In utero betamethasone affects 3β-hydroxysteroid dehydrogenase and inhibin-α immunoexpression during testis development.

abstract：:Early-life intervention to reduce obesity and poor dental health through early-life nutrition will improve health outcomes in later life. This study examined the prevalence of overweight and obesity and visual dental decay in 4-year old children in New Zealand between 2013 and 2017, and the impact of a nutrition and p...

journal_title：Journal of developmental origins of health and disease

authors： Rush E,Kirk M,Parmar P,Young L,Obolonkin V

更新日期：2019-06-01 00:00:00

abstract：:Prenatal exposure to persistent organic pollutants (POPs) has been associated with the development of metabolic syndrome-related diseases in offspring. According to epidemiological studies, father's transmission of environmental effects in addition to mother's can influence offspring health. Moreover, maternal prenata...

journal_title：Journal of developmental origins of health and disease

authors： Navarro P,Dalvai M,Charest PL,Herst PM,Lessard M,Marcotte B,Mitchell PL,Leblanc N,Kimmins S,Trasler J,MacFarlane AJ,Marette A,Bailey JL,Jacques H

更新日期：2019-09-16 00:00:00

abstract：:An estimated 200 million children worldwide fail to meet their development potential due to poverty, poor health and unstimulating environments. Missing developmental milestones has lasting effects on adult human capital. Africa has a large burden of risk factors for poor child development. The objective of this paper...

journal_title：Journal of developmental origins of health and disease

authors： Ford ND,Stein AD

更新日期：2016-04-01 00:00:00

abstract：:Donor-conceived neonates have poorer birth outcomes, including low birth weight and preterm delivery that are associated with poorer long-term health in adulthood through the developmental origins of health and disease (DOHaD) theory. The aim of this study was to conduct the first investigation of the adult health out...

journal_title：Journal of developmental origins of health and disease

authors： Adams DH,Gerace A,Davies MJ,de Lacey S

更新日期：2020-08-28 00:00:00

abstract：:A developmental approach to public health focuses attention on better nourishing girls and young women, especially those of low socio-economic status, to improve mothers' nutrition and thereby the health of future generations. There have been significant advances in the behavioural sciences that may allow us to unders...

journal_title：Journal of developmental origins of health and disease

authors： Barker M

更新日期：2015-10-01 00:00:00

abstract：:Although abundant evidence exists that adverse events during pregnancy lead to chronic conditions, there is limited information on the impact of acute insults such as sepsis. This study tested the hypothesis that impaired fetal development leads to altered organ responses to a septic insult in both male and female adu...

journal_title：Journal of developmental origins of health and disease

authors： Khazaee R,Vinokurtseva A,McCaig LA,Yamashita C,Hardy DB,Arany E,Veldhuizen RAW

更新日期：2020-12-23 00:00:00

abstract：:Ilex paraguariensis (yerba mate) has a beneficial effect in the management of obesity. Here, we studied the effects of yerba mate on hypothalamic changes in leptin and insulin signalling, oxidative stress and liver morphology and metabolism in postnatal early overfeeding (EO) Wistar rats. To induce EO, the litter size...

journal_title：Journal of developmental origins of health and disease

authors： Conceição EP,Kaezer AR,Peixoto-Silva N,Felzenszwalb I,de Oliveira E,Moura EG,Lisboa PC

更新日期：2017-02-01 00:00:00

abstract：:Bisphenol-A (BPA) is a widely used endocrine-disrupting chemical. Prenatal exposure to BPA is known to affect birth weight, but its impact on the cardiovascular system has not been studied in detail. In this study, we investigated the effects of prenatal BPA treatment and its interaction with postnatal overfeeding on ...

journal_title：Journal of developmental origins of health and disease

authors： MohanKumar SM,Rajendran TD,Vyas AK,Hoang V,Asirvatham-Jeyaraj N,Veiga-Lopez A,Olivier NB,Padmanabhan V,MohanKumar PS

更新日期：2017-02-01 00:00:00

abstract：:Pregnant women, children under 2 and the first thousand days of life have been principal targets for Developmental Origins of Health and Disease interventions. This paradigm has been criticized for laying responsibility for health outcomes on pregnant women and mothers and through the thousand days focus inadvertently...

journal_title：Journal of developmental origins of health and disease

authors： Pentecost M,Ross FC,Macnab A

更新日期：2018-02-01 00:00:00

abstract：:Rates of obesity are increasing in women of child bearing age with negative impacts on maternal and offspring health. Emerging evidence suggests in utero origins of respiratory health in offspring of obese mothers but mechanisms are unknown. Changes in maternal cortisol levels are one potential factor as cortisol leve...

