Abstract：
BACKGROUND:Anaphylaxis is an acute multisystemic and potentially fatal reaction, resulting from the rapid release of inflammatory mediators. Its exact prevalence is unknown. In children, foods are the most significant triggers for IgE-mediated anaphylaxis. OBJECTIVES:To characterise the cases of anaphylaxis evaluated in an Allergy Division of a Central Paediatric Hospital. MATERIAL AND METHODS:A review of all cases of anaphylaxis evaluated from 2001 to 2009. Anaphylaxis was defined according to Sampson's 2006 criteria. RESULTS:Seventy-three children had anaphylactic reactions (47 male), of which 64% had history of atopy. Age at time of reaction ranged between 17 days and 15 years old (median: four years). Food was the most frequently identified cause (n=57), followed by drugs (n=8), hymenoptera venom (n=2), and cold (n=1). In five cases there was no identifiable cause. Among foods, cow's milk was the culprit agent in 27 children. The most severe reaction was a cardiorespiratory arrest. The most frequent symptoms were respiratory and cutaneous in 51 cases. Hypotension was present in nine cases. There were no fatalities. Most acute reactions were treated with corticosteroids and/or antihistamines. Adrenaline was used in only about one quarter of children. CONCLUSIONS:The most important causes of anaphylaxis in our study were foods, and the most common symptoms were respiratory and cutaneous. The prevalence of anaphylaxis was higher in males and, in two thirds of patients there was a history of atopy. Despite being the primary and most important treatment for anaphylaxis, adrenaline is still used in only a minority of these cases.
journal_name
Allergol Immunopathol (Madr)journal_title
Allergologia et immunopathologiaauthors
Silva R,Gomes E,Cunha L,Falcão Hdoi
10.1016/j.aller.2010.12.012subject
Has Abstractpub_date
2012-01-01 00:00:00pages
31-6issue
1eissn
0301-0546issn
1578-1267pii
S0301-0546(11)00120-0journal_volume
40pub_type
杂志文章abstract：INTRODUCTION:Omalizumab has been demonstrated to be a successful therapy in the management of asthma through reduction of patient's symptoms and use of inhaled corticosteroids. The effect of omalizumab is achieved by immunoglobulin E (IgE) blockage and other secondary mechanisms resulting from this blockage. Because ot...
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journal_title：Allergologia et immunopathologia
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journal_title：Allergologia et immunopathologia
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doi：
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journal_title：Allergologia et immunopathologia
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journal_title：Allergologia et immunopathologia
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journal_title：Allergologia et immunopathologia
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journal_title：Allergologia et immunopathologia
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journal_title：Allergologia et immunopathologia
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doi：
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journal_title：Allergologia et immunopathologia
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doi：
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journal_title：Allergologia et immunopathologia
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doi：
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journal_title：Allergologia et immunopathologia
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