Poor perinatal growth impairs baboon aortic windkessel function.

Abstract:

:The ability of the aorta to buffer blood flow and provide diastolic perfusion (Windkessel function) is a determinant of cardiovascular health. We have reported cardiac dysfunction indicating downstream vascular abnormalities in young adult baboons who were intrauterine growth restricted (IUGR) at birth as a result of moderate maternal nutrient reduction. Using 3 T MRI, we examined IUGR offspring (eight male, eight female; 5.7 years; human equivalent 25 years) and age-matched controls (eight male, eight female; 5.6 years) to quantify distal descending aortic cross-section (AC) and distensibility (AD). ANOVA showed decreased IUGR AC/body surface area (0.9±0.05 cm2/m2 v. 1.2±0.06 cm2/m2, M±s.e.m., P<0.005) and AD (1.7±0.2 v. 4.0±0.5×10-3/mmHg, P<0.005) without sex difference or group-sex interaction, suggesting intrinsic vascular pathology and impaired development persisting in adulthood. Future studies should evaluate potential consequences of these changes on coronary perfusion, afterload and blood pressure.

journal_name

J Dev Orig Health Dis

authors

Kuo AH,Li J,Li C,Huber HF,Nathanielsz PW,Clarke GD

doi

10.1017/S2040174417000770

subject

Has Abstract

pub_date

2018-04-01 00:00:00

pages

137-142

issue

2

eissn

2040-1744

issn

2040-1752

pii

S2040174417000770

journal_volume

9

pub_type

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