Abstract：
:The proliferative and stimulatory capacities in allogeneic and autologous mixed lymphocyte reactions were evaluated in 5 patients affected by renal insufficiency undergoing maintenance hemodialysis. The expression of HLA class II antigens and Interleukin 2 production by PHA-activated T cells were also investigated. Furthermore the immunomodulatory effects of uremic serum and serum fractions on mixed lymphocyte reactions performed with lymphocytes from normal subjects were analyzed. The results show that both responsive and stimulatory capacities in allogeneic and autologous mixed lymphocyte reactions of non-T/T and T/T type are clearly impaired. The expression of HLA class II antigens by PHA-activated T cells was reduced whereas the production of Interleukin 2 was normal. The autologous and allogeneic mixed lymphocyte reactions of normal lymphocytes were inhibited by unfractionated uremic serum and by a wide range of serum fractions with different molecular weights. All the above mentioned immune defects were not corrected by the dialytic treatment. The present study extends previous reports concerning the defective immunocompetence associated with chronic renal insufficiency showing that: a) the autologous mixed lymphocyte reactions of both non-T/T and T/T type are impaired; b) the uremic serum contains several factors inhibiting the autologous mixed lymphocyte reactions of normal lymphocytes; c) the chronic hemodialytic treatment does not correct these defects.
journal_name
Allergol Immunopathol (Madr)journal_title
Allergologia et immunopathologiaauthors
Puppo F,Gurreri G,Pattarini R,Ranise A,Indiveri Fsubject
Has Abstractpub_date
1991-07-01 00:00:00pages
167-73issue
4eissn
0301-0546issn
1578-1267journal_volume
19pub_type
杂志文章abstract：BACKGROUND:It is thought that airway inflammation is more common in obese asthmatic patients because inflammation is harder to control and does not respond well to glucocorticoid treatment. OBJECTIVE:This study's aim was to investigate the effect of obesity on airway and systemic inflammation in children with asthma a...
journal_title：Allergologia et immunopathologia
pub_type： 杂志文章
doi：10.1016/j.aller.2017.01.013
更新日期：2017-01-01 00:00:00
abstract：BACKGROUND:Migrants from developing to Western countries tend to become more sensitised to host than to origin country allergens, although substantial changes in migration patterns have occurred in recent decades. METHODS:We investigated adult immigrants with respiratory allergy, first tested for allergic sensitisatio...
journal_title：Allergologia et immunopathologia
pub_type： 杂志文章
doi：10.1016/j.aller.2014.07.007
更新日期：2015-09-01 00:00:00
abstract：:Asthma is a complex disease determined by the interaction of different genes and environmental factors. The first genetic investigations in asthma were candidate gene association studies and linkage studies. In recent years research has focused on association studies that scan the entire genome without any prior condi...
journal_title：Allergologia et immunopathologia
pub_type： 杂志文章,评审
doi：10.1016/j.aller.2014.07.004
更新日期：2015-11-01 00:00:00
abstract：:The modulation by norepinephrine and serotonin of the persistent antibody response to autologous and heterologous erythrocytes has been studied in [(C27Bl6xCBA/Ca) F1] mice. Serotonin (subcutaneously administered) transiently decreased the response to both autologous erythrocytes and rat erythrocytes; nevertheless, in...
journal_title：Allergologia et immunopathologia
pub_type： 杂志文章
doi：
更新日期：1989-05-01 00:00:00
abstract：:This work deals with a study of the changes observed throughout the four seasons of the year concerning the number of fungi which can be found in the atmosphere of Barcelona. The results obtained will bring us to the conclusion that during the autumn and winter months the number of conidia per m3 is greater than in sp...
journal_title：Allergologia et immunopathologia
pub_type： 杂志文章
doi：
更新日期：1983-07-01 00:00:00
abstract：BACKGROUND:Few data are available concerning the time trends and risk factors associated with allergic rhinitis (AR) in schoolchildren in Hungary. METHODS:At an interval of six years, parents of 6-12-year-old children completed identical ISAAC-based and additional questionnaires related to possible risk factors. RESU...
journal_title：Allergologia et immunopathologia
pub_type： 杂志文章
doi：10.1016/j.aller.2017.02.010
更新日期：2017-01-01 00:00:00
abstract：BACKGROUND:Few previous reports of carrot-induced asthma have been confirmed by objective tests. Hypersensitivity to carrot is frequently associated with allergy to Apiaceae spices and sensitization to birch and mugwort pollens. CLINICAL CASE:A 40-year-old cook woman was seen with sneezing, rhinorrhea, contact urticar...
journal_title：Allergologia et immunopathologia
pub_type： 杂志文章
doi：10.1157/13080934
更新日期：2005-09-01 00:00:00
abstract：BACKGROUND:Autosomal dominant hyper-IgE syndrome (AD-HIES) is a primary immunodeficiency mainly caused by mutations in STAT3, a signalling molecule implicated in the development of appropriate immune responses. We aimed to characterise the innate immune response in AD-HIES. METHODS:The frequency of innate immune cells...
