Abstract:
PURPOSE:The purpose of this article was to report the efficacy of intravitreal bevacizumab to resolve secondary angle-closure glaucoma caused by biliary tract carcinoma metastasis to the iris. MATERIALS AND METHODS:A 52-year-old white woman who was under systemic chemotherapy for biliary tract carcinoma presented with a metastatic tumor in the left iris. At presentation, her visual acuity was at the 20/50 level. The tumor was occupying the nasal half of the iris, and had already occupied 5.5 clock hours of the angle, resulting in intraocular pressure elevation to 34 mm Hg. Several small clumps of tumor seeds were also observed on the iris and along the angle. Her intraocular pressure remained high despite full medical therapy with dorzolamide, timolol, brimonidine, and oral acetozolamide. Because of the vascularized nature of the tumor, antivascular endothelial growth factor (anti-VEGF) treatment with 3 repeated injections of bevacizumab (1.25 mg/0.05 mL) was applied 1-month apart. Bevacizumab treatment resulted in an abrupt decrease in tumor mass and disappearance of tumoral seeds from the anterior chamber. The patient's vision improved to 20/20, and intraocular pressure decreased to normal levels. CONCLUSIONS:Anti-VEGF treatment with intravitreal bevacizumab can restore sight and achieve intraocular pressure control in metastatic iris tumors complicated with secondary glaucoma. Anti-VEGF drugs are viable alternatives for the treatment of secondary angle-closure glaucoma induced by metastatic iris tumors and can prevent enucleation of these eyes.
journal_name
J Glaucomajournal_title
Journal of glaucomaauthors
Aydin R,Tezel THdoi
10.1097/IJG.0000000000000959subject
Has Abstractpub_date
2018-06-01 00:00:00pages
e113-e116issue
6eissn
1057-0829issn
1536-481Xjournal_volume
27pub_type
杂志文章abstract:PRCIS:Ahmed glaucoma valve implantation using the upside-down technique resulted in an aqueous humor outflow pathway, occurring primarily on the scleral side and secondarily on the conjunctival side, and was effective in treating refractory glaucoma. PURPOSE:To describe the Ahmed glaucoma valve (AGV) surgical techniqu...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0000000000001791
更新日期:2021-01-13 00:00:00
abstract:AIM:Dietary deficiencies in ω-3 polyunsaturated fatty acids are known to effect retinal function including retinal ganglion cell (RGC) activity, which may have implications for glaucoma. In this study we consider retinal function after dietary manipulation and intraocular pressure (IOP) stress designed to compromise RG...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0b013e318237cac7
更新日期:2013-04-01 00:00:00
abstract:PURPOSE:To determine the level of adherence to the American Academy of Ophthalmology preferred practice pattern (PPP) guidelines for quality primary open-angle glaucoma (POAG) and POAG suspect (POAGS) care among retail-based optometrists. METHODS:Patients with a diagnosis of POAG or POAGS who participated in a telemed...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0000000000001093
更新日期:2018-12-01 00:00:00
abstract:PURPOSE:To describe the appearance of a defect in the parapapillary region of a highly myopic eye. METHODS:During a routine ophthalmologic examination, in a 26-year-old man with a visual acuity of 0.80 and a refractive error of -10.25 D, a dehiscence in the parapapillary region was detected. A choroidal vessel appeare...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/01.ijg.0000438610.31653.48
更新日期:2013-12-01 00:00:00
abstract:PURPOSE:To determine if there is a difference in response of the adrenal gland to intramuscular adrenocorticotropic hormone (ACTH) between normals and ocular hypertensives (OHs) plus primary open-angle glaucomas (POAGs) without pigmented angles. METHODS:Intramuscular ACTH was given to 29 normals and 24 OH plus POAG ho...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0b013e3180334ff6
更新日期:2007-05-01 00:00:00
abstract:PURPOSE:To identify and characterize 'reversal' of optic nerve cupping following intraocular pressure (IOP) lowering in scanning laser tomography (SLT) longitudinal image series. METHODS:Modification was made to a previously described analytical approach to longitudinally study putatively increased rim area following ...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/01.ijg.0000133151.82804.e3
更新日期:2004-10-01 00:00:00
abstract:PRECIS:The association between primary open-angle glaucoma (POAG) and subsequent development of chronic kidney disease (CKD) was investigated using a nationwide, population-based, retrospective cohort in South Korea. POAG increases the risk of subsequent CKD development. PURPOSE:The purpose of this study was to invest...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0000000000001390
更新日期:2019-12-01 00:00:00
abstract:PURPOSE:The aim of this study was to examine the effects of selective laser trabeculoplasty (SLT) treatment on habitual intraocular pressure (IOP) fluctuations in patients with normal-tension glaucoma (NTG) using a SENSIMED Triggerfish contact lens sensor (CLS). MATERIALS AND METHODS:Ten patients diagnosed with NTG we...
