Abstract:
:In view of the excellent results we had obtained using KETOTIFEN in the treatment of respiratory allergies, we decided to carry out a study of its protective action in cases of allergies of purely alimentary etiology; that is, in patients symptoms only appeared after the ingestion of certain foodstuffs. The subjects of this study were 16 patients, 8 men and 8 women, aged from 13 to 49. The diagnosis of food allergy was reached by means of a clear and detailed history, skin tests, hemagglutination tests and positive oral provocation tests with the tested antigens in all patients. The basal oral provocation tests were carried out when the patients were fasting, using progressively larger doses of the antigens until a positive response was obtained, consisting of an exact reproduction of the symptomatology described in the history. After an interval of at least 10 days, a second oral provocation test was performed under identical conditions, using the same dose of antigens, after a treatment consisting of 1 capsule (1 mg.) of KETOTIFEN every 12 hours during the 5 days prior to the test. Clinical symptoms appearing singly or together in the OPT were dermal in 8 patients (50%), respiratory in 7 patients (42.85%) and gastrointestinal in 3 patients (18.75%). In 7 patients whose shock organ was the expiratory system, (group A) shows the decrease in FEV1 in each patient. It clearly shows that the patients had a smaller decrease in FEV1 after treatment, as compared with baseline values after OPT. On the other hand, 9 patients whose shock organ was the skin and the gut (group B), the protection ws complete in 6 patients (66%). The drug was well tolerated, the only side effects observed being somnolence in one patient and dryness of the mouth in another (12.5%). No changes were observed in the hemogram, ESR, blood tests, pulse, blood sugar and urinalysis. The most recent studies of the mechanism of action of KETOTIFEN are suggestive, but have not yet provided a complete explanation. This drug inhibits the release of histamine and SRS-A from mast cells, basophils and neutrophils. The fact that, as distinct from DSCG, it acts on neutrophils, inhibiting the release of SRS-A, suggests that its mode of action does not only concern those reactions mediated by IgE.
journal_name
Allergol Immunopathol (Madr)journal_title
Allergologia et immunopathologiaauthors
Neffen H,Oehling A,Subirá MLsubject
Has Abstractpub_date
1980-03-01 00:00:00pages
97-104issue
2eissn
0301-0546issn
1578-1267journal_volume
8pub_type
杂志文章abstract::A prospective, multicenter pharmacovigilance study was carried out to evaluate the safety of a new 7-dose treatment schedule of subcutaneous immunotherapy as opposed to the conventional 13 doses normally recommended. The study was carried out in 14 centers and included 261 patients (children and adults) with respirato...
journal_title:Allergologia et immunopathologia
pub_type: 杂志文章,多中心研究
doi:10.1016/s0301-0546(04)79217-4
更新日期:2004-01-01 00:00:00
abstract::Leguminous are a cheap source of protein that are cultivated practically throughout the world. They are the main source of food in developing countries. In the Mediterranean area and Middle East, the most commonly consumed legumes are lentils and chickpea. In the United States, United Kingdom and south-east Asia, the ...
journal_title:Allergologia et immunopathologia
pub_type: 杂志文章,评审
doi:10.1016/s0301-0546(02)79152-0
更新日期:2002-11-01 00:00:00
abstract:BACKGROUND:Allergic diseases are very common, with the estimated cumulative prevalence in Colombia for asthma and allergic rhinitis being 22.7% and 31.3% respectively, and with a clear upward trend. A major social as well as economic impact associated with allergic disease has been described. Because in Colombia there ...
journal_title:Allergologia et immunopathologia
pub_type: 杂志文章
doi:10.1016/j.aller.2011.11.008
更新日期:2012-11-01 00:00:00
abstract::We report the case of a 51-year-old woman who had an immediate skin reaction after subcutaneous administration of a local anesthetic (LA) composed of articaine and epinephrine before a dental procedure. The patient subsequently underwent further dental procedures without LA. Skin prick tests performed with commercial ...
