Abstract:
:Prenatal diethylstilbestrol (DES) exposure is associated with increased risk of hormonally mediated cancers and other medical conditions. We evaluated the association between DES and risk of pancreatic cancer and pancreatic disorders, type 2 diabetes, and gallbladder disease, which may be involved with this malignancy. Our analyses used follow-up data from the US National Cancer Institute DES Combined Cohort Study. Cox proportional hazards models estimated hazard ratios (HRs) and 95% confidence intervals (CIs) adjusted for age, sex, cohort, body mass index, smoking, and alcohol for the association between prenatal DES exposure and type 2 diabetes, gallbladder disease (mainly cholelithiasis), pancreatic disorders (mainly pancreatitis), and pancreatic cancer among 5667 exposed and 3315 unexposed individuals followed from 1990 to 2017. Standardized incidence rate (SIR) ratios for pancreatic cancer were based on age-, race-, and calendar year-specific general population cancer incidence rates. In women and men combined, the hazards for total pancreatic disorders and pancreatitis were greater in the prenatally DES exposed than the unexposed (HR = 11, 95% CI 2.6-51 and HR = 7.0, 95% CI 1.5-33, respectively). DES was not associated overall with gallbladder disease (HR = 1.2, 95% CI 0.88-1.5) or diabetes (HR = 1.1, 95% CI 0.9-1.2). In women, but not in men, DES exposure was associated with increased risk of pancreatic cancer compared with the unexposed (HR: 4.1, 95% CI 0.84-20) or general population (SIR: 1.9, 95% CI 1.0-3.2). Prenatal DES exposure may increase the risk of pancreatic disorders, including pancreatitis in women and men. The data suggested elevated pancreatic cancer risk in DES-exposed women, but not in exposed men.
journal_name
J Dev Orig Health Disjournal_title
Journal of developmental origins of health and diseaseauthors
Troisi R,Hyer M,Titus L,Palmer JR,Hatch EE,Huo D,Aagaard KM,Strohsnitter WC,Hoover RNdoi
10.1017/S2040174420000872subject
Has Abstractpub_date
2020-10-28 00:00:00pages
1-8eissn
2040-1744issn
2040-1752pii
S2040174420000872pub_type
杂志文章abstract::Although abundant evidence exists that adverse events during pregnancy lead to chronic conditions, there is limited information on the impact of acute insults such as sepsis. This study tested the hypothesis that impaired fetal development leads to altered organ responses to a septic insult in both male and female adu...
journal_title:Journal of developmental origins of health and disease
pub_type: 杂志文章
doi:10.1017/S2040174420001269
更新日期:2020-12-23 00:00:00
abstract::Overweight/obesity has become a worldwide epidemic, and factors such as a sedentary lifestyle and inadequate eating habits directly contribute to the development of this condition. Studies indicate that rapid weight gain at critical development stages, such as the lactation period, is associated with the development o...
journal_title:Journal of developmental origins of health and disease
pub_type: 杂志文章
doi:10.1017/S2040174419000163
更新日期:2019-12-01 00:00:00
abstract::Associations between different forms of malnutrition and environmental conditions, including water, sanitation and hygiene (WASH), may contribute towards persistently poor child health, growth and cognitive development. Experiencing poor nutrition in utero or during early childhood is furthermore associated with chron...
journal_title:Journal of developmental origins of health and disease
pub_type: 杂志文章
doi:10.1017/S2040174419000898
更新日期:2021-02-01 00:00:00
abstract::Foetal growth restriction impairs skeletal muscle development and adult muscle mitochondrial biogenesis. We hypothesized that key genes involved in muscle development and mitochondrial biogenesis would be altered following uteroplacental insufficiency in rat pups, and improving postnatal nutrition by cross-fostering w...
journal_title:Journal of developmental origins of health and disease
pub_type: 杂志文章
doi:10.1017/S204017441100064X
更新日期:2012-02-01 00:00:00
abstract::Associations between maternal salivary testosterone at 36 weeks' gestation with birth weight and infant weight gain through 6 months of age were examined in a group of 49 healthy, pregnant women and their offspring. The diurnal decline of maternal testosterone was conserved in late pregnancy, and levels showed signifi...
journal_title:Journal of developmental origins of health and disease
pub_type: 杂志文章
doi:10.1017/S2040174413000135
更新日期:2013-08-01 00:00:00
abstract::Rates of obesity are increasing in women of child bearing age with negative impacts on maternal and offspring health. Emerging evidence suggests in utero origins of respiratory health in offspring of obese mothers but mechanisms are unknown. Changes in maternal cortisol levels are one potential factor as cortisol leve...
journal_title:Journal of developmental origins of health and disease
pub_type: 杂志文章
doi:10.1017/S2040174414000312
更新日期:2014-10-01 00:00:00
abstract::The effect of maternal Ramadan-type fasting (RTF) on the outcome of pregnancy, kidney development and nephron number in male rat offspring was investigated in current study. Pregnant rats were given food and water ad libitum during pregnancy (control) or restricted for 16 h per day (RTF). Kidney structure was examined...
