当前位置： SCI文献检索 > ALLERGOLOGIA ET IMMUNOPATHOLOGIA期刊下所有文献 > Evaluation of interleukin-12 receptor β1 and interferon gamma receptor 1 deficiency in patients with disseminated BCG infection.

Evaluation of interleukin-12 receptor β1 and interferon gamma receptor 1 deficiency in patients with disseminated BCG infection.

Abstract：

INTRODUCTION:Disseminated BCG infections among other complications of Bacillus Calmette-Guérin (BCG) vaccine are rare and have occurred in children with immunodeficiency disorders such as mendelian susceptibility to mycobacterial disease (MSMD) which could be due to defects in some elements of IL-12/IFN-γ axis. MSMD-causing mutations have been identified in 10 genes during the last two decades. Among them, mutations in the IL12Rβ1 and IFNγR1 genes constitute about 80% of recorded cases of MSMD syndrome. The aim of this study was to investigate IL-12Rβ1 and IFN-γR1 deficiencies in patients with disseminated BCG infection. METHODS:This study was performed on 31 children with disseminated BCG infections who referred to children's medical center. Whole blood cell culture was performed in presence of BCG, IL-12 and IFN-γ stimulators. The supernatants were assayed for IFN-γ and IL-12p70 by ELISA method. In order to evaluate IL12Rβ1 and IFN-γR1 receptors expression, flow cytometry staining was performed on the patients' T-cells stimulated with PHA. RESULTS:Flow cytometry staining of 31 Iranian patients with disseminated BCG infections with the average age of 43 months showed lack of the expression of IL-12Rβ1 and IFN-γR1 genes in PHA-T-cells of the nine and one patients, respectively in whom the incomplete production of IFN-γ and IL-12 was reported by ELISA. Among these 10 patients, eight cases had related parents (80%). CONCLUSION:It is recommended that to avoid BCG complications, screening be performed for MSMD before BCG inoculation in individuals with positive family history of primary immunodeficiency diseases and inhabitants of areas with high frequency of consanguinity.

journal_name

Allergol Immunopathol (Madr)

journal_title

Allergologia et immunopathologia

authors

Pourakbari B,Hosseinpour Sadeghi R,Mahmoudi S,Parvaneh N,Keshavarz Valian S,Mamishi S

doi

10.1016/j.aller.2018.06.005

subject

Has Abstract

pub_date

2019-01-01 00:00:00

pages

38-42

issue

1

eissn

0301-0546

issn

1578-1267

pii

S0301-0546(18)30116-2

journal_volume

47

pub_type

杂志文章

相关文献

ALLERGOLOGIA ET IMMUNOPATHOLOGIA文献大全
  • Thymectomy does not affect tumour rejection and cytophilic activity in a murine allogeneic lymphoma model.

    abstract：:An experimental model was devised in which an AKR lymphoma is conditioned to grow in BALB mice leading to reproducible tumor incidence which makes tumor-bearing (progressor) and tumor-rejecting (regressor) animals simultaneously available. The object of this paper was to determine the effect of neonatal thymectomy (xT...

    journal_title：Allergologia et immunopathologia

    pub_type： 杂志文章

    doi：

    authors： Barrera CN,Mazzolli AB,Colmerauer ME,Pasqualini CD

    更新日期：1978-09-01 00:00:00

  • Biomarkers of airway and systemic inflammation in obese asthmatic paediatric patients.

    abstract：BACKGROUND:It is thought that airway inflammation is more common in obese asthmatic patients because inflammation is harder to control and does not respond well to glucocorticoid treatment. OBJECTIVE:This study's aim was to investigate the effect of obesity on airway and systemic inflammation in children with asthma a...

    journal_title：Allergologia et immunopathologia

    pub_type： 杂志文章

    doi：10.1016/j.aller.2017.01.013

    authors： Nacaroglu HT,Gayret OB,Erol M,Buke O,Zengi O,Tasdemir M,Tasdemir Z,Yigit O

    更新日期：2017-01-01 00:00:00

  • Allergic reaction caused by articaine.

    abstract：:We report the case of a 51-year-old woman who had an immediate skin reaction after subcutaneous administration of a local anesthetic (LA) composed of articaine and epinephrine before a dental procedure. The patient subsequently underwent further dental procedures without LA. Skin prick tests performed with commercial ...

