当前位置： SCI文献检索 > ALLERGOLOGIA ET IMMUNOPATHOLOGIA期刊下所有文献 > Montelukast in early childhood asthma. Predict value of IgG in clinical reply in children 2 to 5 years old?

Montelukast in early childhood asthma. Predict value of IgG in clinical reply in children 2 to 5 years old?

Abstract：

BACKGROUND:According to current knowledge, asthma is basically an inflammatory process. Its causes and physiopathological mechanisms are various. The final result is a recurrent obstructive bronchial process, with sibilants and/or dypnea, which causes an upset in functional respiratory tests, among which the maximum respiratory peak flow meter diminished for the age, sex, and height of patient. AIMS:Our aim is to evaluate if response to treatment with Montelukast has any link with immnuloglobin values (IgG, IgA, IgM, IgE) at start of treatment. MATERIALS AND METHODS:Included in the study were 32 children, of whom 2 did not begin and 1 who did not provide personal data. There were 29 patients in total, 11 girls and 18 boys. Each made three visits: first where they were instructed, together with their parents, in how to manage the meter and where they received the peak flow meter, Vitalograph, and personal data sheet, where personal and family medical history were noted. The second visit was after 4 weeks, for a clinical assessment and the third visit after 8 weeks. The value register of the PEF would be made morning and night, noting the highest value of three measurements. IgG, IgA, IgM, IgA values were quantified before treatment began. The statistic package STATA 2001 was used in the treatment of data statistics. RESULTS:Our between the value reached by the PEF after treatment and the IgG values at the beginning of treatment (0.712). In lesser measurement for IgA values (0.660). For each 100 mg/ml of increase in the value of IgG, an increase of 10 l/min in the PEF measurement before and following treatment with Montelukast was produced. CONCLUSIONS:IgG values increase with age. Children with a greater IgG value at the beginning of treatment reached higher PEF values after same. It is not known if the results would be similar with another type of treatment and the way in which IgG influences the results. What appears to be confirmed by available studies is that this relation is found in a group of small children, the aim of our study.

journal_name

Allergol Immunopathol (Madr)

journal_title

Allergologia et immunopathologia

authors

Hernando SV,Rodríguez M,Ayala SJ,Costa GF,Chumilla VM,García CM,Jiménez FJ,Lorente GS,Navarro GF,Orihuela CC,Ortuño MM,Pelegrín LB

doi

10.1016/s0301-0546(04)79240-x

keywords:

subject

Has Abstract

pub_date

2004-07-01 00:00:00

pages

204-11

issue

eissn

0301-0546

issn

1578-1267

pii

13064924

journal_volume

pub_type

杂志文章

在线工具

Montelukast in early childhood asthma. Predict value of IgG in clinical reply in children 2 to 5 years old?