Abstract：
BACKGROUND:Cord IgE and ECP levels are major atopic markers implicated in early childhood allergy development. Most epidemiological studies to date have not utilised current technology to establish baseline cord IgE levels, further aggravated by lack of data in this region. This study also attempts to identify a relationship between cord IgE and ECP levels as a mean to improve sensitivity for early prediction of atopy. METHODS:A total of 3183 cord blood IgE including 44 cord ECP samples of term neonates from Malay parentage were recruited. Total IgE and ECP levels were determined by ImmunoCAP and fluoroimmunoenzymatic, respectively. RESULTS:Cord IgE geometric mean was 0.15 kU/L. Males had higher IgE geometric mean than females (0.17 vs. 0.13). IgE values between 17 pair of twins was not significant (p=0.169). Frequency of males (29.9%) in >0.9 kU/L IgE category was higher than females (26.1%). In the <0.35 kU/L category, females had a higher frequency (44.8%) than males (39.1%). Males had significantly (p=0.023) higher IgE level than females. November and February had the highest mean and median cord IgE level whereas October and December were the lowest, respectively. IgE level across months was not significant (p=0.234). Cord ECP mean was 5.21 g/L and median was 3.75 μg/L. There was no significant correlation (p=0.513; r=-0.101) between cord blood ECP and IgE levels. CONCLUSION:Cord blood IgE level of Malay male neonates was significantly higher than females. These results do not support cord ECP as plausible adjunct parameter to IgE for early atopic detection.
journal_name
Allergol Immunopathol (Madr)journal_title
Allergologia et immunopathologiaauthors
Yadav A,Naidu Rdoi
10.1016/j.aller.2012.08.007subject
Has Abstractpub_date
2013-11-01 00:00:00pages
364-8issue
6eissn
0301-0546issn
1578-1267pii
S0301-0546(12)00285-6journal_volume
41pub_type
杂志文章abstract：:A retrospective study on 52,900 individuals tested in 177 Italian Medical Centres for AIDS and related syndromes is reported. The data confirm that I.V. drug users are the group at highest risk in Italy (46% were seropositive and more than one half of these presented PGL or ARC) and that the epidemic probably started ...
journal_title：Allergologia et immunopathologia
pub_type： 杂志文章
doi：
更新日期：1991-01-01 00:00:00
abstract：:Asthma morbidity and mortality has increased. One of the possible causes is the excessive use of beta agonists. The aim of this study is to compare the effects of six week treatment with beclomethasone alone (Ibec) or the combination of beclomethasone-salmeterol (Ibe + Isal) on serum potassium (K), CPK-MB and ECG in c...
journal_title：Allergologia et immunopathologia
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0301-0546(01)79010-6
更新日期：2001-01-01 00:00:00
abstract：:In 1975, Miller and Nussenzweig described a new function of the Complement (C'): the Capacity of this substance to solubilize "in vitro" antigen/antibody complexes previously formed. Subsequent studies of these authors and other researches (particularly Takahashi and his group) demonstrated that this process is mediat...
journal_title：Allergologia et immunopathologia
pub_type： 杂志文章,评审
doi：
更新日期：1994-09-01 00:00:00
abstract：BACKGROUND:The sharon fruit is the edible fruit of the persimmon tree (Diospyros kaki) which belongs to the Ebenaceae family. There are few references of allergic reaction to this fruit. We introduce a case of a 33-years old man with a anaphylactic reaction immediately after ingestion of sharon fruit. METHODS:Skin pri...
journal_title：Allergologia et immunopathologia
pub_type： 杂志文章
doi：10.1016/s0301-0546(01)79021-0
更新日期：2001-03-01 00:00:00
abstract：OBJECTIVE:Exhaled breath condensate (EBC) is a completely non-invasive method for the collection of airway secretions to measure intense inflammation in the airways of asthmatics. It has been shown that the childhood asthma control test (c-ACT) is a good tool for use in the evaluation of asthmatics. Whether the c-ACT s...
journal_title：Allergologia et immunopathologia
pub_type： 杂志文章
doi：10.1016/j.aller.2012.09.003
更新日期：2014-05-01 00:00:00
abstract：BACKGROUND:Assessment of asthma with a control test has been suggested as a relevant approach in recent years. However, no biomarker of systemic inflammation has been included in the assessment of asthma control. OBJECTIVE:To evaluate plasma paraoxonase (PON1), total oxidant status (TOS), and total antioxidant status ...
journal_title：Allergologia et immunopathologia
pub_type： 杂志文章
doi：10.1016/j.aller.2014.05.009
更新日期：2015-07-01 00:00:00
abstract：BACKGROUND:Although it has been hypothesized that infections may play a preventive role in allergic diseases, the role of Helicobacter pylori (H. pylori) is not clear. In this study we aimed to determine the association between H. pylori infection and allergic inflammation. METHODS:H. pylori infection was assessed in ...
