaucoma specialists independently graded the baseline and most recent optic disc photographs for optic disc progression. Optic disc progression was defined as: new or increased neuroretinal rim thinning (2 or more clock hours), notching (1 clock hour or less of thinning of the neuroretinal rim), excavation (undermining of the neuroretinal rim or disc margin), and nerve fiber layer defect(s). They also determined the location of these changes. RESULTS:Ninety-two of 336 eyes (27.4%) showed optic disc progression after a median of 6.1 years. Of those with progression, excavation occurred in 89% of eyes; rim thinning occurring in 54%; and notching occurring in 16%. Fifty-six percent (56%) had 2 or more features of progression. The inferotemporal quadrant was the most common location for progression, but more than 1 location of progression occurred in at least 30% of eyes with progression. CONCLUSIONS:Optic disc progression occurred frequently in this cohort of ocular hypertension and early glaucoma patients. When evaluating the optic disc for glaucomatous progression, eye care providers should pay particular attention to increased excavation and neuroretinal rim thinning-especially in the inferotemporal quadrant.
journal_name
J Glaucomajournal_title
Journal of glaucomaauthors
Lloyd MJ,Mansberger SL,Fortune BA,Nguyen H,Torres R,Demirel S,Gardiner SK,Johnson CA,Cioffi GAdoi
10.1097/IJG.0b013e31824c9251subject
Has Abstractpub_date
2013-06-01 00:00:00pages
343-8issue
5eissn
1057-0829issn
1536-481Xpii
00061198-201306000-00001journal_volume
22pub_type
杂志文章abstract:PURPOSE:To report the efficacy and safety of Ahmed glaucoma valve (AGV) insertion into the ciliary sulcus in pseudophakic/aphakic patients. PATIENTS AND METHODS:A chart review was done on patients with uncontrolled glaucoma, who underwent AGV implantation with tube inserted into the ciliary sulcus. Baseline intraocula...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0b013e318265bc0b
更新日期:2014-02-01 00:00:00
abstract:PURPOSE:To investigate the efficacy and safety of a treatment strategy with latanoprost and dorzolamide in primary pediatric glaucoma patients partially responsive to surgery. PATIENTS AND METHODS:Children with primary pediatric glaucoma having postsurgical untreated intraocular pressure (IOP) between 22 and 26 mm Hg ...
journal_title:Journal of glaucoma
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1097/IJG.0000000000000773
更新日期:2017-11-01 00:00:00
abstract:PURPOSE:To estimate resource use and costs associated with the diagnosis and treatment of glaucoma and ocular hypertension in the Netherlands in 1996 and to determine how costs differed between patients, diagnoses, and hospitals. PATIENTS AND METHODS:Patient characteristics and glaucoma-related resource use were colle...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/00061198-200106000-00007
更新日期:2001-06-01 00:00:00
abstract:PURPOSE:To evaluate the local variability of anterior chamber angle (ACA) metrics obtained by time domain (TD) and spectral domain (SD) optical coherence tomography (OCT). MATERIALS AND METHODS:Anterior-segment OCT imaging was performed on 30 normal eyes using Visante TD-OCT and 40 normal eyes using Cirrus SD-OCT. For...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0000000000000169
更新日期:2016-01-01 00:00:00
abstract::Many of these techniques have been adapted to investigate hemodynamic alterations, not only in glaucoma, but in diverse disorders such as diabetic retinopathy, macular degeneration, retinal dystrophies, and nonglaucomatous optic neuropathies. However, each of these techniques has limitations and there is not a single ...
journal_title:Journal of glaucoma
pub_type: 杂志文章,评审
doi:10.1097/00061198-200110001-00022
更新日期:2001-10-01 00:00:00
abstract::We report 2 bilateral cases that presented as primary ocular hypertension and primary angle-closure glaucoma, respectively; however, they were subsequently discovered to be harboring secretory pituitary tumors. After transsphenoidal tumor resection, intraocular pressures (IOPs) in all 4 eyes returned to normal levels....