journal_title：Allergologia et immunopathologia
pub_type： 杂志文章
doi：10.1016/j.aller.2014.11.002
更新日期：2015-11-01 00:00:00
abstract：BACKGROUND:Assessment of asthma with a control test has been suggested as a relevant approach in recent years. However, no biomarker of systemic inflammation has been included in the assessment of asthma control. OBJECTIVE:To evaluate plasma paraoxonase (PON1), total oxidant status (TOS), and total antioxidant status ...
journal_title：Allergologia et immunopathologia
pub_type： 杂志文章
doi：10.1016/j.aller.2014.05.009
更新日期：2015-07-01 00:00:00
abstract：OBJECTIVE:This study aimed to assess the regular use of long-term asthma-control medication and to determine inhaler techniques in asthmatic children. METHODS:The study was conducted on asthmatic children aged 6-18 years. Information on rescue and controller medications was given and the proper inhalation technique wa...
journal_title：Allergologia et immunopathologia
pub_type： 杂志文章
doi：10.1016/j.aller.2019.06.009
更新日期：2020-01-01 00:00:00
abstract：:In the recent years immunological abnormalities, including defective polymorphonuclear neutrophils (PMN) chemotaxis and both quantitative and functional defects in T-lymphocytes, have been reported in atopic dermatitis (AD). To date there is still a controversy regarding the causes of PMN chemotaxis defect and the pos...
journal_title：Allergologia et immunopathologia
pub_type： 杂志文章
doi：
更新日期：1983-05-01 00:00:00
abstract：:Some authors succeded in binding the bradykinin in form of a haptene by an azo-bridge to the human gammaglobulin as a vehicle. In this way, the bradykinin has been supplemented to a complete antigen. The bradykinin as a strongly vasoactive substance causes--after a local intradermal injection--an intensive circumscrib...
journal_title：Allergologia et immunopathologia
pub_type： 杂志文章
doi：
更新日期：1977-03-01 00:00:00
abstract：:Although not yet clear, the etiology of sarcoidosis may be linked to seasonal, environmental and genetic factors; mycobacterial or other infections. To the best of our knowledge there is no data suggesting any connection between the onset of sarcoidosis and specific allergen immunotherapy in the medical literature. Du...
journal_title：Allergologia et immunopathologia
pub_type： 杂志文章
doi：10.1157/13099093
更新日期：2007-01-01 00:00:00
abstract：BACKGROUND:Atopy results from the interaction between genetic and environmental factors. The aim of our study was to clarify the association between the FcRIint2 polymorphic variant, the Glu237Gly mutation in exon 7 of FcepsilonRIbeta and (-590 C/T) Il-4 gene promoter polymorphism with atopy in a randomized Polish samp...
journal_title：Allergologia et immunopathologia
pub_type： 杂志文章
doi：10.1016/s0301-0546(04)79227-7
更新日期：2004-03-01 00:00:00
abstract：:This study was undertaken for two reasons: 1) It is more difficult to diagnose hypersensitivity to molds than to other allergens, so an evaluation of diagnostic tests was needed. 2) Alternaria is the principal cause of mold sensitization in our area. Sixty-six patients (20 +/- 4 years) were selected and divided into t...
journal_title：Allergologia et immunopathologia
pub_type： 杂志文章
doi：
更新日期：1993-07-01 00:00:00
abstract：BACKGROUND:Diamine oxidase (DAO) is a polyamine-degrading enzyme also implicated in histamine metabolism. Chronic urticaria (CU) has a wide spectrum of clinical presentations and causes. Anisakis sensitisation associated chronic urticaria (CU+) has been characterised as a phenotype with different clinical and immunolog...
journal_title：Allergologia et immunopathologia
pub_type： 杂志文章
doi：10.1016/j.aller.2015.01.009
更新日期：2015-11-01 00:00:00
abstract：:Excessive accumulation of histamine in the body leads to miscellaneous symptoms mediated by its bond to corresponding receptors (H1-H4). Increased concentration of histamine in blood can occur in healthy individuals after ingestion of foods with high contents of histamine, leading to histamine intoxication. In individ...
journal_title：Allergologia et immunopathologia
pub_type： 杂志文章,评审
doi：10.1016/j.aller.2015.05.001
更新日期：2015-09-01 00:00:00
abstract：:A better understanding of the ocular immune responses should help us determine the etiology and pathophysiology of many uveitides. Ocular immune "privilege" is the result of the interaction of factors such as the blood-ocular barrier, the absence of lymphatic vessels, the sequestration of retinal antigens, the presenc...
journal_title：Allergologia et immunopathologia
pub_type： 杂志文章,评审
doi：
更新日期：1994-01-01 00:00:00
abstract：:A 34-year-old woman referred episodes of gastrointestinal disorders and sometimes angioedema of the lips which appeared within 2 hours from the ingestion of packed food like biscuits, cereals or fruit juice. A patch test with the standard European series and with food preservatives was positive for fragrances mix. The...
