The stimulatory effect of a single intravenous dose of propranolol of some immune parameters in humans.

Abstract:

:Propranolol (PRO) is a beta-adrenergic receptor antagonist. The studies were aimed to evaluate the effect of a single intravenous PRO injection at a dose of 0.1 mg/kg on some immune parameters, and were performed on 12 men, including 9 duodenal ulcer patients and 3 healthy subjects, aged 19-23 years (mean 20.5 +/- 1.2). Blood samples were drawn before, 30 and 150 min following the injection. Results obtained in duodenal ulcer patients and healthy subjects revealed the same type of changes. A single PRO injection did not significantly affect total peripheral blood lymphocyte, Th cell and monocyte counts; however, it slightly but significantly lowered numbers of T and Ts cells, which was accompanied by a rise in Th/Ts cell number ratio and NK cell numbers. PRO significantly augmented spontaneous as well as PHA-stimulated IL-2 receptor expression, IL-2 generation, NK cell activity and AMLR observed at 30 and 150 min after the drug injection. Possible mechanisms of these changes are discussed.

authors

Malec P,Markiewicz K,Tchórzewski H,Zeman K,Baj Z,Nowak Z,Majewska E

subject

Has Abstract

pub_date

1988-03-01 00:00:00

pages

85-9

issue

2

eissn

0301-0546

issn

1578-1267

journal_volume

16

pub_type

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