Abstract：
:Carboplatin (CP) hypersensitivity reactions have been reported in nearly 12 % of patients treated with this drug. The pathophysiologic mechanisms of these reactions have not been entirely elucidated. Various hypotheses are under discussion. CP hypersensitivity reactions could be IgE-mediated, caused by low-molecular platinum compounds acting as haptens. Platinum salts are also able to release histamine from basophils and mast cells, and some events seem to be non-immune-mediated direct histamine release. We report a case of CP tolerance induction in a 65-year-old man. During the third course of CP he experienced an anaphylactic reaction. Skin testing was negative. Suspecting the possibility of an anaphylactoid reaction due to histamine release, we developed a protocol to induce tolerance. Pre-medication with corticosteroid and antihistaminic was performed before intravenous CP infusion. The bag with CP was first infused 60 ml/h for 30 minutes; the infusion was well tolerated and infusion was continued at 100 ml/h for the next 60 minutes and thereafter at 120 ml/h until the bag was finished. Following this "desensitization", monthly courses of CP using the same protocol have been well tolerated.
journal_name
Allergol Immunopathol (Madr)journal_title
Allergologia et immunopathologiaauthors
Moreno-Ancillo A,Domínguez-Noche C,Gil-Adrados AC,Cosmes PM,Duarte I,Mateos Ydoi
10.1016/s0301-0546(03)79209-xkeywords:
subject
Has Abstractpub_date
2003-11-01 00:00:00pages
342-4issue
6eissn
0301-0546issn
1578-1267pii
13055214journal_volume
31pub_type
杂志文章abstract：BACKGROUND:The objective was to estimate the incidence of asthma in young adults from 13-15 years old to 23-25 years old, and associated factors. METHODS:In 2012, a population-based prospective cohort study was carried out in Castellon from the cohort who had participated in the International Study of Asthma and Aller...
journal_title：Allergologia et immunopathologia
pub_type： 杂志文章
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更新日期：2018-01-01 00:00:00
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journal_title：Allergologia et immunopathologia
pub_type： 杂志文章
doi：10.1016/j.aller.2015.10.005
更新日期：2016-07-01 00:00:00
abstract：BACKGROUND:Despite growing evidence suggesting potential association between innate and adaptive immunity in viral-induced acute asthma, there is paucity of data in this area. OBJECTIVE:This study aimed to investigate the association of innate and adaptive immunity with acute asthma attacks by analysing the role of IF...
journal_title：Allergologia et immunopathologia
pub_type： 杂志文章
doi：10.1016/j.aller.2016.07.003
更新日期：2017-01-01 00:00:00
abstract：:Scabies is observed with relatively high frequency in Allergy and Dermatology clinics in developing countries where poor sanitary conditions are prevalent and increasingly in some areas of the world with increased immigrant populations. Since the immunological response to scabies mites includes the production of IgE c...
journal_title：Allergologia et immunopathologia
pub_type： 杂志文章,评审
doi：10.1016/j.aller.2017.05.006
更新日期：2018-01-01 00:00:00
abstract：:Shellfish is one of the most frequent causes of food allergy. We studied 48 patients (25 male and 23 female) with a mean age of 24.2 +/- 1.8 with shellfish hypersensitivity. A clinical questionnaire was carried out and prick tests were performed using a series of aeroallergens and a battery of extracts of squid, shrim...
journal_title：Allergologia et immunopathologia
pub_type： 杂志文章,评审
doi：
更新日期：1994-03-01 00:00:00
abstract：BACKGROUND:Allergy to cow's milk proteins has often been associated with dysfunction of the intestinal mucosa caused by chronic inflammation in infants. This study evaluated the protective effect of taurine on intestinal damage induced by beta-lactoglobulin (β-Lg) in Balb/c mice used as an animal model of allergy to co...
journal_title：Allergologia et immunopathologia
pub_type： 杂志文章
doi：10.1016/j.aller.2018.07.010
更新日期：2019-01-01 00:00:00
abstract：:The influence of disodium-cromoglycate on different humoral and cellular immune reactions was examined. When injected intravenously DSCG reduces the formation of specific IgG producing (plaque forming) spleen cells in mice. It reduces also the mitogen induced macrophage migration inhibition in vitro. The same reduced ...
journal_title：Allergologia et immunopathologia
pub_type： 杂志文章
doi：
更新日期：1982-05-01 00:00:00
abstract：:As knowledge of the stage and grade of tumour are essential to the selection of the appropriate therapeutic modality and subsequent management of the patient, the patient's immunological competence is equally significant. In the present communication a broad spectrum of cellular and humorally-mediated parameters of im...
journal_title：Allergologia et immunopathologia
pub_type： 杂志文章
doi：
更新日期：1976-07-01 00:00:00
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journal_title：Allergologia et immunopathologia
pub_type： 杂志文章
doi：10.1016/j.aller.2011.05.010
更新日期：2012-09-01 00:00:00
abstract：:Common variable immunodeficiency is a disorder characterised by hypogammaglobulinemia with B-lymphocytes in peripheral blood and repeated infections. We report a child with a diagnosis of diabetes mellitus and celiac disease during lactation, and in whom common variable immunodeficiency was diagnosed at the age of 5. ...
journal_title：Allergologia et immunopathologia
pub_type： 杂志文章
doi：
更新日期：2000-11-01 00:00:00
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journal_title：Allergologia et immunopathologia
pub_type： 杂志文章,评审
doi：10.1157/13115668
更新日期：2008-01-01 00:00:00
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journal_title：Allergologia et immunopathologia
pub_type： 杂志文章
doi：
更新日期：1985-01-01 00:00:00
abstract：:A 25 year old, 70 kg female chimpanzee had a 12 year history of intermittent signs of upper respiratory tract allergic disease. In June 1987, she was given Terfenadinea, 60 mg b.i.d., with excellent resolution of symptoms. During her annual physical examination, while maintained under ketamine anesthesia, the chimp wa...