journal_title：Journal of developmental origins of health and disease

authors： de Vries A,Reynolds RM,Seckl JR,van der Wal M,Bonsel GJ,Vrijkotte TG

更新日期：2014-10-01 00:00:00

abstract：:Low birth weight and a rapid weight gain in early childhood may lead to an increased risk for developing cardiovascular disease later in life, such as hypertension and dyslipidaemia. In this study, we examined the associations between size at birth, relative weight gain in infancy and childhood with specific cardiovas...

journal_title：Journal of developmental origins of health and disease

authors： Musa MG,Kagura J,Pisa PT,Norris SA

更新日期：2016-04-01 00:00:00

abstract：:Postnatal and antenatal depression present significant public health concerns. Current opinion on the use of these terms is noted. Previous research findings demonstrate that detrimental effects of untreated maternal depression/anxiety are potentially severe and impact on the whole family; longer-term effects on child...

journal_title：Journal of developmental origins of health and disease

authors： Hall P

更新日期：2012-08-01 00:00:00

abstract：:Rates of weight gain in infancy and early childhood can influence later neurocognitive, metabolic and cardiovascular health. We studied the relationship of weight gain during infancy and early childhood to intelligence quotient (IQ), blood pressure (BP) and body mass index (BMI) at age 9 in children born with very low...

journal_title：Journal of developmental origins of health and disease

authors： Washburn L,Nixon P,Snively B,Tennyson A,O'Shea TM

更新日期：2010-10-01 00:00:00

abstract：:Foetal growth restriction impairs skeletal muscle development and adult muscle mitochondrial biogenesis. We hypothesized that key genes involved in muscle development and mitochondrial biogenesis would be altered following uteroplacental insufficiency in rat pups, and improving postnatal nutrition by cross-fostering w...

journal_title：Journal of developmental origins of health and disease

authors： Laker RC,Wadley GD,McConell GK,Wlodek ME

更新日期：2012-02-01 00:00:00

abstract：:The consumption of fructose has increased in children and adolescents and is partially responsible for the high incidence of metabolic diseases. The lifestyle during postnatal development can result in altered metabolic programming, thereby impairing the reproductive system and fertility during adulthood. Therefore, t...

journal_title：Journal of developmental origins of health and disease

authors： Medaglia DSA,Vieira HR,Silveira SDS,Siervo GEML,Marcon MSDS,Mathias PCF,Fernandes GSA

更新日期：2021-01-14 00:00:00

abstract：:Extremely premature birth is associated with a permanent disruption of energy metabolism. The underlying mechanisms are poorly understood. The oxidative stress induced by parenteral nutrition (PN) during the first week of life is suspected to reprogram energy metabolism in the liver. Full-term male Hartley guinea pigs...

journal_title：Journal of developmental origins of health and disease

authors： Teixeira V,Guiraut C,Mohamed I,Lavoie JC

更新日期：2020-08-03 00:00:00

abstract：:Embryonal rhabdomyosarcoma is one of the major defined histologic variants of rhabdomyosarcoma that is mainly reported in children. The histologic appearance of this neoplastic entity recapitulates normal myogenesis. The tumor cells variably exhibit the different cellular phases of myogenesis ranging from undifferenti...

journal_title：Journal of developmental origins of health and disease

authors： Lav R,Heera R,Cherian LM

更新日期：2015-06-01 00:00:00

abstract：:Pregnant individuals who overeat are more likely to predispose their fetus to the development of metabolic disorders in adulthood. Physical training is a prevention and treatment interventional strategy that could treat these disorders, since it improves metabolism and body composition. This study assessed the protect...

journal_title：Journal of developmental origins of health and disease

authors： Martins Terra M,Schaeffer Fontoura T,Oliveira Nogueira A,Ferraz Lopes J,de Freitas Mathias PC,Andreazzi AE,de Oliveira Guerra M,Maria Peters V

更新日期：2020-04-01 00:00:00

abstract：:Despite the interest in the relationship of fetal exposures to adult cardiovascular disease, few studies have examined indicators of adult fatty liver disease as an outcome. Previous results are inconsistent, and indicate possible variation by sex. Adult liver enzymes [γ-glutamyl transferase (GGT), alanine transaminas...

journal_title：Journal of developmental origins of health and disease

authors： Harville EW,Chen W,Bazzano L,Oikonen M,Hutri-Kähönen N,Raitakari O

更新日期：2017-04-01 00:00:00

abstract：:Although numerous studies have been conducted to examine the causal factors of childhood obesity, the implications of intrauterine oxidative stress on early postnatal adiposity development remain to be elucidated. The Universiti Sains Malaysia Birth Cohort Study aimed to investigate the effects of prenatal oxidative s...

journal_title：Journal of developmental origins of health and disease

authors： Loy SL,Sirajudeen KN,Hamid Jan JM

更新日期：2014-04-01 00:00:00

abstract：:The association between lower birth weight and increased disease risk in adulthood has drawn attention to the physiological processes that shape the gestational environment. We implement genome-wide transcriptional profiling of maternal blood samples to identify subsets of genes and associated transcription control pa...

