Abstract:
:The evidence underpinning the developmental origins of health and disease (DOHaD) is overwhelming. As the emphasis shifts more towards interventions and the translational strategies for disease prevention, it is important to capitalize on collaboration and knowledge sharing to maximize opportunities for discovery and replication. DOHaD meetings are facilitating this interaction. However, strategies to perpetuate focussed discussions and collaborations around and between conferences are more likely to facilitate the development of DOHaD research. For this reason, the DOHaD Society of Australia and New Zealand (DOHaD ANZ) has initiated themed Working Groups, which convened at the 2014-2015 conferences. This report introduces the DOHaD ANZ Working Groups and summarizes their plans and activities. One of the first Working Groups to form was the ActEarly birth cohort group, which is moving towards more translational goals. Reflecting growing emphasis on the impact of early life biodiversity - even before birth - we also have a Working Group titled Infection, inflammation and the microbiome. We have several Working Groups exploring other major non-cancerous disease outcomes over the lifespan, including Brain, behaviour and development and Obesity, cardiovascular and metabolic health. The Epigenetics and Animal Models Working Groups cut across all these areas and seeks to ensure interaction between researchers. Finally, we have a group focussed on 'Translation, policy and communication' which focusses on how we can best take the evidence we produce into the community to effect change. By coordinating and perpetuating DOHaD discussions in this way we aim to enhance DOHaD research in our region.
journal_name
J Dev Orig Health Disjournal_title
Journal of developmental origins of health and diseaseauthors
Prescott SL,Allen K,Armstrong K,Collins C,Dickinson H,Gardiner K,Jacka F,Jasoni C,Moore T,Moritz KM,Muhlhausler B,Siero W,Sim K,Nanan R,Saffery R,Singh G,Vickers MH,Craig JMdoi
10.1017/S2040174416000167subject
Has Abstractpub_date
2016-10-01 00:00:00pages
433-439issue
5eissn
2040-1744issn
2040-1752pii
S2040174416000167journal_volume
7pub_type
杂志文章abstract::Tobacco smoke has both carcinogenic effects and anti-estrogenic properties and its inconsistent association with breast cancer risk in observational studies may be because of these competing effects across the lifecourse. We conducted a prospective study of prenatal smoke exposure, childhood household smoke exposure, ...
journal_title:Journal of developmental origins of health and disease
pub_type: 杂志文章
doi:10.1017/S2040174411000614
更新日期:2011-12-01 00:00:00
abstract::This study was undertaken to compare amino acid concentrations in maternal and newborn infants' serum in normal pregnancy and two groups of obese women who were born themselves with normal and small for gestational age (SGA) birth weight. Maternal cholesterol, lipoproteins concentrations and maternal and infants amino...
journal_title:Journal of developmental origins of health and disease
pub_type: 杂志文章
doi:10.1017/S2040174415001117
更新日期:2015-08-01 00:00:00
abstract::Predisposition to offspring metabolic dysfunction due to poor maternal nutrition differs with the developmental stage at exposure. Post-weaning nutrition also influences offspring phenotype in either adverse or beneficial ways. We studied a well-established rat maternal protein-restriction model to determine whether p...
journal_title:Journal of developmental origins of health and disease
pub_type: 杂志文章
doi:10.1017/S2040174415001051
更新日期:2015-08-01 00:00:00
abstract::Placental weight is a valuable indicator of its function, predicting both pregnancy outcome and lifelong health. Population-based centile charts of weight-for-gestational-age and parity are useful for identifying extremes of placental weight but fail to consider maternal size. To address this deficit, a multiple regre...
journal_title:Journal of developmental origins of health and disease
pub_type: 杂志文章
doi:10.1017/S2040174419000576
更新日期:2019-10-07 00:00:00
abstract::Overweight/obesity has become a worldwide epidemic, and factors such as a sedentary lifestyle and inadequate eating habits directly contribute to the development of this condition. Studies indicate that rapid weight gain at critical development stages, such as the lactation period, is associated with the development o...
journal_title:Journal of developmental origins of health and disease
pub_type: 杂志文章
doi:10.1017/S2040174419000163
更新日期:2019-12-01 00:00:00
abstract::Adipose tissue (AT) dysfunction links obesity of any cause with cardiometabolic disease, but whether early-life nutritional deficiency can program adipocyte dysfunction independently of obesity is untested. In 3-5-month-old juvenile microswine offspring exposed to isocaloric perinatal maternal protein restriction (MPR...
journal_title:Journal of developmental origins of health and disease
pub_type: 杂志文章
doi:10.1017/S2040174412000232
更新日期:2012-06-01 00:00:00
abstract::The early embryo and periconceptional period is a window during which environmental factors may cause permanent change in the pattern and characteristics of development leading to risk of adult onset disease. This has now been demonstrated across small and large animal models and also in the human. Most evidence of pe...
