Antenatal exposure to chorioamnionitis affects lipid metabolism in 7-week-old sheep.

Abstract:

:Antenatal exposure of the fetus to inflammation may alter postnatal organ development. In our previous work, we demonstrated that the fetal liver is involved in the systemic inflammation associated with chorioamnionitis, leading to metabolic changes. On the basis of these findings, we hypothesized that chorioamnionitis can lead to postnatal inflammation-related liver injury and disturbed lipid metabolism. Chorioamnionitis was induced in sheep by intra-amniotic injection of lipopolysaccharide (LPS) or saline at 90, 100 and 110 days of gestation. Liver homeostasis and lipid metabolism were analyzed at term and at 7 weeks of age. At term, hepatic T-lymphocytes and apoptotic hepatocytes were increased. In addition, hepatic cholesterol and triglyceride levels were decreased in LPS-exposed animals compared with controls. At 7 weeks of age, no hepatic inflammation could be detected. However, liver triglycerides and plasma cholesterol levels were increased in LPS-exposed animals relative to controls. The changes in lipid levels at 7 weeks of age were associated with increased leptin receptor mRNA levels, increased lipid peroxidation, increased expression of cytochrome c oxidase subunit 4 as a marker for mitochondrial function and increased circulating ceramide levels. These findings demonstrate that chorioamnionitis-mediated antenatal inflammation-related liver disturbances have long-lasting postnatal effects on lipid metabolism.

journal_name

J Dev Orig Health Dis

authors

Vlassaks E,Gavilanes AW,Bieghs V,Reinartz A,Gassler N,Van Gorp PJ,Gijbels MJ,Bekers O,Zimmermann LJ,Pillow JJ,Polglase GR,Nitsos I,Newnham JP,Kallapur SG,Jobe AH,Shiri-Sverdlov R,Kramer BW

doi

10.1017/S2040174412000049

subject

Has Abstract

pub_date

2012-04-01 00:00:00

pages

103-10

issue

2

eissn

2040-1744

issn

2040-1752

pii

S2040174412000049

journal_volume

3

pub_type

杂志文章
  • Decoding the 'embryonic' nature of embryonal rhabdomyosarcoma.

    abstract::Embryonal rhabdomyosarcoma is one of the major defined histologic variants of rhabdomyosarcoma that is mainly reported in children. The histologic appearance of this neoplastic entity recapitulates normal myogenesis. The tumor cells variably exhibit the different cellular phases of myogenesis ranging from undifferenti...

    journal_title:Journal of developmental origins of health and disease

    pub_type: 杂志文章,评审

    doi:10.1017/S204017441500015X

    authors: Lav R,Heera R,Cherian LM

    更新日期:2015-06-01 00:00:00

  • Psychosocial determinants of cigarette smoking among university students in Jordan.

    abstract::The objectives of this study were to describe the prevalence of cigarette use and water pipe smoking in Jordanian university students and to analyze differences in determinants between cigarette smokers and non-smokers. A cross-sectional questionnaire was administered to a random sample of 400 students (18-24 years, 5...

    journal_title:Journal of developmental origins of health and disease

    pub_type: 杂志文章

    doi:10.1017/S2040174411000122

    authors: Farajat M,Hoving C,De Vries H

    更新日期:2011-06-01 00:00:00

  • Improvement in metabolic effects by dietary intervention is dependent on the precise nature of the developmental programming challenge.

    abstract::Predisposition to offspring metabolic dysfunction due to poor maternal nutrition differs with the developmental stage at exposure. Post-weaning nutrition also influences offspring phenotype in either adverse or beneficial ways. We studied a well-established rat maternal protein-restriction model to determine whether p...

    journal_title:Journal of developmental origins of health and disease

    pub_type: 杂志文章

    doi:10.1017/S2040174415001051

    authors: Bautista CJ,Guzmán C,Rodríguez-González GL,Zambrano E

    更新日期:2015-08-01 00:00:00

  • Water, sanitation and hygiene (WASH) in sub-Saharan Africa and associations with undernutrition, and governance in children under five years of age: a systematic review.

    abstract::Associations between different forms of malnutrition and environmental conditions, including water, sanitation and hygiene (WASH), may contribute towards persistently poor child health, growth and cognitive development. Experiencing poor nutrition in utero or during early childhood is furthermore associated with chron...

