Sex-specific associations of maternal prenatal testosterone levels with birth weight and weight gain in infancy.

abstract：:Iron deficiency is common in pregnant and lactating women and is associated with reduced cognitive development of the offspring. Since iron affects lipid metabolism, the availability of fatty acids, particularly the polyunsaturated fatty acids required for early neural development, was investigated in the offspring of...

journal_title：Journal of developmental origins of health and disease

authors： Rees WD,Hay SM,Hayes HE,Stevens VJ,Gambling L,McArdle HJ

更新日期：2020-06-01 00:00:00

abstract：:We sought to examine whether rat maternal food restriction (MFR) affects the expression of steroidogenesis-related genes Cyp19, Cyp17a1, Insl3 and Gdf-9 in the ovaries of offspring from the first (FRG1) and second (FRG2) generations at pre-pubertal age (week 4) and during adulthood (week 8). At week 4, MFR significant...

journal_title：Journal of developmental origins of health and disease

authors： Harrath AH,Alrezaki A,Alwasel SH,Semlali A

更新日期：2019-10-01 00:00:00

abstract：:Foetal growth restriction impairs skeletal muscle development and adult muscle mitochondrial biogenesis. We hypothesized that key genes involved in muscle development and mitochondrial biogenesis would be altered following uteroplacental insufficiency in rat pups, and improving postnatal nutrition by cross-fostering w...

journal_title：Journal of developmental origins of health and disease

authors： Laker RC,Wadley GD,McConell GK,Wlodek ME

更新日期：2012-02-01 00:00:00

abstract：:The Developmental Origins of Health and Disease (DOHaD) framework aims to understand how environmental exposures in early life shape lifecycle health. Our understanding and the ability to prevent poor health outcomes and enrich for resiliency remain limited, in part, because exposure-outcome relationships are complex ...

journal_title：Journal of developmental origins of health and disease

authors： Abdul-Hussein A,Kareem A,Tewari S,Bergeron J,Briollais L,Challis JRG,Davidge ST,Delrieux C,Fortier I,Goldowitz D,Nepomnaschy P,Wazana A,Connor KL

更新日期：2020-08-04 00:00:00

abstract：:The risk for many chronic diseases appears to be mediated in part by birth weight. Among Aboriginal Canadians, the prevalence of end-stage renal disease and cardiovascular disease risk is disproportionately high, largely because of elevated diabetes prevalence. The relationships between birth weight (and other potenti...

journal_title：Journal of developmental origins of health and disease

authors： Oster RT,Luyckx VA,Toth EL

更新日期：2013-04-01 00:00:00

abstract：:Childhood obesity rates are higher among Indigenous compared with non-Indigenous Australian children. It has been hypothesized that early-life influences beginning with the intrauterine environment predict the development of obesity in the offspring. The aim of this paper was to assess, in 227 mother-child dyads from ...

journal_title：Journal of developmental origins of health and disease

authors： Pringle KG,Lee YQ,Weatherall L,Keogh L,Diehm C,Roberts CT,Eades S,Brown A,Smith R,Lumbers ER,Brown LJ,Collins CE,Rae KM

更新日期：2019-02-01 00:00:00

abstract：:Extremely premature birth is associated with a permanent disruption of energy metabolism. The underlying mechanisms are poorly understood. The oxidative stress induced by parenteral nutrition (PN) during the first week of life is suspected to reprogram energy metabolism in the liver. Full-term male Hartley guinea pigs...

journal_title：Journal of developmental origins of health and disease

authors： Teixeira V,Guiraut C,Mohamed I,Lavoie JC

更新日期：2020-08-03 00:00:00

abstract：:Intrauterine factors important for cognitive development, such as birth weight, chorionicity and umbilical cord characteristics were investigated. A total of 663 twin pairs completed the Wechsler Intelligence Scale for Children-Revised and scores were available for Performance, Verbal and Total Intelligence Quotient (...

journal_title：Journal of developmental origins of health and disease

authors： Antoniou EE,Fowler T,Thiery E,Southwood TR,van Gestel S,Jacobs N,Vlietinck R,van Os J,Rijsdijk FV,Derom C,Zeegers MP

更新日期：2013-12-01 00:00:00

abstract：:Donor-conceived neonates have poorer birth outcomes, including low birth weight and preterm delivery that are associated with poorer long-term health in adulthood through the developmental origins of health and disease (DOHaD) theory. The aim of this study was to conduct the first investigation of the adult health out...

journal_title：Journal of developmental origins of health and disease

authors： Adams DH,Gerace A,Davies MJ,de Lacey S

更新日期：2020-08-28 00:00:00

abstract：:The evidence underpinning the developmental origins of health and disease (DOHaD) is overwhelming. As the emphasis shifts more towards interventions and the translational strategies for disease prevention, it is important to capitalize on collaboration and knowledge sharing to maximize opportunities for discovery and ...