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0b013e31829521f2
更新日期:2015-03-01 00:00:00
abstract:PURPOSE:To evaluate the relationship between time-domain and spectral domain-scanning laser ophthalmoscopy/optical coherence tomography (SD-SLO/OCT), and to compare the ability of these methods to detect glaucoma. METHODS:Forty-nine glaucoma and 43 healthy participants were imaged by SD-SLO/OCT and Stratus OCT. Bland-...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0b013e3181d1d332
更新日期:2011-01-01 00:00:00
abstract:PURPOSE:To investigate the effects of dehydration and fasting on retrobulbar-vessel blood velocity in healthy subjects. METHODS:Twenty-eight eyes of 28 normal subjects without ocular disease were enrolled in this study. Each subject had a baseline color-Doppler imaging ultrasound of the central retinal artery, tempora...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/00061198-200210000-00007
更新日期:2002-10-01 00:00:00
abstract:PURPOSE:To evaluate the intraocular pressure (IOP) lowering effect of the XEN140 microfistula gel stent implant for the surgical treatment of open-angle glaucoma. PATIENTS AND METHODS:Forty-nine eyes of 49 patients with an IOP>18 mm Hg and ≤35 mm Hg were studied in a prospective nonrandomized multicenter cohort trial ...
journal_title:Journal of glaucoma
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1097/IJG.0000000000000352
更新日期:2016-07-01 00:00:00
abstract:PURPOSE:To compare the rates of retinal nerve fiber layer (RNFL) thickness loss using optical coherence tomography (OCT) in progressing versus nonprogressing eyes using 4 methods to define functional progression. METHODS:Normal and glaucomatous eyes with ≥3 years of follow up were prospectively enrolled. Standard auto...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0b013e3182071cc7
更新日期:2012-04-01 00:00:00
abstract:INTRODUCTION:Glaucoma in patients with nonbullous congenital ichthyosiform erythroderma (NBCIE) is a rare entity that has not been described in a histologically confirmed case. We present a unique case of coexisting glaucoma, ichthyosis, and dwarfism that has not been previously described. METHODS:We present a case of...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0000000000001016
更新日期:2018-11-01 00:00:00
abstract:PURPOSE:Traditionally, during trabeculectomy, Mitomycin-C (MMC) is applied to the tissues using surgical sponges. However, alternate modes of application exist. This study assessed the success rates, complication rates, final intraocular pressure (IOP), and bleb characteristics between patients receiving subtenon MMC a...
journal_title:Journal of glaucoma
pub_type: 杂志文章,随机对照试验
doi:10.1097/IJG.0000000000000830
更新日期:2018-02-01 00:00:00
abstract:PURPOSE:Our purpose was to investigate the effects of the calcium channel blocker verapamil on intraocular pressure and blood circulation in the human optic nerve head. METHODS:The effects of three different concentrations of topical verapamil (0.063%, 0.125%, and 0.25%) on intraocular pressure and optic nerve head ca...
journal_title:Journal of glaucoma
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:1996-06-01 00:00:00
abstract:PRECIS:Citicoline eyedrops in patients with progressing glaucoma. PURPOSE:This study aimed to test whether the additional therapy with citicoline eyedrops to intraocular pressure (IOP)-lowering treatment could slow glaucoma progression in patients with worsening of damage and IOP 18 mm Hg or less. DESIGN:This was a r...
journal_title:Journal of glaucoma
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1097/IJG.0000000000001565
更新日期:2020-07-01 00:00:00
abstract:OBJECTIVES:This study was conducted to evaluate the effect of long-term intraocular pressure reduction with timolol on the incidence of glaucomatous visual field defects and optic nerve cupping in individuals with ocular hypertension and to compare this incidence with that of a similar group on no treatment. ...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:
更新日期:1993-01-01 00:00:00
abstract:STUDY OBJECTIVES:The association between obstructive sleep apnea syndrome (OSAS) and retinal nerve fiber layer (RNFL) thickness has been examined in many studies. However, the findings are inconsistent. Our goal is to evaluate the association between OSAS and RNFL thickness by performing a meta-analysis. METHODS:We co...
journal_title:Journal of glaucoma
pub_type: 杂志文章,meta分析
doi:10.1097/IJG.0000000000000349
更新日期:2016-04-01 00:00:00
abstract:PURPOSE:To compare the effect of unoprostone isopropyl 0.12% to that of timolol maleate 0.5% solution given twice daily on the diurnal curve of intraocular pressure (IOP) in patients with primary open-angle glaucoma or ocular hypertension. METHODS:In this investigator-masked, single-center, parallel-group comparison, ...
journal_title:Journal of glaucoma
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:1998-12-01 00:00:00
abstract:PURPOSE:The measurement of intraocular pressure (IOP) by Goldmann applanation tonometry (GAT) is based on assumptions about corneal parameters. To correct for variations in corneal curvature and thickness, a number of equations have been proposed. This study evaluates the in vivo accuracy of these equations from indivi...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0000000000000588
更新日期:2017-03-01 00:00:00
abstract:PURPOSE OF THE STUDY:The purpose of the study was to evaluate the clinical efficacy of swept-source optical coherence tomography (SS-OCT), we compared the intradevice repeatability of thickness measurements obtained using SS-OCT to that of measurements obtained using spectral domain OCT (SD-OCT), and assessed the inter...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0000000000000536
更新日期:2017-02-01 00:00:00
abstract:PURPOSE:The purpose of this study is to determinate the long-term effect of a cycle ergometer sprint training program against heavy and light resistances on baseline intraocular pressure (IOP), and on the acute IOP response to cycling sprints. METHODS:A total 27 physically active males were randomly assigned to a heav...