    journal_title：Allergologia et immunopathologia

    pub_type： 杂志文章

    doi：10.1157/13072924

    authors： El-Qutob D,Morales C,Peláez A

    更新日期：2005-03-01 00:00:00

  • Shellfish hypersensitivity: clinical and immunological characteristics.

    abstract：:Shellfish is one of the most frequent causes of food allergy. We studied 48 patients (25 male and 23 female) with a mean age of 24.2 +/- 1.8 with shellfish hypersensitivity. A clinical questionnaire was carried out and prick tests were performed using a series of aeroallergens and a battery of extracts of squid, shrim...

    journal_title：Allergologia et immunopathologia

    pub_type： 杂志文章,评审

    doi：

    authors： Castillo R,Carrilo T,Blanco C,Quiralte J,Cuevas M

    更新日期：1994-03-01 00:00:00

  • [House-dust allergens. II. Correlations of intradermal reactions of house-dust extract and extract of "D. pteronyssinus"].

    abstract：:In a previous study we had found a high correlation between the positive reaction to standard house dust and to a mites pool extract of 0.86. The study had indicated that the dominant mite found in standard house dust in Barcelona seemed to be D. pteronyssinus. We wished to further confirm this finding by comparing sk...

    journal_title：Allergologia et immunopathologia

    pub_type： 杂志文章

    doi：

    authors： Pérez AO

    更新日期：1976-01-01 00:00:00

  • Therapeutic effects of the anti-tumor necrosis factor monoclonal antibody, infliximab, in four children with refractory juvenile idiopathic arthritis.

    abstract：OBJECTIVE:To report the results of treatment with infliximab in patients with refractory juvenile idiopathic arthritis (JIA). PATIENTS AND METHODS:A prospective study of four children with refractory JIA was carried out. Infliximab (100 mg) was administered in weeks 0, 2 and 6. Subsequently, the drug was administered ...

    journal_title：Allergologia et immunopathologia

    pub_type： 杂志文章

    doi：10.1157/13101338

    authors： Norambuena R X,Mallol J,Ríos M G,Quevedo R F,Quezada L A

    更新日期：2007-03-01 00:00:00

  • [Angioedema due to sensitization to chicken meat].

    abstract：BACKGROUND:Egg is the most frequent cause of food allergy in children. The bird-egg syndrome, found in a group of patients sensitized to egg through bird proteins, was infrequent in children. We report a patient with former history of hypersensitivity to egg who developed episodes of angioedema after ingestion of hen m...

    journal_title：Allergologia et immunopathologia

    pub_type： 杂志文章

    doi：10.1016/s0301-0546(03)79164-2

    authors： Martínez Alonso JC,Domínguez Ortega FJ,Fuentes Gonzalo MJ

    更新日期：2003-01-01 00:00:00

  • Mast cell quantification in the skin of children with atopic dermatitis: its value in diagnosis and in assessing the effectiveness of therapy.

    abstract：:This study reports on the usefulness of skin mast cell quantification (mast cells(mm2) as a parameter for the diagnosis of atopic dermatitis (AD) and for determining the efficacy of the therapeutic measures employed. Fifteen children with AD of moderate to extreme severity, and which started within the first two years...

    journal_title：Allergologia et immunopathologia

    pub_type： 杂志文章

    doi：

    authors： Guerra Júnior G,de Luca IM,Leonardo MB,Vilela MM

    更新日期：1995-07-01 00:00:00

  • Evaluation of total IgE in diverse allergosis. Comparative study with other techniques. Part II.

    abstract：:A total of 181 allergic patients were studied and classified according to the causal antigen, 92 patients were sensitized to the mixed grass pollen, 55 to house dust, 28 to Candida albicans, 31 patients with egg allergy and 25 with milk allergy. All of them presented strong positivity to anamnesis, intracutaneous test...

    journal_title：Allergologia et immunopathologia

    pub_type： 杂志文章

    doi：

    authors： Subirá ML,Oehling A,Crisci CD,Martín-Gil D

    更新日期：1976-01-01 00:00:00

  • Perception of bronchodilation assessed by Visual Analogue Scale in children with asthma.

    abstract：BACKGROUND:Visual Analogue Scale (VAS) has been proposed as a useful tool for assessing the perception of asthma symptoms, a cornerstone in disease management. While airway flow limitation and its reversibility are thought to be a useful marker of disease severity, there are very few studies that evaluated the response...