journal_title：Allergologia et immunopathologia
pub_type： 杂志文章
doi：10.1157/13120393
更新日期：2008-03-01 00:00:00
abstract：:It has recently been published patients suffering from urticaria or anaphylaxia induced by nematodes usually parasitizing fishs or cephalopode, in whom, Anisakis simplex (AK) sensitization prevalence was detected up to 37%. We tried out a prospective study to evaluate the presence of AK specific-IgE in an asthmatic po...
journal_title：Allergologia et immunopathologia
pub_type： 杂志文章
doi：
更新日期：1997-03-01 00:00:00
abstract：BACKGROUND:Clinical research has shown that sublingual immunotherapy (SLIT) is effective and safe in moderate-severe allergic rhinitis (AR) induced by house dust mite (HDM). However, the sample size in many studies is small. Meanwhile, the controversy on the efficacy and safety in the very young children younger than f...
journal_title：Allergologia et immunopathologia
pub_type： 杂志文章
doi：10.1016/j.aller.2016.10.016
更新日期：2017-01-01 00:00:00
abstract：BACKGROUND:The relationship between GERD and asthma is complex. It is not yet clear whether GERD is an accompanying finding or a cause of asthma, or even if it is an aggravating factor. The aim of this study was to determine the frequency of asthma and allergic diseases in patients who underwent 24-h pH monitoring for ...
journal_title：Allergologia et immunopathologia
pub_type： 杂志文章
doi：10.1016/j.aller.2012.08.009
更新日期：2014-03-01 00:00:00
abstract：:We studied a group of asthmatic patients with aspirin intolerance who were RAST-negative for house-dust and Dermatophagoides-pteronyssinus despite having positive skin tests and positive inhalation tests to these allergens. Total haemolytic activity (CH50), C3, C4 and C3PA were measured after allergen-induced bronchos...
journal_title：Allergologia et immunopathologia
pub_type： 杂志文章
doi：
更新日期：1983-11-01 00:00:00
abstract：BACKGROUND:Atopy results from the interaction between genetic and environmental factors. The aim of our study was to clarify the association between the FcRIint2 polymorphic variant, the Glu237Gly mutation in exon 7 of FcepsilonRIbeta and (-590 C/T) Il-4 gene promoter polymorphism with atopy in a randomized Polish samp...
journal_title：Allergologia et immunopathologia
pub_type： 杂志文章
doi：10.1016/s0301-0546(04)79227-7
更新日期：2004-03-01 00:00:00
abstract：INTRODUCTION:Chronic granulomatous disease (CGD) is an uncommon primary immune deficiency (affecting 1/200,000 newborn infants) caused by a defect in phagocyte production of oxygen metabolites, and resulting in bacterial infections produced by catalase-positive microorganisms and fungal diseases that occasionally may p...
journal_title：Allergologia et immunopathologia
pub_type： 杂志文章
doi：10.1157/13106774
更新日期：2007-05-01 00:00:00
abstract：:Anaphylaxis is a systemic reaction which can be very dangerous in many patients. In addition to the most common antigens (drugs, venoms, foods), physical exercise can provoke anaphylaxis in the sensitized patients. The mechanism of this reaction is still unknown. In this report, we describe a case of exercise-induced ...
journal_title：Allergologia et immunopathologia
pub_type： 杂志文章
doi：
更新日期：1986-09-01 00:00:00
abstract：:We have investigated plasma kallikrein amidolytic activity in the following groups of patients: 1. Normal control group of blood donors. 2. Extrinsic pollen-activated bronchial asthma patients, during periods of symptomatology and at a later time after the spring. 3. Subjects with atopic bronchial asthma in acute phas...
journal_title：Allergologia et immunopathologia
pub_type： 杂志文章
doi：
更新日期：1992-09-01 00:00:00
abstract：BACKGROUND:Macrolides are useful in a wide range of bacterial infections including upper and lower respiratory tract, skin, and sexually transmitted diseases and are used in Helicobacter pylori eradication regimen. Skin symptoms occurring during drug therapy are mostly attributed to the antibiotic, causing considerable...
journal_title：Allergologia et immunopathologia
pub_type： 杂志文章
doi：10.1016/j.aller.2010.06.008
更新日期：2011-07-01 00:00:00
abstract：:Thanks to its excellent safety profile, sublingual immunotherapy has served as a basis for launching two important lines of research in current allergology: sublingual immunotherapy with pharmaceutical registry (oral lyophilizates or tablets), and sublingual immunotherapy with food. At present, clinical trials are bei...
journal_title：Allergologia et immunopathologia
pub_type： 杂志文章
doi：10.1016/s0301-0546(08)75223-6
更新日期：2008-09-01 00:00:00
abstract：:We report the induction of tolerance in four patients with severe IgE-mediated cow's milk allergy, with an oral rush desensitization by introducing increasing daily doses of cow's milk (CM) for 5 days under clinical conditions in order to enable the patients to tolerate 200 ml of CM daily. Our results indicate that we...
journal_title：Allergologia et immunopathologia
pub_type： 杂志文章
doi：10.1157/13110311
更新日期：2007-09-01 00:00:00
abstract：:Employing peripheral blood leucocytes as the model of the study, we proved how ketotifen blocks the inhibiting effect that the antigen induces over the adenyl cyclase activity in asthmatic individuals with sensitization to Dermatophagoides pteronyssinus. The strength of the Ketotifen effect is comparable to that produ...
