Abstract：
INTRODUCTION:Intravenous immunoglobulin (IVIG) therapy is an effective treatment in patients with different diseases. This product must comply with all the regulatory requirements established by the World Health Organization and the European Pharmacopoeia for clinical tolerance, therapeutic efficacy, and viral safety. Although IVIG are effective and safe products, in some patients they may cause adverse reactions. OBJECTIVES:The aim of this study was to assess the clinical tolerance of two pharmaceutical forms (lyophilized and liquid) of Imunoglobulina G Endovenosa UNC (IVIG UNC), a regional IVIG preparation, and to compare the reported data. PATIENTS AND METHODS:The pharmacovigilance reports of 149 infusions in 51 patients treated with lyophilized IVIG UNC and of 157 infusions in 53 patients treated with liquid IVIG UNC were statistically evaluated. Clinical tolerance was evaluated through the adverse reactions reported. RESULTS:Lyophilized IVIG UNC: adverse reactions were reported in 6.7 % of the total number of infusions. Of these reactions, 4.0 % were mild, 2.0 % were moderate, and 0.7 % severe. Liquid IVIG UNC: adverse reactions were reported in 3.2 % of the total number of infusions; of these, 1.3 % were mild, 1.9 % were moderate, and 0.0 % were severe. Statistical analysis showed no association between tolerance and the pharmaceutical form used (p > 0.05) and indicated similar tolerance for both preparations. CONCLUSIONS:Based on the results obtained, the excellent clinical tolerance of both pharmaceutical forms of IVIG UNC can be confirmed.
journal_name
Allergol Immunopathol (Madr)journal_title
Allergologia et immunopathologiaauthors
Mahieu AC,Sisti AM,Joekes S,Manfredi MJdoi
10.1157/13095871subject
Has Abstractpub_date
2006-11-01 00:00:00pages
242-7issue
6eissn
0301-0546issn
1578-1267pii
13095871journal_volume
34pub_type
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journal_title：Allergologia et immunopathologia
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doi：
更新日期：1988-03-01 00:00:00
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journal_title：Allergologia et immunopathologia
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更新日期：1980-03-01 00:00:00
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journal_title：Allergologia et immunopathologia
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更新日期：1976-09-01 00:00:00
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journal_title：Allergologia et immunopathologia
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pub_type： 杂志文章,评审
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journal_title：Allergologia et immunopathologia
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journal_title：Allergologia et immunopathologia
pub_type： 杂志文章
doi：
更新日期：1984-09-01 00:00:00
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journal_title：Allergologia et immunopathologia
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journal_title：Allergologia et immunopathologia
pub_type： 杂志文章
doi：
更新日期：1981-07-01 00:00:00
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journal_title：Allergologia et immunopathologia
pub_type： 杂志文章
doi：10.1016/s0301-0546(02)79084-8
更新日期：2002-01-01 00:00:00
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doi：10.1016/s0301-0546(01)79035-0
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journal_title：Allergologia et immunopathologia
pub_type： 杂志文章
doi：
更新日期：1982-05-01 00:00:00
abstract：BACKGROUND:Clinical research has shown that sublingual immunotherapy (SLIT) is effective and safe in moderate-severe allergic rhinitis (AR) induced by house dust mite (HDM). However, the sample size in many studies is small. Meanwhile, the controversy on the efficacy and safety in the very young children younger than f...
journal_title：Allergologia et immunopathologia
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doi：10.1016/j.aller.2016.10.016
更新日期：2017-01-01 00:00:00
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journal_title：Allergologia et immunopathologia
pub_type： 杂志文章
doi：
更新日期：1993-07-01 00:00:00
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journal_title：Allergologia et immunopathologia
pub_type： 杂志文章
doi：
更新日期：1996-03-01 00:00:00
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journal_title：Allergologia et immunopathologia
pub_type： 杂志文章
doi：
更新日期：1993-11-01 00:00:00
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journal_title：Allergologia et immunopathologia
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doi：
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journal_title：Allergologia et immunopathologia
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doi：
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journal_title：Allergologia et immunopathologia
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doi：
更新日期：1993-09-01 00:00:00
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journal_title：Allergologia et immunopathologia
pub_type： 杂志文章
doi：
更新日期：1993-03-01 00:00:00
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journal_title：Allergologia et immunopathologia
pub_type： 杂志文章
doi：
更新日期：1976-07-01 00:00:00
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doi：10.1016/j.aller.2015.09.004
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doi：10.1016/j.aller.2013.04.003
更新日期：2014-09-01 00:00:00
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更新日期：2020-01-01 00:00:00
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更新日期：1995-09-01 00:00:00
abstract：BACKGROUND:High sensitive C-reactive protein (hs-CRP) has been shown to be associated with asthma in recent studies. However, the relationship between hs-CRP and the control of asthma has not been clearly identified yet. OBJECTIVE:To investigate the association of hs-CRP with asthma control test (ACT), which reveals t...
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doi：10.1016/j.aller.2011.10.002
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