journal_title:Journal of glaucoma
pub_type: 杂志文章,随机对照试验
doi:10.1097/IJG.0000000000000893
更新日期:2018-04-01 00:00:00
abstract:PURPOSE:To report the safety and the effectiveness of deep sclerectomy (DS) with a new nonabsorbable uveoscleral hema implant (Esnoper-Clip) designed to increase trabecular and uveoscleral outflow and to achieve higher intrascleral blebs. MATERIALS AND METHODS:Twenty-seven eyes of 27 patients with open-angle glaucoma,...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0000000000000253
更新日期:2015-08-01 00:00:00
abstract::We herein report 2 eyes with significant loss of vision after glaucoma filtering surgery that was accompanied by progressive macular thinning detected on macular optical coherence tomography imaging. The findings provide evidence that progressive retinal ganglion cell loss is one of the causes of visual loss after unc...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0000000000001202
更新日期:2019-06-01 00:00:00
abstract:PURPOSE:To report the histopathologic and immunohistochemical findings from the iridectomy specimen of a patient with acquired unilateral iris heterochromia due to latanoprost. PATIENT AND METHODS:A 45-year-old woman with open-angle glaucoma and unilateral iris heterochromia was evaluated for uncontrolled intraocular ...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/00061198-200110000-00009
更新日期:2001-10-01 00:00:00
abstract:PURPOSE:To examine the reproducibility of the new digital Goldmann applanation tonometer AT 900D (DGT) for measuring intraocular pressure and to compare its readings with those provided by the conventional analog Goldmann tonometer (AGT). METHODS:In 3 different sessions (S1, S2, and S3), 3 intraocular pressure measure...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0b013e31820bd1e9
更新日期:2012-03-01 00:00:00
abstract:PRECIS:As the only microinvasive glaucoma surgery (MIGS) with a reusable component, the cost per procedure of endoscopic cyclophotocoagulation (ECP) diminishes with each successive use. We present a cost comparison of ECP with other MIGS devices, based on our clinical practice. PURPOSE:ECP delivers diode laser via a r...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0000000000001245
更新日期:2019-06-01 00:00:00
abstract:PRECIS:In a cohort study of 120,307 participants with 25+ years of follow-up, a history of nonmelanoma skin cancer (NMSC) was associated with a 40% higher exfoliation glaucoma (XFG) risk. PURPOSE:The purpose of this study was to evaluate the relationship between NMSC (a marker of ultraviolet radiation exposure) and XF...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0000000000001496
更新日期:2020-06-01 00:00:00
abstract:PRECIS:The VisuALL head-mounted perimetry in normal subjects and glaucoma patients had a moderate to strong correlation with the Humphrey Field Analyzer (HFA). PURPOSE:Visual field testing has a vital role in diagnosing and managing glaucoma. The current clinical practice relies on large, table-based testing units. Th...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0000000000001670
更新日期:2021-01-01 00:00:00
abstract::A 78-year-old man with angle closure glaucoma and on treatment with oral anticoagulants, underwent phacoemulsification. An early acute suprachoroidal hemorrhage (SCH) occurred and the surgical wound was rapidly sutured without complete soft lens matter removal, nor insertion of intraocular lens. The SCH was managed co...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0000000000001170
更新日期:2019-05-01 00:00:00
abstract:PURPOSE:To determine the within-trial and between-trial repeatability of pattern electroretinogram (PERG) measurements in healthy and patient eyes, using a new clinical instrument, the PERGLA. STUDY DESIGN:In all, 70 eyes of 35 healthy individuals (intraocular pressure <22 mm Hg, healthy optic disc by stereophotograph...
journal_title:Journal of glaucoma
pub_type: 临床试验,杂志文章
doi:10.1097/IJG.0b013e31818c6f44
更新日期:2009-08-01 00:00:00
abstract:PURPOSE:To determine the impact of 8 multicenter randomized clinical trials (RCTs) on glaucoma practice. METHODS:An electronic survey was distributed to the members of the American Glaucoma Society (AGS). Each participant was asked 2 study-specific questions and 1 standard question common to all 8 RCTs assessing the s...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0b013e318295200b
更新日期:2015-01-01 00:00:00