    journal_title：Allergologia et immunopathologia

    pub_type： 杂志文章

    doi：10.1016/j.aller.2012.06.002

    authors： Tosca MA,Silvestri M,Rossi GA,Ciprandi G

    更新日期：2013-11-01 00:00:00

  • The immunological events leading to the "in vitro" response to PPD.

    abstract：:In normal individuals the 5/9 monoclonal antibody (5/9 MAb) recognizes a T-cell fraction that includes all T lymphocytes with inducer activities. Here, circulating 5/9+ and 5/9- T lymphocytes were isolated from tuberculim skin-positive subjects and the proliferative response induced by PPD was investigated. The result...

    journal_title：Allergologia et immunopathologia

    pub_type： 杂志文章

    doi：

    authors： Scordamaglia A,Orlandini A,Zucchi L,Caria M,Zocchi E,Bisetti A,Canónica GW

    更新日期：1987-03-01 00:00:00

  • Is abnormal liver function correlated with food sensitisation in adults? US NHANES, 2005-2006.

    abstract：BACKGROUND:Associations between liver function and serum IgE levels have recently been observed in children. However, the relationship in adults is unclear. Therefore, it was aimed to study associations of liver function and serum total and food-specific IgE concentrations in a national and population-based study. MET...

    journal_title：Allergologia et immunopathologia

    pub_type： 杂志文章

    doi：10.1016/j.aller.2014.02.009

    authors： Shiue I

    更新日期：2015-07-01 00:00:00

  • Improving T-cell assays for diagnosis of latent TB infection: Confirmation of the potential role of testing Interleukin-2 release in Iranian patients.

    abstract：BACKGROUND:Since gamma interferon release assays (IGRAs) cannot differentiate between active tuberculosis and latent tuberculosis infection (LTBI), development of rapid and specific diagnosis tools are essential for discriminating between active tuberculosis (TB) from LTBI. Both IGRAs are based on Mycobacterium tubercu...

    journal_title：Allergologia et immunopathologia

    pub_type： 杂志文章

    doi：10.1016/j.aller.2015.09.004

    authors： Mamishi S,Pourakbari B,Shams H,Marjani M,Mahmoudi S

    更新日期：2016-07-01 00:00:00

  • IgE receptors (FcR epsilon) modifications. I. Effect of regulator soluble factors of human IgE synthesis isolated by affinity chromatography.

    abstract：:After isolating the soluble factors and observing their biological activity of "in vitro" IgE synthesis, we decided to study the changes these molecules exercise on the expression of lymphocytes of IgE (FcR epsilon). We saw that the fractions from healthy subjects inhibited the expression of receptors quantified by im...

    journal_title：Allergologia et immunopathologia

    pub_type： 杂志文章

    doi：

    authors： Tabar AI,Sanz ML,Oehling A

    更新日期：1990-01-01 00:00:00

  • The possible role of bradykinin as a mediator in bronchial asthma.

    abstract：:A variety of antiasthmatic drugs were examined in a bioassay of uterine cornua of rats for determining their influence upon Bradykinin induced contractions. 4 different actions were seen: pronounced, moderate and weak suppression of enhancement of Bradykinin-activity. The most pronounced blocking effect was seen with ...

    journal_title：Allergologia et immunopathologia

    pub_type： 杂志文章

    doi：

    authors： Brenner M,Baumgarten C,Kunkel G,Rudolph R,Kirchhof E

    更新日期：1982-11-01 00:00:00

  • Matrix effect on baked milk tolerance in children with IgE cow milk allergy.

    abstract：BACKGROUND:Children with IgE-mediated cow's milk allergy (IgE-CMA) often tolerate baked milk within a wheat matrix. In our study we evaluated the impact of wheat matrix and of little standardised cooking procedures on tolerance of baked milk. We also tested tolerance versus parmigiano reggiano (PR) and whey-based parti...

    journal_title：Allergologia et immunopathologia

    pub_type： 杂志文章

    doi：10.1016/j.aller.2016.03.005

    authors： Miceli Sopo S,Greco M,Monaco S,Bianchi A,Cuomo B,Liotti L,Iacono ID

    更新日期：2016-01-01 00:00:00

  • The effect of alcoholism on the lymphocyte populations and prognosis of chronic active hepatitis.

    abstract：:The effect of alcohol ingestion on the prognosis of chronic liver diseases was studied'n. Among 880 patients with chronic liver diseases the percentage of alcoholics was high, 33%, compared to 3.2% in the control group. The period of survival time is decreased by one half in patients with regular alcohol ingestion. Ac...

