Pulmonary computed tomography scan findings in chronic granulomatous disease.

Abstract:

BACKGROUND:Chronic granulomatous disease is a phagocyte defect, characterised by recurrent infections in different organs due to a defect in NADPH oxidase complex. This study was performed to investigate pulmonary problems of CGD in a group of patients who underwent computed tomography (CT) scan. METHODS:Computed tomography scan was performed in 24 patients with CGD. The findings of the CT scan were documented in all of these patients. RESULTS:Areas of consolidation and scan formation were the most common findings, which were detected in 79% of the patients. Other abnormalities in order of frequencies were as follows: small pulmonary nodules (58%); mediastinal lymphadenopathy (38%); pleural thickening (25%); unilateral hilar lymphadenopathy (25%); axillary lymphadenopathy (21%); bronchiectasis (17%); abscess formation (17%); pulmonary large nodules or masses (8%); and free pleural effusion (8%). CONCLUSION:The pulmonary CT scans of the patients with CGD demonstrated a variety of respiratory abnormalities in the majority of the patients. While recurrent respiratory infections and abscesses are considered as prominent features of CGD, early diagnosis and precise check-up of the respiratory systems are needed to prevent further pulmonary complications.

authors

Mahdaviani SA,Mehrian P,Najafi A,Khalilzadeh S,Eslampanah S,Nasri A,Karam MB,Rezaei N,Velayati AA

doi

10.1016/j.aller.2013.04.003

subject

Has Abstract

pub_date

2014-09-01 00:00:00

pages

444-8

issue

5

eissn

0301-0546

issn

1578-1267

pii

S0301-0546(13)00149-3

journal_volume

42

pub_type

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