journal_title:Allergologia et immunopathologia
pub_type: 杂志文章
doi:10.1157/13072924
更新日期:2005-03-01 00:00:00
abstract::Lymphocyte subpopulations were determined by indirect immunofluorescence using monoclonal antibodies T11, T4, T8 and B1 on three different days in a group of thirteen normal subjects. Although there was considerable intersubject variation, the percentages of lymphocyte subpopulations as well as absolute numbers did no...
journal_title:Allergologia et immunopathologia
pub_type: 杂志文章
doi:
更新日期:1984-09-01 00:00:00
abstract::This study reports on the usefulness of skin mast cell quantification (mast cells(mm2) as a parameter for the diagnosis of atopic dermatitis (AD) and for determining the efficacy of the therapeutic measures employed. Fifteen children with AD of moderate to extreme severity, and which started within the first two years...
journal_title:Allergologia et immunopathologia
pub_type: 杂志文章
doi:
更新日期:1995-07-01 00:00:00
abstract::The proliferative and stimulatory capacities in allogeneic and autologous mixed lymphocyte reactions were evaluated in 5 patients affected by renal insufficiency undergoing maintenance hemodialysis. The expression of HLA class II antigens and Interleukin 2 production by PHA-activated T cells were also investigated. Fu...
journal_title:Allergologia et immunopathologia
pub_type: 杂志文章
doi:
更新日期:1991-07-01 00:00:00
abstract:BACKGROUND:Pollens represent a rich source of proteins that are also potential elicitors of IgE-mediated pollen allergy. Sensitisation to panallergens could play an important role in diagnosis and specific immunotherapy, because these molecules are present in different plant pollens and plant foods and have marked stru...
journal_title:Allergologia et immunopathologia
pub_type: 杂志文章
doi:10.1016/j.aller.2015.05.002
更新日期:2016-03-01 00:00:00
abstract:BACKGROUND:Clinical research has shown that sublingual immunotherapy (SLIT) is effective and safe in moderate-severe allergic rhinitis (AR) induced by house dust mite (HDM). However, the sample size in many studies is small. Meanwhile, the controversy on the efficacy and safety in the very young children younger than f...
journal_title:Allergologia et immunopathologia
pub_type: 杂志文章
doi:10.1016/j.aller.2016.10.016
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND:Leukotrienes are among the most important mediators associated with inflammatory responses in patients with exercise induced asthma (EIA). The aim of this study was to investigate the impact of exercise on the urinary leukotriene profile. Hence, we compared post exercise changes of urinary leukotriene E4 (LT...
journal_title:Allergologia et immunopathologia
pub_type: 杂志文章
doi:10.1016/j.aller.2011.03.012
更新日期:2012-05-01 00:00:00
abstract::A lot of recent works point out the role of the eosinophil as one of the most harmful cells in asthma. Eosinophilic granules contain strongly basiec cytotoxic proteins. Some of these proteins were shown to damage airway epithelial cells and degranulate basophils and mast cells. The concentration of eosinophil-derived ...
journal_title:Allergologia et immunopathologia
pub_type: 杂志文章,评审
doi:
更新日期:1989-03-01 00:00:00
abstract:BACKGROUND:The objective was to estimate the incidence of asthma in young adults from 13-15 years old to 23-25 years old, and associated factors. METHODS:In 2012, a population-based prospective cohort study was carried out in Castellon from the cohort who had participated in the International Study of Asthma and Aller...
journal_title:Allergologia et immunopathologia
pub_type: 杂志文章
doi:10.1016/j.aller.2017.03.003
更新日期:2018-01-01 00:00:00
abstract:BACKGROUND:The clinical relevance of elevated basal serum tryptase (eBST ≥ 11.4 ng/ml) often remains unclear. METHODS:BST was assessed in 15,298 patients attending our outpatient clinic. Frequency and severity of anaphylaxis was compared in 900 patients with eBST and 900 patients with normal BST. The prevalence of eBS...
