Abstract:
PURPOSE:To compare the correlation of the fellow-eye's intraocular pressure (IOP) response in one-eye trials performed separately for each eye with that of bilateral treatment in normal subjects. METHODS:A one-eye trial with topical latanoprost applied once daily for 7 days was carried out in the right eye and then in the left eye of 41 normal subjects. Bilateral treatment was performed in a different set of 41 normal subjects. IOPs were measured at 3 time points on day 0 and on day 7. RESULTS:Latanoprost significantly reduced IOP of treated eyes in one-eye trials (2.8+/-1.6 and 2.7+/-1.6 mm Hg in the first and second trial, respectively) and in bilateral treatments (2.8+/-1.3 and 2.6+/-1.4 mm Hg in the right and left eye, respectively). Correlation of mean diurnal IOP reduction between 2 one-eye trials was poor (r2=0.102), even after subtracting the nontreated eye IOP fluctuations from the treated eye IOPs (r2=0.097), but that between fellow eyes in bilateral treatment was excellent (r=0.849). Correlation of baseline IOP at each time point between fellow eyes in one-eye trials and bilateral treatment (r2=0.729 to 0.949) was better than that in the same eye between 2 one-eye trials (r2=0.319 to 0.631). CONCLUSIONS:Fellow eyes in normal subjects showed a symmetrical IOP response to short-term bilateral treatment with latanoprost, although they did not respond symmetrically to one-eye trials performed separately for each eye. Poor correlation of IOP changes between 2 one-eye trials may be caused by different IOP responsiveness to latanoprost at each trial, rather than asymmetrical IOP fluctuations.
journal_name
J Glaucomajournal_title
Journal of glaucomaauthors
Takahashi M,Higashide T,Sakurai M,Sugiyama Kdoi
10.1097/IJG.0b013e318157a16dsubject
Has Abstractpub_date
2008-04-01 00:00:00pages
169-74issue
3eissn
1057-0829issn
1536-481Xpii
00061198-200804000-00002journal_volume
17pub_type
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journal_title:Journal of glaucoma
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pub_type: 杂志文章,评审
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更新日期:2013-06-01 00:00:00
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pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2007-06-01 00:00:00
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journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:
更新日期:1997-04-01 00:00:00
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journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0000000000001412
更新日期:2020-02-01 00:00:00
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journal_title:Journal of glaucoma
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pub_type: 杂志文章
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journal_title:Journal of glaucoma
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
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更新日期:2003-08-01 00:00:00
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pub_type: 杂志文章,随机对照试验
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journal_title:Journal of glaucoma
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更新日期:2004-10-01 00:00:00
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更新日期:2000-02-01 00:00:00
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更新日期:2018-11-01 00:00:00