journal_title:Journal of developmental origins of health and disease
pub_type: 杂志文章,评审
doi:10.1017/S2040174415001105
更新日期:2015-10-01 00:00:00
abstract::Preterm birth affects over 12% of all infants born in the US yet the biology of early delivery remains unclear, including whether epigenetic mechanisms are involved. We examined associations of maternal and umbilical cord blood long interspersed nuclear element-1 (LINE-1) DNA methylation with length of gestation and o...
journal_title:Journal of developmental origins of health and disease
pub_type: 杂志文章
doi:10.1017/s2040174412000104
更新日期:2012-06-01 00:00:00
abstract::The consumption of fructose has increased in children and adolescents and is partially responsible for the high incidence of metabolic diseases. The lifestyle during postnatal development can result in altered metabolic programming, thereby impairing the reproductive system and fertility during adulthood. Therefore, t...
journal_title:Journal of developmental origins of health and disease
pub_type: 杂志文章
doi:10.1017/S2040174420001385
更新日期:2021-01-14 00:00:00
abstract::Despite the interest in the relationship of fetal exposures to adult cardiovascular disease, few studies have examined indicators of adult fatty liver disease as an outcome. Previous results are inconsistent, and indicate possible variation by sex. Adult liver enzymes [γ-glutamyl transferase (GGT), alanine transaminas...
journal_title:Journal of developmental origins of health and disease
pub_type: 杂志文章
doi:10.1017/S2040174416000635
更新日期:2017-04-01 00:00:00
abstract::The association between lower birth weight and increased disease risk in adulthood has drawn attention to the physiological processes that shape the gestational environment. We implement genome-wide transcriptional profiling of maternal blood samples to identify subsets of genes and associated transcription control pa...
journal_title:Journal of developmental origins of health and disease
pub_type: 杂志文章
doi:10.1017/S2040174419000175
更新日期:2019-12-01 00:00:00
abstract::Approximately 10% of all babies worldwide are born preterm, and preterm birth is the leading cause of perinatal mortality in developed countries. Although preterm birth is associated with adverse short- and long-term health outcomes, it is not yet clear whether this relationship is causal. Rather, there is evidence th...
journal_title:Journal of developmental origins of health and disease
pub_type: 杂志文章
doi:10.1017/S2040174412000736
更新日期:2013-06-01 00:00:00
abstract::Intrauterine growth restriction (IUGR) from uteroplacental dysfunction causes impaired nephrogenesis and ultimately hypertension, but it is unknown whether IUGR caused by insufficient space for placental development seen in uterine anomalies and/or multifetal gestation exerts the same effects. Fetal renal development ...
journal_title:Journal of developmental origins of health and disease
pub_type: 杂志文章
doi:10.1017/S2040174413000329
更新日期:2013-10-01 00:00:00
abstract::In this study, diabetes mellitus (DM) was induced in Wistar rats during pregnancy and maintained in the postpartum period (PP) and we evaluated systolic blood pressure (SBP), glomerular filtration rate (GFR) and renal immunohistochemical and morphometric studies from different groups: G1 (non-pregnant control rats), G...
journal_title:Journal of developmental origins of health and disease
pub_type: 杂志文章
doi:10.1017/S2040174417000605
更新日期:2018-02-01 00:00:00
abstract::A life-course approach to reduction of risk of non-communicable diseases (NCD) suggests that early-life interventions may be more effective than lifestyle modifications in middle age. Knowledge translation to develop understanding of the Developmental Origins of Health and Disease (DOHaD) within the community offers t...
journal_title:Journal of developmental origins of health and disease
pub_type: 杂志文章
doi:10.1017/S2040174412000505
更新日期:2012-12-01 00:00:00
abstract::Ilex paraguariensis (yerba mate) has a beneficial effect in the management of obesity. Here, we studied the effects of yerba mate on hypothalamic changes in leptin and insulin signalling, oxidative stress and liver morphology and metabolism in postnatal early overfeeding (EO) Wistar rats. To induce EO, the litter size...
journal_title:Journal of developmental origins of health and disease
pub_type: 杂志文章
doi:10.1017/S2040174416000519
更新日期:2017-02-01 00:00:00
abstract::With brown adipose tissue (BAT) becoming a possible therapeutic target to counteract obesity, the prenatal environment could represent a critical window to modify BAT function and browning of white AT. We investigated if levels of uncoupling protein 1 (UCP1) and UCP1-mediated thermogenesis are altered in offspring exp...
journal_title:Journal of developmental origins of health and disease
pub_type: 杂志文章
doi:10.1017/S2040174418000107
更新日期:2018-08-01 00:00:00
abstract::Prenatal diethylstilbestrol (DES) exposure is associated with increased risk of hormonally mediated cancers and other medical conditions. We evaluated the association between DES and risk of pancreatic cancer and pancreatic disorders, type 2 diabetes, and gallbladder disease, which may be involved with this malignancy...
journal_title:Journal of developmental origins of health and disease
pub_type: 杂志文章
doi:10.1017/S2040174420000872
更新日期:2020-10-28 00:00:00
abstract::Low birth weight and a rapid weight gain in early childhood may lead to an increased risk for developing cardiovascular disease later in life, such as hypertension and dyslipidaemia. In this study, we examined the associations between size at birth, relative weight gain in infancy and childhood with specific cardiovas...
