Abstract：
:Tobacco smoke has both carcinogenic effects and anti-estrogenic properties and its inconsistent association with breast cancer risk in observational studies may be because of these competing effects across the lifecourse. We conducted a prospective study of prenatal smoke exposure, childhood household smoke exposure, and adult active smoke exposure and mammographic density, a strong intermediate marker of breast cancer risk, in an adult follow-up of existing US birth cohorts. Specifically, we followed up women who were born between 1959 and 1967 and whose mothers participated in either the Collaborative Perinatal Project (Boston and Providence sites) or the Childhood Health and Development Study in California. Of the 1134 women interviewed in adulthood (ranging in age from 39 to 49 years at interview), 79% had a screening mammogram. Cigarette smoking was reported by mothers at the time of their pregnancy; 40% of mothers smoked while pregnant. Women whose mothers smoked during pregnancy had a 3.1% (95% confidence interval (CI) = -6.0%, -0.2%) lower mammographic density than women whose mothers did not smoke during pregnancy. When we further accounted for adult body mass index and adult smoking status, the association remained (β = -2.7, 95% CI = -5.0, -0.3). When we examined patterns of smoking, prenatal smoke exposure without adult smoke exposure was associated with a 5.6% decrease in mammographic density (β = -5.6, 95% CI = -9.6, -1.6). Given the strength of mammographic density as an intermediate marker for breast cancer, the inverse associations between mammographic density and smoking patterns across the lifecourse may help explain the complex association between cigarette smoking and breast cancer risk.
journal_name
J Dev Orig Health Disjournal_title
Journal of developmental origins of health and diseaseauthors
Terry MB,Schaefer CA,Flom JD,Wei Y,Tehranifar P,Liao Y,Buka S,Michels KBdoi
10.1017/S2040174411000614subject
Has Abstractpub_date
2011-12-01 00:00:00pages
340-52issue
6eissn
2040-1744issn
2040-1752pii
S2040174411000614journal_volume
2pub_type
杂志文章abstract：:The principles embodied by the Developmental Origins of Health and Disease (DOHaD) view of 'life history' trajectory are increasingly underpinned by biological data arising from molecular-based epigenomic and transcriptomic studies. Although a number of 'omic' platforms are now routinely and widely used in biology and...
journal_title：Journal of developmental origins of health and disease
pub_type： 杂志文章
doi：10.1017/S2040174414000476
更新日期：2015-02-01 00:00:00
abstract：:The development and life performance of 404 high-producing Holstein dairy cows was studied from birth onwards and during two lactations. The management, environment and parental genetics of the cows were known in detail. Cluster analysis identified four performance 'types': high-yielding (HY) cows and persistently hig...
journal_title：Journal of developmental origins of health and disease
pub_type： 杂志文章
doi：10.1017/S2040174414000361
更新日期：2014-10-01 00:00:00
abstract：:Embryonal rhabdomyosarcoma is one of the major defined histologic variants of rhabdomyosarcoma that is mainly reported in children. The histologic appearance of this neoplastic entity recapitulates normal myogenesis. The tumor cells variably exhibit the different cellular phases of myogenesis ranging from undifferenti...
journal_title：Journal of developmental origins of health and disease
pub_type： 杂志文章,评审
doi：10.1017/S204017441500015X
更新日期：2015-06-01 00:00:00
abstract：:Ilex paraguariensis (yerba mate) has a beneficial effect in the management of obesity. Here, we studied the effects of yerba mate on hypothalamic changes in leptin and insulin signalling, oxidative stress and liver morphology and metabolism in postnatal early overfeeding (EO) Wistar rats. To induce EO, the litter size...
journal_title：Journal of developmental origins of health and disease
pub_type： 杂志文章
doi：10.1017/S2040174416000519
更新日期：2017-02-01 00:00:00
abstract：:In this study, diabetes mellitus (DM) was induced in Wistar rats during pregnancy and maintained in the postpartum period (PP) and we evaluated systolic blood pressure (SBP), glomerular filtration rate (GFR) and renal immunohistochemical and morphometric studies from different groups: G1 (non-pregnant control rats), G...
journal_title：Journal of developmental origins of health and disease
pub_type： 杂志文章
doi：10.1017/S2040174417000605
更新日期：2018-02-01 00:00:00
abstract：:The evidence underpinning the developmental origins of health and disease (DOHaD) is overwhelming. As the emphasis shifts more towards interventions and the translational strategies for disease prevention, it is important to capitalize on collaboration and knowledge sharing to maximize opportunities for discovery and ...
journal_title：Journal of developmental origins of health and disease
pub_type： 杂志文章
doi：10.1017/S2040174416000167
更新日期：2016-10-01 00:00:00
abstract：:Predisposition to offspring metabolic dysfunction due to poor maternal nutrition differs with the developmental stage at exposure. Post-weaning nutrition also influences offspring phenotype in either adverse or beneficial ways. We studied a well-established rat maternal protein-restriction model to determine whether p...
