Early ovarian follicular development in prepubertal Wistar rats acutely exposed to androgens.

abstract：:Embryonal rhabdomyosarcoma is one of the major defined histologic variants of rhabdomyosarcoma that is mainly reported in children. The histologic appearance of this neoplastic entity recapitulates normal myogenesis. The tumor cells variably exhibit the different cellular phases of myogenesis ranging from undifferenti...

journal_title：Journal of developmental origins of health and disease

authors： Lav R,Heera R,Cherian LM

更新日期：2015-06-01 00:00:00

abstract：:Tobacco smoke has both carcinogenic effects and anti-estrogenic properties and its inconsistent association with breast cancer risk in observational studies may be because of these competing effects across the lifecourse. We conducted a prospective study of prenatal smoke exposure, childhood household smoke exposure, ...

journal_title：Journal of developmental origins of health and disease

authors： Terry MB,Schaefer CA,Flom JD,Wei Y,Tehranifar P,Liao Y,Buka S,Michels KB

更新日期：2011-12-01 00:00:00

abstract：:Predisposition to offspring metabolic dysfunction due to poor maternal nutrition differs with the developmental stage at exposure. Post-weaning nutrition also influences offspring phenotype in either adverse or beneficial ways. We studied a well-established rat maternal protein-restriction model to determine whether p...

journal_title：Journal of developmental origins of health and disease

authors： Bautista CJ,Guzmán C,Rodríguez-González GL,Zambrano E

更新日期：2015-08-01 00:00:00

abstract：:Early-life intervention to reduce obesity and poor dental health through early-life nutrition will improve health outcomes in later life. This study examined the prevalence of overweight and obesity and visual dental decay in 4-year old children in New Zealand between 2013 and 2017, and the impact of a nutrition and p...

journal_title：Journal of developmental origins of health and disease

authors： Rush E,Kirk M,Parmar P,Young L,Obolonkin V

更新日期：2019-06-01 00:00:00

abstract：:Iron deficiency is common in pregnant and lactating women and is associated with reduced cognitive development of the offspring. Since iron affects lipid metabolism, the availability of fatty acids, particularly the polyunsaturated fatty acids required for early neural development, was investigated in the offspring of...

journal_title：Journal of developmental origins of health and disease

authors： Rees WD,Hay SM,Hayes HE,Stevens VJ,Gambling L,McArdle HJ

更新日期：2020-06-01 00:00:00

abstract：:Prenatal exposure to persistent organic pollutants (POPs) has been associated with the development of metabolic syndrome-related diseases in offspring. According to epidemiological studies, father's transmission of environmental effects in addition to mother's can influence offspring health. Moreover, maternal prenata...

journal_title：Journal of developmental origins of health and disease

authors： Navarro P,Dalvai M,Charest PL,Herst PM,Lessard M,Marcotte B,Mitchell PL,Leblanc N,Kimmins S,Trasler J,MacFarlane AJ,Marette A,Bailey JL,Jacques H

更新日期：2019-09-16 00:00:00

abstract：:The developmental origins hypothesis suggests that morbidity and premature mortality arise, in part, from adverse exposures in utero and early in development. Evidence suggests a connection between early nutritional deficits and adult morbidity; however, the effects on mortality have been less well studied and previou...

journal_title：Journal of developmental origins of health and disease

authors： Saxton K,Falconi A,Goldman-Mellor S,Catalano R

更新日期：2013-02-01 00:00:00

abstract：:Placental weight is a valuable indicator of its function, predicting both pregnancy outcome and lifelong health. Population-based centile charts of weight-for-gestational-age and parity are useful for identifying extremes of placental weight but fail to consider maternal size. To address this deficit, a multiple regre...

journal_title：Journal of developmental origins of health and disease

authors： Wallace JM,Agard JP,Horgan GW

更新日期：2019-10-07 00:00:00

abstract：:The early embryo and periconceptional period is a window during which environmental factors may cause permanent change in the pattern and characteristics of development leading to risk of adult onset disease. This has now been demonstrated across small and large animal models and also in the human. Most evidence of pe...

journal_title：Journal of developmental origins of health and disease

authors： Fleming TP,Velazquez MA,Eckert JJ

更新日期：2015-10-01 00:00:00

abstract：:Antenatal exposure of the fetus to inflammation may alter postnatal organ development. In our previous work, we demonstrated that the fetal liver is involved in the systemic inflammation associated with chorioamnionitis, leading to metabolic changes. On the basis of these findings, we hypothesized that chorioamnioniti...

journal_title：Journal of developmental origins of health and disease

authors： Vlassaks E,Gavilanes AW,Bieghs V,Reinartz A,Gassler N,Van Gorp PJ,Gijbels MJ,Bekers O,Zimmermann LJ,Pillow JJ,Polglase GR,Nitsos I,Newnham JP,Kallapur SG,Jobe AH,Shiri-Sverdlov R,Kramer BW