journal_title：Allergologia et immunopathologia
pub_type： 杂志文章
doi：10.1157/13112995
更新日期：2007-11-01 00:00:00
abstract：:Multiple sensitizations to pollens are common clinical situations in Spain, and alter the efficacy of allergen-specific immunotherapy. We now know that optimization of the diagnosis is required to define the best suited treatment for each patient. All pollen allergens belong to 29 families of proteins - the most abund...
journal_title：Allergologia et immunopathologia
pub_type： 杂志文章,评审
doi：10.1157/13115668
更新日期：2008-01-01 00:00:00
abstract：:Lumry described 6 patients who presented hypertrophic rhinosinusitis, positive nasal eosinophilia and intolerance to nonsteroidal antiinflammatory drugs, manifested exclusively with naso-ocular symptomatology. We present three patients with clinical manifestations of chronic rhinitis who had noticed before their first...
journal_title：Allergologia et immunopathologia
pub_type： 临床试验,杂志文章
doi：
更新日期：1986-03-01 00:00:00
abstract：:This ISAAC Phase Three synthesis provides summarised information on the main findings of the study, regional tables and figures related to the prevalence and severity of current symptoms of asthma, rhinoconjunctivitis and eczema in the main regions of the world. The large number of surveyed children (≈1,200,000), the ...
journal_title：Allergologia et immunopathologia
pub_type： 杂志文章,多中心研究
doi：10.1016/j.aller.2012.03.001
更新日期：2013-03-01 00:00:00
abstract：:We studied the function of monocyte-mediated suppression in the proliferative responses of depressed T-cells of patients with advanced lung cancer, with both local (Stage III) and extrapulmonary metastasis (Stage IV). The mononuclear cells of 13 non-treated patients showed a significant drop in proliferation upon stim...
journal_title：Allergologia et immunopathologia
pub_type： 杂志文章
doi：
更新日期：1985-05-01 00:00:00
abstract：:An experimental model was devised in which an AKR lymphoma is conditioned to grow in BALB mice leading to reproducible tumor incidence which makes tumor-bearing (progressor) and tumor-rejecting (regressor) animals simultaneously available. The object of this paper was to determine the effect of neonatal thymectomy (xT...
journal_title：Allergologia et immunopathologia
pub_type： 杂志文章
doi：
更新日期：1978-09-01 00:00:00
abstract：:The search for specific antibodies against the Human Immunodeficiency Virus type-1 (Ab anti HIV 1), using an immunoenzymatic test and a subsequent confirmation test (Western Blot-WB) in patients who were previously positive or borderline at the first test, singled out from about 12500 tested subjects, fifteen patients...
journal_title：Allergologia et immunopathologia
pub_type： 杂志文章
doi：
更新日期：1993-03-01 00:00:00
abstract：:The relationship between ingestion of cow's milk and lymphocyte transformation in cow's milk allergic children was studied. Fifty-six children were selected. Nineteen of them suffered from cow's milk hypersensitivity (HCM); 22 were allergic to several agents except to cow's milk (HOE) and 15 normal and healthy childre...
journal_title：Allergologia et immunopathologia
pub_type： 杂志文章
doi：
更新日期：1989-01-01 00:00:00
abstract：:The results of the cutaneous tests with fungus, and the repercussion of the fungal allergens in asthma via inhalatory route has been a controversial subject for many years. The lack of characterization, purification and standardization of the allergens make the results of the cutaneous tests highly variable. The diagn...
journal_title：Allergologia et immunopathologia
pub_type： 杂志文章
doi：
更新日期：1986-07-01 00:00:00
abstract：:We have investigated plasma kallikrein amidolytic activity in the following groups of patients: 1. Normal control group of blood donors. 2. Extrinsic pollen-activated bronchial asthma patients, during periods of symptomatology and at a later time after the spring. 3. Subjects with atopic bronchial asthma in acute phas...
journal_title：Allergologia et immunopathologia
pub_type： 杂志文章
doi：
更新日期：1992-09-01 00:00:00
abstract：OBJECTIVE/HYPOTHESIS:We systematically reviewed the associations between allergic rhinitis or allergy and otitis media with effusion, by reference to published data. STUDY DESIGN:A meta-analysis of case-controlled studies. DATA SOURCE:Five databases (Pubmed, Highwire, Medline, Wanfang, and China National Knowledge In...
journal_title：Allergologia et immunopathologia
pub_type： 杂志文章,meta分析
doi：10.1016/j.aller.2016.03.004
更新日期：2017-01-01 00:00:00
abstract：BACKGROUND:Yellow dye tartrazine is a potential cause of exacerbations of asthma, allergic rhinitis and urticaria in atopic patients. The Brazilian Sanitary Surveillance Agency (ANVISA) published a consultation about the possibility of issuing a label warning addressing these potential effects of food and drugs contain...
journal_title：Allergologia et immunopathologia
pub_type： 杂志文章
doi：10.1016/j.aller.2009.09.009
更新日期：2010-05-01 00:00:00