journal_title:Journal of glaucoma
pub_type: 临床试验,杂志文章
doi:10.1097/IJG.0000000000000026
更新日期:2014-10-01 00:00:00
abstract:OBJECTIVE:Pachymetry plays a crucial role in the diagnosis and management of glaucoma and corneal diseases. There have been several outbreaks of epidemic ocular infections in ophthalmology clinics worldwide with reports of viral, parasitic, and prion disease. Contact pachymetry is a possible vehicle of transmission due...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0000000000001525
更新日期:2020-08-01 00:00:00
abstract::We report a case of an explanted stainless steel miniature glaucoma drainage device (EX-PRESS) implanted under a scleral flap for pseudoexfoliation open-angle glaucoma surgical treatment. The glaucoma shunt was implanted in a 75-year-old white man with medically refractive glaucoma. Cataract surgery was performed simu...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0000000000000521
更新日期:2017-01-01 00:00:00
abstract:PURPOSE:To evaluate morphological features of filtering blebs after trabeculectomy with limbus-based versus fornix-based conjunctival flaps (LBCF and FBCF, respectively) using in vivo confocal microscopy (IVCM) and ultrasound biomicroscopy (UBM). PATIENTS AND METHODS:Seventy-five eyes of 62 patients with glaucoma were...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0b013e3182120a08
更新日期:2012-08-01 00:00:00
abstract:PURPOSE:The authors identify any diurnal intraocular pressure (IOP) variation in healthy Cayo Santiago macaques, as well as Cayo Santiago macaques with normotensive and hypertensive primary open-angle glaucoma (POAG), to further evaluate their potential value as a model for human POAG. METHODS:Twenty-four monkeys (eig...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:
更新日期:1998-04-01 00:00:00
abstract:PURPOSE:To assess the efficacy and safety of botulinum toxin type A (BoNT-A) injection in patients suffering from intractable periorbital pain after acute angle closure glaucoma (AACG). PATIENTS AND METHODS:In this prospective randomized intervention study, 19 patients suffering from periorbital pain after an AACG att...
journal_title:Journal of glaucoma
pub_type: 杂志文章,随机对照试验
doi:10.1097/IJG.0b013e3181ca76a9
更新日期:2010-10-01 00:00:00
abstract:PURPOSE:To assess how glaucoma patients use their topical medications. METHODS:142 subjects were tested before an examiner as to how they used their eyedrops. RESULTS:Fifty-six patients (39.4%) used one drop. The number of drops instilled increased with age. The tip of the bottle touched the ocular surface in 78 (54....
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:
更新日期:1995-06-01 00:00:00
abstract:PURPOSE:To study resident compliance with the American Academy of Ophthalmology (AAO) Preferred Practice Patterns (PPPs) for primary open-angle glaucoma suspect (POAGS) in a resident ophthalmology clinic. PATIENTS AND METHODS:Two hundred charts were selected for analysis of adult patients with the International Classi...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0000000000000548
更新日期:2016-12-01 00:00:00
abstract:PURPOSE:The purpose of this study is to describe the outcomes of mitomycin C (MMC)-augmented trabeculectomy performed following a failed MMC-augmented XEN-45 implantation. DESIGN:Retrospective case series. METHODS:All consecutive cases of MMC-augmented trabeculectomy performed after MMC-augmented XEN-45 in the Glauco...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0000000000001000
更新日期:2018-10-01 00:00:00
abstract:PURPOSE:The study investigated the applicability of the inferior≥superior≥nasal≥temporal neuroretinal rim thickness (ISNT) rule to rim thickness measured using Cirrus high-definition spectral-domain optical coherence tomography (Cirrus HD-OCT) in healthy eyes and eyes with glaucoma. METHODS:Rim thicknesses of 4 quadra...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0000000000000015
更新日期:2015-09-01 00:00:00
abstract:PURPOSE OF THE STUDY:The purpose of the study was to evaluate the long-term effectiveness and safety profile of Baerveldt glaucoma implant (BGI) in patients with refractory glaucoma operated using a modified technique to avoid postoperative complications. PATIENTS AND METHODS:A total of 160 eyes from 147 glaucomatous ...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0000000000000488
更新日期:2016-12-01 00:00:00
abstract:PRCIS:Use of toric intraocular lenses is a reasonable option for better visual outcomes when a combined minimally invasive glaucoma surgery (MIGS) and cataract surgery is performed in eyes with corneal astigmatism. PURPOSE:To assess the efficacy of toric intraocular lenses (IOLs) in combined cataract and MIGS, visual ...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0000000000001705
更新日期:2021-01-01 00:00:00
abstract:PRECIS:Surgeons that perform cataract surgery combined with endocyclophotocoagulation should rely on their preferred IOL calculation formula. There is no need to perform any correction to the IOL power, as this procedure does not modify the refractive outcome. PURPOSE:To compare postoperative refractive outcomes in pa...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0000000000001777
更新日期:2020-12-29 00:00:00
abstract:OBJECTIVE:To evaluate the risk of developing glaucoma in patients taking systemic fluoroquinolones. METHODS:A case-control study was carried out among a cohort of subjects who had visited an ophthalmologist in the Province of British Columbia, Canada from 2000 to 2007. Cases were identified as those newly diagnosed wi...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0b013e31829463c1
更新日期:2014-09-01 00:00:00
abstract:STUDY OBJECTIVES:The association between obstructive sleep apnea syndrome (OSAS) and retinal nerve fiber layer (RNFL) thickness has been examined in many studies. However, the findings are inconsistent. Our goal is to evaluate the association between OSAS and RNFL thickness by performing a meta-analysis. METHODS:We co...
