Effects of bunazosin hydrochloride on ciliary muscle constriction and matrix metalloproteinase activities.

Abstract:

PURPOSE:To clarify the mechanism by which bunazosin hydrochloride (BZ), a selective alpha1-adrenoceptor antagonist, increases uveoscleral outflow. METHODS:The effects of BZ on matrix metalloproteinase (MMP) activities in cultured monkey ciliary muscle cells, and on phenylephrine hydrochloride-induced constriction in bovine ciliary muscles, were examined. Also, the possible additive ocular hypotensive effects of BZ and latanoprost (LP) were evaluated in ocular normotensive monkeys. RESULTS:Although BZ at 10 to 10 M did not increase MMP-2, -3, and -9 activities in the culture medium of ciliary muscle cells, BZ at 10 to 10 M inhibited phenylephrine hydrochloride-induced constriction in ciliary muscles. The maximal reduction in intraocular pressure of concomitant administration of BZ and LP was greater than that of BZ alone and tended to be greater than that of LP alone. CONCLUSION:These findings, in normotensive monkeys, indicate that the mechanism whereby BZ increases uveoscleral outflow is independent of an effect on MMPs and is partly due to relaxation of the ciliary muscle. This effect is different from that of LP, which might help to explain the finding that topical concomitant administration of BZ and LP increased AUC(0-6h) value (IOP reduction) to 201% and 145% of BZ and LP given alone, respectively.

journal_name

J Glaucoma

journal_title

Journal of glaucoma

authors

Akaishi T,Takagi Y,Matsugi T,Ishida N,Hara H,Kashiwagi K

doi

10.1097/00061198-200408000-00009

keywords:

subject

Has Abstract

pub_date

2004-08-01 00:00:00

pages

312-8

issue

4

eissn

1057-0829

issn

1536-481X

pii

00061198-200408000-00009

journal_volume

13

pub_type

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