Abstract:
BACKGROUND:Common variable immunodeficiency (CVID) is characterised by hypogammaglobulinaemia and a broad clinical spectrum, mainly showing recurrent bacterial infections accompanied sometimes by increased susceptibility to chronic lung disease, autoimmunity, and neoplastic diseases. OBJECTIVES:To evaluate the clinical and immunological characteristics of patients with CVID in Mexico. METHODS:This is a retrospective analysis of 43 patients with CVID from the Immunology Division of seven different reference centres in Mexico. Patients were diagnosed according to the diagnostic criteria of the European Society for Immunodeficiency Diseases. We collected demographics, clinical and immunological data from each patient and a statistical analysis was performed. RESULTS:There were 23 (53.5%) male and 20 (46.5%) female patients. Median age at onset of disease was 13.7 years, and median age at diagnosis was 19 years. Average delay in diagnosis was 12.5 years. The median total serum levels of IgG, IgM, and IgA at diagnosis were 175, 18, and 17.8mg/dL, respectively. The mean percentage of CD19+ B cells was 8.15%. Sinusitis (83%), pneumonia (83%), gastrointestinal infection (70%), and acute otitis media (49%) were the most common manifestations. Bronchiectasis was present in 51% of the patients, 44% manifested non-infectious chronic diarrhoea, and 70% experienced weight loss. Autoimmunity was present in 23% of the patients; haemolytic anaemia and autoimmune thrombocytopenic purpura were the most common presentations. Allergy was present in 30.2% of patients, with allergic rhinitis and asthma being the most frequent types. Two patients developed malignancy. All the patients received Intravenous immunoglobulin (IVIG) as a fundamental part of the treatment at a mean dose of 408mg/kg. CONCLUSION:This is the first cohort of CVID reported in Mexico We found that infection diseases were the most frequent presentations at onset. Moreover, patients had an average diagnosis delay of twelve years and thus a major prevalence of bronchiectasis. We suggest performing an extended analysis of patients with CVID patients in other Latin American countries.
journal_name
Allergol Immunopathol (Madr)journal_title
Allergologia et immunopathologiaauthors
Ramírez-Vargas N,Arablin-Oropeza SE,Mojica-Martínez D,Yamazaki-Nakashimada MA,de la Luz García-Cruz M,Terán-Juárez LM,Cortés-Grimaldo RM,Torres-Lozano C,Madrigal-Beas I,Ortega-Cisneros M,Vargas-Camaño ME,Staines-Boone T,Pietropaodoi
10.1016/j.aller.2013.01.007subject
Has Abstractpub_date
2014-05-01 00:00:00pages
235-40issue
3eissn
0301-0546issn
1578-1267pii
S0301-0546(13)00055-4journal_volume
42pub_type
杂志文章abstract::We studied the function of monocyte-mediated suppression in the proliferative responses of depressed T-cells of patients with advanced lung cancer, with both local (Stage III) and extrapulmonary metastasis (Stage IV). The mononuclear cells of 13 non-treated patients showed a significant drop in proliferation upon stim...
journal_title:Allergologia et immunopathologia
pub_type: 杂志文章
doi:
更新日期:1985-05-01 00:00:00
abstract:BACKGROUND:Pseudo-allergic reactions against aspirin (ASA) and non-steroidal anti-inflammatory drugs (NSAIDs) are quite frequent. OBJECTIVE:Our aim was to determine tolerance of Celecoxib, a selective inhibitor of cyclooxygenase-2 (Cox-2), by oral challenge test in patients who showed skin reactions (diffuse erythema ...
journal_title:Allergologia et immunopathologia
pub_type: 杂志文章
doi:10.1157/13108222
更新日期:2007-07-01 00:00:00
abstract:BACKGROUND:Chronic granulomatous disease is a phagocyte defect, characterised by recurrent infections in different organs due to a defect in NADPH oxidase complex. This study was performed to investigate pulmonary problems of CGD in a group of patients who underwent computed tomography (CT) scan. METHODS:Computed tomo...
journal_title:Allergologia et immunopathologia
pub_type: 杂志文章
doi:10.1016/j.aller.2013.04.003
更新日期:2014-09-01 00:00:00
abstract::The authors selected 28 severe asthmatic children in order to compare the effect of different prophylactic regimens. Patients experiencing at least one wheezing attack per week were included in the study. In a randomized manner, they were allocated Zaditen or Intal. After 8 weeks of active treatment and a 2 week wash-...
journal_title:Allergologia et immunopathologia
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:1983-01-01 00:00:00
abstract::The percentages and absolute numbers of T, B and "null" cells were studied in 100 allergic patients and compared with values observed in 35 healthy age matched control subjects. T cells were identified by their ability to form spontaneous rosettes with SRBC (E-RFC) and B cells by their complement receptor that allows ...
journal_title:Allergologia et immunopathologia
pub_type: 杂志文章
doi:
更新日期:1978-01-01 00:00:00
abstract:BACKGROUND:Inhaled corticosteroids are used to treat infants with troublesome asthma-like symptoms but their effect on the lung function of these young patients is controversial. MATERIAL AND METHODS:Forty-four infants with recurrent wheezing (more than 3 episodes) and family history of asthma completed this randomise...
