Abstract：
:The in vivo response to laser trabeculoplasty (LTP) was evaluated by measuring the incorporation of thymidine into DNA in the nuclei of trabecular meshwork cells. incorporation into DNA was analyzed by light microscopic autoradiography and by scintillation counting of trabecular extracts. Sixteen cats received argon LTP at a power setting of either 0.3 or 1.0 watt with the contralateral eye serving as a control; a 48-h exposure to HT began 1, 5, or 12 days later. The level of HT incorporation into DNA for LTP-treated eyes was significantly higher than controls for the earliest labeling period, but not at the later time points. This pattern was observed for both 0.3-and 1.0-watt treatments. In a second experiment, LTP was performed on six animals; a power setting of 0.3 watt was used in the left eye, and a power setting of 1 watt was used in the right eye. All 12 eyes were radiolabeled for 48 h with HT beginning 1 day after LTP. A small but significant difference in incorporation levels was found between these two power settings. Trabecular cell division may play a role in the therapeutic efficacy of LTP in glaucoma patients.
journal_name
J Glaucomajournal_title
Journal of glaucomaauthors
Bylsma SS,Samples JR,Acott TS,Pirouzkar B,Van Buskirk EMsubject
Has Abstractpub_date
1994-04-01 00:00:00pages
36-43issue
1eissn
1057-0829issn
1536-481Xpii
00061198-199400310-00008journal_volume
3pub_type
杂志文章abstract：PRECIS:Surgeons that perform cataract surgery combined with endocyclophotocoagulation should rely on their preferred IOL calculation formula. There is no need to perform any correction to the IOL power, as this procedure does not modify the refractive outcome. PURPOSE:To compare postoperative refractive outcomes in pa...
journal_title：Journal of glaucoma
pub_type： 杂志文章
doi：10.1097/IJG.0000000000001777
更新日期：2020-12-29 00:00:00
abstract：PURPOSE:To evaluate the effect of a single treatment of contact diode laser transscleral cyclophotocoagulation (TSCP) on intraocular pressure (IOP) in patients with refractory glaucoma and perform a historical meta-analysis of the relationship between successful IOP control and various laser parameters. METHODS:Clinic...
journal_title：Journal of glaucoma
pub_type： 杂志文章,meta分析
doi：10.1097/00061198-200208000-00009
更新日期：2002-08-01 00:00:00
abstract：PURPOSE:The aim of this study was to quantitatively study the retinal nerve fiber layer (RNFL) thickness in children born prematurely with isolated optic nerve cupping. PATIENTS AND METHODS:Six otherwise healthy premature children with clinical evidence of increased cup to disc ratios were enrolled in this observation...
journal_title：Journal of glaucoma
pub_type： 杂志文章
doi：10.1097/IJG.0000000000000006
更新日期：2014-01-01 00:00:00
abstract：OBJECTIVE:The objective of this article was to study longitudinal changes in bleb morphology (presence of microcysts and bleb height and vascularity) in subjects enrolled in the Singapore 5-Fluorouracil (5-FU) trabeculectomy study. STUDY DESIGN:Retrospective subgroup analysis of a randomized controlled trial. MATERIA...
journal_title：Journal of glaucoma
pub_type： 杂志文章,随机对照试验
doi：10.1097/IJG.0000000000000967
更新日期：2018-07-01 00:00:00
abstract：:The most effective way to control glaucoma is by lowering intraocular pressure (IOP) in order to prevent the progression of the disease. Glaucoma drainage devices (GDDs) are surgical option reserved for refractory cases and have been designed to address known complications of conventional filtering surgery. They are, ...
journal_title：Journal of glaucoma
pub_type： 杂志文章
doi：10.1097/IJG.0000000000001417
更新日期：2020-02-01 00:00:00
abstract：INTRODUCTION:Corneal integrity has long been a preoccupation of glaucoma surgeons considering glaucoma drainage device surgery or antimetabolite-enhanced trabeculectomy. Despite having demonstrated a good safety profile and significant intraocular pressure-lowering capacities, the impact of XEN gel stents on endothelia...
journal_title：Journal of glaucoma
pub_type： 杂志文章
doi：10.1097/IJG.0000000000001430
更新日期：2020-03-01 00:00:00
abstract：OBJECTIVE:To describe reoperations in the operating room for complications encountered within 90 days after glaucoma surgery at a single institution over a 2-year period. DESIGN:Retrospective case series. SUBJECTS:Adult patients who have undergone glaucoma surgery including a tube shunt, trabeculectomy with mitomycin...
journal_title：Journal of glaucoma
pub_type： 杂志文章
doi：10.1097/IJG.0000000000001484
更新日期：2020-05-01 00:00:00
abstract：PURPOSE:To compare the effect of unoprostone isopropyl 0.12% to that of timolol maleate 0.5% solution given twice daily on the diurnal curve of intraocular pressure (IOP) in patients with primary open-angle glaucoma or ocular hypertension. METHODS:In this investigator-masked, single-center, parallel-group comparison, ...
