Iron deficiency during pregnancy and lactation modifies the fatty acid composition of the brain of neonatal rats.

abstract：:As the resident macrophage of the central nervous system, microglia are thought to contribute to Alzheimer's disease (AD) pathology through lack of neuroprotection. The role of immune dysfunction in AD may be due to disruption of regulatory signals for the activation of microglia that may occur early in development. W...

journal_title：Journal of developmental origins of health and disease

authors： vonderEmbse AN,Hu Q,DeWitt JC

更新日期：2017-08-01 00:00:00

abstract：:Prenatal glucocorticoids, commonly used in women at risk of preterm delivery, can predispose the newborn to disease in later life. Since male reproductive function is likely to reflect testis development during fetal life, we studied the effects of prenatal glucocorticoids on two key intra-testicular factors that play...

journal_title：Journal of developmental origins of health and disease

authors： Pedrana G,Viotti H,Lombide P,Sanguinetti G,Pino C,Cavestany D,Sloboda DM,Martin GB

更新日期：2016-08-01 00:00:00

abstract：:Preterm birth affects over 12% of all infants born in the US yet the biology of early delivery remains unclear, including whether epigenetic mechanisms are involved. We examined associations of maternal and umbilical cord blood long interspersed nuclear element-1 (LINE-1) DNA methylation with length of gestation and o...

journal_title：Journal of developmental origins of health and disease

authors： Burris HH,Rifas-Shiman SL,Baccarelli A,Tarantini L,Boeke CE,Kleinman K,Litonjua AA,Rich-Edwards JW,Gillman MW

更新日期：2012-06-01 00:00:00

abstract：:Hepatitis B and hepatitis C (HBV/HCV) are important global public health concerns. We aimed to evaluate the association between maternal HBV/HCV carrier status and long-term offspring neurological hospitalisations. A population-based cohort analysis compared the risk for long-term childhood neurological hospitalisatio...

journal_title：Journal of developmental origins of health and disease

authors： Yoles I,Sheiner E,Abu-Freha N,Wainstock T

更新日期：2021-01-21 00:00:00

abstract：:Hypertension (HTN) remains a common complication after kidney transplantation among paediatric patients. Although low birth weight (LBW) has been implicated as an important risk factor for cardiovascular diseases, its effect on transplantation patients has not yet been addressed. It is essential to determine whether c...

journal_title：Journal of developmental origins of health and disease

authors： Santos LB,Borges LM,Souza LV,Felipe CR,Medina-Pestana JO,Franco MDC

更新日期：2020-02-01 00:00:00

abstract：:The early embryo and periconceptional period is a window during which environmental factors may cause permanent change in the pattern and characteristics of development leading to risk of adult onset disease. This has now been demonstrated across small and large animal models and also in the human. Most evidence of pe...

journal_title：Journal of developmental origins of health and disease

authors： Fleming TP,Velazquez MA,Eckert JJ

更新日期：2015-10-01 00:00:00

abstract：:Children of parents with major mood and psychotic disorders are at increased risk of psychopathology, including psychotic symptoms. It has been suggested that the risk of psychosis may be more often transmitted from parent to opposite-sex offspring (e.g., from father to daughter) than to same-sex offspring (e.g., from...

journal_title：Journal of developmental origins of health and disease

authors： Aylott A,Zwicker A,MacKenzie LE,Cumby J,Propper L,Abidi S,Bagnell A,Fisher HL,Pavlova B,Alda M,Uher R

更新日期：2019-02-01 00:00:00

abstract：:The hypothesis was that maternal intake of the antioxidant alpha-lipoid acid (ALA), during the developmental period of the hypothalamic orexigenic neurons, causes a permanent beneficial effect in offspring metabolism. Pregnant Wistar rats were fed with standard diet (food) + ALA (0.4% wt/wt) from day 14 of gestation t...

journal_title：Journal of developmental origins of health and disease

authors： Rabaglino MB,Moreira-Espinoza MJ,Lagares C,Garay MI,Quiroga P,Pasqualini ME,Francini F,Beltramo D

更新日期：2020-12-11 00:00:00

abstract：:The effect of maternal Ramadan-type fasting (RTF) on the outcome of pregnancy, kidney development and nephron number in male rat offspring was investigated in current study. Pregnant rats were given food and water ad libitum during pregnancy (control) or restricted for 16 h per day (RTF). Kidney structure was examined...

journal_title：Journal of developmental origins of health and disease

authors： Mohany M,Ashton N,Harrath AH,Nyengaard JR,Alomar SY,Alwasel S

更新日期：2018-06-01 00:00:00

abstract：:The endocannabinoid system (ECS), modulated by metabolites of linoleic acid (LA), is important in regulating cardiovascular function. In pregnancy, LA is vital for foetal development. We investigated the effects of elevated LA in H9c2 cardiomyoblasts in vitro and of a high linoleic acid (HLA, 6.21%) or low linoleic ac...

