Embryos, DOHaD and David Barker.

abstract：:Maternal protein restriction (MPR) during pregnancy impaired the reproduction of male offspring. We investigated, during the first wave of spermatogenesis, whether MPR exerts deleterious effects on germ cell proliferation and differentiation, as well as androgen receptor (AR) protein expression, which was used as a ma...

journal_title：Journal of developmental origins of health and disease

authors： Rodríguez-González GL,Vigueras-Villaseñor RM,Millán S,Moran N,Trejo R,Nathanielsz PW,Larrea F,Zambrano E

更新日期：2012-10-01 00:00:00

abstract：:The Developmental Origins of Health and Disease (DOHaD) framework aims to understand how environmental exposures in early life shape lifecycle health. Our understanding and the ability to prevent poor health outcomes and enrich for resiliency remain limited, in part, because exposure-outcome relationships are complex ...

journal_title：Journal of developmental origins of health and disease

authors： Abdul-Hussein A,Kareem A,Tewari S,Bergeron J,Briollais L,Challis JRG,Davidge ST,Delrieux C,Fortier I,Goldowitz D,Nepomnaschy P,Wazana A,Connor KL

更新日期：2020-08-04 00:00:00

abstract：:Despite the interest in the relationship of fetal exposures to adult cardiovascular disease, few studies have examined indicators of adult fatty liver disease as an outcome. Previous results are inconsistent, and indicate possible variation by sex. Adult liver enzymes [γ-glutamyl transferase (GGT), alanine transaminas...

journal_title：Journal of developmental origins of health and disease

authors： Harville EW,Chen W,Bazzano L,Oikonen M,Hutri-Kähönen N,Raitakari O

更新日期：2017-04-01 00:00:00

abstract：:Depression and anxiety in the antenatal period are of public health concern given potential adverse effects for both mother and infant. Both are under-researched in the first trimester of pregnancy, especially in Africa. We examine the prevalence of first trimester antenatal depression and anxiety in a cohort of South...

journal_title：Journal of developmental origins of health and disease

authors： Redinger S,Norris SA,Pearson RM,Richter L,Rochat T

更新日期：2018-02-01 00:00:00

abstract：:The developmental origins hypothesis suggests that morbidity and premature mortality arise, in part, from adverse exposures in utero and early in development. Evidence suggests a connection between early nutritional deficits and adult morbidity; however, the effects on mortality have been less well studied and previou...

journal_title：Journal of developmental origins of health and disease

authors： Saxton K,Falconi A,Goldman-Mellor S,Catalano R

更新日期：2013-02-01 00:00:00

abstract：:The objectives of this study were to describe the prevalence of cigarette use and water pipe smoking in Jordanian university students and to analyze differences in determinants between cigarette smokers and non-smokers. A cross-sectional questionnaire was administered to a random sample of 400 students (18-24 years, 5...

journal_title：Journal of developmental origins of health and disease

authors： Farajat M,Hoving C,De Vries H

更新日期：2011-06-01 00:00:00

abstract：:Intrauterine factors important for cognitive development, such as birth weight, chorionicity and umbilical cord characteristics were investigated. A total of 663 twin pairs completed the Wechsler Intelligence Scale for Children-Revised and scores were available for Performance, Verbal and Total Intelligence Quotient (...

journal_title：Journal of developmental origins of health and disease

authors： Antoniou EE,Fowler T,Thiery E,Southwood TR,van Gestel S,Jacobs N,Vlietinck R,van Os J,Rijsdijk FV,Derom C,Zeegers MP

更新日期：2013-12-01 00:00:00

abstract：:Associations between different forms of malnutrition and environmental conditions, including water, sanitation and hygiene (WASH), may contribute towards persistently poor child health, growth and cognitive development. Experiencing poor nutrition in utero or during early childhood is furthermore associated with chron...

journal_title：Journal of developmental origins of health and disease

authors： Momberg DJ,Ngandu BC,Voth-Gaeddert LE,Cardoso Ribeiro K,May J,Norris SA,Said-Mohamed R

更新日期：2021-02-01 00:00:00

abstract：:Low birth weight is associated with increased risk of cardiovascular disease in adulthood. Intrauterine growth restriction (IUGR) hearts have fewer CMs in early postnatal life, which may impair postnatal cardiovascular function and hence, explain increased disease risk, but whether the cardiomyocyte deficit persists t...

journal_title：Journal of developmental origins of health and disease

authors： Vranas S,Heinemann GK,Liu H,De Blasio MJ,Owens JA,Gatford KL,Black MJ

更新日期：2017-10-01 00:00:00

abstract：:Our objective was to investigate associations of body size (birth weight and body mass index (BMI)) and growth in height, body fat (adiposity) and lean mass during childhood and adolescence, with risk markers for diabetes in young South Asian adults. We studied 357 men and women aged 21 years from the Pune Children's ...