journal_title:Allergologia et immunopathologia
pub_type: 杂志文章,随机对照试验
doi:10.1016/s0301-0546(09)71105-x
更新日期:2009-03-01 00:00:00
abstract::Toll-like receptors (TLRs) are a family of transmembrane receptors that have been preserved throughout evolution and which selectively recognize a broad spectrum of microbial components and endogenous molecules released by injured tissue. Identification of these ligands by TLRs triggers signalling pathways which lead ...
journal_title:Allergologia et immunopathologia
pub_type: 杂志文章,评审
doi:10.1016/j.aller.2009.04.004
更新日期:2009-09-01 00:00:00
abstract::The classic histamine release test involved washing and isolating of leukocytes from heparinized whole blood. Siraganian automatized the extraction procedure, working initially with isolated leukocytes in Tris-human serum albumin-Ca++Mg++ buffer, with optimal results. One year later, he described a continuous flow sys...
journal_title:Allergologia et immunopathologia
pub_type: 杂志文章
doi:
更新日期:1982-05-01 00:00:00
abstract::Scabies is observed with relatively high frequency in Allergy and Dermatology clinics in developing countries where poor sanitary conditions are prevalent and increasingly in some areas of the world with increased immigrant populations. Since the immunological response to scabies mites includes the production of IgE c...
journal_title:Allergologia et immunopathologia
pub_type: 杂志文章,评审
doi:10.1016/j.aller.2017.05.006
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abstract::In a study carried out between 1982-1986, 68 asthmatic patients of different ages were followed-up in the Outpatient Department of the King Fahd University Hospital, Al-Khobar. Fifty-two patients were Saudis (78%) while the rest were of other nationalities (22%). The sex distribution was 39 (55.9%) females and 30 male...
journal_title:Allergologia et immunopathologia
pub_type: 杂志文章
doi:
更新日期:1987-11-01 00:00:00
abstract:BACKGROUND:Approximately 150 species of Lepidoptera have been described as causing damage to human skin. One of these species is the pine processionary caterpillar, which is responsible for dermatitis, contact urticaria, ocular lesions and rarely respiratory signs and anaphylactic reactions through IgE-mediated or non-...
journal_title:Allergologia et immunopathologia
pub_type: 杂志文章
doi:10.1157/13091043
更新日期:2006-07-01 00:00:00
abstract:BACKGROUND:High sensitive C-reactive protein (hs-CRP) has been shown to be associated with asthma in recent studies. However, the relationship between hs-CRP and the control of asthma has not been clearly identified yet. OBJECTIVE:To investigate the association of hs-CRP with asthma control test (ACT), which reveals t...
journal_title:Allergologia et immunopathologia
pub_type: 杂志文章
doi:10.1016/j.aller.2011.10.002
更新日期:2012-11-01 00:00:00
abstract::A lot of recent works point out the role of the eosinophil as one of the most harmful cells in asthma. Eosinophilic granules contain strongly basiec cytotoxic proteins. Some of these proteins were shown to damage airway epithelial cells and degranulate basophils and mast cells. The concentration of eosinophil-derived ...
journal_title:Allergologia et immunopathologia
pub_type: 杂志文章,评审
doi:
更新日期:1989-03-01 00:00:00
abstract::We report the induction of tolerance in four patients with severe IgE-mediated cow's milk allergy, with an oral rush desensitization by introducing increasing daily doses of cow's milk (CM) for 5 days under clinical conditions in order to enable the patients to tolerate 200 ml of CM daily. Our results indicate that we...
journal_title:Allergologia et immunopathologia
pub_type: 杂志文章
doi:10.1157/13110311
更新日期:2007-09-01 00:00:00
abstract::We report the cases of 2 patients diagnosed as having primula dermatitis. Both patients were housewives who had been exposed to primula plants. Although only one related her clinical manifestations with looking after plants, the symptoms of both remitted when contact with primula was avoided. The diagnosis was carried...
journal_title:Allergologia et immunopathologia
pub_type: 杂志文章
doi:
更新日期:1999-01-01 00:00:00
abstract::Perioperative anaphylactic reactions are immediate, hypersensitive reactions that are potentially life-threatening resulting from a sudden release of mediators from mast cells and basophiles, due to either immune (IgE or non-IgE mediated) or non-immune mechanisms. The most frequent causing agents are neuromuscular blo...
journal_title:Allergologia et immunopathologia
pub_type: 杂志文章,评审
doi:10.1016/j.aller.2013.07.012
更新日期:2015-03-01 00:00:00
abstract::The system that protects body from infectious agents is immune system. On occasions, the system seldom reacts with some foreign particles and causes allergy. Allergies of the ear, nose and throat (ENT) often have serious consequences, including impairment and emotional strain that lowers the quality of life of patient...
journal_title:Allergologia et immunopathologia
pub_type: 杂志文章,评审
doi:10.1016/j.aller.2016.10.010
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abstract:BACKGROUND:House dust mites are a ubiquitous air allergen in the human habitat. It has been shown that exposure to them is a fundamental factor in sensitisation and development of atopic disease. The objective of the study was to analyse changes in sensitisation to Dermatophagoides pteronyssinus (Der p.) in children tr...