journal_title:Allergologia et immunopathologia
pub_type: 杂志文章
doi:10.1016/j.aller.2014.05.002
更新日期:2014-11-01 00:00:00
abstract::Some authors succeded in binding the bradykinin in form of a haptene by an azo-bridge to the human gammaglobulin as a vehicle. In this way, the bradykinin has been supplemented to a complete antigen. The bradykinin as a strongly vasoactive substance causes--after a local intradermal injection--an intensive circumscrib...
journal_title:Allergologia et immunopathologia
pub_type: 杂志文章
doi:
更新日期:1977-03-01 00:00:00
abstract:BACKGROUND:Atopy results from the interaction between genetic and environmental factors. The aim of our study was to clarify the association between the FcRIint2 polymorphic variant, the Glu237Gly mutation in exon 7 of FcepsilonRIbeta and (-590 C/T) Il-4 gene promoter polymorphism with atopy in a randomized Polish samp...
journal_title:Allergologia et immunopathologia
pub_type: 杂志文章
doi:10.1016/s0301-0546(04)79227-7
更新日期:2004-03-01 00:00:00
abstract:INTRODUCTION AND OBJECTIVES:Atopic dermatitis is common among children of 0-5 years old. Treatment consists of emollients and topical corticosteroids. Due to corticophobia, however, adherence to topical corticosteroids is low. Our aim was to find factors that influence opinions about topical corticosteroids among paren...
journal_title:Allergologia et immunopathologia
pub_type: 杂志文章
doi:10.1016/j.aller.2018.05.007
更新日期:2019-01-01 00:00:00
abstract::The gaseous phase cultures of alveolar macrophages (AMs) of guinea pig were exposed to the saline extracts of the dust-borne bacteria Micropolyspora faeni (syn. Faenia rectivirgula) and Erwinia herbicola (syn. Enterobacter agglomerans) which have been added at the concentration of 1 microgram/ml to culture medium with...
journal_title:Allergologia et immunopathologia
pub_type: 杂志文章
doi:
更新日期:1990-07-01 00:00:00
abstract::A variety of antiasthmatic drugs were examined in a bioassay of uterine cornua of rats for determining their influence upon Bradykinin induced contractions. 4 different actions were seen: pronounced, moderate and weak suppression of enhancement of Bradykinin-activity. The most pronounced blocking effect was seen with ...
journal_title:Allergologia et immunopathologia
pub_type: 杂志文章
doi:
更新日期:1982-11-01 00:00:00
abstract:BACKGROUND:Cord IgE and ECP levels are major atopic markers implicated in early childhood allergy development. Most epidemiological studies to date have not utilised current technology to establish baseline cord IgE levels, further aggravated by lack of data in this region. This study also attempts to identify a relati...
journal_title:Allergologia et immunopathologia
pub_type: 杂志文章
doi:10.1016/j.aller.2012.08.007
更新日期:2013-11-01 00:00:00
abstract:BACKGROUND:Angiotensin converting enzyme (ACE) is expressed at high levels in the lungs and plays a role in the metabolism of the endogenous peptides involved in asthma pathogenesis. ACE gene polymorphisms have been reported to be linked to asthma. However, the results are conflicting, with no reported studies on Egypt...
journal_title:Allergologia et immunopathologia
pub_type: 杂志文章
doi:10.1016/j.aller.2011.05.010
更新日期:2012-09-01 00:00:00
abstract::The effect of alcohol ingestion on the prognosis of chronic liver diseases was studied'n. Among 880 patients with chronic liver diseases the percentage of alcoholics was high, 33%, compared to 3.2% in the control group. The period of survival time is decreased by one half in patients with regular alcohol ingestion. Ac...
