Abstract：
BACKGROUND:Inhaled corticosteroids are used to treat infants with troublesome asthma-like symptoms but their effect on the lung function of these young patients is controversial. MATERIAL AND METHODS:Forty-four infants with recurrent wheezing (more than 3 episodes) and family history of asthma completed this randomised, parallel, double-blind, controlled trial to compare the effect on lung function (main endpoint) of once-daily inhaled fluticasone (375 microg) versus placebo for 3 months. Pulmonary function was measured while infants were asymptomatic, using the raised volume rapid thoracic compression technique (spirometry-like), and values were converted to z-scores. RESULTS:The fluticasone group showed a significant increase in forced flows, (p < 0.001), a lower number of physician diagnosed wheezing episodes (p < 0.002), and a significant decrease in the parent-reported number of wheezing episodes per month (p < 0.03), as compared to placebo. One third of parents in the placebo group reported a clinical improvement in their infants. There was no significant difference in morning plasma cortisol between groups at entry or discharge. CONCLUSIONS:We conclude that once-daily treatment with 375 microg fluticasone increased forced flows and controlled symptoms in infants with recurrent wheezing without altering plasma cortisol levels. The spirometry-like technique is a useful tool to objectively assess the efficacy of anti-asthma medications in infants with repeated troublesome asthma-like symptoms.
journal_name
Allergol Immunopathol (Madr)journal_title
Allergologia et immunopathologiaauthors
Mallol J,Aguirre V,Barrueto L,Wandalsen G,Tepper Rdoi
10.1016/s0301-0546(09)71105-xsubject
Has Abstractpub_date
2009-03-01 00:00:00pages
57-62issue
2eissn
0301-0546issn
1578-1267pii
S0301-0546(09)71105-Xjournal_volume
37pub_type
杂志文章,随机对照试验abstract：BACKGROUND:The sharon fruit is the edible fruit of the persimmon tree (Diospyros kaki) which belongs to the Ebenaceae family. There are few references of allergic reaction to this fruit. We introduce a case of a 33-years old man with a anaphylactic reaction immediately after ingestion of sharon fruit. METHODS:Skin pri...
journal_title：Allergologia et immunopathologia
pub_type： 杂志文章
doi：10.1016/s0301-0546(01)79021-0
更新日期：2001-03-01 00:00:00
abstract：OBJECTIVE:This study aimed to assess the regular use of long-term asthma-control medication and to determine inhaler techniques in asthmatic children. METHODS:The study was conducted on asthmatic children aged 6-18 years. Information on rescue and controller medications was given and the proper inhalation technique wa...
journal_title：Allergologia et immunopathologia
pub_type： 杂志文章
doi：10.1016/j.aller.2019.06.009
更新日期：2020-01-01 00:00:00
abstract：INTRODUCTION AND OBJECTIVES:The reproducibility of the adverse reaction increases the suggestiveness of a history of food allergy. However, the positive predictive value (PPV) of multiple adverse reaction episodes for the diagnosis of IgE-mediated food allergy is not known. This evaluation was the objective of our stud...
journal_title：Allergologia et immunopathologia
pub_type： 杂志文章
doi：10.1016/j.aller.2018.10.006
更新日期：2019-01-01 00:00:00
abstract：:Excessive accumulation of histamine in the body leads to miscellaneous symptoms mediated by its bond to corresponding receptors (H1-H4). Increased concentration of histamine in blood can occur in healthy individuals after ingestion of foods with high contents of histamine, leading to histamine intoxication. In individ...
journal_title：Allergologia et immunopathologia
pub_type： 杂志文章,评审
doi：10.1016/j.aller.2015.05.001
更新日期：2015-09-01 00:00:00
abstract：:The Bordeles School of Le Coulant described in 1966, a contact dermatitis produced by "hepatics" of the Frullania genus. The hepatics together with the mosses and sphagnus form the group of Bryophytes. Only the hepatics with leaves or Jungermaniales have a capacity to cause sensitivity. They grow in dark colour plates...
journal_title：Allergologia et immunopathologia
pub_type： 杂志文章
doi：
更新日期：1976-07-01 00:00:00
abstract：:A lot of recent works point out the role of the eosinophil as one of the most harmful cells in asthma. Eosinophilic granules contain strongly basiec cytotoxic proteins. Some of these proteins were shown to damage airway epithelial cells and degranulate basophils and mast cells. The concentration of eosinophil-derived ...
journal_title：Allergologia et immunopathologia
pub_type： 杂志文章,评审
doi：
更新日期：1989-03-01 00:00:00
abstract：:The aim of this study was to analyze the prevalence of every RAST (Radio-Allergo-Sorbent-Test) class in terms of total IgE serum level, and to establish the existing relationship between the total IgE level and the probability to obtain a definite specific IgE concentration. The analyzed sample was 352 total IgE value...
journal_title：Allergologia et immunopathologia
pub_type： 杂志文章
doi：
更新日期：1998-09-01 00:00:00
abstract：:Lymphocyte subpopulations were determined by indirect immunofluorescence using monoclonal antibodies T11, T4, T8 and B1 on three different days in a group of thirteen normal subjects. Although there was considerable intersubject variation, the percentages of lymphocyte subpopulations as well as absolute numbers did no...