journal_title：Journal of developmental origins of health and disease

authors： Sleep SL,Shrestha N,Cuffe JSM,Holland OJ,Headrick JP,McAinch AJ,Hryciw DH

更新日期：2020-12-01 00:00:00

abstract：:Breast milk constitutes one of the most important sources of postnatal microbes. However, the influence of perinatal factors on the milk microbiome is still poorly understood. The aim of our study was to assess the impact of mode of delivery on the microbiome composition and diversity present in breast milk of healthy...

journal_title：Journal of developmental origins of health and disease

authors： Cabrera-Rubio R,Mira-Pascual L,Mira A,Collado MC

更新日期：2016-02-01 00:00:00

abstract：:Ilex paraguariensis (yerba mate) has a beneficial effect in the management of obesity. Here, we studied the effects of yerba mate on hypothalamic changes in leptin and insulin signalling, oxidative stress and liver morphology and metabolism in postnatal early overfeeding (EO) Wistar rats. To induce EO, the litter size...

journal_title：Journal of developmental origins of health and disease

authors： Conceição EP,Kaezer AR,Peixoto-Silva N,Felzenszwalb I,de Oliveira E,Moura EG,Lisboa PC

更新日期：2017-02-01 00:00:00

abstract：:Intrauterine factors important for cognitive development, such as birth weight, chorionicity and umbilical cord characteristics were investigated. A total of 663 twin pairs completed the Wechsler Intelligence Scale for Children-Revised and scores were available for Performance, Verbal and Total Intelligence Quotient (...

journal_title：Journal of developmental origins of health and disease

authors： Antoniou EE,Fowler T,Thiery E,Southwood TR,van Gestel S,Jacobs N,Vlietinck R,van Os J,Rijsdijk FV,Derom C,Zeegers MP

更新日期：2013-12-01 00:00:00

abstract：:Antenatal exposure of the fetus to inflammation may alter postnatal organ development. In our previous work, we demonstrated that the fetal liver is involved in the systemic inflammation associated with chorioamnionitis, leading to metabolic changes. On the basis of these findings, we hypothesized that chorioamnioniti...

journal_title：Journal of developmental origins of health and disease

authors： Vlassaks E,Gavilanes AW,Bieghs V,Reinartz A,Gassler N,Van Gorp PJ,Gijbels MJ,Bekers O,Zimmermann LJ,Pillow JJ,Polglase GR,Nitsos I,Newnham JP,Kallapur SG,Jobe AH,Shiri-Sverdlov R,Kramer BW

更新日期：2012-04-01 00:00:00

abstract：:Tobacco smoke has both carcinogenic effects and anti-estrogenic properties and its inconsistent association with breast cancer risk in observational studies may be because of these competing effects across the lifecourse. We conducted a prospective study of prenatal smoke exposure, childhood household smoke exposure, ...

journal_title：Journal of developmental origins of health and disease

authors： Terry MB,Schaefer CA,Flom JD,Wei Y,Tehranifar P,Liao Y,Buka S,Michels KB

更新日期：2011-12-01 00:00:00

abstract：:A life-course approach to reduction of risk of non-communicable diseases (NCD) suggests that early-life interventions may be more effective than lifestyle modifications in middle age. Knowledge translation to develop understanding of the Developmental Origins of Health and Disease (DOHaD) within the community offers t...

journal_title：Journal of developmental origins of health and disease

authors： Bay JL,Mora HA,Sloboda DM,Morton SM,Vickers MH,Gluckman PD

更新日期：2012-12-01 00:00:00

abstract：:An adverse early life environment can increase the risk of metabolic and other disorders later in life. Genetic variation can modify an individual's susceptibility to these environmental challenges. These gene by environment interactions are important, but difficult, to dissect. The nucleus is the primary organelle wh...

journal_title：Journal of developmental origins of health and disease

authors： Jacobson E,Vickers MH,Perry JK,O'Sullivan JM

更新日期：2018-06-01 00:00:00

abstract：:Preterm birth (delivery <37 weeks of gestation) is associated with impaired glomerular capillary growth in neonates; if this persists, it may be a contributing factor in the increased risk of hypertension and chronic kidney disease in people born preterm. Therefore, in this study, we aimed to determine the long-term i...

journal_title：Journal of developmental origins of health and disease

authors： Sutherland MR,Malik W,Nguyen VB,Tran V,Polglase GR,Black MJ

更新日期：2020-12-10 00:00:00

abstract：:The principles embodied by the Developmental Origins of Health and Disease (DOHaD) view of 'life history' trajectory are increasingly underpinned by biological data arising from molecular-based epigenomic and transcriptomic studies. Although a number of 'omic' platforms are now routinely and widely used in biology and...

journal_title：Journal of developmental origins of health and disease

authors： Pleasants AB,Wake GC,Shorten PR,Hassell-Sweatman CZ,McLean CA,Holbrook JD,Gluckman PD,Sheppard AM