journal_title:Allergologia et immunopathologia
pub_type: 杂志文章
doi:
更新日期:1981-09-01 00:00:00
abstract::Urticaria and angioedema are common diseases in children and adults. Approximately 15-25% of the population will have urticaria or angioedema at least once in their life-time. Urticaria is characterized as the appearance of erythematous, circumscribed, elevated, pruritic, edematous swelling of the upper dermal tissue....
journal_title:Allergologia et immunopathologia
pub_type: 杂志文章,评审
doi:
更新日期:1999-03-01 00:00:00
abstract::Carrot is frequently involved in food allergies and oral allergy syndromes, usually in association with other foods. Nevertheless, carrot alone is rarely responsible for severe systemic reactions. We report a case of anaphylactic shock due to the inadvertent ingestion of carrot as a hidden allergen contained in an ice...
journal_title:Allergologia et immunopathologia
pub_type: 杂志文章
doi:10.1016/s0301-0546(02)79128-3
更新日期:2002-07-01 00:00:00
abstract:INTRODUCTION AND OBJECTIVES:The reproducibility of the adverse reaction increases the suggestiveness of a history of food allergy. However, the positive predictive value (PPV) of multiple adverse reaction episodes for the diagnosis of IgE-mediated food allergy is not known. This evaluation was the objective of our stud...
journal_title:Allergologia et immunopathologia
pub_type: 杂志文章
doi:10.1016/j.aller.2018.10.006
更新日期:2019-01-01 00:00:00
abstract::We report the cases of 2 patients diagnosed as having primula dermatitis. Both patients were housewives who had been exposed to primula plants. Although only one related her clinical manifestations with looking after plants, the symptoms of both remitted when contact with primula was avoided. The diagnosis was carried...
journal_title:Allergologia et immunopathologia
pub_type: 杂志文章
doi:
更新日期:1999-01-01 00:00:00
abstract::We report immunological studies performed in 19 sera from 4 children with idiopathic pulmonary hemosiderosis (IPH). Circulating C1q binding immune complexes (IC) were found in 3/4 of the patients during the acute phase. One child showed IC in 4 consecutive crises but they disappeared very rapidly (within 36 hours). On...
journal_title:Allergologia et immunopathologia
pub_type: 杂志文章
doi:
更新日期:1984-01-01 00:00:00
abstract::The increase in the consumption of tropical nuts in the Northern Hemisphere during the last years, has evolved in a simultaneous enhancement of allergic IgE mediated (Hypersensitivity type 1) reported cases produced by this kind of food. The Brazil nut is the seed of the Bertholletia excelsa tree (Family Lecythidaceae...
journal_title:Allergologia et immunopathologia
pub_type: 杂志文章
doi:
更新日期:1997-05-01 00:00:00
abstract::All classes of immunoglobulins and albumin have been studied in different phases of disease, both in blood and in the nasal secretions of 75 patients with pollen allergy. There were 20 healthy persons in the test group. Total correlational analysis was done to determine interdependence of the researched indexes. The p...
journal_title:Allergologia et immunopathologia
pub_type: 杂志文章
doi:
更新日期:1990-11-01 00:00:00
abstract:BACKGROUND:One of the factors affecting compliance is the pharmaceutical formulation used. Many patients find it difficult to swallow tablets or capsules. The fast dissolving tablet (FDT) formulation could help to enhance patient compliance, because of its ease of administration and because no liquid is required to hel...
journal_title:Allergologia et immunopathologia
pub_type: 杂志文章,多中心研究
doi:10.1157/13088176
更新日期:2006-05-01 00:00:00
abstract:BACKGROUND:Few data are available concerning the time trends and risk factors associated with allergic rhinitis (AR) in schoolchildren in Hungary. METHODS:At an interval of six years, parents of 6-12-year-old children completed identical ISAAC-based and additional questionnaires related to possible risk factors. RESU...
journal_title:Allergologia et immunopathologia
pub_type: 杂志文章
doi:10.1016/j.aller.2017.02.010
更新日期:2017-01-01 00:00:00