journal_title:Journal of developmental origins of health and disease
pub_type: 杂志文章
doi:10.1017/S204017441700109X
更新日期:2018-06-01 00:00:00
abstract::Extremely premature birth is associated with a permanent disruption of energy metabolism. The underlying mechanisms are poorly understood. The oxidative stress induced by parenteral nutrition (PN) during the first week of life is suspected to reprogram energy metabolism in the liver. Full-term male Hartley guinea pigs...
journal_title:Journal of developmental origins of health and disease
pub_type: 杂志文章
doi:10.1017/S2040174420000719
更新日期:2020-08-03 00:00:00
abstract::In this study, diabetes mellitus (DM) was induced in Wistar rats during pregnancy and maintained in the postpartum period (PP) and we evaluated systolic blood pressure (SBP), glomerular filtration rate (GFR) and renal immunohistochemical and morphometric studies from different groups: G1 (non-pregnant control rats), G...
journal_title:Journal of developmental origins of health and disease
pub_type: 杂志文章
doi:10.1017/S2040174417000605
更新日期:2018-02-01 00:00:00
abstract::The hypothesis that vitamin content of the diet during gestation alters macronutrient choice, food intake and the expression of serotonin receptors and proopiomelanocortin (POMC) in the hypothalamus of the offspring was investigated. Pregnant Wistar rats (n = 10/group) were fed the AIN-93G diet containing a multivitam...
journal_title:Journal of developmental origins of health and disease
pub_type: 杂志文章
doi:10.1017/S2040174410000565
更新日期:2010-12-01 00:00:00
abstract::The early embryo and periconceptional period is a window during which environmental factors may cause permanent change in the pattern and characteristics of development leading to risk of adult onset disease. This has now been demonstrated across small and large animal models and also in the human. Most evidence of pe...
journal_title:Journal of developmental origins of health and disease
pub_type: 杂志文章,评审
doi:10.1017/S2040174415001105
更新日期:2015-10-01 00:00:00
abstract::Footprints in Time: The Longitudinal Study of Indigenous Children (LSIC) is a national study of 1759 Australian Aboriginal and Torres Strait Islander children living across urban, regional and remote areas of Australia. The study is in its 11th wave of annual data collection, having collected extensive data on topics ...
journal_title:Journal of developmental origins of health and disease
pub_type: 杂志文章
doi:10.1017/S204017441800017X
更新日期:2019-02-01 00:00:00
abstract::The endocannabinoid system (ECS), modulated by metabolites of linoleic acid (LA), is important in regulating cardiovascular function. In pregnancy, LA is vital for foetal development. We investigated the effects of elevated LA in H9c2 cardiomyoblasts in vitro and of a high linoleic acid (HLA, 6.21%) or low linoleic ac...
journal_title:Journal of developmental origins of health and disease
pub_type: 杂志文章
doi:10.1017/S2040174419000813
更新日期:2020-12-01 00:00:00
abstract::Here we analyze the outcomes of unlimited access to a low-energy (LE) diet in dams and their offspring. At 3 weeks' gestation, pregnant Wistar rats were divided into two groups: (1) the control group received a normoenergetic diet; and (2) the experimental group received the LE diet. In dams, lactation outcomes, food ...
journal_title:Journal of developmental origins of health and disease
pub_type: 杂志文章
doi:10.1017/S2040174413000482
更新日期:2014-02-01 00:00:00
abstract::Depression and anxiety in the antenatal period are of public health concern given potential adverse effects for both mother and infant. Both are under-researched in the first trimester of pregnancy, especially in Africa. We examine the prevalence of first trimester antenatal depression and anxiety in a cohort of South...
journal_title:Journal of developmental origins of health and disease
pub_type: 杂志文章
doi:10.1017/S204017441700071X
更新日期:2018-02-01 00:00:00
abstract::Pregnant individuals who overeat are more likely to predispose their fetus to the development of metabolic disorders in adulthood. Physical training is a prevention and treatment interventional strategy that could treat these disorders, since it improves metabolism and body composition. This study assessed the protect...
journal_title:Journal of developmental origins of health and disease
pub_type: 杂志文章
doi:10.1017/S2040174419000503
更新日期:2020-04-01 00:00:00
abstract::As the resident macrophage of the central nervous system, microglia are thought to contribute to Alzheimer's disease (AD) pathology through lack of neuroprotection. The role of immune dysfunction in AD may be due to disruption of regulatory signals for the activation of microglia that may occur early in development. W...
journal_title:Journal of developmental origins of health and disease
pub_type: 杂志文章
doi:10.1017/S2040174417000277
更新日期:2017-08-01 00:00:00
abstract::Bisphenol-A (BPA) is a widely used endocrine-disrupting chemical. Prenatal exposure to BPA is known to affect birth weight, but its impact on the cardiovascular system has not been studied in detail. In this study, we investigated the effects of prenatal BPA treatment and its interaction with postnatal overfeeding on ...
journal_title:Journal of developmental origins of health and disease
pub_type: 杂志文章
doi:10.1017/S204017441600057X
更新日期:2017-02-01 00:00:00
abstract::Adverse uterine environments caused by maternal stress (such as bacterial endotoxin) can alter programming of the fetal hypothalamic-pituitary-adrenal axis (HPAA) rendering offspring susceptible to various adulthood diseases. Thus, protection against this type of stress may be critical for ensuring offspring health. T...