journal_title：Journal of developmental origins of health and disease

authors： Prescott SL,Allen K,Armstrong K,Collins C,Dickinson H,Gardiner K,Jacka F,Jasoni C,Moore T,Moritz KM,Muhlhausler B,Siero W,Sim K,Nanan R,Saffery R,Singh G,Vickers MH,Craig JM

更新日期：2016-10-01 00:00:00

abstract：:The identification of early-life determinants of overweight is crucial to start early prevention. As weight gain accelerates between 2 and 6 years, we studied the association between diet quality in children aged 3 years and the change in BMI and overweight incidence in the following 7 years. From the Dutch GECKO Dren...

journal_title：Journal of developmental origins of health and disease

authors： Vinke PC,Luitjens MHHS,Blijleven KA,Navis G,Kromhout D,Corpeleijn E

更新日期：2020-12-11 00:00:00

abstract：:Rates of obesity are increasing in women of child bearing age with negative impacts on maternal and offspring health. Emerging evidence suggests in utero origins of respiratory health in offspring of obese mothers but mechanisms are unknown. Changes in maternal cortisol levels are one potential factor as cortisol leve...

journal_title：Journal of developmental origins of health and disease

authors： de Vries A,Reynolds RM,Seckl JR,van der Wal M,Bonsel GJ,Vrijkotte TG

更新日期：2014-10-01 00:00:00

abstract：:Preterm birth (delivery <37 weeks of gestation) is associated with impaired glomerular capillary growth in neonates; if this persists, it may be a contributing factor in the increased risk of hypertension and chronic kidney disease in people born preterm. Therefore, in this study, we aimed to determine the long-term i...

journal_title：Journal of developmental origins of health and disease

authors： Sutherland MR,Malik W,Nguyen VB,Tran V,Polglase GR,Black MJ

更新日期：2020-12-10 00:00:00

abstract：:Maternal protein restriction (MPR) during pregnancy impaired the reproduction of male offspring. We investigated, during the first wave of spermatogenesis, whether MPR exerts deleterious effects on germ cell proliferation and differentiation, as well as androgen receptor (AR) protein expression, which was used as a ma...

journal_title：Journal of developmental origins of health and disease

authors： Rodríguez-González GL,Vigueras-Villaseñor RM,Millán S,Moran N,Trejo R,Nathanielsz PW,Larrea F,Zambrano E

更新日期：2012-10-01 00:00:00

abstract：:Placental weight is a valuable indicator of its function, predicting both pregnancy outcome and lifelong health. Population-based centile charts of weight-for-gestational-age and parity are useful for identifying extremes of placental weight but fail to consider maternal size. To address this deficit, a multiple regre...

journal_title：Journal of developmental origins of health and disease

authors： Wallace JM,Agard JP,Horgan GW

更新日期：2019-10-07 00:00:00

abstract：:An appropriate foetal cardiovascular (CV) response to reduced substrate supply (e.g. oxygen or other nutrients) is vital for growth and development, and may impact on CV control. The prevailing nutritional environment and associated CV changes may influence subsequent CV responses to challenges during late gestation, ...

journal_title：Journal of developmental origins of health and disease

authors： Cleal JK,Bagby S,Hanson MA,Gardiner HM,Green LR

更新日期：2010-02-01 00:00:00

abstract：:Low birth weight and a rapid weight gain in early childhood may lead to an increased risk for developing cardiovascular disease later in life, such as hypertension and dyslipidaemia. In this study, we examined the associations between size at birth, relative weight gain in infancy and childhood with specific cardiovas...

journal_title：Journal of developmental origins of health and disease

authors： Musa MG,Kagura J,Pisa PT,Norris SA

更新日期：2016-04-01 00:00:00

abstract：:Breast milk constitutes one of the most important sources of postnatal microbes. However, the influence of perinatal factors on the milk microbiome is still poorly understood. The aim of our study was to assess the impact of mode of delivery on the microbiome composition and diversity present in breast milk of healthy...

journal_title：Journal of developmental origins of health and disease

authors： Cabrera-Rubio R,Mira-Pascual L,Mira A,Collado MC

更新日期：2016-02-01 00:00:00

abstract：:Preterm birth affects over 12% of all infants born in the US yet the biology of early delivery remains unclear, including whether epigenetic mechanisms are involved. We examined associations of maternal and umbilical cord blood long interspersed nuclear element-1 (LINE-1) DNA methylation with length of gestation and o...

journal_title：Journal of developmental origins of health and disease

authors： Burris HH,Rifas-Shiman SL,Baccarelli A,Tarantini L,Boeke CE,Kleinman K,Litonjua AA,Rich-Edwards JW,Gillman MW

更新日期：2012-06-01 00:00:00

abstract：:The consumption of fructose has increased in children and adolescents and is partially responsible for the high incidence of metabolic diseases. The lifestyle during postnatal development can result in altered metabolic programming, thereby impairing the reproductive system and fertility during adulthood. Therefore, t...