journal_title：Allergologia et immunopathologia
pub_type： 杂志文章
doi：
更新日期：1988-05-01 00:00:00
abstract：BACKGROUND:Autosomal dominant hyper-IgE syndrome (AD-HIES) is a primary immunodeficiency mainly caused by mutations in STAT3, a signalling molecule implicated in the development of appropriate immune responses. We aimed to characterise the innate immune response in AD-HIES. METHODS:The frequency of innate immune cells...
journal_title：Allergologia et immunopathologia
pub_type： 杂志文章
doi：10.1016/j.aller.2014.11.002
更新日期：2015-11-01 00:00:00
abstract：INTRODUCTION:Intravenous immunoglobulin (IVIG) therapy is an effective treatment in patients with different diseases. This product must comply with all the regulatory requirements established by the World Health Organization and the European Pharmacopoeia for clinical tolerance, therapeutic efficacy, and viral safety. ...
journal_title：Allergologia et immunopathologia
pub_type： 杂志文章
doi：10.1157/13095871
更新日期：2006-11-01 00:00:00
abstract：:The inflammation markers in asthma can help the prognosis, diagnosis and monitoring of the respiratory illness. The adhesion molecules (AM) are membrane glycoproteins that intervene in the contact between the two cells or between the cell and the extracellular matrix. Their aim is to maintain the contact between two c...
journal_title：Allergologia et immunopathologia
pub_type： 杂志文章,评审
doi：
更新日期：2000-05-01 00:00:00
abstract：:The presence of autoantibodies in 125 patients with cryptogenic chronic hepatitis (CH) was assessed by indirect immunofluorescence (IFL) on standard tissue sections and on Hep-2 cells. Smooth muscle antibodies (SMA) were found in a high percentage of patients without any difference between the anti-HBc positive and th...
journal_title：Allergologia et immunopathologia
pub_type： 杂志文章
doi：
更新日期：1991-05-01 00:00:00
abstract：:A procedure is described for the cytochemical detection of esterase alpha naphtyl acetate (ANAE) and beta glucuronidase (BG) activity in the circulating lymphocytes of man. The number of BG positive cells (TBG) as evaluated on the smears of Ficoll Urovision purified cells, correlated well with the number of T gamma (E...
journal_title：Allergologia et immunopathologia
pub_type： 杂志文章
doi：
更新日期：1982-03-01 00:00:00
abstract：:Local administration of drugs by means of aerosol device is widely used in the treatment of asthma. Nevertheless, the effectiveness of this method depends on an adequate inhalation technique (IT), which available evidence has shown to be rather problematic. The aim of this study was to assess IT in out-patients with b...
journal_title：Allergologia et immunopathologia
pub_type： 杂志文章
doi：
更新日期：1998-03-01 00:00:00
abstract：:Platelet-activating factor (PAF), identified as 1-O-alkyl-2-acetyl-sn-glyceryl-3-phosphorylcholine, exhibits potent proinflammatory properties. PAF is produced by numerous cell types, including endothelial cells, neutrophils, monocytes, macrophages, basophils, eosinophils and mastocytes. Since the discovery and identi...
journal_title：Allergologia et immunopathologia
pub_type： 杂志文章,评审
doi：
更新日期：1997-09-01 00:00:00
abstract：:We report immunological studies performed in 19 sera from 4 children with idiopathic pulmonary hemosiderosis (IPH). Circulating C1q binding immune complexes (IC) were found in 3/4 of the patients during the acute phase. One child showed IC in 4 consecutive crises but they disappeared very rapidly (within 36 hours). On...
journal_title：Allergologia et immunopathologia
pub_type： 杂志文章
doi：
更新日期：1984-01-01 00:00:00
abstract：INTRODUCTION AND OBJECTIVES:Atopic dermatitis is common among children of 0-5 years old. Treatment consists of emollients and topical corticosteroids. Due to corticophobia, however, adherence to topical corticosteroids is low. Our aim was to find factors that influence opinions about topical corticosteroids among paren...
journal_title：Allergologia et immunopathologia
pub_type： 杂志文章
doi：10.1016/j.aller.2018.05.007
更新日期：2019-01-01 00:00:00
abstract：:Specific immunotherapy consists of the administration of allergen extracts to patients with allergic disease to achieve clinical tolerance to the causative allergens. Currently, it is the only etiologic treatment for respiratory allergy. A World Health Organization opinion paper published in 1997 defines immunotherapy...
journal_title：Allergologia et immunopathologia
pub_type： 杂志文章,评审
doi：10.1016/s0301-0546(04)79300-3
更新日期：2004-05-01 00:00:00
abstract：:A better understanding of the ocular immune responses should help us determine the etiology and pathophysiology of many uveitides. Ocular immune "privilege" is the result of the interaction of factors such as the blood-ocular barrier, the absence of lymphatic vessels, the sequestration of retinal antigens, the presenc...
journal_title：Allergologia et immunopathologia
pub_type： 杂志文章,评审
doi：
更新日期：1994-01-01 00:00:00