    journal_title：Allergologia et immunopathologia

    pub_type： 杂志文章

    doi：

    authors： Fehér J,Kiss A,Pozsonyi T,Lengyel G,Jakab L

    更新日期：1981-09-01 00:00:00

  • Cofactors and comorbidities in patients with aspirin/NSAID hypersensitivity.

    abstract：:Hypersensitivity reactions to aspirin and other NSAIDs occur in individuals genetically predisposed and exhibit different clinical manifestations, especially respiratory, cutaneous, and generalised. Five different phenotypes define distinct clinical pictures: aspirin-exacerbated respiratory disease, aspirin/NSAID cuta...

    journal_title：Allergologia et immunopathologia

    pub_type： 杂志文章,评审

    doi：10.1016/j.aller.2016.08.010

    authors： Sánchez-Borges M,Caballero-Fonseca F,Capriles-Hulett A

    更新日期：2017-01-01 00:00:00

  • Immunobiochemical evaluation of bronchoalveolar lavage (BAL) in atopic bronchial asthma, chronic bronchitis and bronchiectasis.

    abstract：:The protease-antiprotease balance and concentration of immunoglobulin was evaluated in some respiratory tract diseases. Analysis was carried out on 24 patients with atopic bronchial asthma, 21 with chronic bronchitis, 27 with bronchiectasis and 18 healthy smokers volunteers. In examination of BAL fluid some selective ...

    journal_title：Allergologia et immunopathologia

    pub_type： 杂志文章

    doi：

    authors： Plusa T,Wäsek Z

    更新日期：1987-07-01 00:00:00

  • Home gardening may be a risk factor for contact dermatitis to Alstroemeria.

    abstract：BACKGROUND:Occupational allergy among florists and people who work in cut flower production of Alstroemeria cultivars (Peruvian lily or Inca lily) has been previously reported. The allergen involved in sensitization is tulipalin A (alpha-methylene-gamma-butyrolactone). CASE REPORT:We describe the case of a 65-year-old...

    journal_title：Allergologia et immunopathologia

    pub_type： 杂志文章

    doi：10.1157/13086751

    authors： Tavares B,Loureiro G,Pereira C,Chieira C

    更新日期：2006-03-01 00:00:00

  • Cytochemical markers for T mu and T gamma. A comparative study.

    abstract：:A procedure is described for the cytochemical detection of esterase alpha naphtyl acetate (ANAE) and beta glucuronidase (BG) activity in the circulating lymphocytes of man. The number of BG positive cells (TBG) as evaluated on the smears of Ficoll Urovision purified cells, correlated well with the number of T gamma (E...

    journal_title：Allergologia et immunopathologia

    pub_type： 杂志文章

    doi：

    authors： Zieliński A,Oehling A

    更新日期：1982-03-01 00:00:00

  • Sleep-related disorders in Latin-American children with atopic dermatitis: A case control study.

    abstract：BACKGROUND:Atopic dermatitis (AD) has been associated with impairment of sleep. The aim of this study was to evaluate sleep disorders in AD Latin-American children (4-10 years) from nine countries, and in normal controls (C). METHODS:Parents from 454 C and 340 AD children from referral clinics answered the Children Sl...

    journal_title：Allergologia et immunopathologia

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.aller.2016.08.014

    authors： Urrutia-Pereira M,Solé D,Rosario NA,Neto HJC,Acosta V,Almendarez CF,Avalos MM,Badellino H,Berroa F,Álvarez-Castelló M,Castillo AJ,Castro-Almarales RL,De la Cruz MM,Cepeda AM,Fernandez C,González-León M,Lozano-Saenz J,Sa

    更新日期：2017-01-01 00:00:00

  • Safety of ingestion of yellow tartrazine by double-blind placebo controlled challenge in 26 atopic adults.

    abstract：BACKGROUND:Yellow dye tartrazine is a potential cause of exacerbations of asthma, allergic rhinitis and urticaria in atopic patients. The Brazilian Sanitary Surveillance Agency (ANVISA) published a consultation about the possibility of issuing a label warning addressing these potential effects of food and drugs contain...

    journal_title：Allergologia et immunopathologia

    pub_type： 杂志文章

    doi：10.1016/j.aller.2009.09.009

    authors： Pestana S,Moreira M,Olej B

    更新日期：2010-05-01 00:00:00

  • Prevalence of self-reported food allergy in Cartagena (Colombia) population.

