Modulation by neurotransmitters (norepinephrine, serotonin) of the murine antibody response to autologous and heterologous erythrocytes.

Abstract:

:The modulation by norepinephrine and serotonin of the persistent antibody response to autologous and heterologous erythrocytes has been studied in [(C27Bl6xCBA/Ca) F1] mice. Serotonin (subcutaneously administered) transiently decreased the response to both autologous erythrocytes and rat erythrocytes; nevertheless, inhibition of serotonin synthesis (with p-chloro-phenylalanine) barely affected the responses. The influence of norepinephrine has been investigated by (subcutaneous) administration of ephedrine (a sympathomimetic) or by neonatal sympathectomy with 6-hydroxydopamine. Neither the sympathomimetic nor the sympathectomy substantially altered the response (of adult mice) to autologous or heterologous erythrocytes. Treatment with p-chloro-phenylalanine of adult mice (which had been neonatally treated with 6-hydroxydopamine) resulted in impaired responses to both autologous and heterologous erythrocytes. On the whole, a fall in the level of norepinephrine or serotonin exerted, at most, a minor influence on the persistent antibody response to self and foreign erythrocytes, but a decrease of both amines exerted a greater influence.

authors

Vidal J

subject

Has Abstract

pub_date

1989-05-01 00:00:00

pages

161-5

issue

3

eissn

0301-0546

issn

1578-1267

journal_volume

17

pub_type

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