Cofactors and comorbidities in patients with aspirin/NSAID hypersensitivity.

Abstract:

:Hypersensitivity reactions to aspirin and other NSAIDs occur in individuals genetically predisposed and exhibit different clinical manifestations, especially respiratory, cutaneous, and generalised. Five different phenotypes define distinct clinical pictures: aspirin-exacerbated respiratory disease, aspirin/NSAID cutaneous disease, NSAID-induced urticaria, angio-oedema and anaphylaxis, single NSAID reactions, and delayed reactions. They are observed more frequently in middle-aged women, and in atopic individuals. While ASA/NSAID hypersensitivity shares comorbidities with asthma, chronic rhinosinusitis, nasal polyposis, chronic urticaria and angio-oedema, ASA and other NSAIDs can also be cofactors for other clinically relevant conditions, especially food-dependent exercise-induced anaphylaxis, angio-oedema induced by angiotensin-converting enzyme inhibitors, and oral mite anaphylaxis. Awareness on these relationships is required for the correct diagnosis, classification, and treatment of affected patients.

authors

Sánchez-Borges M,Caballero-Fonseca F,Capriles-Hulett A

doi

10.1016/j.aller.2016.08.010

subject

Has Abstract

pub_date

2017-01-01 00:00:00

pages

573-578

issue

6

eissn

0301-0546

issn

1578-1267

pii

S0301-0546(16)30121-5

journal_volume

45

pub_type

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