journal_title：Journal of developmental origins of health and disease
pub_type： 杂志文章
doi：10.1017/S2040174415001051
更新日期：2015-08-01 00:00:00
abstract：:The association between lower birth weight and increased disease risk in adulthood has drawn attention to the physiological processes that shape the gestational environment. We implement genome-wide transcriptional profiling of maternal blood samples to identify subsets of genes and associated transcription control pa...
journal_title：Journal of developmental origins of health and disease
pub_type： 杂志文章
doi：10.1017/S2040174419000175
更新日期：2019-12-01 00:00:00
abstract：:The consumption of fructose has increased in children and adolescents and is partially responsible for the high incidence of metabolic diseases. The lifestyle during postnatal development can result in altered metabolic programming, thereby impairing the reproductive system and fertility during adulthood. Therefore, t...
journal_title：Journal of developmental origins of health and disease
pub_type： 杂志文章
doi：10.1017/S2040174420001385
更新日期：2021-01-14 00:00:00
abstract：:Obesity and its complications occur at alarming rates worldwide. Epidemiological data have associated perinatal conditions, such as malnutrition, with the development of some disorders, such as obesity, dyslipidemia, diabetes, and cardiovascular diseases, in childhood and adulthood. Exclusive breastfeeding has been as...
journal_title：Journal of developmental origins of health and disease
pub_type： 杂志文章
doi：10.1017/S2040174420000410
更新日期：2020-10-01 00:00:00
abstract：:Early-life intervention to reduce obesity and poor dental health through early-life nutrition will improve health outcomes in later life. This study examined the prevalence of overweight and obesity and visual dental decay in 4-year old children in New Zealand between 2013 and 2017, and the impact of a nutrition and p...
journal_title：Journal of developmental origins of health and disease
pub_type： 杂志文章
doi：10.1017/S2040174418000788
更新日期：2019-06-01 00:00:00
abstract：:Although numerous studies have been conducted to examine the causal factors of childhood obesity, the implications of intrauterine oxidative stress on early postnatal adiposity development remain to be elucidated. The Universiti Sains Malaysia Birth Cohort Study aimed to investigate the effects of prenatal oxidative s...
journal_title：Journal of developmental origins of health and disease
pub_type： 杂志文章
doi：10.1017/S204017441300055X
更新日期：2014-04-01 00:00:00
abstract：:Hypertension (HTN) remains a common complication after kidney transplantation among paediatric patients. Although low birth weight (LBW) has been implicated as an important risk factor for cardiovascular diseases, its effect on transplantation patients has not yet been addressed. It is essential to determine whether c...
journal_title：Journal of developmental origins of health and disease
pub_type： 杂志文章
doi：10.1017/S2040174419000448
更新日期：2020-02-01 00:00:00
abstract：:The risk for many chronic diseases appears to be mediated in part by birth weight. Among Aboriginal Canadians, the prevalence of end-stage renal disease and cardiovascular disease risk is disproportionately high, largely because of elevated diabetes prevalence. The relationships between birth weight (and other potenti...
journal_title：Journal of developmental origins of health and disease
pub_type： 杂志文章
doi：10.1017/S2040174412000724
更新日期：2013-04-01 00:00:00
abstract：:The hypothesis was that maternal intake of the antioxidant alpha-lipoid acid (ALA), during the developmental period of the hypothalamic orexigenic neurons, causes a permanent beneficial effect in offspring metabolism. Pregnant Wistar rats were fed with standard diet (food) + ALA (0.4% wt/wt) from day 14 of gestation t...
journal_title：Journal of developmental origins of health and disease
pub_type： 杂志文章
doi：10.1017/S2040174420001178
更新日期：2020-12-11 00:00:00
abstract：:Footprints in Time: The Longitudinal Study of Indigenous Children (LSIC) is a national study of 1759 Australian Aboriginal and Torres Strait Islander children living across urban, regional and remote areas of Australia. The study is in its 11th wave of annual data collection, having collected extensive data on topics ...
journal_title：Journal of developmental origins of health and disease
pub_type： 杂志文章
doi：10.1017/S204017441800017X
更新日期：2019-02-01 00:00:00
abstract：:The effect of maternal Ramadan-type fasting (RTF) on the outcome of pregnancy, kidney development and nephron number in male rat offspring was investigated in current study. Pregnant rats were given food and water ad libitum during pregnancy (control) or restricted for 16 h per day (RTF). Kidney structure was examined...
journal_title：Journal of developmental origins of health and disease
pub_type： 杂志文章
doi：10.1017/S204017441700109X
更新日期：2018-06-01 00:00:00
abstract：:Prenatal glucocorticoids, commonly used in women at risk of preterm delivery, can predispose the newborn to disease in later life. Since male reproductive function is likely to reflect testis development during fetal life, we studied the effects of prenatal glucocorticoids on two key intra-testicular factors that play...
journal_title：Journal of developmental origins of health and disease
pub_type： 杂志文章
doi：10.1017/S2040174416000118
更新日期：2016-08-01 00:00:00
abstract：:Preterm birth affects over 12% of all infants born in the US yet the biology of early delivery remains unclear, including whether epigenetic mechanisms are involved. We examined associations of maternal and umbilical cord blood long interspersed nuclear element-1 (LINE-1) DNA methylation with length of gestation and o...