更新日期：2012-04-01 00:00:00

abstract：:Bisphenol-A (BPA) is a widely used endocrine-disrupting chemical. Prenatal exposure to BPA is known to affect birth weight, but its impact on the cardiovascular system has not been studied in detail. In this study, we investigated the effects of prenatal BPA treatment and its interaction with postnatal overfeeding on ...

journal_title：Journal of developmental origins of health and disease

authors： MohanKumar SM,Rajendran TD,Vyas AK,Hoang V,Asirvatham-Jeyaraj N,Veiga-Lopez A,Olivier NB,Padmanabhan V,MohanKumar PS

更新日期：2017-02-01 00:00:00

abstract：:Although abundant evidence exists that adverse events during pregnancy lead to chronic conditions, there is limited information on the impact of acute insults such as sepsis. This study tested the hypothesis that impaired fetal development leads to altered organ responses to a septic insult in both male and female adu...

journal_title：Journal of developmental origins of health and disease

authors： Khazaee R,Vinokurtseva A,McCaig LA,Yamashita C,Hardy DB,Arany E,Veldhuizen RAW

更新日期：2020-12-23 00:00:00

abstract：:Children of parents with major mood and psychotic disorders are at increased risk of psychopathology, including psychotic symptoms. It has been suggested that the risk of psychosis may be more often transmitted from parent to opposite-sex offspring (e.g., from father to daughter) than to same-sex offspring (e.g., from...

journal_title：Journal of developmental origins of health and disease

authors： Aylott A,Zwicker A,MacKenzie LE,Cumby J,Propper L,Abidi S,Bagnell A,Fisher HL,Pavlova B,Alda M,Uher R

更新日期：2019-02-01 00:00:00

abstract：:Maternal undernutrition is known to adversely impact fetal health and development. Insults experienced in utero alter development of the fetus as it adapts to microenvironment stressors, leading to growth restriction and subsequent low birth weight. Infants born small for gestational age have significantly increased r...

journal_title：Journal of developmental origins of health and disease

authors： Schlegel RN,Moritz KM,Paravicini TM

更新日期：2016-10-01 00:00:00

abstract：:The objectives of this study were to describe the prevalence of cigarette use and water pipe smoking in Jordanian university students and to analyze differences in determinants between cigarette smokers and non-smokers. A cross-sectional questionnaire was administered to a random sample of 400 students (18-24 years, 5...

journal_title：Journal of developmental origins of health and disease

authors： Farajat M,Hoving C,De Vries H

更新日期：2011-06-01 00:00:00

abstract：:An adverse early life environment can increase the risk of metabolic and other disorders later in life. Genetic variation can modify an individual's susceptibility to these environmental challenges. These gene by environment interactions are important, but difficult, to dissect. The nucleus is the primary organelle wh...

journal_title：Journal of developmental origins of health and disease

authors： Jacobson E,Vickers MH,Perry JK,O'Sullivan JM

更新日期：2018-06-01 00:00:00

abstract：:Postnatal and antenatal depression present significant public health concerns. Current opinion on the use of these terms is noted. Previous research findings demonstrate that detrimental effects of untreated maternal depression/anxiety are potentially severe and impact on the whole family; longer-term effects on child...

journal_title：Journal of developmental origins of health and disease

authors： Hall P

更新日期：2012-08-01 00:00:00

abstract：:Preterm birth (delivery <37 weeks of gestation) is associated with impaired glomerular capillary growth in neonates; if this persists, it may be a contributing factor in the increased risk of hypertension and chronic kidney disease in people born preterm. Therefore, in this study, we aimed to determine the long-term i...

journal_title：Journal of developmental origins of health and disease

authors： Sutherland MR,Malik W,Nguyen VB,Tran V,Polglase GR,Black MJ

更新日期：2020-12-10 00:00:00

abstract：:The evidence underpinning the developmental origins of health and disease (DOHaD) is overwhelming. As the emphasis shifts more towards interventions and the translational strategies for disease prevention, it is important to capitalize on collaboration and knowledge sharing to maximize opportunities for discovery and ...

journal_title：Journal of developmental origins of health and disease

authors： Prescott SL,Allen K,Armstrong K,Collins C,Dickinson H,Gardiner K,Jacka F,Jasoni C,Moore T,Moritz KM,Muhlhausler B,Siero W,Sim K,Nanan R,Saffery R,Singh G,Vickers MH,Craig JM

更新日期：2016-10-01 00:00:00

abstract：:The principles embodied by the Developmental Origins of Health and Disease (DOHaD) view of 'life history' trajectory are increasingly underpinned by biological data arising from molecular-based epigenomic and transcriptomic studies. Although a number of 'omic' platforms are now routinely and widely used in biology and...

journal_title：Journal of developmental origins of health and disease

authors： Pleasants AB,Wake GC,Shorten PR,Hassell-Sweatman CZ,McLean CA,Holbrook JD,Gluckman PD,Sheppard AM

更新日期：2015-02-01 00:00:00

abstract：:With brown adipose tissue (BAT) becoming a possible therapeutic target to counteract obesity, the prenatal environment could represent a critical window to modify BAT function and browning of white AT. We investigated if levels of uncoupling protein 1 (UCP1) and UCP1-mediated thermogenesis are altered in offspring exp...