    journal_title:Journal of developmental origins of health and disease

    pub_type: 杂志文章

    doi:10.1017/S2040174419000898

    authors: Momberg DJ,Ngandu BC,Voth-Gaeddert LE,Cardoso Ribeiro K,May J,Norris SA,Said-Mohamed R

    更新日期:2021-02-01 00:00:00

  • Increased maternal BMI is associated with infant wheezing in early life: a prospective cohort study.

    abstract::Rates of obesity are increasing in women of child bearing age with negative impacts on maternal and offspring health. Emerging evidence suggests in utero origins of respiratory health in offspring of obese mothers but mechanisms are unknown. Changes in maternal cortisol levels are one potential factor as cortisol leve...

    journal_title:Journal of developmental origins of health and disease

    pub_type: 杂志文章

    doi:10.1017/S2040174414000312

    authors: de Vries A,Reynolds RM,Seckl JR,van der Wal M,Bonsel GJ,Vrijkotte TG

    更新日期:2014-10-01 00:00:00

  • Associations of LINE-1 DNA Methylation with Preterm Birth in a Prospective Cohort Study.

    abstract::Preterm birth affects over 12% of all infants born in the US yet the biology of early delivery remains unclear, including whether epigenetic mechanisms are involved. We examined associations of maternal and umbilical cord blood long interspersed nuclear element-1 (LINE-1) DNA methylation with length of gestation and o...

    journal_title:Journal of developmental origins of health and disease

    pub_type: 杂志文章

    doi:10.1017/s2040174412000104

    authors: Burris HH,Rifas-Shiman SL,Baccarelli A,Tarantini L,Boeke CE,Kleinman K,Litonjua AA,Rich-Edwards JW,Gillman MW

    更新日期:2012-06-01 00:00:00

  • Early ovarian follicular development in prepubertal Wistar rats acutely exposed to androgens.

    abstract::Androgens may directly modulate early ovarian follicular development in preantral stages and androgen excess before puberty may disrupt this physiological process. Therefore, the aim of this study was to investigate the dynamics of follicular morphology and circulating androgen and estradiol levels in prepubertal Wist...

    journal_title:Journal of developmental origins of health and disease

    pub_type: 杂志文章

    doi:10.1017/S2040174416000222

    authors: Paixão L,Velez LM,Santos BR,Tusset C,Lecke SB,Motta AB,Spritzer PM

    更新日期:2016-08-01 00:00:00

  • Sex-specific associations of maternal prenatal testosterone levels with birth weight and weight gain in infancy.

    abstract::Associations between maternal salivary testosterone at 36 weeks' gestation with birth weight and infant weight gain through 6 months of age were examined in a group of 49 healthy, pregnant women and their offspring. The diurnal decline of maternal testosterone was conserved in late pregnancy, and levels showed signifi...

    journal_title:Journal of developmental origins of health and disease

    pub_type: 杂志文章

    doi:10.1017/S2040174413000135

    authors: Voegtline KM,Costigan KA,Kivlighan KT,Henderson JL,DiPietro JA

    更新日期:2013-08-01 00:00:00

  • Evolution of perinatal outcomes and sociodemographic variables in Chile (1996-2017).

    abstract::The evolution of birth weight (BW), birth length (BL), and gestational age at delivery (GAD) and their correlation with various maternal sociodemographic variables were studied in Chilean newborns from years 1996 to 2017. A slight decrease in the mean values of these perinatal outcomes was observed; however, their ris...

    journal_title:Journal of developmental origins of health and disease

    pub_type: 杂志文章

    doi:10.1017/S2040174420001117

    authors: Mardones F,Acuña J

    更新日期:2020-12-04 00:00:00

  • In utero betamethasone affects 3β-hydroxysteroid dehydrogenase and inhibin-α immunoexpression during testis development.

    abstract::Prenatal glucocorticoids, commonly used in women at risk of preterm delivery, can predispose the newborn to disease in later life. Since male reproductive function is likely to reflect testis development during fetal life, we studied the effects of prenatal glucocorticoids on two key intra-testicular factors that play...

    journal_title:Journal of developmental origins of health and disease

    pub_type: 杂志文章

    doi:10.1017/S2040174416000118

    authors: Pedrana G,Viotti H,Lombide P,Sanguinetti G,Pino C,Cavestany D,Sloboda DM,Martin GB

    更新日期:2016-08-01 00:00:00

  • The impact of maternal protein restriction during perinatal life on the response to a septic insult in adult rats.