journal_title:Journal of developmental origins of health and disease
pub_type: 杂志文章
doi:10.1017/S2040174415007953
更新日期:2016-04-01 00:00:00
abstract::The aim of this study was to observe the association between maternal undernutrition and metabolic risk indicators in newborns at birth. Fifty-nine expectant mothers between 28 and 40 weeks of gestation were included after obtaining their informed consent. Mothers were divided into undernourished, normally nourished a...
journal_title:Journal of developmental origins of health and disease
pub_type: 杂志文章
doi:10.1017/S2040174415001142
更新日期:2015-08-01 00:00:00
abstract::The Developmental Origins of Health and Disease (DOHaD) framework aims to understand how environmental exposures in early life shape lifecycle health. Our understanding and the ability to prevent poor health outcomes and enrich for resiliency remain limited, in part, because exposure-outcome relationships are complex ...
journal_title:Journal of developmental origins of health and disease
pub_type: 杂志文章
doi:10.1017/S2040174420000689
更新日期:2020-08-04 00:00:00
abstract::Associations between different forms of malnutrition and environmental conditions, including water, sanitation and hygiene (WASH), may contribute towards persistently poor child health, growth and cognitive development. Experiencing poor nutrition in utero or during early childhood is furthermore associated with chron...
journal_title:Journal of developmental origins of health and disease
pub_type: 杂志文章
doi:10.1017/S2040174419000898
更新日期:2021-02-01 00:00:00
abstract::The effect of maternal Ramadan-type fasting (RTF) on the outcome of pregnancy, kidney development and nephron number in male rat offspring was investigated in current study. Pregnant rats were given food and water ad libitum during pregnancy (control) or restricted for 16 h per day (RTF). Kidney structure was examined...
journal_title:Journal of developmental origins of health and disease
pub_type: 杂志文章
doi:10.1017/S204017441700109X
更新日期:2018-06-01 00:00:00
abstract::Rates of obesity are increasing in women of child bearing age with negative impacts on maternal and offspring health. Emerging evidence suggests in utero origins of respiratory health in offspring of obese mothers but mechanisms are unknown. Changes in maternal cortisol levels are one potential factor as cortisol leve...
journal_title:Journal of developmental origins of health and disease
pub_type: 杂志文章
doi:10.1017/S2040174414000312
更新日期:2014-10-01 00:00:00
abstract::The evolution of birth weight (BW), birth length (BL), and gestational age at delivery (GAD) and their correlation with various maternal sociodemographic variables were studied in Chilean newborns from years 1996 to 2017. A slight decrease in the mean values of these perinatal outcomes was observed; however, their ris...
journal_title:Journal of developmental origins of health and disease
pub_type: 杂志文章
doi:10.1017/S2040174420001117
更新日期:2020-12-04 00:00:00
abstract::Obesity and its complications occur at alarming rates worldwide. Epidemiological data have associated perinatal conditions, such as malnutrition, with the development of some disorders, such as obesity, dyslipidemia, diabetes, and cardiovascular diseases, in childhood and adulthood. Exclusive breastfeeding has been as...
journal_title:Journal of developmental origins of health and disease
pub_type: 杂志文章
doi:10.1017/S2040174420000410
更新日期:2020-10-01 00:00:00
abstract::Donor-conceived neonates have poorer birth outcomes, including low birth weight and preterm delivery that are associated with poorer long-term health in adulthood through the developmental origins of health and disease (DOHaD) theory. The aim of this study was to conduct the first investigation of the adult health out...
journal_title:Journal of developmental origins of health and disease
pub_type: 杂志文章
doi:10.1017/S204017442000080X
更新日期:2020-08-28 00:00:00
abstract::Iron deficiency is common in pregnant and lactating women and is associated with reduced cognitive development of the offspring. Since iron affects lipid metabolism, the availability of fatty acids, particularly the polyunsaturated fatty acids required for early neural development, was investigated in the offspring of...
journal_title:Journal of developmental origins of health and disease
pub_type: 杂志文章
doi:10.1017/S2040174419000552
更新日期:2020-06-01 00:00:00
abstract::Postnatal and antenatal depression present significant public health concerns. Current opinion on the use of these terms is noted. Previous research findings demonstrate that detrimental effects of untreated maternal depression/anxiety are potentially severe and impact on the whole family; longer-term effects on child...
journal_title:Journal of developmental origins of health and disease
pub_type: 杂志文章
doi:10.1017/S2040174412000013
更新日期:2012-08-01 00:00:00
abstract::Maternal protein restriction (MPR) during pregnancy impaired the reproduction of male offspring. We investigated, during the first wave of spermatogenesis, whether MPR exerts deleterious effects on germ cell proliferation and differentiation, as well as androgen receptor (AR) protein expression, which was used as a ma...
journal_title:Journal of developmental origins of health and disease
pub_type: 杂志文章
doi:10.1017/S2040174412000360
更新日期:2012-10-01 00:00:00