journal_title:Allergologia et immunopathologia
pub_type: 杂志文章
doi:10.1016/j.aller.2016.09.002
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abstract::Propranolol (PRO) is a beta-adrenergic receptor antagonist. The studies were aimed to evaluate the effect of a single intravenous PRO injection at a dose of 0.1 mg/kg on some immune parameters, and were performed on 12 men, including 9 duodenal ulcer patients and 3 healthy subjects, aged 19-23 years (mean 20.5 +/- 1.2...
journal_title:Allergologia et immunopathologia
pub_type: 杂志文章
doi:
更新日期:1988-03-01 00:00:00
abstract::In normal individuals the 5/9 monoclonal antibody (5/9 MAb) recognizes a T-cell fraction that includes all T lymphocytes with inducer activities. Here, circulating 5/9+ and 5/9- T lymphocytes were isolated from tuberculim skin-positive subjects and the proliferative response induced by PPD was investigated. The result...
journal_title:Allergologia et immunopathologia
pub_type: 杂志文章
doi:
更新日期:1987-03-01 00:00:00
abstract:BACKGROUND:The inhalation of Parietaria judaica pollen is a common cause of allergic respiratory diseases in the Mediterranean area. The objective of this study was to investigate the safety and clinical efficacy of a chemically modified (depigmented and glutaraldehyde-polymerized) vaccine of Parietaria judaica. METHO...
journal_title:Allergologia et immunopathologia
pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:Allergologia et immunopathologia
pub_type: 杂志文章
doi:10.1016/j.aller.2014.07.007
更新日期:2015-09-01 00:00:00
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journal_title:Allergologia et immunopathologia
pub_type: 杂志文章
doi:10.1157/13077746
更新日期:2005-07-01 00:00:00
abstract:OBJECTIVES:To characterize the most frequently found radiological findings in intestinal anisakiasis. MATERIAL AND METHODS:The medical records of 14 patients diagnosed with intestinal anisakiasis between 2000 and 2003 in the Hospital Clinico Universitario Lozano Blesa in Zaragoza (Spain) were retrospectively reviewed....
journal_title:Allergologia et immunopathologia
pub_type: 杂志文章,评审
doi:10.1157/13070605
更新日期:2005-01-01 00:00:00
abstract:OBJECTIVE:To report the results of treatment with infliximab in patients with refractory juvenile idiopathic arthritis (JIA). PATIENTS AND METHODS:A prospective study of four children with refractory JIA was carried out. Infliximab (100 mg) was administered in weeks 0, 2 and 6. Subsequently, the drug was administered ...
journal_title:Allergologia et immunopathologia
pub_type: 杂志文章
doi:10.1157/13101338
更新日期:2007-03-01 00:00:00
abstract:BACKGROUND:Scarcity of reliable data on food allergy prevalence exists in Turkey. We aimed to assess reported and confirmed IgE-mediated food allergy prevalence, and define the spectrum of allergenic food. METHODS:We prospectively evaluated the ISAAC Phase II study population for food allergy. Participants that report...
journal_title:Allergologia et immunopathologia
pub_type: 杂志文章,多中心研究
doi:10.1016/j.aller.2012.05.005
更新日期:2013-11-01 00:00:00
abstract::Anaphylaxis is a systemic reaction which can be very dangerous in many patients. In addition to the most common antigens (drugs, venoms, foods), physical exercise can provoke anaphylaxis in the sensitized patients. The mechanism of this reaction is still unknown. In this report, we describe a case of exercise-induced ...
journal_title:Allergologia et immunopathologia
pub_type: 杂志文章
doi:
更新日期:1986-09-01 00:00:00
abstract::Thanks to its excellent safety profile, sublingual immunotherapy has served as a basis for launching two important lines of research in current allergology: sublingual immunotherapy with pharmaceutical registry (oral lyophilizates or tablets), and sublingual immunotherapy with food. At present, clinical trials are bei...
journal_title:Allergologia et immunopathologia
pub_type: 杂志文章
doi:10.1016/s0301-0546(08)75223-6
更新日期:2008-09-01 00:00:00
abstract:BACKGROUND:Angiotensin Converting Enzyme inhibitors (ACEi) may cause angioedema, with an incidence of 0.1 % to 1 %, which may be life-threatening. ACEi induce angioedema by increasing the levels of bradykinin. Angiotensin II receptor blockers (ATRB), have a pharmacological profile similar to ACEi. The polymorphism of t...
journal_title:Allergologia et immunopathologia
pub_type: 杂志文章
doi:
更新日期:2008-05-01 00:00:00
abstract::A procedure is described for the cytochemical detection of esterase alpha naphtyl acetate (ANAE) and beta glucuronidase (BG) activity in the circulating lymphocytes of man. The number of BG positive cells (TBG) as evaluated on the smears of Ficoll Urovision purified cells, correlated well with the number of T gamma (E...
journal_title:Allergologia et immunopathologia
pub_type: 杂志文章
doi:
更新日期:1982-03-01 00:00:00