Abstract：
BACKGROUND:House dust mites are a ubiquitous air allergen in the human habitat. It has been shown that exposure to them is a fundamental factor in sensitisation and development of atopic disease. The objective of the study was to analyse changes in sensitisation to Dermatophagoides pteronyssinus (Der p.) in children treated in a tertiary level care hospital in Mexico City for a period of 11 years and compare with other studies carried out in Mexico. METHODS:A retrospective study was performed at the Hospital Infantil de México Federico Gómez (HIMFG). Information was gathered from skin tests for Der p. performed in the Allergy Laboratory from January 2004 to April 2015. Patients 2-18 years old who presented for examination of some type of allergic condition and who had immediate hypersensitivity tests to Der p. were included in the study. Results were compared with prior reports from other institutions. Descriptive analysis and χ2 statistics were used. RESULTS:A total of 8794 patients were included in the study; 49.3% of the tests (95% CI 48-50) were positive for Der p. The percentage of monosensitised to mites was 2.7% for Der p. (95% CI 2-3). A significant difference was found between the results of older patients and those <6 years old. The frequency of sensitisation had a tendency to decrease during the 11 years analysed in all age groups. CONCLUSIONS AND CLINICAL RELEVANCE:The frequency of sensitisation to Der p. increased with age until reaching adolescence. In the last 11 years a decrease in sensitisation to this air allergen was observed.
journal_name
Allergol Immunopathol (Madr)journal_title
Allergologia et immunopathologiaauthors
Navarrete-Rodríguez EM,Fernández-Soto JR,Del Rio-Navarro BE,Saucedo-Ramírez OJ,Sienra-Monge JJdoi
10.1016/j.aller.2016.09.002subject
Has Abstractpub_date
2017-01-01 00:00:00pages
11-17issue
1eissn
0301-0546issn
1578-1267pii
S0301-0546(16)30151-3journal_volume
45pub_type
杂志文章abstract：:The classic histamine release test involved washing and isolating of leukocytes from heparinized whole blood. Siraganian automatized the extraction procedure, working initially with isolated leukocytes in Tris-human serum albumin-Ca++Mg++ buffer, with optimal results. One year later, he described a continuous flow sys...
journal_title：Allergologia et immunopathologia
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journal_title：Allergologia et immunopathologia
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更新日期：1983-11-01 00:00:00
abstract：:Toll-like receptors (TLRs) are a family of transmembrane receptors that have been preserved throughout evolution and which selectively recognize a broad spectrum of microbial components and endogenous molecules released by injured tissue. Identification of these ligands by TLRs triggers signalling pathways which lead ...
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journal_title：Allergologia et immunopathologia
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journal_title：Allergologia et immunopathologia
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journal_title：Allergologia et immunopathologia
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journal_title：Allergologia et immunopathologia
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journal_title：Allergologia et immunopathologia
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doi：
更新日期：1993-03-01 00:00:00
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journal_title：Allergologia et immunopathologia
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doi：
更新日期：1982-11-01 00:00:00
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journal_title：Allergologia et immunopathologia
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doi：
更新日期：1990-07-01 00:00:00
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journal_title：Allergologia et immunopathologia
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更新日期：1986-09-01 00:00:00
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journal_title：Allergologia et immunopathologia
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doi：
更新日期：1988-09-01 00:00:00
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journal_title：Allergologia et immunopathologia
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doi：
更新日期：1998-09-01 00:00:00
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journal_title：Allergologia et immunopathologia
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doi：
更新日期：1987-07-01 00:00:00
