Abstract：
BACKGROUND:It is thought that airway inflammation is more common in obese asthmatic patients because inflammation is harder to control and does not respond well to glucocorticoid treatment. OBJECTIVE:This study's aim was to investigate the effect of obesity on airway and systemic inflammation in children with asthma and to identify the biomarkers that play a role in this inflammation. METHODS:The study included patients aged 6-16 years who were diagnosed with asthma in the paediatric allergy outpatient clinic of Bagcilar Training and Research Hospital in Turkey. Complete blood count parameters were compared between three groups: obese asthmatic (n=43), obese non-asthmatic (n=45), and non-obese non-asthmatic (control group, n=30). Levels of high-sensitive CRP (hs-CRP), neutrophil gelatinase-associated lipocalin (NGAL), osteopontin (OPN), and matrix metalloproteinase-9 (MMP-9), and 25(OH)-vitamin D were compared between the groups. RESULTS:No statistically significant differences were observed in 25(OH)-vitamin D, NGAL, OPN, hs-CRP, and MMP-9 levels between groups. There was a statistically significant negative correlation between FEV1/FVC and NGAL and MMP-9. CONCLUSION:This is the first study to investigate levels of hs-CRP, NGAL, OPN, MMP-9, and 25(OH)-vitamin D in obese asthmatic children. Larger studies with sputum and BAL examinations are required to determine the potential of biomarkers for identifying inflammation in obese asthmatic children.
journal_name
Allergol Immunopathol (Madr)journal_title
Allergologia et immunopathologiaauthors
Nacaroglu HT,Gayret OB,Erol M,Buke O,Zengi O,Tasdemir M,Tasdemir Z,Yigit Odoi
10.1016/j.aller.2017.01.013subject
Has Abstractpub_date
2017-01-01 00:00:00pages
534-540issue
6eissn
0301-0546issn
1578-1267pii
S0301-0546(17)30063-0journal_volume
45pub_type
杂志文章abstract：:In a 19 year old patient suffering from CMC since the first months of life, clinical improvement accompanied by correction of the immunologic defect was achieved by Transfer Factor therapy. After 12 months from the last administration of Transfer Factor the improvement persisted. The positive outcome of the treatment ...
journal_title：Allergologia et immunopathologia
pub_type： 杂志文章
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更新日期：1976-09-01 00:00:00
abstract：BACKGROUND:Cord IgE and ECP levels are major atopic markers implicated in early childhood allergy development. Most epidemiological studies to date have not utilised current technology to establish baseline cord IgE levels, further aggravated by lack of data in this region. This study also attempts to identify a relati...
journal_title：Allergologia et immunopathologia
pub_type： 杂志文章
doi：10.1016/j.aller.2012.08.007
更新日期：2013-11-01 00:00:00
abstract：:The mechanisms of action of prophylactic antiallergic drugs, especially disodium cromoglycate (DSCG), have been reviewed. Some evidence is presented that suggests that DSCG acts not only as an inhibitor of mediator release from mast cells, but also by inhibiting the effects of mediators on bronchial and intestinal smo...
journal_title：Allergologia et immunopathologia
pub_type： 杂志文章,评审
doi：
更新日期：1981-11-01 00:00:00
abstract：BACKGROUND:Asthma hospitalization rates in Chilean children have increased in the last 14 years, but little is known about the factors associated with this. OBJECTIVE:Describe clinical characteristics of children hospitalized for asthma exacerbation. METHODS:Observational prospective cohort study in 14 hospitals. Ove...
journal_title：Allergologia et immunopathologia
pub_type： 杂志文章,多中心研究
doi：10.1016/j.aller.2018.02.006
更新日期：2018-01-01 00:00:00
abstract：:A total of 181 allergic patients were studied and classified according to the causal antigen, 92 patients were sensitized to the mixed grass pollen, 55 to house dust, 28 to Candida albicans, 31 patients with egg allergy and 25 with milk allergy. All of them presented strong positivity to anamnesis, intracutaneous test...
journal_title：Allergologia et immunopathologia
pub_type： 杂志文章
doi：
更新日期：1976-01-01 00:00:00
abstract：:Asthma morbidity and mortality has increased. One of the possible causes is the excessive use of beta agonists. The aim of this study is to compare the effects of six week treatment with beclomethasone alone (Ibec) or the combination of beclomethasone-salmeterol (Ibe + Isal) on serum potassium (K), CPK-MB and ECG in c...
journal_title：Allergologia et immunopathologia
pub_type： 临床试验,杂志文章,随机对照试验
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更新日期：2001-01-01 00:00:00
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journal_title：Allergologia et immunopathologia
pub_type： 杂志文章,评审
doi：
更新日期：2000-05-01 00:00:00
abstract：:A variety of antiasthmatic drugs were examined in a bioassay of uterine cornua of rats for determining their influence upon Bradykinin induced contractions. 4 different actions were seen: pronounced, moderate and weak suppression of enhancement of Bradykinin-activity. The most pronounced blocking effect was seen with ...
journal_title：Allergologia et immunopathologia
pub_type： 杂志文章
doi：
更新日期：1982-11-01 00:00:00
abstract：BACKGROUND:Diagnosing asthma in children is a challenge and using a single biomarker from exhaled breath condensate (EBC) showed the lack of improvement in it. OBJECTIVE:The aim of this study was to assess the diagnostic potential of a pattern of simple chemical biomarkers from EBC in diagnosing asthma in children in ...
journal_title：Allergologia et immunopathologia
pub_type： 杂志文章
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journal_title：Allergologia et immunopathologia
pub_type： 杂志文章
doi：
更新日期：1978-01-01 00:00:00
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journal_title：Allergologia et immunopathologia
pub_type： 杂志文章,评审
doi：
更新日期：1998-05-01 00:00:00
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journal_title：Allergologia et immunopathologia
pub_type： 杂志文章
doi：
更新日期：2000-11-01 00:00:00
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journal_title：Allergologia et immunopathologia
pub_type： 杂志文章,多中心研究
doi：10.1016/j.aller.2012.05.011
更新日期：2013-05-01 00:00:00
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journal_title：Allergologia et immunopathologia
pub_type： 杂志文章
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更新日期：2016-03-01 00:00:00
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journal_title：Allergologia et immunopathologia
pub_type： 杂志文章
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pub_type： 杂志文章,评审
doi：
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journal_title：Allergologia et immunopathologia
pub_type： 杂志文章
doi：10.1016/j.aller.2014.07.007
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journal_title：Allergologia et immunopathologia
pub_type： 杂志文章
doi：
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journal_title：Allergologia et immunopathologia
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doi：
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journal_title：Allergologia et immunopathologia
pub_type： 杂志文章
doi：10.1016/s0301-0546(03)79209-x
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journal_title：Allergologia et immunopathologia
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journal_title：Allergologia et immunopathologia
pub_type： 杂志文章
doi：
更新日期：1985-01-01 00:00:00
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journal_title：Allergologia et immunopathologia
pub_type： 杂志文章,多中心研究
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journal_title：Allergologia et immunopathologia
pub_type： 杂志文章
doi：
更新日期：1993-11-01 00:00:00
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journal_title：Allergologia et immunopathologia
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journal_title：Allergologia et immunopathologia
pub_type： 杂志文章
doi：
更新日期：1990-01-01 00:00:00
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journal_title：Allergologia et immunopathologia
pub_type： 杂志文章
doi：
更新日期：1998-03-01 00:00:00
