Abstract：
:A prospective, multicenter pharmacovigilance study was carried out to evaluate the safety of a new 7-dose treatment schedule of subcutaneous immunotherapy as opposed to the conventional 13 doses normally recommended. The study was carried out in 14 centers and included 261 patients (children and adults) with respiratory allergic disease due to sensitization to mites (Dermatophagoides pteronyssinus and/or farinae). A total of 2290 doses were administered under the direct supervision of the participating specialists. One hundred and ten reactions in 63 patients (24.1%) were recorded, representing 4.8% of the total doses administered. Most of the reactions (98) were local. Only 12 were systemic (0.5% of the administered doses) and occurred in 10 patients (3.8% of the sample). Ten reactions reverted quickly with rescue medication. The maintenance dose had to be lowered in one patient and another patient was withdrawn from the study after suffering two asthmatic crises after two consecutive doses. In view of the results obtained, we can conclude that the new schedule shows an acceptable tolerance profile and does not present a greater risk of reactions than the conventional scheme of 13 doses using an identical extract. Moreover, the new schedule represents substantial savings in the number of doses and visits required to reach the maintenance dose.
journal_name
Allergol Immunopathol (Madr)journal_title
Allergologia et immunopathologiaauthors
Gamboa P,González G,Jauregui I,Jorró G,Molero I,Eseverri JL,González R,Luna I,Marcos C,Miró J,Pulido Z,Gracia T,Iriarte P,Carreño A,Navarro JA,Rocafort S,García-Robaina JC,Souto I,Casas R,Lleonart R,Nevot S,Asendoi
10.1016/s0301-0546(04)79217-4keywords:
subject
Has Abstractpub_date
2004-01-01 00:00:00pages
13-7issue
1eissn
0301-0546issn
1578-1267pii
13057764journal_volume
32pub_type
杂志文章,多中心研究abstract：INTRODUCTION:Omalizumab has been demonstrated to be a successful therapy in the management of asthma through reduction of patient's symptoms and use of inhaled corticosteroids. The effect of omalizumab is achieved by immunoglobulin E (IgE) blockage and other secondary mechanisms resulting from this blockage. Because ot...
journal_title：Allergologia et immunopathologia
pub_type： 杂志文章,评审
doi：10.1016/j.aller.2011.09.011
更新日期：2012-09-01 00:00:00
abstract：BACKGROUND:Asthma morbidity and mortality have been increasing. Data of asthma and respiratory mortality rates in Brazil are scarse. METHODS:We studied asthma and respiratory disease mortality rates in the state of So Paulo (capital and country side) from 1970 to 1996, as its relation with sales of drugs usually used ...
journal_title：Allergologia et immunopathologia
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abstract：BACKGROUND:Pseudo-allergic reactions against aspirin (ASA) and non-steroidal anti-inflammatory drugs (NSAIDs) are quite frequent. OBJECTIVE:Our aim was to determine tolerance of Celecoxib, a selective inhibitor of cyclooxygenase-2 (Cox-2), by oral challenge test in patients who showed skin reactions (diffuse erythema ...
journal_title：Allergologia et immunopathologia
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journal_title：Allergologia et immunopathologia
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doi：10.1157/13086751
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journal_title：Allergologia et immunopathologia
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更新日期：1998-09-01 00:00:00
abstract：BACKGROUND:Due to the high prevalence of recurrent wheezing in the pediatric population, it is important to be able to identify environmental risk factors that may affect the etiology of asthma in several regions. OBJECTIVE:to identify possible risk factors associated with asthma in children (9-12 years old) in Passo ...
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abstract：:Local administration of drugs by means of aerosol device is widely used in the treatment of asthma. Nevertheless, the effectiveness of this method depends on an adequate inhalation technique (IT), which available evidence has shown to be rather problematic. The aim of this study was to assess IT in out-patients with b...
journal_title：Allergologia et immunopathologia
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更新日期：1998-03-01 00:00:00
abstract：BACKGROUND:Allergy to cow's milk proteins has often been associated with dysfunction of the intestinal mucosa caused by chronic inflammation in infants. This study evaluated the protective effect of taurine on intestinal damage induced by beta-lactoglobulin (β-Lg) in Balb/c mice used as an animal model of allergy to co...