journal_title：Journal of developmental origins of health and disease
pub_type： 杂志文章
doi：10.1017/s2040174412000104
更新日期：2012-06-01 00:00:00
abstract：:Despite the interest in the relationship of fetal exposures to adult cardiovascular disease, few studies have examined indicators of adult fatty liver disease as an outcome. Previous results are inconsistent, and indicate possible variation by sex. Adult liver enzymes [γ-glutamyl transferase (GGT), alanine transaminas...
journal_title：Journal of developmental origins of health and disease
pub_type： 杂志文章
doi：10.1017/S2040174416000635
更新日期：2017-04-01 00:00:00
abstract：:Pregnant women, children under 2 and the first thousand days of life have been principal targets for Developmental Origins of Health and Disease interventions. This paradigm has been criticized for laying responsibility for health outcomes on pregnant women and mothers and through the thousand days focus inadvertently...
journal_title：Journal of developmental origins of health and disease
pub_type： 杂志文章
doi：10.1017/S2040174417000629
更新日期：2018-02-01 00:00:00
abstract：:Intrauterine factors important for cognitive development, such as birth weight, chorionicity and umbilical cord characteristics were investigated. A total of 663 twin pairs completed the Wechsler Intelligence Scale for Children-Revised and scores were available for Performance, Verbal and Total Intelligence Quotient (...
journal_title：Journal of developmental origins of health and disease
pub_type： 杂志文章
doi：10.1017/S2040174413000287
更新日期：2013-12-01 00:00:00
abstract：:Bisphenol-A (BPA) is a widely used endocrine-disrupting chemical. Prenatal exposure to BPA is known to affect birth weight, but its impact on the cardiovascular system has not been studied in detail. In this study, we investigated the effects of prenatal BPA treatment and its interaction with postnatal overfeeding on ...
journal_title：Journal of developmental origins of health and disease
pub_type： 杂志文章
doi：10.1017/S204017441600057X
更新日期：2017-02-01 00:00:00
abstract：:Iron deficiency is common in pregnant and lactating women and is associated with reduced cognitive development of the offspring. Since iron affects lipid metabolism, the availability of fatty acids, particularly the polyunsaturated fatty acids required for early neural development, was investigated in the offspring of...
journal_title：Journal of developmental origins of health and disease
pub_type： 杂志文章
doi：10.1017/S2040174419000552
更新日期：2020-06-01 00:00:00
abstract：:A developmental approach to public health focuses attention on better nourishing girls and young women, especially those of low socio-economic status, to improve mothers' nutrition and thereby the health of future generations. There have been significant advances in the behavioural sciences that may allow us to unders...
journal_title：Journal of developmental origins of health and disease
pub_type： 杂志文章,评审
doi：10.1017/S2040174415001312
更新日期：2015-10-01 00:00:00
abstract：:A life-course approach to reduction of risk of non-communicable diseases (NCD) suggests that early-life interventions may be more effective than lifestyle modifications in middle age. Knowledge translation to develop understanding of the Developmental Origins of Health and Disease (DOHaD) within the community offers t...
journal_title：Journal of developmental origins of health and disease
pub_type： 杂志文章
doi：10.1017/S2040174412000505
更新日期：2012-12-01 00:00:00
abstract：:With brown adipose tissue (BAT) becoming a possible therapeutic target to counteract obesity, the prenatal environment could represent a critical window to modify BAT function and browning of white AT. We investigated if levels of uncoupling protein 1 (UCP1) and UCP1-mediated thermogenesis are altered in offspring exp...
journal_title：Journal of developmental origins of health and disease
pub_type： 杂志文章
doi：10.1017/S2040174418000107
更新日期：2018-08-01 00:00:00
abstract：:Maternal undernutrition is known to adversely impact fetal health and development. Insults experienced in utero alter development of the fetus as it adapts to microenvironment stressors, leading to growth restriction and subsequent low birth weight. Infants born small for gestational age have significantly increased r...
journal_title：Journal of developmental origins of health and disease
pub_type： 杂志文章
doi：10.1017/S2040174416000106
更新日期：2016-10-01 00:00:00
abstract：:Pregnant individuals who overeat are more likely to predispose their fetus to the development of metabolic disorders in adulthood. Physical training is a prevention and treatment interventional strategy that could treat these disorders, since it improves metabolism and body composition. This study assessed the protect...
journal_title：Journal of developmental origins of health and disease
pub_type： 杂志文章
doi：10.1017/S2040174419000503
更新日期：2020-04-01 00:00:00
abstract：:Here we analyze the outcomes of unlimited access to a low-energy (LE) diet in dams and their offspring. At 3 weeks' gestation, pregnant Wistar rats were divided into two groups: (1) the control group received a normoenergetic diet; and (2) the experimental group received the LE diet. In dams, lactation outcomes, food ...
journal_title：Journal of developmental origins of health and disease
pub_type： 杂志文章
doi：10.1017/S2040174413000482
更新日期：2014-02-01 00:00:00