journal_title：Allergologia et immunopathologia
pub_type： 杂志文章
doi：
更新日期：1984-09-01 00:00:00
abstract：:Lumry described 6 patients who presented hypertrophic rhinosinusitis, positive nasal eosinophilia and intolerance to nonsteroidal antiinflammatory drugs, manifested exclusively with naso-ocular symptomatology. We present three patients with clinical manifestations of chronic rhinitis who had noticed before their first...
journal_title：Allergologia et immunopathologia
pub_type： 临床试验,杂志文章
doi：
更新日期：1986-03-01 00:00:00
abstract：OBJECTIVE/HYPOTHESIS:We systematically reviewed the associations between allergic rhinitis or allergy and otitis media with effusion, by reference to published data. STUDY DESIGN:A meta-analysis of case-controlled studies. DATA SOURCE:Five databases (Pubmed, Highwire, Medline, Wanfang, and China National Knowledge In...
journal_title：Allergologia et immunopathologia
pub_type： 杂志文章,meta分析
doi：10.1016/j.aller.2016.03.004
更新日期：2017-01-01 00:00:00
abstract：BACKGROUND:Since gamma interferon release assays (IGRAs) cannot differentiate between active tuberculosis and latent tuberculosis infection (LTBI), development of rapid and specific diagnosis tools are essential for discriminating between active tuberculosis (TB) from LTBI. Both IGRAs are based on Mycobacterium tubercu...
journal_title：Allergologia et immunopathologia
pub_type： 杂志文章
doi：10.1016/j.aller.2015.09.004
更新日期：2016-07-01 00:00:00
abstract：OBJECTIVE:To assess concordance in the measurement of peak expiratory flow (PEF) and forced expiratory volume ino ne second (FEV(1)) between the portable device Piko-1 (Ferraris) and a pneumotachograph. PATIENTS AND METHODS:Forced spirometry (Master Screen Jaeger) was performed according to ATS/ERS norms, selecting th...
journal_title：Allergologia et immunopathologia
pub_type： 杂志文章
doi：10.1016/j.aller.2009.03.004
更新日期：2009-09-01 00:00:00
abstract：:Toll-like receptors (TLRs) are a family of transmembrane receptors that have been preserved throughout evolution and which selectively recognize a broad spectrum of microbial components and endogenous molecules released by injured tissue. Identification of these ligands by TLRs triggers signalling pathways which lead ...
journal_title：Allergologia et immunopathologia
pub_type： 杂志文章,评审
doi：10.1016/j.aller.2009.04.004
更新日期：2009-09-01 00:00:00
abstract：BACKGROUND:Differences in latex allergen sensitization profiles have been described between children undergoing repeated surgical interventions and health care workers. The purpose of this study was to determine whether such sensitization profiles are associated with differences in the expression of latex allergen betw...
journal_title：Allergologia et immunopathologia
pub_type： 杂志文章
doi：10.1157/13094028
更新日期：2006-09-01 00:00:00
abstract：BACKGROUND:The prevalence of food allergy is on the rise on a global scale. OBJECTIVE:To determine the prevalence of food hypersensitivity (FHS) and probable food allergy (PFA), as well as the foods and factors associated with these occurrences. METHODS:A cross-sectional study was carried out among 1992 adolescents (...
journal_title：Allergologia et immunopathologia
pub_type： 杂志文章
doi：10.1016/j.aller.2018.09.004
更新日期：2019-01-01 00:00:00
abstract：BACKGROUND:High sensitive C-reactive protein (hs-CRP) has been shown to be associated with asthma in recent studies. However, the relationship between hs-CRP and the control of asthma has not been clearly identified yet. OBJECTIVE:To investigate the association of hs-CRP with asthma control test (ACT), which reveals t...
journal_title：Allergologia et immunopathologia
pub_type： 杂志文章
doi：10.1016/j.aller.2011.10.002
更新日期：2012-11-01 00:00:00
abstract：:A prospective, multicenter pharmacovigilance study was carried out to evaluate the safety of a new 7-dose treatment schedule of subcutaneous immunotherapy as opposed to the conventional 13 doses normally recommended. The study was carried out in 14 centers and included 261 patients (children and adults) with respirato...
journal_title：Allergologia et immunopathologia
pub_type： 杂志文章,多中心研究
doi：10.1016/s0301-0546(04)79217-4
更新日期：2004-01-01 00:00:00
abstract：:In clinical allergology and particularly during childhood, we quite frequently encounter patients who are allergic to milk. This has usually been confirmed by the clinical history and by skin testing. Statistics show a sensitization to cows' milk of between 0.3 and 7% of the world's population. In view of the diversit...
journal_title：Allergologia et immunopathologia
pub_type： 杂志文章
doi：
更新日期：1978-05-01 00:00:00
abstract：:In this study we attempt to investigate if collagen type 1 from bovine Achilles tendon is capable of causing an inflammatory response. Thus, we immunized rats with a collagen emulsion injected in the right hind paw, via subplantar, and intradermally on the back. Seven days later, the rats were reimmunized by intraderm...
