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Is low birth weight an additional risk factor for hypertension in paediatric patients after kidney transplantation?

Abstract：

:Hypertension (HTN) remains a common complication after kidney transplantation among paediatric patients. Although low birth weight (LBW) has been implicated as an important risk factor for cardiovascular diseases, its effect on transplantation patients has not yet been addressed. It is essential to determine whether children with LBW who undergo transplantation are more likely to develop post-transplantation HTN. For this study, the medical records of 96 kidney recipients were retrospectively examined. A total of 83 patients fulfilled the inclusion criteria. Overall, post-transplantation HTN was observed in 54% of the recipients. Multivariate logistic regression revealed that time from transplantation >14 months (odds ratio (OR) 3.6; 95% confidence interval (CI) 1.31-10.06; P = 0.013), current CKD (OR 2.6; 95% CI 1.01-7.20; P = 0.045), presence of LBW (OR 3.6; 95% CI 1.04-12.32; P = 0.044) and current overweight/obesity (OR 3.7; 95% CI 1.02-13.91; P = 0.047) were associated with post-transplantation HTN. In conclusion, our data provide evidence for the first time that LBW is a significant predictive factor in the development of post-transplantation HTN. This finding has important clinical implications as it serves to alert clinicians about this additional risk factor in paediatric patients undergoing kidney transplant.

journal_name

J Dev Orig Health Dis

journal_title

Journal of developmental origins of health and disease

authors

Santos LB,Borges LM,Souza LV,Felipe CR,Medina-Pestana JO,Franco MDC

doi

10.1017/S2040174419000448

subject

Has Abstract

pub_date

2020-02-01 00:00:00

pages

3-6

issue

1

eissn

2040-1744

issn

2040-1752

pii

S2040174419000448

journal_volume

11

pub_type

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