    abstract::Although abundant evidence exists that adverse events during pregnancy lead to chronic conditions, there is limited information on the impact of acute insults such as sepsis. This study tested the hypothesis that impaired fetal development leads to altered organ responses to a septic insult in both male and female adu...

    journal_title:Journal of developmental origins of health and disease

    pub_type: 杂志文章

    doi:10.1017/S2040174420001269

    authors: Khazaee R,Vinokurtseva A,McCaig LA,Yamashita C,Hardy DB,Arany E,Veldhuizen RAW

    更新日期:2020-12-23 00:00:00

  • Maternal aging affects life performance of progeny in a Holstein dairy cow model.

    abstract::The development and life performance of 404 high-producing Holstein dairy cows was studied from birth onwards and during two lactations. The management, environment and parental genetics of the cows were known in detail. Cluster analysis identified four performance 'types': high-yielding (HY) cows and persistently hig...

    journal_title:Journal of developmental origins of health and disease

    pub_type: 杂志文章

    doi:10.1017/S2040174414000361

    authors: Astiz S,Gonzalez-Bulnes A,Sebastian F,Fargas O,Cano I,Cuesta P

    更新日期:2014-10-01 00:00:00

  • Diabetes and pregnancy in Wistar rats: renal effects for mothers in the postpartum period.

    abstract::In this study, diabetes mellitus (DM) was induced in Wistar rats during pregnancy and maintained in the postpartum period (PP) and we evaluated systolic blood pressure (SBP), glomerular filtration rate (GFR) and renal immunohistochemical and morphometric studies from different groups: G1 (non-pregnant control rats), G...

    journal_title:Journal of developmental origins of health and disease

    pub_type: 杂志文章

    doi:10.1017/S2040174417000605

    authors: França-Silva N,Reis NG,Santos PF,Balbi APC

    更新日期:2018-02-01 00:00:00

  • First trimester antenatal depression and anxiety: prevalence and associated factors in an urban population in Soweto, South Africa.

    abstract::Depression and anxiety in the antenatal period are of public health concern given potential adverse effects for both mother and infant. Both are under-researched in the first trimester of pregnancy, especially in Africa. We examine the prevalence of first trimester antenatal depression and anxiety in a cohort of South...

    journal_title:Journal of developmental origins of health and disease

    pub_type: 杂志文章

    doi:10.1017/S204017441700071X

    authors: Redinger S,Norris SA,Pearson RM,Richter L,Rochat T

    更新日期:2018-02-01 00:00:00

  • Maternal and newborn infants amino acid concentrations in obese women born themselves with normal and small for gestational age birth weight.

    abstract::This study was undertaken to compare amino acid concentrations in maternal and newborn infants' serum in normal pregnancy and two groups of obese women who were born themselves with normal and small for gestational age (SGA) birth weight. Maternal cholesterol, lipoproteins concentrations and maternal and infants amino...

    journal_title:Journal of developmental origins of health and disease

    pub_type: 杂志文章

    doi:10.1017/S2040174415001117

    authors: Tsyvian PB,Bashmakova NV,Kovtun OP,Makarenko LV,Pestryaeva LA

    更新日期:2015-08-01 00:00:00

  • Developmental origins, behaviour change and the new public health.

    abstract::A developmental approach to public health focuses attention on better nourishing girls and young women, especially those of low socio-economic status, to improve mothers' nutrition and thereby the health of future generations. There have been significant advances in the behavioural sciences that may allow us to unders...

    journal_title:Journal of developmental origins of health and disease

    pub_type: 杂志文章,评审

    doi:10.1017/S2040174415001312

    authors: Barker M

    更新日期:2015-10-01 00:00:00

  • Profiles of gene expression in maternal blood predict offspring birth weight in normal pregnancy.

    abstract::The association between lower birth weight and increased disease risk in adulthood has drawn attention to the physiological processes that shape the gestational environment. We implement genome-wide transcriptional profiling of maternal blood samples to identify subsets of genes and associated transcription control pa...

    journal_title:Journal of developmental origins of health and disease

    pub_type: 杂志文章

    doi:10.1017/S2040174419000175

    authors: McDade TW,Kuzawa CW,Borja J,Arevalo JMG,Miller G,Cole SW

    更新日期:2019-12-01 00:00:00

  • Self-reported physical health status of donor sperm-conceived adults.