journal_title：Allergologia et immunopathologia
pub_type： 杂志文章
doi：
更新日期：1989-09-01 00:00:00
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journal_title：Allergologia et immunopathologia
pub_type： 杂志文章,随机对照试验
doi：10.1016/s0301-0546(09)71105-x
更新日期：2009-03-01 00:00:00
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journal_title：Allergologia et immunopathologia
pub_type： 杂志文章
doi：10.1016/j.aller.2019.03.004
更新日期：2019-01-01 00:00:00
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journal_title：Allergologia et immunopathologia
pub_type： 杂志文章
doi：10.1016/s0301-0546(02)79084-8
更新日期：2002-01-01 00:00:00
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journal_title：Allergologia et immunopathologia
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：1995-03-01 00:00:00
abstract：UNLABELLED:Hypersensitivity reactions to hymenoptera venom are infrequent in paediatric patients. A study was made to determine the incidence of this pathology in children, based on an epidemiological survey targeted to all members of the SEICAP (Sociedad Española de Inmunología Clínica y Alergia Pediátrica/Spanish Soc...
journal_title：Allergologia et immunopathologia
pub_type： 杂志文章
doi：10.1016/j.aller.2010.02.004
更新日期：2010-09-01 00:00:00
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journal_title：Allergologia et immunopathologia
pub_type： 杂志文章
doi：10.1157/13084226
更新日期：2006-01-01 00:00:00
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journal_title：Allergologia et immunopathologia
pub_type： 杂志文章
doi：
更新日期：1983-05-01 00:00:00
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pub_type： 杂志文章,多中心研究
doi：10.1016/j.aller.2018.02.006
更新日期：2018-01-01 00:00:00
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journal_title：Allergologia et immunopathologia
pub_type： 杂志文章
doi：
更新日期：1997-03-01 00:00:00
abstract：:The present prospective, open, observational study assessed the effect of the use of standard environmental control measures together with the application of an acaricide-containing aerosol of esbiol/benzyl benzoate/piperonyl butoxide/2-phenylphenol (Frontac) on several clinical and environmental parameters in patient...
journal_title：Allergologia et immunopathologia
pub_type： 杂志文章,多中心研究
doi：10.1016/s0301-0546(02)79096-4
更新日期：2002-03-01 00:00:00
abstract：BACKGROUND:Several authors have reported an increase in leukotriene C4 in the premenstrual phase in women with severe premenstrual asthma, indicating that antileukotrienes could be used in treatment. OBJECTIVE:To analyse the role of leukotrienes in premenstrual asthma. METHODS:A questionnaire on respiratory symptoms ...
journal_title：Allergologia et immunopathologia
pub_type： 杂志文章
doi：10.1016/j.aller.2011.09.007
更新日期：2012-11-01 00:00:00
abstract：BACKGROUND:Autosomal dominant hyper-IgE syndrome (AD-HIES) is a primary immunodeficiency mainly caused by mutations in STAT3, a signalling molecule implicated in the development of appropriate immune responses. We aimed to characterise the innate immune response in AD-HIES. METHODS:The frequency of innate immune cells...
journal_title：Allergologia et immunopathologia
pub_type： 杂志文章
doi：10.1016/j.aller.2014.11.002
更新日期：2015-11-01 00:00:00
abstract：:Five patients with atopic dermatitis, three males and two females, aged 2 to 17 years, had positive reactions to air allergens (Dermatophagoides pteronyssinus and/or farinae). All the patients suffered from severe recurrent dermatophytosis that responded poorly to antifungal treatment. The results of immunologic evalu...
journal_title：Allergologia et immunopathologia
pub_type： 杂志文章
doi：10.1016/s0301-0546(02)79135-0
更新日期：2002-09-01 00:00:00
abstract：:Thanks to its excellent safety profile, sublingual immunotherapy has served as a basis for launching two important lines of research in current allergology: sublingual immunotherapy with pharmaceutical registry (oral lyophilizates or tablets), and sublingual immunotherapy with food. At present, clinical trials are bei...
journal_title：Allergologia et immunopathologia
pub_type： 杂志文章
doi：10.1016/s0301-0546(08)75223-6
更新日期：2008-09-01 00:00:00
abstract：:The results of previous studies on the proliferative response of resting cord blood mononuclear cells (CBMC) of term neonates to human recombinant interleukin 2 (hrIL-2) are contrasting. Some authors have reported a good and others a poor response. In our study we have obtained a significant reactivity, compared with ...
journal_title：Allergologia et immunopathologia
pub_type： 杂志文章
doi：
更新日期：1992-05-01 00:00:00
abstract：BACKGROUND:Occupational allergy among florists and people who work in cut flower production of Alstroemeria cultivars (Peruvian lily or Inca lily) has been previously reported. The allergen involved in sensitization is tulipalin A (alpha-methylene-gamma-butyrolactone). CASE REPORT:We describe the case of a 65-year-old...
journal_title：Allergologia et immunopathologia
pub_type： 杂志文章
doi：10.1157/13086751
更新日期：2006-03-01 00:00:00
abstract：AIM:To prospectively evaluate interferences between viruses of the upper respiratory tract in asymptomatic preschool children. METHODS:Nasal-pharyngeal swabs from 233 preschool aged children were prospectively collected over four consecutive time periods, during one school year. The samples were tested using a RT-PCR ...
journal_title：Allergologia et immunopathologia
pub_type： 杂志文章
doi：10.1016/j.aller.2018.07.005
更新日期：2019-01-01 00:00:00