    abstract：BACKGROUND:Food allergy (FA) is an important health problem in western societies; however, there are no data available from developing countries. Studies based on self-reported symptoms range from 1.4 % to 33 %, and it is supposed that FA is more prevalent early in life. To our knowledge in Latin America there has not ...

    journal_title：Allergologia et immunopathologia

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/s0301-0546(08)75863-4

    authors： Marrugo J,Hernández L,Villalba V

    更新日期：2008-11-01 00:00:00

  • Obesity and asthma: an association modified by age.

    abstract：BACKGROUND:Some studies indicate some causal relationship between obesity and asthma, while others show inconsistent results. Our objective was to evaluate the prevalence of asthma according to obesity in children. METHODS:A cross-sectional study, following the ISAAC study methodology, was conducted on two randomly se...

    journal_title：Allergologia et immunopathologia

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.aller.2012.05.011

    authors： Gonzalez-Barcala FJ,Pertega S,Perez-Castro T,Sampedro M,Sanchez-Lastres J,San-Jose-Gonzalez MA,Bamonde L,Garnelo L,Valdés-Cuadrado L,Moure JD,Carreira JM,Lopez-Silvarrey A

    更新日期：2013-05-01 00:00:00

  • Genetic variants of FcepsilonRIbeta and Il-4 and atopy in a Polish population.

    abstract：BACKGROUND:Atopy results from the interaction between genetic and environmental factors. The aim of our study was to clarify the association between the FcRIint2 polymorphic variant, the Glu237Gly mutation in exon 7 of FcepsilonRIbeta and (-590 C/T) Il-4 gene promoter polymorphism with atopy in a randomized Polish samp...

    journal_title：Allergologia et immunopathologia

    pub_type： 杂志文章

    doi：10.1016/s0301-0546(04)79227-7

    authors： Korzycka-Zaborowska B,Hopkin JM,Górski P

    更新日期：2004-03-01 00:00:00

  • Respiratory allergy in immigrants to a highly industrialised area in Italy according to area of origin and time period.

    abstract：BACKGROUND:Migrants from developing to Western countries tend to become more sensitised to host than to origin country allergens, although substantial changes in migration patterns have occurred in recent decades. METHODS:We investigated adult immigrants with respiratory allergy, first tested for allergic sensitisatio...

    journal_title：Allergologia et immunopathologia

    pub_type： 杂志文章

    doi：10.1016/j.aller.2014.07.007

    authors： Minetti S,Raffetti E,Lodi-Rizzini F,Facchetti S,Schlanser E,Colombo E,Cinquini M,Donato F,Tosoni C

    更新日期：2015-09-01 00:00:00

  • A study of the protective effect of ketotifen in food allergy.

    abstract：:In view of the excellent results we had obtained using KETOTIFEN in the treatment of respiratory allergies, we decided to carry out a study of its protective action in cases of allergies of purely alimentary etiology; that is, in patients symptoms only appeared after the ingestion of certain foodstuffs. The subjects o...

    journal_title：Allergologia et immunopathologia

    pub_type： 杂志文章

    doi：

    authors： Neffen H,Oehling A,Subirá ML

    更新日期：1980-03-01 00:00:00

  • Differential expression of allergens on the internal and external surfaces of latex surgical gloves.

    abstract：BACKGROUND:Differences in latex allergen sensitization profiles have been described between children undergoing repeated surgical interventions and health care workers. The purpose of this study was to determine whether such sensitization profiles are associated with differences in the expression of latex allergen betw...

    journal_title：Allergologia et immunopathologia

    pub_type： 杂志文章

    doi：10.1157/13094028

    authors： Peixinho C,Tavares P,Tomáz MR,Taborda-Barata L,Tomáz C

    更新日期：2006-09-01 00:00:00

  • The spread of HIV-1 infection in Italy: seropositivity and AIDS related syndromes.

    abstract：:A retrospective study on 52,900 individuals tested in 177 Italian Medical Centres for AIDS and related syndromes is reported. The data confirm that I.V. drug users are the group at highest risk in Italy (46% were seropositive and more than one half of these presented PGL or ARC) and that the epidemic probably started ...

    journal_title：Allergologia et immunopathologia

    pub_type： 杂志文章

    doi：

    authors： Luzi G,Greco D,Sasse H,Rezza G,Aiuti F

    更新日期：1991-01-01 00:00:00