    abstract::Donor-conceived neonates have poorer birth outcomes, including low birth weight and preterm delivery that are associated with poorer long-term health in adulthood through the developmental origins of health and disease (DOHaD) theory. The aim of this study was to conduct the first investigation of the adult health out...

    journal_title:Journal of developmental origins of health and disease

    pub_type: 杂志文章

    doi:10.1017/S204017442000080X

    authors: Adams DH,Gerace A,Davies MJ,de Lacey S

    更新日期:2020-08-28 00:00:00

  • Secular trends 2013-2017 in overweight and visible dental decay in New Zealand preschool children: influence of ethnicity, deprivation and the Under-5-Energize nutrition and physical activity programme.

    abstract::Early-life intervention to reduce obesity and poor dental health through early-life nutrition will improve health outcomes in later life. This study examined the prevalence of overweight and obesity and visual dental decay in 4-year old children in New Zealand between 2013 and 2017, and the impact of a nutrition and p...

    journal_title:Journal of developmental origins of health and disease

    pub_type: 杂志文章

    doi:10.1017/S2040174418000788

    authors: Rush E,Kirk M,Parmar P,Young L,Obolonkin V

    更新日期:2019-06-01 00:00:00

  • Effects of prenatal bisphenol-A exposure and postnatal overfeeding on cardiovascular function in female sheep.

    abstract::Bisphenol-A (BPA) is a widely used endocrine-disrupting chemical. Prenatal exposure to BPA is known to affect birth weight, but its impact on the cardiovascular system has not been studied in detail. In this study, we investigated the effects of prenatal BPA treatment and its interaction with postnatal overfeeding on ...

    journal_title:Journal of developmental origins of health and disease

    pub_type: 杂志文章

    doi:10.1017/S204017441600057X

    authors: MohanKumar SM,Rajendran TD,Vyas AK,Hoang V,Asirvatham-Jeyaraj N,Veiga-Lopez A,Olivier NB,Padmanabhan V,MohanKumar PS

    更新日期:2017-02-01 00:00:00

  • Intrauterine environment and cognitive development in young twins.

    abstract::Intrauterine factors important for cognitive development, such as birth weight, chorionicity and umbilical cord characteristics were investigated. A total of 663 twin pairs completed the Wechsler Intelligence Scale for Children-Revised and scores were available for Performance, Verbal and Total Intelligence Quotient (...

    journal_title:Journal of developmental origins of health and disease

    pub_type: 杂志文章

    doi:10.1017/S2040174413000287

    authors: Antoniou EE,Fowler T,Thiery E,Southwood TR,van Gestel S,Jacobs N,Vlietinck R,van Os J,Rijsdijk FV,Derom C,Zeegers MP

    更新日期:2013-12-01 00:00:00

  • Current considerations of the effects of untreated maternal perinatal depression and the National Perinatal Depression Initiative.

    abstract::Postnatal and antenatal depression present significant public health concerns. Current opinion on the use of these terms is noted. Previous research findings demonstrate that detrimental effects of untreated maternal depression/anxiety are potentially severe and impact on the whole family; longer-term effects on child...

    journal_title:Journal of developmental origins of health and disease

    pub_type: 杂志文章

    doi:10.1017/S2040174412000013

    authors: Hall P

    更新日期:2012-08-01 00:00:00

  • Isolated oligohydramnios and long-term neurological morbidity of the offspring.

    abstract::This study aimed to assess the association between maternal-isolated oligohydramnios (IO) and offspring long-term neurological complications. A population-based retrospective cohort study was conducted, including all births at a single tertiary medical center in Israel between the years 1991 and 2014. Multiple pregnan...

    journal_title:Journal of developmental origins of health and disease

    pub_type: 杂志文章

    doi:10.1017/S2040174419000795

    authors: Dorot A,Wainstock T,Sheiner E,Walfisch A,Landau D,Harlev A

    更新日期:2020-12-01 00:00:00

  • Maternal folic acid supplementation does not counteract the deleterious impact of prenatal exposure to environmental pollutants on lipid homeostasis in male rat descendants.

    abstract::Prenatal exposure to persistent organic pollutants (POPs) has been associated with the development of metabolic syndrome-related diseases in offspring. According to epidemiological studies, father's transmission of environmental effects in addition to mother's can influence offspring health. Moreover, maternal prenata...