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journal_title：Allergologia et immunopathologia
pub_type： 杂志文章
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更新日期：1989-05-01 00:00:00
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journal_title：Allergologia et immunopathologia
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journal_title：Allergologia et immunopathologia
pub_type： 杂志文章,评审
doi：
更新日期：1994-03-01 00:00:00
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journal_title：Allergologia et immunopathologia
pub_type： 杂志文章
doi：10.1016/j.aller.2016.07.003
更新日期：2017-01-01 00:00:00
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journal_title：Allergologia et immunopathologia
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doi：10.1016/j.aller.2012.09.003
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abstract：:Although not yet clear, the etiology of sarcoidosis may be linked to seasonal, environmental and genetic factors; mycobacterial or other infections. To the best of our knowledge there is no data suggesting any connection between the onset of sarcoidosis and specific allergen immunotherapy in the medical literature. Du...
journal_title：Allergologia et immunopathologia
pub_type： 杂志文章
doi：10.1157/13099093
更新日期：2007-01-01 00:00:00
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journal_title：Allergologia et immunopathologia
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更新日期：2018-01-01 00:00:00
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journal_title：Allergologia et immunopathologia
pub_type： 杂志文章
doi：
更新日期：1986-09-01 00:00:00
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journal_title：Allergologia et immunopathologia
pub_type： 杂志文章
doi：
更新日期：1993-11-01 00:00:00
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journal_title：Allergologia et immunopathologia
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journal_title：Allergologia et immunopathologia
pub_type： 杂志文章
doi：
更新日期：1979-05-01 00:00:00
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journal_title：Allergologia et immunopathologia
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pub_type： 杂志文章,多中心研究
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更新日期：2018-01-01 00:00:00
abstract：:The occurrence of allergic diseases depends on genetic and environmental factors. Genetic factors determine individual risk and these persons should undergo early detection. However, the methods currently available (mainly clinical history and IgE in umbilical cord blood) have poor predictive value so their use in the...
journal_title：Allergologia et immunopathologia
pub_type： 杂志文章,评审
doi：
更新日期：1998-05-01 00:00:00
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journal_title：Allergologia et immunopathologia
pub_type： 杂志文章
doi：
更新日期：1997-07-01 00:00:00
abstract：AIM:To prospectively evaluate interferences between viruses of the upper respiratory tract in asymptomatic preschool children. METHODS:Nasal-pharyngeal swabs from 233 preschool aged children were prospectively collected over four consecutive time periods, during one school year. The samples were tested using a RT-PCR ...
journal_title：Allergologia et immunopathologia
pub_type： 杂志文章
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更新日期：2019-01-01 00:00:00
abstract：:The classic histamine release test involved washing and isolating of leukocytes from heparinized whole blood. Siraganian automatized the extraction procedure, working initially with isolated leukocytes in Tris-human serum albumin-Ca++Mg++ buffer, with optimal results. One year later, he described a continuous flow sys...
journal_title：Allergologia et immunopathologia
pub_type： 杂志文章
doi：
更新日期：1982-05-01 00:00:00
abstract：:Scabies is observed with relatively high frequency in Allergy and Dermatology clinics in developing countries where poor sanitary conditions are prevalent and increasingly in some areas of the world with increased immigrant populations. Since the immunological response to scabies mites includes the production of IgE c...
journal_title：Allergologia et immunopathologia
pub_type： 杂志文章,评审
doi：10.1016/j.aller.2017.05.006
更新日期：2018-01-01 00:00:00
abstract：BACKGROUND:Leukotrienes are among the most important mediators associated with inflammatory responses in patients with exercise induced asthma (EIA). The aim of this study was to investigate the impact of exercise on the urinary leukotriene profile. Hence, we compared post exercise changes of urinary leukotriene E4 (LT...
journal_title：Allergologia et immunopathologia
pub_type： 杂志文章
doi：10.1016/j.aller.2011.03.012
更新日期：2012-05-01 00:00:00
abstract：OBJECTIVE/HYPOTHESIS:We systematically reviewed the associations between allergic rhinitis or allergy and otitis media with effusion, by reference to published data. STUDY DESIGN:A meta-analysis of case-controlled studies. DATA SOURCE:Five databases (Pubmed, Highwire, Medline, Wanfang, and China National Knowledge In...
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doi：10.1016/j.aller.2016.03.004
更新日期：2017-01-01 00:00:00