journal_title：Journal of developmental origins of health and disease

authors： Bytautiene Prewit E,Porter C,La Rosa M,Bhattarai N,Yin H,Gamble P,Kechichian T,Sidossis LS

更新日期：2018-08-01 00:00:00

abstract：:Associations between maternal salivary testosterone at 36 weeks' gestation with birth weight and infant weight gain through 6 months of age were examined in a group of 49 healthy, pregnant women and their offspring. The diurnal decline of maternal testosterone was conserved in late pregnancy, and levels showed signifi...

journal_title：Journal of developmental origins of health and disease

authors： Voegtline KM,Costigan KA,Kivlighan KT,Henderson JL,DiPietro JA

更新日期：2013-08-01 00:00:00

abstract：:Hypertension (HTN) remains a common complication after kidney transplantation among paediatric patients. Although low birth weight (LBW) has been implicated as an important risk factor for cardiovascular diseases, its effect on transplantation patients has not yet been addressed. It is essential to determine whether c...

journal_title：Journal of developmental origins of health and disease

authors： Santos LB,Borges LM,Souza LV,Felipe CR,Medina-Pestana JO,Franco MDC

更新日期：2020-02-01 00:00:00

abstract：:Renin is essential for renal development and in adult kidneys vitamin D deficiency increases renin gene expression. We aimed to determine whether maternal vitamin D deficiency upregulates fetal renal renin expression, and if this is sustained. We also examined growth and the long-term renal effects in offspring on a n...

journal_title：Journal of developmental origins of health and disease

authors： Boyce AC,Palmer-Aronsten BJ,Kim MY,Gibson KJ

更新日期：2013-10-01 00:00:00

abstract：:Low birth weight is associated with increased risk of cardiovascular disease in adulthood. Intrauterine growth restriction (IUGR) hearts have fewer CMs in early postnatal life, which may impair postnatal cardiovascular function and hence, explain increased disease risk, but whether the cardiomyocyte deficit persists t...

journal_title：Journal of developmental origins of health and disease

authors： Vranas S,Heinemann GK,Liu H,De Blasio MJ,Owens JA,Gatford KL,Black MJ

更新日期：2017-10-01 00:00:00

abstract：:Prenatal glucocorticoids, commonly used in women at risk of preterm delivery, can predispose the newborn to disease in later life. Since male reproductive function is likely to reflect testis development during fetal life, we studied the effects of prenatal glucocorticoids on two key intra-testicular factors that play...

journal_title：Journal of developmental origins of health and disease

authors： Pedrana G,Viotti H,Lombide P,Sanguinetti G,Pino C,Cavestany D,Sloboda DM,Martin GB

更新日期：2016-08-01 00:00:00

abstract：:Breast milk constitutes one of the most important sources of postnatal microbes. However, the influence of perinatal factors on the milk microbiome is still poorly understood. The aim of our study was to assess the impact of mode of delivery on the microbiome composition and diversity present in breast milk of healthy...

journal_title：Journal of developmental origins of health and disease

authors： Cabrera-Rubio R,Mira-Pascual L,Mira A,Collado MC

更新日期：2016-02-01 00:00:00

abstract：:Ilex paraguariensis (yerba mate) has a beneficial effect in the management of obesity. Here, we studied the effects of yerba mate on hypothalamic changes in leptin and insulin signalling, oxidative stress and liver morphology and metabolism in postnatal early overfeeding (EO) Wistar rats. To induce EO, the litter size...

journal_title：Journal of developmental origins of health and disease

authors： Conceição EP,Kaezer AR,Peixoto-Silva N,Felzenszwalb I,de Oliveira E,Moura EG,Lisboa PC

更新日期：2017-02-01 00:00:00

abstract：:Pregnant individuals who overeat are more likely to predispose their fetus to the development of metabolic disorders in adulthood. Physical training is a prevention and treatment interventional strategy that could treat these disorders, since it improves metabolism and body composition. This study assessed the protect...

journal_title：Journal of developmental origins of health and disease

authors： Martins Terra M,Schaeffer Fontoura T,Oliveira Nogueira A,Ferraz Lopes J,de Freitas Mathias PC,Andreazzi AE,de Oliveira Guerra M,Maria Peters V

更新日期：2020-04-01 00:00:00

abstract：:Here we analyze the outcomes of unlimited access to a low-energy (LE) diet in dams and their offspring. At 3 weeks' gestation, pregnant Wistar rats were divided into two groups: (1) the control group received a normoenergetic diet; and (2) the experimental group received the LE diet. In dams, lactation outcomes, food ...

journal_title：Journal of developmental origins of health and disease

authors： do Nascimento E,de Santana Muniz G,das Graças de Santana Muniz M,de Souza Alexandre L,da Rocha LS,Leandro CG,de Castro RM,Bolaños-Jimenez F

更新日期：2014-02-01 00:00:00