journal_title：Journal of developmental origins of health and disease

authors： Kumaran K,Lubree H,Bhat DS,Joshi S,Joglekar C,Yajnik P,Bhave S,Pandit A,Fall CHD,Yajnik CS

更新日期：2020-08-05 00:00:00

abstract：:The aim of this study was to observe the association between maternal undernutrition and metabolic risk indicators in newborns at birth. Fifty-nine expectant mothers between 28 and 40 weeks of gestation were included after obtaining their informed consent. Mothers were divided into undernourished, normally nourished a...

journal_title：Journal of developmental origins of health and disease

authors： Shaikh F,Basit A,Hakeem R,Fawwad A,Hussain A

更新日期：2015-08-01 00:00:00

abstract：:Low birth weight and a rapid weight gain in early childhood may lead to an increased risk for developing cardiovascular disease later in life, such as hypertension and dyslipidaemia. In this study, we examined the associations between size at birth, relative weight gain in infancy and childhood with specific cardiovas...

journal_title：Journal of developmental origins of health and disease

authors： Musa MG,Kagura J,Pisa PT,Norris SA

更新日期：2016-04-01 00:00:00

abstract：:Associations between maternal salivary testosterone at 36 weeks' gestation with birth weight and infant weight gain through 6 months of age were examined in a group of 49 healthy, pregnant women and their offspring. The diurnal decline of maternal testosterone was conserved in late pregnancy, and levels showed signifi...

journal_title：Journal of developmental origins of health and disease

authors： Voegtline KM,Costigan KA,Kivlighan KT,Henderson JL,DiPietro JA

更新日期：2013-08-01 00:00:00

abstract：:In this study, diabetes mellitus (DM) was induced in Wistar rats during pregnancy and maintained in the postpartum period (PP) and we evaluated systolic blood pressure (SBP), glomerular filtration rate (GFR) and renal immunohistochemical and morphometric studies from different groups: G1 (non-pregnant control rats), G...

journal_title：Journal of developmental origins of health and disease

authors： França-Silva N,Reis NG,Santos PF,Balbi APC

更新日期：2018-02-01 00:00:00

abstract：:This study was undertaken to compare amino acid concentrations in maternal and newborn infants' serum in normal pregnancy and two groups of obese women who were born themselves with normal and small for gestational age (SGA) birth weight. Maternal cholesterol, lipoproteins concentrations and maternal and infants amino...

journal_title：Journal of developmental origins of health and disease

authors： Tsyvian PB,Bashmakova NV,Kovtun OP,Makarenko LV,Pestryaeva LA

更新日期：2015-08-01 00:00:00

abstract：:The hypothesis that vitamin content of the diet during gestation alters macronutrient choice, food intake and the expression of serotonin receptors and proopiomelanocortin (POMC) in the hypothalamus of the offspring was investigated. Pregnant Wistar rats (n = 10/group) were fed the AIN-93G diet containing a multivitam...

journal_title：Journal of developmental origins of health and disease

authors： Szeto IM,Payne ME,Jahan-Mihan A,Duan J,Anderson GH

更新日期：2010-12-01 00:00:00

abstract：:Hepatitis B and hepatitis C (HBV/HCV) are important global public health concerns. We aimed to evaluate the association between maternal HBV/HCV carrier status and long-term offspring neurological hospitalisations. A population-based cohort analysis compared the risk for long-term childhood neurological hospitalisatio...

journal_title：Journal of developmental origins of health and disease

authors： Yoles I,Sheiner E,Abu-Freha N,Wainstock T

更新日期：2021-01-21 00:00:00

abstract：:Prenatal glucocorticoids, commonly used in women at risk of preterm delivery, can predispose the newborn to disease in later life. Since male reproductive function is likely to reflect testis development during fetal life, we studied the effects of prenatal glucocorticoids on two key intra-testicular factors that play...

journal_title：Journal of developmental origins of health and disease

authors： Pedrana G,Viotti H,Lombide P,Sanguinetti G,Pino C,Cavestany D,Sloboda DM,Martin GB

更新日期：2016-08-01 00:00:00

abstract：:Approximately 10% of all babies worldwide are born preterm, and preterm birth is the leading cause of perinatal mortality in developed countries. Although preterm birth is associated with adverse short- and long-term health outcomes, it is not yet clear whether this relationship is causal. Rather, there is evidence th...

journal_title：Journal of developmental origins of health and disease

authors： Harding JE,Derraik JG,Berry MJ,Jaquiery AL,Alsweiler JM,Cormack BE,Bloomfield FH

更新日期：2013-06-01 00:00:00

abstract：:Prenatal diethylstilbestrol (DES) exposure is associated with increased risk of hormonally mediated cancers and other medical conditions. We evaluated the association between DES and risk of pancreatic cancer and pancreatic disorders, type 2 diabetes, and gallbladder disease, which may be involved with this malignancy...