journal_title：Journal of glaucoma
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：1998-12-01 00:00:00
abstract：PURPOSE:To identify and characterize 'reversal' of optic nerve cupping following intraocular pressure (IOP) lowering in scanning laser tomography (SLT) longitudinal image series. METHODS:Modification was made to a previously described analytical approach to longitudinally study putatively increased rim area following ...
journal_title：Journal of glaucoma
pub_type： 杂志文章
doi：10.1097/01.ijg.0000133151.82804.e3
更新日期：2004-10-01 00:00:00
abstract：:While working with a large data set of Goldmann applanation tonometry (GAT) intraocular pressure (IOP) measurements for a separate investigation, we observed that the IOP distribution favored even-numbered values. Study of this phenomenon has been limited, and this larger data set enabled inquiry that showed new insig...
journal_title：Journal of glaucoma
pub_type： 杂志文章
doi：10.1097/IJG.0000000000001412
更新日期：2020-02-01 00:00:00
abstract：PURPOSE:To evaluate the usefulness of the spectral-domain optical coherence tomography (SD OCT)-determined ganglion cell complex thickness to total retinal thickness ratio (G/T ratio) in diagnosing glaucoma. METHODS:A total of 99 eyes with primary open-angle glaucoma and 35 normal eyes were enrolled in the study. SD O...
journal_title：Journal of glaucoma
pub_type： 杂志文章
doi：10.1097/IJG.0b013e31825af58a
更新日期：2013-12-01 00:00:00
abstract：:We present a case of conjunctival melting over the tube of a glaucoma shunt, which was successfully repaired with amniotic membrane transplantation. ...
journal_title：Journal of glaucoma
pub_type： 杂志文章
doi：10.1097/01.ijg.0000212292.93292.80
更新日期：2007-01-01 00:00:00
abstract：PURPOSE:The pattern of the distribution of nerve fiber layer (NFL) thickness values across the retina may provide an early anatomic indication of glaucomatous disruption. We developed a method of analyzing polarimetry measurements that emphasizes the shape of the pattern of NFL thickness values. Sensitivity and specifi...
journal_title：Journal of glaucoma
pub_type： 杂志文章
doi：10.1097/00061198-200012000-00005
更新日期：2000-12-01 00:00:00
abstract：PURPOSE:To compare the correlation of the fellow-eye's intraocular pressure (IOP) response in one-eye trials performed separately for each eye with that of bilateral treatment in normal subjects. METHODS:A one-eye trial with topical latanoprost applied once daily for 7 days was carried out in the right eye and then in...
journal_title：Journal of glaucoma
pub_type： 杂志文章
doi：10.1097/IJG.0b013e318157a16d
更新日期：2008-04-01 00:00:00
abstract：:We report 2 bilateral cases that presented as primary ocular hypertension and primary angle-closure glaucoma, respectively; however, they were subsequently discovered to be harboring secretory pituitary tumors. After transsphenoidal tumor resection, intraocular pressures (IOPs) in all 4 eyes returned to normal levels....
journal_title：Journal of glaucoma
pub_type： 杂志文章
doi：10.1097/IJG.0b013e31829521f2
更新日期：2015-03-01 00:00:00
abstract：PURPOSE:To investigate changes in scanning laser polarimetry with variable corneal compensation (GDx-VCC) parameters caused by posterior capsular opacification (PCO). METHODS:In this comparative case-control series, 20 eyes due to undergo YAG laser capsulotomy for PCO were recruited. GDx-VCC was performed before and a...
journal_title：Journal of glaucoma
pub_type： 杂志文章
doi：10.1097/01.ijg.0000243469.05719.0d
更新日期：2007-01-01 00:00:00
abstract：PURPOSE:To determine if there is a difference in response of the adrenal gland to intramuscular adrenocorticotropic hormone (ACTH) between normals and ocular hypertensives (OHs) plus primary open-angle glaucomas (POAGs) without pigmented angles. METHODS:Intramuscular ACTH was given to 29 normals and 24 OH plus POAG ho...
journal_title：Journal of glaucoma
pub_type： 杂志文章
doi：10.1097/IJG.0b013e3180334ff6
更新日期：2007-05-01 00:00:00
abstract：:PRéCIS:: Four parameters of the noninvasive, portable RETeval electroretinogram (ERG) system were found to correlate with visual field mean deviation and optical coherence tomography (OCT) thickness parameters, and may therefore be suitable for glaucoma detection. PURPOSE:To investigate the RETeval full-field ERG par...
journal_title：Journal of glaucoma
pub_type： 杂志文章
doi：10.1097/IJG.0000000000001509
更新日期：2020-07-01 00:00:00
abstract：PURPOSE:To investigate the effect of nepafenac on intraocular pressure (IOP) in primary open-angle glaucoma (POAG) patients treated with prostaglandin (PG) analogs. MATERIALS AND METHODS:This prospective clinical study included 35 patients who had been receiving latanoprost (n=12), travoprost (n=12), or bimatoprost (n...