更新日期：2015-02-01 00:00:00

abstract：:Early-life intervention to reduce obesity and poor dental health through early-life nutrition will improve health outcomes in later life. This study examined the prevalence of overweight and obesity and visual dental decay in 4-year old children in New Zealand between 2013 and 2017, and the impact of a nutrition and p...

journal_title：Journal of developmental origins of health and disease

authors： Rush E,Kirk M,Parmar P,Young L,Obolonkin V

更新日期：2019-06-01 00:00:00

abstract：:Embryonal rhabdomyosarcoma is one of the major defined histologic variants of rhabdomyosarcoma that is mainly reported in children. The histologic appearance of this neoplastic entity recapitulates normal myogenesis. The tumor cells variably exhibit the different cellular phases of myogenesis ranging from undifferenti...

journal_title：Journal of developmental origins of health and disease

authors： Lav R,Heera R,Cherian LM

更新日期：2015-06-01 00:00:00

abstract：:Rates of weight gain in infancy and early childhood can influence later neurocognitive, metabolic and cardiovascular health. We studied the relationship of weight gain during infancy and early childhood to intelligence quotient (IQ), blood pressure (BP) and body mass index (BMI) at age 9 in children born with very low...

journal_title：Journal of developmental origins of health and disease

authors： Washburn L,Nixon P,Snively B,Tennyson A,O'Shea TM

更新日期：2010-10-01 00:00:00

abstract：:Depression and anxiety in the antenatal period are of public health concern given potential adverse effects for both mother and infant. Both are under-researched in the first trimester of pregnancy, especially in Africa. We examine the prevalence of first trimester antenatal depression and anxiety in a cohort of South...

journal_title：Journal of developmental origins of health and disease

authors： Redinger S,Norris SA,Pearson RM,Richter L,Rochat T

更新日期：2018-02-01 00:00:00

abstract：:The development and life performance of 404 high-producing Holstein dairy cows was studied from birth onwards and during two lactations. The management, environment and parental genetics of the cows were known in detail. Cluster analysis identified four performance 'types': high-yielding (HY) cows and persistently hig...

journal_title：Journal of developmental origins of health and disease

authors： Astiz S,Gonzalez-Bulnes A,Sebastian F,Fargas O,Cano I,Cuesta P

更新日期：2014-10-01 00:00:00

abstract：:Here we analyze the outcomes of unlimited access to a low-energy (LE) diet in dams and their offspring. At 3 weeks' gestation, pregnant Wistar rats were divided into two groups: (1) the control group received a normoenergetic diet; and (2) the experimental group received the LE diet. In dams, lactation outcomes, food ...

journal_title：Journal of developmental origins of health and disease

authors： do Nascimento E,de Santana Muniz G,das Graças de Santana Muniz M,de Souza Alexandre L,da Rocha LS,Leandro CG,de Castro RM,Bolaños-Jimenez F

更新日期：2014-02-01 00:00:00

abstract：:Donor-conceived neonates have poorer birth outcomes, including low birth weight and preterm delivery that are associated with poorer long-term health in adulthood through the developmental origins of health and disease (DOHaD) theory. The aim of this study was to conduct the first investigation of the adult health out...

journal_title：Journal of developmental origins of health and disease

authors： Adams DH,Gerace A,Davies MJ,de Lacey S

更新日期：2020-08-28 00:00:00

abstract：:The hypothesis that vitamin content of the diet during gestation alters macronutrient choice, food intake and the expression of serotonin receptors and proopiomelanocortin (POMC) in the hypothalamus of the offspring was investigated. Pregnant Wistar rats (n = 10/group) were fed the AIN-93G diet containing a multivitam...

journal_title：Journal of developmental origins of health and disease

authors： Szeto IM,Payne ME,Jahan-Mihan A,Duan J,Anderson GH

更新日期：2010-12-01 00:00:00

abstract：:The ability of the aorta to buffer blood flow and provide diastolic perfusion (Windkessel function) is a determinant of cardiovascular health. We have reported cardiac dysfunction indicating downstream vascular abnormalities in young adult baboons who were intrauterine growth restricted (IUGR) at birth as a result of ...

journal_title：Journal of developmental origins of health and disease

authors： Kuo AH,Li J,Li C,Huber HF,Nathanielsz PW,Clarke GD

更新日期：2018-04-01 00:00:00

abstract：:Postnatal and antenatal depression present significant public health concerns. Current opinion on the use of these terms is noted. Previous research findings demonstrate that detrimental effects of untreated maternal depression/anxiety are potentially severe and impact on the whole family; longer-term effects on child...

journal_title：Journal of developmental origins of health and disease

authors： Hall P

更新日期：2012-08-01 00:00:00

abstract：:Pregnant women, children under 2 and the first thousand days of life have been principal targets for Developmental Origins of Health and Disease interventions. This paradigm has been criticized for laying responsibility for health outcomes on pregnant women and mothers and through the thousand days focus inadvertently...

journal_title：Journal of developmental origins of health and disease

authors： Pentecost M,Ross FC,Macnab A

更新日期：2018-02-01 00:00:00