journal_title：Journal of developmental origins of health and disease

authors： McDade TW,Kuzawa CW,Borja J,Arevalo JMG,Miller G,Cole SW

更新日期：2019-12-01 00:00:00

abstract：:The Developmental Origins of Health and Disease (DOHaD) framework aims to understand how environmental exposures in early life shape lifecycle health. Our understanding and the ability to prevent poor health outcomes and enrich for resiliency remain limited, in part, because exposure-outcome relationships are complex ...

journal_title：Journal of developmental origins of health and disease

authors： Abdul-Hussein A,Kareem A,Tewari S,Bergeron J,Briollais L,Challis JRG,Davidge ST,Delrieux C,Fortier I,Goldowitz D,Nepomnaschy P,Wazana A,Connor KL

更新日期：2020-08-04 00:00:00

abstract：:Iron deficiency is common in pregnant and lactating women and is associated with reduced cognitive development of the offspring. Since iron affects lipid metabolism, the availability of fatty acids, particularly the polyunsaturated fatty acids required for early neural development, was investigated in the offspring of...

journal_title：Journal of developmental origins of health and disease

authors： Rees WD,Hay SM,Hayes HE,Stevens VJ,Gambling L,McArdle HJ

更新日期：2020-06-01 00:00:00

abstract：:Overweight/obesity has become a worldwide epidemic, and factors such as a sedentary lifestyle and inadequate eating habits directly contribute to the development of this condition. Studies indicate that rapid weight gain at critical development stages, such as the lactation period, is associated with the development o...

journal_title：Journal of developmental origins of health and disease

authors： Costa VMG,Andreazzi AE,Bolotari M,Lade CG,Guerra MO,Peters VM

更新日期：2019-12-01 00:00:00

abstract：:The effect of maternal Ramadan-type fasting (RTF) on the outcome of pregnancy, kidney development and nephron number in male rat offspring was investigated in current study. Pregnant rats were given food and water ad libitum during pregnancy (control) or restricted for 16 h per day (RTF). Kidney structure was examined...

journal_title：Journal of developmental origins of health and disease

authors： Mohany M,Ashton N,Harrath AH,Nyengaard JR,Alomar SY,Alwasel S

更新日期：2018-06-01 00:00:00

abstract：:Breast milk constitutes one of the most important sources of postnatal microbes. However, the influence of perinatal factors on the milk microbiome is still poorly understood. The aim of our study was to assess the impact of mode of delivery on the microbiome composition and diversity present in breast milk of healthy...

journal_title：Journal of developmental origins of health and disease

authors： Cabrera-Rubio R,Mira-Pascual L,Mira A,Collado MC

更新日期：2016-02-01 00:00:00

abstract：:Approximately 10% of all babies worldwide are born preterm, and preterm birth is the leading cause of perinatal mortality in developed countries. Although preterm birth is associated with adverse short- and long-term health outcomes, it is not yet clear whether this relationship is causal. Rather, there is evidence th...

journal_title：Journal of developmental origins of health and disease

authors： Harding JE,Derraik JG,Berry MJ,Jaquiery AL,Alsweiler JM,Cormack BE,Bloomfield FH

更新日期：2013-06-01 00:00:00

abstract：:The identification of early-life determinants of overweight is crucial to start early prevention. As weight gain accelerates between 2 and 6 years, we studied the association between diet quality in children aged 3 years and the change in BMI and overweight incidence in the following 7 years. From the Dutch GECKO Dren...

journal_title：Journal of developmental origins of health and disease

authors： Vinke PC,Luitjens MHHS,Blijleven KA,Navis G,Kromhout D,Corpeleijn E

更新日期：2020-12-11 00:00:00

abstract：:The risk for many chronic diseases appears to be mediated in part by birth weight. Among Aboriginal Canadians, the prevalence of end-stage renal disease and cardiovascular disease risk is disproportionately high, largely because of elevated diabetes prevalence. The relationships between birth weight (and other potenti...

journal_title：Journal of developmental origins of health and disease

authors： Oster RT,Luyckx VA,Toth EL

更新日期：2013-04-01 00:00:00

abstract：:Childhood obesity rates are higher among Indigenous compared with non-Indigenous Australian children. It has been hypothesized that early-life influences beginning with the intrauterine environment predict the development of obesity in the offspring. The aim of this paper was to assess, in 227 mother-child dyads from ...

journal_title：Journal of developmental origins of health and disease

authors： Pringle KG,Lee YQ,Weatherall L,Keogh L,Diehm C,Roberts CT,Eades S,Brown A,Smith R,Lumbers ER,Brown LJ,Collins CE,Rae KM

更新日期：2019-02-01 00:00:00