    journal_title:Journal of developmental origins of health and disease

    pub_type: 杂志文章

    doi:10.1017/S2040174419000497

    authors: Navarro P,Dalvai M,Charest PL,Herst PM,Lessard M,Marcotte B,Mitchell PL,Leblanc N,Kimmins S,Trasler J,MacFarlane AJ,Marette A,Bailey JL,Jacques H

    更新日期:2019-09-16 00:00:00

  • Iron deficiency during pregnancy and lactation modifies the fatty acid composition of the brain of neonatal rats.

    abstract::Iron deficiency is common in pregnant and lactating women and is associated with reduced cognitive development of the offspring. Since iron affects lipid metabolism, the availability of fatty acids, particularly the polyunsaturated fatty acids required for early neural development, was investigated in the offspring of...

    journal_title:Journal of developmental origins of health and disease

    pub_type: 杂志文章

    doi:10.1017/S2040174419000552

    authors: Rees WD,Hay SM,Hayes HE,Stevens VJ,Gambling L,McArdle HJ

    更新日期:2020-06-01 00:00:00

  • Genome organization: connecting the developmental origins of disease and genetic variation.

    abstract::An adverse early life environment can increase the risk of metabolic and other disorders later in life. Genetic variation can modify an individual's susceptibility to these environmental challenges. These gene by environment interactions are important, but difficult, to dissect. The nucleus is the primary organelle wh...

    journal_title:Journal of developmental origins of health and disease

    pub_type: 杂志文章,评审

    doi:10.1017/S2040174417000678

    authors: Jacobson E,Vickers MH,Perry JK,O'Sullivan JM

    更新日期:2018-06-01 00:00:00

  • Optimum feeding and growth in preterm neonates.

    abstract::Approximately 10% of all babies worldwide are born preterm, and preterm birth is the leading cause of perinatal mortality in developed countries. Although preterm birth is associated with adverse short- and long-term health outcomes, it is not yet clear whether this relationship is causal. Rather, there is evidence th...

    journal_title:Journal of developmental origins of health and disease

    pub_type: 杂志文章

    doi:10.1017/S2040174412000736

    authors: Harding JE,Derraik JG,Berry MJ,Jaquiery AL,Alsweiler JM,Cormack BE,Bloomfield FH

    更新日期:2013-06-01 00:00:00

  • Nutrition beyond the first 1000 days: diet quality and 7-year change in BMI and overweight in 3-year old children from the Dutch GECKO Drenthe birth cohort.

    abstract::The identification of early-life determinants of overweight is crucial to start early prevention. As weight gain accelerates between 2 and 6 years, we studied the association between diet quality in children aged 3 years and the change in BMI and overweight incidence in the following 7 years. From the Dutch GECKO Dren...

    journal_title:Journal of developmental origins of health and disease

    pub_type: 杂志文章

    doi:10.1017/S204017442000118X

    authors: Vinke PC,Luitjens MHHS,Blijleven KA,Navis G,Kromhout D,Corpeleijn E

    更新日期:2020-12-11 00:00:00

  • Adolescent understanding of DOHaD concepts: a school-based intervention to support knowledge translation and behaviour change.

    abstract::A life-course approach to reduction of risk of non-communicable diseases (NCD) suggests that early-life interventions may be more effective than lifestyle modifications in middle age. Knowledge translation to develop understanding of the Developmental Origins of Health and Disease (DOHaD) within the community offers t...

    journal_title:Journal of developmental origins of health and disease

    pub_type: 杂志文章

    doi:10.1017/S2040174412000505

    authors: Bay JL,Mora HA,Sloboda DM,Morton SM,Vickers MH,Gluckman PD

    更新日期:2012-12-01 00:00:00

  • Unlimited access to low-energy diet causes acute malnutrition in dams and alters biometric and biochemical parameters in offspring.

    abstract::Here we analyze the outcomes of unlimited access to a low-energy (LE) diet in dams and their offspring. At 3 weeks' gestation, pregnant Wistar rats were divided into two groups: (1) the control group received a normoenergetic diet; and (2) the experimental group received the LE diet. In dams, lactation outcomes, food ...

    journal_title:Journal of developmental origins of health and disease

    pub_type: 杂志文章

    doi:10.1017/S2040174413000482

    authors: do Nascimento E,de Santana Muniz G,das Graças de Santana Muniz M,de Souza Alexandre L,da Rocha LS,Leandro CG,de Castro RM,Bolaños-Jimenez F

    更新日期:2014-02-01 00:00:00