journal_title：Journal of glaucoma
pub_type： 杂志文章
doi：10.1097/IJG.0000000000000204
更新日期：2016-03-01 00:00:00
abstract：PURPOSE:To determine the clinical features and anatomic parameters in asymptomatic (creeping) and symptomatic, chronic, primary angle-closure glaucoma (PACG) as compared with open-angle glaucoma (OAG) and with control subjects with normal eyes. METHODS:Forty consecutive patients with each of the following four types o...
journal_title：Journal of glaucoma
pub_type： 杂志文章
doi：10.1097/00061198-200006000-00002
更新日期：2000-06-01 00:00:00
abstract：PURPOSE:To investigate the relationship between the peripapillary retinal nerve fiber layer (RNFL) thickness, as measured by Stratus time domain optical coherence tomography (OCT) (Stratus OCT) and Cirrus spectral domain OCT (Cirrus HD-OCT), and the severity indices of the visual field (VF) defects in glaucoma patients...
journal_title：Journal of glaucoma
pub_type： 杂志文章
doi：10.1097/IJG.0b013e3181efb371
更新日期：2011-08-01 00:00:00
abstract：PURPOSE:This study determined the rate of response to latanoprost compared with timolol in patients with glaucoma or ocular hypertension, whether some patients convert from non-responders to responders after more prolonged therapy, and whether this conversion represents a delayed response or random fluctuation. METHOD...
journal_title：Journal of glaucoma
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1097/00061198-200312000-00004
更新日期：2003-12-01 00:00:00
abstract：SUMMARY:Subconjunctival fibrosis is one of the major causes of most bleb failures. To inhibit the wound-healing process and to achieve a better intraocular pressure (IOP) lowering effect as well as bleb formation, we performed a sclerostomy using a THC:YAG laser (thulium, holmium, and chromium-doped yttrium-aluminum-ga...
journal_title：Journal of glaucoma
pub_type： 杂志文章
doi：
更新日期：1993-01-01 00:00:00
abstract：PURPOSE:To evaluate the intraocular pressure (IOP) lowering effect of the XEN140 microfistula gel stent implant for the surgical treatment of open-angle glaucoma. PATIENTS AND METHODS:Forty-nine eyes of 49 patients with an IOP>18 mm Hg and ≤35 mm Hg were studied in a prospective nonrandomized multicenter cohort trial ...
journal_title：Journal of glaucoma
pub_type： 临床试验,杂志文章,多中心研究
doi：10.1097/IJG.0000000000000352
更新日期：2016-07-01 00:00:00
abstract：PURPOSE:To evaluate tonometric outcomes of patients with primary angle closure glaucoma (PACG) who have undergone trabeculectomy with mitomycin C (MMC) with and without concurrent phacoemulsification and to identify risk factors for postoperative failure. PATIENTS AND METHODS:Retrospective cohort study of 44 eyes of 3...
journal_title：Journal of glaucoma
pub_type： 杂志文章
doi：10.1097/IJG.0000000000000493
更新日期：2016-09-01 00:00:00
abstract：OBJECTIVES:This study was conducted to evaluate the effect of long-term intraocular pressure reduction with timolol on the incidence of glaucomatous visual field defects and optic nerve cupping in individuals with ocular hypertension and to compare this incidence with that of a similar group on no treatment. ...
journal_title：Journal of glaucoma
pub_type： 杂志文章
doi：
更新日期：1993-01-01 00:00:00
abstract：PURPOSE:To determine if treatment with prostaglandin (PG) analogues affects keratocyte density as an indirect measure of extracellular matrix in the corneal stroma. PATIENTS AND METHODS:In this case control study, 129 eyes from 68 patients were examined: 52 eyes had only PG analogue therapy for at least 3 years, 37 ey...
journal_title：Journal of glaucoma
pub_type： 杂志文章
doi：10.1097/IJG.0b013e3181ca7c7a
更新日期：2010-12-01 00:00:00
abstract：:The multifunctional protein clusterin (CLU) is a secreted glycoprotein ubiquitously expressed throughout the body, including in the eye. Its primary function is to act as an extracellular molecular chaperone, preventing the precipitation and aggregation of misfolded extracellular proteins. Clusterin is commonly identi...
journal_title：Journal of glaucoma
pub_type： 杂志文章,评审
doi：10.1097/IJG.0000000000000916
更新日期：2018-07-01 00:00:00
abstract：PURPOSE:Axenfeld-Rieger syndrome is a genetically heterogeneous, autosomal dominant disorder that is characterized by anterior segment defects, glaucoma, and extraocular anomalies. This study examined the two genes known to cause Rieger syndrome, PITX2 and FOXC1, for mutations in five Brazilian families with Axenfeld-R...
journal_title：Journal of glaucoma
pub_type： 杂志文章
doi：10.1097/00061198-200202000-00010
更新日期：2002-02-01 00:00:00
abstract：PURPOSE:To measure the serum bile acids (SBA) in patients with primary open-angle glaucoma (POAG) and to compare with nonglaucomatous controls. PATIENTS AND METHODS:A hospital-based case control study of 90 patients above the age of 40 years was conducted. Patients with POAG formed the study group and individuals with...
journal_title：Journal of glaucoma
pub_type： 杂志文章
doi：10.1097/IJG.0000000000000993
更新日期：2018-08-01 00:00:00