journal_title：Allergologia et immunopathologia
pub_type： 杂志文章
doi：
更新日期：1989-05-01 00:00:00
abstract：OBJECTIVE:To investigate whether the genetic variants of TGFB1, TLE4, MUC22 and IKZF3 are associated with the development of asthma in Chinese children. METHODS:572 adolescent asthma patients and 590 age-matched healthy controls were included in this study. A total of four SNPs were genotyped, including rs2241715 of T...
journal_title：Allergologia et immunopathologia
pub_type： 杂志文章
doi：10.1016/j.aller.2016.10.021
更新日期：2017-01-01 00:00:00
abstract：:All classes of immunoglobulins and albumin have been studied in different phases of disease, both in blood and in the nasal secretions of 75 patients with pollen allergy. There were 20 healthy persons in the test group. Total correlational analysis was done to determine interdependence of the researched indexes. The p...
journal_title：Allergologia et immunopathologia
pub_type： 杂志文章
doi：
更新日期：1990-11-01 00:00:00
abstract：:The effect of intra-lymphatic administration of Lipiodol-l131 on the number of T and B lymphocytes, and on the in vivo response to common antigens and to DNCB, was investigated in uremic patients in the pre-transplant period. T lymphocytes have been detected by rosette formation with sheep erythrocytes (E) and B lymph...
journal_title：Allergologia et immunopathologia
pub_type： 杂志文章
doi：
更新日期：1975-09-01 00:00:00
abstract：:Common variable immunodeficiency is a disorder characterised by hypogammaglobulinemia with B-lymphocytes in peripheral blood and repeated infections. We report a child with a diagnosis of diabetes mellitus and celiac disease during lactation, and in whom common variable immunodeficiency was diagnosed at the age of 5. ...
journal_title：Allergologia et immunopathologia
pub_type： 杂志文章
doi：
更新日期：2000-11-01 00:00:00
abstract：OBJECTIVE:To report the results of treatment with infliximab in patients with refractory juvenile idiopathic arthritis (JIA). PATIENTS AND METHODS:A prospective study of four children with refractory JIA was carried out. Infliximab (100 mg) was administered in weeks 0, 2 and 6. Subsequently, the drug was administered ...
journal_title：Allergologia et immunopathologia
pub_type： 杂志文章
doi：10.1157/13101338
更新日期：2007-03-01 00:00:00
abstract：:In view of the excellent results we had obtained using KETOTIFEN in the treatment of respiratory allergies, we decided to carry out a study of its protective action in cases of allergies of purely alimentary etiology; that is, in patients symptoms only appeared after the ingestion of certain foodstuffs. The subjects o...
journal_title：Allergologia et immunopathologia
pub_type： 杂志文章
doi：
更新日期：1980-03-01 00:00:00
abstract：BACKGROUND:One of the factors affecting compliance is the pharmaceutical formulation used. Many patients find it difficult to swallow tablets or capsules. The fast dissolving tablet (FDT) formulation could help to enhance patient compliance, because of its ease of administration and because no liquid is required to hel...
journal_title：Allergologia et immunopathologia
pub_type： 杂志文章,多中心研究
doi：10.1157/13088176
更新日期：2006-05-01 00:00:00
abstract：AIM:To prospectively evaluate interferences between viruses of the upper respiratory tract in asymptomatic preschool children. METHODS:Nasal-pharyngeal swabs from 233 preschool aged children were prospectively collected over four consecutive time periods, during one school year. The samples were tested using a RT-PCR ...
journal_title：Allergologia et immunopathologia
pub_type： 杂志文章
doi：10.1016/j.aller.2018.07.005
更新日期：2019-01-01 00:00:00
abstract：BACKGROUND:Lung involvement in rheumatologic disease in children has been described with low frequency. OBJECTIVE:To describe the lung function test and the radiological findings in a group of paediatric patients with rheumatologic diseases. METHODS:Descriptive study. Pulmonary function was evaluated with spirometry,...
journal_title：Allergologia et immunopathologia
pub_type： 杂志文章
doi：10.1016/j.aller.2011.02.009
更新日期：2012-03-01 00:00:00
abstract：:An epidemiological study was performed in the students of Hacettepe University from various parts of Turkey to find the prevalence of asthma and allergic diseases and search for geographical differences in Turkey. A questionnaire related with symptoms of asthma and allergic diseases was distributed to 4600 students an...
journal_title：Allergologia et immunopathologia
pub_type： 杂志文章
doi：
更新日期：1996-07-01 00:00:00
abstract：:The gaseous phase cultures of alveolar macrophages (AMs) of guinea pig were exposed to the saline extracts of the dust-borne bacteria Micropolyspora faeni (syn. Faenia rectivirgula) and Erwinia herbicola (syn. Enterobacter agglomerans) which have been added at the concentration of 1 microgram/ml to culture medium with...
journal_title：Allergologia et immunopathologia
pub_type： 杂志文章
doi：
更新日期：1990-07-01 00:00:00
