Abstract：
INTRODUCTION:Omalizumab has been demonstrated to be a successful therapy in the management of asthma through reduction of patient's symptoms and use of inhaled corticosteroids. The effect of omalizumab is achieved by immunoglobulin E (IgE) blockage and other secondary mechanisms resulting from this blockage. Because other diseases have an important IgE mediation in their physiopathology, the question arises as to if omalizumab would be useful in the treatment of other IgE-mediated diseases. OBJECTIVE:We present an overview of the experimental studies and clinical reports evaluating the use of omalizumab in diseases different to asthma including atopic dermatitis, urticaria, eosinophilic gastrointestinal disorders, idiopathic anaphylaxis, latex allergy, hymenoptera venom allergy, and other IgE diseases. METHODS:We reviewed the literature using PUBMED, EMBASE, and LILACS for publications which used omalizumab in the treatment of patients with allergic diseases or any other diseases. Complete articles published in English, Spanish or Portuguese were included. CONCLUSION:There is not enough evidence to support the regular use of omalizumab in IgE diseases other than asthma. However, some experimental and clinical investigations indicate that omalizumab could be a therapeutic option in several allergic diseases like atopic dermatitis, urticaria, and eosinophilic gastrointestinal disorders. More control studies are needed in each IgE disease to evaluate the efficacy and safety of omalizumab in IgE mediated diseases.
journal_name
Allergol Immunopathol (Madr)journal_title
Allergologia et immunopathologiaauthors
Sanchez J,Ramirez R,Diez S,Sus S,Echenique A,Olivares M,Cardona Rdoi
10.1016/j.aller.2011.09.011subject
Has Abstractpub_date
2012-09-01 00:00:00pages
306-15issue
5eissn
0301-0546issn
1578-1267pii
S0301-0546(11)00360-0journal_volume
40pub_type
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journal_title：Allergologia et immunopathologia
pub_type： 杂志文章
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journal_title：Allergologia et immunopathologia
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更新日期：1985-03-01 00:00:00
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journal_title：Allergologia et immunopathologia
pub_type： 临床试验,杂志文章,多中心研究
doi：
更新日期：1995-09-01 00:00:00
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journal_title：Allergologia et immunopathologia
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doi：10.1016/s0301-0546(02)79084-8
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pub_type： 杂志文章,评审
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doi：10.1016/j.aller.2012.10.006
更新日期：2014-03-01 00:00:00
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