journal_title:Journal of glaucoma
pub_type: 杂志文章,meta分析
doi:10.1097/IJG.0000000000000349
更新日期:2016-04-01 00:00:00
abstract:BACKGROUND:To compare the efficacy, safety, and long-term results of intraocular pressure (IOP) reduction by diode laser contact cyclophotocoagulation (DCPC) and Ahmed glaucoma valve (AGV) implant in cases of neovascular glaucoma. METHODS:A total of 66 eyes of 66 patients with neovascular glaucoma were prospectively a...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0b013e31817d235c
更新日期:2009-03-01 00:00:00
abstract::Gonioscopy-assisted transluminal trabeculotomy (GATT) is a minimally invasive ab interno procedure, performed with guidance of an illuminating microcatheter device (iTrack). The pathophysiology of raised intraocular pressure (IOP) in uveitic glaucoma is commonly due to increased resistance at the trabecular meshwork-S...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0000000000001641
更新日期:2020-10-01 00:00:00
abstract:INTRODUCTION:Corneal integrity has long been a preoccupation of glaucoma surgeons considering glaucoma drainage device surgery or antimetabolite-enhanced trabeculectomy. Despite having demonstrated a good safety profile and significant intraocular pressure-lowering capacities, the impact of XEN gel stents on endothelia...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0000000000001430
更新日期:2020-03-01 00:00:00
abstract:PURPOSE:To clarify the mechanism by which bunazosin hydrochloride (BZ), a selective alpha1-adrenoceptor antagonist, increases uveoscleral outflow. METHODS:The effects of BZ on matrix metalloproteinase (MMP) activities in cultured monkey ciliary muscle cells, and on phenylephrine hydrochloride-induced constriction in b...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/00061198-200408000-00009
更新日期:2004-08-01 00:00:00
abstract::While working with a large data set of Goldmann applanation tonometry (GAT) intraocular pressure (IOP) measurements for a separate investigation, we observed that the IOP distribution favored even-numbered values. Study of this phenomenon has been limited, and this larger data set enabled inquiry that showed new insig...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0000000000001412
更新日期:2020-02-01 00:00:00
abstract:PURPOSE:To report a simple technique for removal of malpositioned Ex-PRESS miniature glaucoma filtration device. PATIENT AND METHODS:A patient who underwent removal of a malpositioned Ex-PRESS shunt from the right eye with wound revision. RESULTS:Description of step-by-step technique for removal of the Ex-PRESS shunt...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0b013e31827b1540
更新日期:2014-09-01 00:00:00
abstract:OBJECTIVE:To describe reoperations in the operating room for complications encountered within 90 days after glaucoma surgery at a single institution over a 2-year period. DESIGN:Retrospective case series. SUBJECTS:Adult patients who have undergone glaucoma surgery including a tube shunt, trabeculectomy with mitomycin...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0000000000001484
更新日期:2020-05-01 00:00:00
abstract::The pressure on glaucoma services is ever-growing, and policymakers seek robust cost-effectiveness arguments in their decisions around resource allocation. The benefits of glaucoma are in preventing or delaying a future loss of vision and associated quality of life, and this expectation is quantified using a metric ca...
journal_title:Journal of glaucoma
pub_type: 杂志文章,评审
doi:10.1097/IJG.0000000000001462
更新日期:2020-04-01 00:00:00