journal_title：Journal of developmental origins of health and disease

authors： Troisi R,Hyer M,Titus L,Palmer JR,Hatch EE,Huo D,Aagaard KM,Strohsnitter WC,Hoover RN

更新日期：2020-10-28 00:00:00

abstract：:The consumption of fructose has increased in children and adolescents and is partially responsible for the high incidence of metabolic diseases. The lifestyle during postnatal development can result in altered metabolic programming, thereby impairing the reproductive system and fertility during adulthood. Therefore, t...

journal_title：Journal of developmental origins of health and disease

authors： Medaglia DSA,Vieira HR,Silveira SDS,Siervo GEML,Marcon MSDS,Mathias PCF,Fernandes GSA

更新日期：2021-01-14 00:00:00

abstract：:Overweight/obesity has become a worldwide epidemic, and factors such as a sedentary lifestyle and inadequate eating habits directly contribute to the development of this condition. Studies indicate that rapid weight gain at critical development stages, such as the lactation period, is associated with the development o...

journal_title：Journal of developmental origins of health and disease

authors： Costa VMG,Andreazzi AE,Bolotari M,Lade CG,Guerra MO,Peters VM

更新日期：2019-12-01 00:00:00

abstract：:A life-course approach to reduction of risk of non-communicable diseases (NCD) suggests that early-life interventions may be more effective than lifestyle modifications in middle age. Knowledge translation to develop understanding of the Developmental Origins of Health and Disease (DOHaD) within the community offers t...

journal_title：Journal of developmental origins of health and disease

authors： Bay JL,Mora HA,Sloboda DM,Morton SM,Vickers MH,Gluckman PD

更新日期：2012-12-01 00:00:00

abstract：:Intrauterine growth restriction (IUGR) from uteroplacental dysfunction causes impaired nephrogenesis and ultimately hypertension, but it is unknown whether IUGR caused by insufficient space for placental development seen in uterine anomalies and/or multifetal gestation exerts the same effects. Fetal renal development ...

journal_title：Journal of developmental origins of health and disease

authors： Meyer-Gesch KM,Sun MY,Koch JM,Ramadoss J,Blohowiak SE,Magness RR,Kling PJ

更新日期：2013-10-01 00:00:00

abstract：:Adverse uterine environments caused by maternal stress (such as bacterial endotoxin) can alter programming of the fetal hypothalamic-pituitary-adrenal axis (HPAA) rendering offspring susceptible to various adulthood diseases. Thus, protection against this type of stress may be critical for ensuring offspring health. T...

journal_title：Journal of developmental origins of health and disease

authors： Fisher RE,Or'Rashid M,Quinton M,AlZahal O,Boermans HJ,McBride BW,Karrow NA

更新日期：2014-06-01 00:00:00

abstract：:We sought to examine whether rat maternal food restriction (MFR) affects the expression of steroidogenesis-related genes Cyp19, Cyp17a1, Insl3 and Gdf-9 in the ovaries of offspring from the first (FRG1) and second (FRG2) generations at pre-pubertal age (week 4) and during adulthood (week 8). At week 4, MFR significant...

journal_title：Journal of developmental origins of health and disease

authors： Harrath AH,Alrezaki A,Alwasel SH,Semlali A

更新日期：2019-10-01 00:00:00

abstract：:Extremely premature birth is associated with a permanent disruption of energy metabolism. The underlying mechanisms are poorly understood. The oxidative stress induced by parenteral nutrition (PN) during the first week of life is suspected to reprogram energy metabolism in the liver. Full-term male Hartley guinea pigs...

journal_title：Journal of developmental origins of health and disease

authors： Teixeira V,Guiraut C,Mohamed I,Lavoie JC

更新日期：2020-08-03 00:00:00

abstract：:The risk for many chronic diseases appears to be mediated in part by birth weight. Among Aboriginal Canadians, the prevalence of end-stage renal disease and cardiovascular disease risk is disproportionately high, largely because of elevated diabetes prevalence. The relationships between birth weight (and other potenti...

journal_title：Journal of developmental origins of health and disease

authors： Oster RT,Luyckx VA,Toth EL

更新日期：2013-04-01 00:00:00

abstract：:An estimated 200 million children worldwide fail to meet their development potential due to poverty, poor health and unstimulating environments. Missing developmental milestones has lasting effects on adult human capital. Africa has a large burden of risk factors for poor child development. The objective of this paper...

journal_title：Journal of developmental origins of health and disease

authors： Ford ND,Stein AD

更新日期：2016-04-01 00:00:00

abstract：:The association between lower birth weight and increased disease risk in adulthood has drawn attention to the physiological processes that shape the gestational environment. We implement genome-wide transcriptional profiling of maternal blood samples to identify subsets of genes and associated transcription control pa...

journal_title：Journal of developmental origins of health and disease

authors： McDade TW,Kuzawa CW,Borja J,Arevalo JMG,Miller G,Cole SW

更新日期：2019-12-01 00:00:00