journal_title：Journal of developmental origins of health and disease

authors： Medaglia DSA,Vieira HR,Silveira SDS,Siervo GEML,Marcon MSDS,Mathias PCF,Fernandes GSA

更新日期：2021-01-14 00:00:00

abstract：:Early-life intervention to reduce obesity and poor dental health through early-life nutrition will improve health outcomes in later life. This study examined the prevalence of overweight and obesity and visual dental decay in 4-year old children in New Zealand between 2013 and 2017, and the impact of a nutrition and p...

journal_title：Journal of developmental origins of health and disease

authors： Rush E,Kirk M,Parmar P,Young L,Obolonkin V

更新日期：2019-06-01 00:00:00

abstract：:A life-course approach to reduction of risk of non-communicable diseases (NCD) suggests that early-life interventions may be more effective than lifestyle modifications in middle age. Knowledge translation to develop understanding of the Developmental Origins of Health and Disease (DOHaD) within the community offers t...

journal_title：Journal of developmental origins of health and disease

authors： Bay JL,Mora HA,Sloboda DM,Morton SM,Vickers MH,Gluckman PD

更新日期：2012-12-01 00:00:00

abstract：:Androgens may directly modulate early ovarian follicular development in preantral stages and androgen excess before puberty may disrupt this physiological process. Therefore, the aim of this study was to investigate the dynamics of follicular morphology and circulating androgen and estradiol levels in prepubertal Wist...

journal_title：Journal of developmental origins of health and disease

authors： Paixão L,Velez LM,Santos BR,Tusset C,Lecke SB,Motta AB,Spritzer PM

更新日期：2016-08-01 00:00:00

abstract：:Maternal undernutrition is known to adversely impact fetal health and development. Insults experienced in utero alter development of the fetus as it adapts to microenvironment stressors, leading to growth restriction and subsequent low birth weight. Infants born small for gestational age have significantly increased r...

journal_title：Journal of developmental origins of health and disease

authors： Schlegel RN,Moritz KM,Paravicini TM

更新日期：2016-10-01 00:00:00

abstract：:Renin is essential for renal development and in adult kidneys vitamin D deficiency increases renin gene expression. We aimed to determine whether maternal vitamin D deficiency upregulates fetal renal renin expression, and if this is sustained. We also examined growth and the long-term renal effects in offspring on a n...

journal_title：Journal of developmental origins of health and disease

authors： Boyce AC,Palmer-Aronsten BJ,Kim MY,Gibson KJ

更新日期：2013-10-01 00:00:00

abstract：:The aim of this study was to observe the association between maternal undernutrition and metabolic risk indicators in newborns at birth. Fifty-nine expectant mothers between 28 and 40 weeks of gestation were included after obtaining their informed consent. Mothers were divided into undernourished, normally nourished a...

journal_title：Journal of developmental origins of health and disease

authors： Shaikh F,Basit A,Hakeem R,Fawwad A,Hussain A

更新日期：2015-08-01 00:00:00

abstract：:Hypertension (HTN) remains a common complication after kidney transplantation among paediatric patients. Although low birth weight (LBW) has been implicated as an important risk factor for cardiovascular diseases, its effect on transplantation patients has not yet been addressed. It is essential to determine whether c...

journal_title：Journal of developmental origins of health and disease

authors： Santos LB,Borges LM,Souza LV,Felipe CR,Medina-Pestana JO,Franco MDC

更新日期：2020-02-01 00:00:00

abstract：:The developmental origins hypothesis suggests that morbidity and premature mortality arise, in part, from adverse exposures in utero and early in development. Evidence suggests a connection between early nutritional deficits and adult morbidity; however, the effects on mortality have been less well studied and previou...

journal_title：Journal of developmental origins of health and disease

authors： Saxton K,Falconi A,Goldman-Mellor S,Catalano R

更新日期：2013-02-01 00:00:00

abstract：:Overweight/obesity has become a worldwide epidemic, and factors such as a sedentary lifestyle and inadequate eating habits directly contribute to the development of this condition. Studies indicate that rapid weight gain at critical development stages, such as the lactation period, is associated with the development o...

journal_title：Journal of developmental origins of health and disease

authors： Costa VMG,Andreazzi AE,Bolotari M,Lade CG,Guerra MO,Peters VM

更新日期：2019-12-01 00:00:00

abstract：:Antenatal exposure of the fetus to inflammation may alter postnatal organ development. In our previous work, we demonstrated that the fetal liver is involved in the systemic inflammation associated with chorioamnionitis, leading to metabolic changes. On the basis of these findings, we hypothesized that chorioamnioniti...

journal_title：Journal of developmental origins of health and disease

authors： Vlassaks E,Gavilanes AW,Bieghs V,Reinartz A,Gassler N,Van Gorp PJ,Gijbels MJ,Bekers O,Zimmermann LJ,Pillow JJ,Polglase GR,Nitsos I,Newnham JP,Kallapur SG,Jobe AH,Shiri-Sverdlov R,Kramer BW

更新日期：2012-04-01 00:00:00