journal_title:Journal of developmental origins of health and disease
pub_type: 杂志文章
doi:10.1017/S2040174414000191
更新日期:2014-06-01 00:00:00
abstract::Children of parents with major mood and psychotic disorders are at increased risk of psychopathology, including psychotic symptoms. It has been suggested that the risk of psychosis may be more often transmitted from parent to opposite-sex offspring (e.g., from father to daughter) than to same-sex offspring (e.g., from...
journal_title:Journal of developmental origins of health and disease
pub_type: 杂志文章
doi:10.1017/S2040174418000612
更新日期:2019-02-01 00:00:00
abstract::Ilex paraguariensis (yerba mate) has a beneficial effect in the management of obesity. Here, we studied the effects of yerba mate on hypothalamic changes in leptin and insulin signalling, oxidative stress and liver morphology and metabolism in postnatal early overfeeding (EO) Wistar rats. To induce EO, the litter size...
journal_title:Journal of developmental origins of health and disease
pub_type: 杂志文章
doi:10.1017/S2040174416000519
更新日期:2017-02-01 00:00:00
abstract::Iron deficiency is common in pregnant and lactating women and is associated with reduced cognitive development of the offspring. Since iron affects lipid metabolism, the availability of fatty acids, particularly the polyunsaturated fatty acids required for early neural development, was investigated in the offspring of...
journal_title:Journal of developmental origins of health and disease
pub_type: 杂志文章
doi:10.1017/S2040174419000552
更新日期:2020-06-01 00:00:00
abstract::Intrauterine factors important for cognitive development, such as birth weight, chorionicity and umbilical cord characteristics were investigated. A total of 663 twin pairs completed the Wechsler Intelligence Scale for Children-Revised and scores were available for Performance, Verbal and Total Intelligence Quotient (...
journal_title:Journal of developmental origins of health and disease
pub_type: 杂志文章
doi:10.1017/S2040174413000287
更新日期:2013-12-01 00:00:00
abstract::Placental weight is a valuable indicator of its function, predicting both pregnancy outcome and lifelong health. Population-based centile charts of weight-for-gestational-age and parity are useful for identifying extremes of placental weight but fail to consider maternal size. To address this deficit, a multiple regre...
journal_title:Journal of developmental origins of health and disease
pub_type: 杂志文章
doi:10.1017/S2040174419000576
更新日期:2019-10-07 00:00:00
abstract::Approximately 10% of all babies worldwide are born preterm, and preterm birth is the leading cause of perinatal mortality in developed countries. Although preterm birth is associated with adverse short- and long-term health outcomes, it is not yet clear whether this relationship is causal. Rather, there is evidence th...
journal_title:Journal of developmental origins of health and disease
pub_type: 杂志文章
doi:10.1017/S2040174412000736
更新日期:2013-06-01 00:00:00
abstract::Preterm birth affects over 12% of all infants born in the US yet the biology of early delivery remains unclear, including whether epigenetic mechanisms are involved. We examined associations of maternal and umbilical cord blood long interspersed nuclear element-1 (LINE-1) DNA methylation with length of gestation and o...
journal_title:Journal of developmental origins of health and disease
pub_type: 杂志文章
doi:10.1017/s2040174412000104
更新日期:2012-06-01 00:00:00
abstract::Early-life intervention to reduce obesity and poor dental health through early-life nutrition will improve health outcomes in later life. This study examined the prevalence of overweight and obesity and visual dental decay in 4-year old children in New Zealand between 2013 and 2017, and the impact of a nutrition and p...
journal_title:Journal of developmental origins of health and disease
pub_type: 杂志文章
doi:10.1017/S2040174418000788
更新日期:2019-06-01 00:00:00
abstract::The development and life performance of 404 high-producing Holstein dairy cows was studied from birth onwards and during two lactations. The management, environment and parental genetics of the cows were known in detail. Cluster analysis identified four performance 'types': high-yielding (HY) cows and persistently hig...
journal_title:Journal of developmental origins of health and disease
pub_type: 杂志文章
doi:10.1017/S2040174414000361
更新日期:2014-10-01 00:00:00
abstract::Breast milk constitutes one of the most important sources of postnatal microbes. However, the influence of perinatal factors on the milk microbiome is still poorly understood. The aim of our study was to assess the impact of mode of delivery on the microbiome composition and diversity present in breast milk of healthy...
journal_title:Journal of developmental origins of health and disease
pub_type: 杂志文章
doi:10.1017/S2040174415001397
更新日期:2016-02-01 00:00:00
abstract::The principles embodied by the Developmental Origins of Health and Disease (DOHaD) view of 'life history' trajectory are increasingly underpinned by biological data arising from molecular-based epigenomic and transcriptomic studies. Although a number of 'omic' platforms are now routinely and widely used in biology and...
journal_title:Journal of developmental origins of health and disease
pub_type: 杂志文章
doi:10.1017/S2040174414000476
更新日期:2015-02-01 00:00:00