Abstract：
BACKGROUND:Epidemiological evidence suggests the existence of a direct link between allergic rhinitis (AR) and asthma. Several studies also support the presence of small-airway dysfunction (SAD) in non-asthmatic children with AR. However, it remains unknown whether SAD can predict the progression of AR to asthma. Our objective was to explore the existence of SAD in non-asthmatic children with AR and to assessed its ability to predict the development of asthma. METHODS:Seventy-three 6-year-old children with intermittent moderate-severe AR but without asthma symptoms/medication within the last two years, underwent spirometry and measurement of respiratory resistance (Rrs) and reactance (Xrs) before and after bronchodilation (BD) (300mcg salbutamol). Lung function measurements were performed in the absence of nasal symptoms and repeated at AR exacerbation. SAD was defined as >30% decrease in Rrs or >50% increase in Xrs at 6 or 8Hz post-BD. Participants were followed for five years. RESULTS:Twenty-three children (31.5%) developed asthma; this group presented significant post-BD changes in Rrs and Xrs, but only at AR exacerbation. The ability of these changes to predict the development of asthma was exceptional and superior to that of the spirometric parameters. SAD (22 children, 30.1%), emerged as the single most efficient predictor of asthma, independently of other risk factors such as parental asthma, personal history of eczema and type of allergic sensitisation. CONCLUSION:SAD precedes the development of asthma in children with AR. Changes in respiratory impedance at AR exacerbation may assist in identifying those at risk to progress to asthma.
journal_name
Allergol Immunopathol (Madr)journal_title
Allergologia et immunopathologiaauthors
Skylogianni E,Triga M,Douros K,Bolis K,Priftis KN,Fouzas S,Anthracopoulos MBdoi
10.1016/j.aller.2017.09.025subject
Has Abstractpub_date
2018-01-01 00:00:00pages
313-321issue
4eissn
0301-0546issn
1578-1267pii
S0301-0546(17)30185-4journal_volume
46pub_type
杂志文章abstract：BACKGROUND:In this work we analyzed the allergological importance of Tyrophagus putrescentiae (Tp) in Huelva (SE Spain). We studied the level of exposition and the grade of sensitization to Tp in a group of patients sensitized to Dermatophagoides pteronyssinus (Dpt). The allergenic cross-reactivity between Dpt and Tp w...
journal_title：Allergologia et immunopathologia
pub_type： 杂志文章
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journal_title：Allergologia et immunopathologia
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journal_title：Allergologia et immunopathologia
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journal_title：Allergologia et immunopathologia
pub_type： 杂志文章
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更新日期：1982-03-01 00:00:00
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pub_type： 杂志文章,多中心研究
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abstract：BACKGROUND:Children with IgE-mediated cow's milk allergy (IgE-CMA) often tolerate baked milk within a wheat matrix. In our study we evaluated the impact of wheat matrix and of little standardised cooking procedures on tolerance of baked milk. We also tested tolerance versus parmigiano reggiano (PR) and whey-based parti...
journal_title：Allergologia et immunopathologia
pub_type： 杂志文章
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journal_title：Allergologia et immunopathologia
pub_type： 杂志文章,评审
doi：10.1016/s0301-0546(01)79035-0
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abstract：:This study was motivated by the discrepancy in the results of published studies on the amount of histamine released following the intravascular administration of iodinated contrast media (ICM) in humans. From a group of patients due to undergo cardiac catheterization, we selected 45 subjects with no history of atopy. ...
journal_title：Allergologia et immunopathologia
pub_type： 杂志文章
doi：
更新日期：1989-11-01 00:00:00
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journal_title：Allergologia et immunopathologia
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更新日期：1978-05-01 00:00:00
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journal_title：Allergologia et immunopathologia
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journal_title：Allergologia et immunopathologia
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journal_title：Allergologia et immunopathologia
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journal_title：Allergologia et immunopathologia
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journal_title：Allergologia et immunopathologia
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journal_title：Allergologia et immunopathologia
pub_type： 杂志文章
doi：
更新日期：1991-01-01 00:00:00
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journal_title：Allergologia et immunopathologia
pub_type： 杂志文章
doi：
更新日期：1975-01-01 00:00:00
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journal_title：Allergologia et immunopathologia
pub_type： 杂志文章
doi：
更新日期：1977-11-01 00:00:00
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journal_title：Allergologia et immunopathologia
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doi：
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journal_title：Allergologia et immunopathologia
pub_type： 杂志文章
doi：
更新日期：1988-01-01 00:00:00
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journal_title：Allergologia et immunopathologia
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doi：
更新日期：1980-01-01 00:00:00
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更新日期：2018-01-01 00:00:00
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journal_title：Allergologia et immunopathologia
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journal_title：Allergologia et immunopathologia
pub_type： 杂志文章
doi：
更新日期：1983-11-01 00:00:00
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journal_title：Allergologia et immunopathologia
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doi：10.1016/j.aller.2016.10.011
更新日期：2017-01-01 00:00:00
