Beyond the dyad: making Developmental Origins of Health and Disease (DOHaD) interventions more inclusive.

abstract：:Ilex paraguariensis (yerba mate) has a beneficial effect in the management of obesity. Here, we studied the effects of yerba mate on hypothalamic changes in leptin and insulin signalling, oxidative stress and liver morphology and metabolism in postnatal early overfeeding (EO) Wistar rats. To induce EO, the litter size...

journal_title：Journal of developmental origins of health and disease

authors： Conceição EP,Kaezer AR,Peixoto-Silva N,Felzenszwalb I,de Oliveira E,Moura EG,Lisboa PC

更新日期：2017-02-01 00:00:00

abstract：:Donor-conceived neonates have poorer birth outcomes, including low birth weight and preterm delivery that are associated with poorer long-term health in adulthood through the developmental origins of health and disease (DOHaD) theory. The aim of this study was to conduct the first investigation of the adult health out...

journal_title：Journal of developmental origins of health and disease

authors： Adams DH,Gerace A,Davies MJ,de Lacey S

更新日期：2020-08-28 00:00:00

abstract：:We sought to examine whether rat maternal food restriction (MFR) affects the expression of steroidogenesis-related genes Cyp19, Cyp17a1, Insl3 and Gdf-9 in the ovaries of offspring from the first (FRG1) and second (FRG2) generations at pre-pubertal age (week 4) and during adulthood (week 8). At week 4, MFR significant...

journal_title：Journal of developmental origins of health and disease

authors： Harrath AH,Alrezaki A,Alwasel SH,Semlali A

更新日期：2019-10-01 00:00:00

abstract：:Maternal protein restriction (MPR) during pregnancy impaired the reproduction of male offspring. We investigated, during the first wave of spermatogenesis, whether MPR exerts deleterious effects on germ cell proliferation and differentiation, as well as androgen receptor (AR) protein expression, which was used as a ma...

journal_title：Journal of developmental origins of health and disease

authors： Rodríguez-González GL,Vigueras-Villaseñor RM,Millán S,Moran N,Trejo R,Nathanielsz PW,Larrea F,Zambrano E

更新日期：2012-10-01 00:00:00

abstract：:Prenatal diethylstilbestrol (DES) exposure is associated with increased risk of hormonally mediated cancers and other medical conditions. We evaluated the association between DES and risk of pancreatic cancer and pancreatic disorders, type 2 diabetes, and gallbladder disease, which may be involved with this malignancy...

journal_title：Journal of developmental origins of health and disease

authors： Troisi R,Hyer M,Titus L,Palmer JR,Hatch EE,Huo D,Aagaard KM,Strohsnitter WC,Hoover RN

更新日期：2020-10-28 00:00:00

abstract：:The effect of maternal Ramadan-type fasting (RTF) on the outcome of pregnancy, kidney development and nephron number in male rat offspring was investigated in current study. Pregnant rats were given food and water ad libitum during pregnancy (control) or restricted for 16 h per day (RTF). Kidney structure was examined...

journal_title：Journal of developmental origins of health and disease

authors： Mohany M,Ashton N,Harrath AH,Nyengaard JR,Alomar SY,Alwasel S

更新日期：2018-06-01 00:00:00

abstract：:Embryonal rhabdomyosarcoma is one of the major defined histologic variants of rhabdomyosarcoma that is mainly reported in children. The histologic appearance of this neoplastic entity recapitulates normal myogenesis. The tumor cells variably exhibit the different cellular phases of myogenesis ranging from undifferenti...

journal_title：Journal of developmental origins of health and disease

authors： Lav R,Heera R,Cherian LM

更新日期：2015-06-01 00:00:00

abstract：:Approximately 10% of all babies worldwide are born preterm, and preterm birth is the leading cause of perinatal mortality in developed countries. Although preterm birth is associated with adverse short- and long-term health outcomes, it is not yet clear whether this relationship is causal. Rather, there is evidence th...

journal_title：Journal of developmental origins of health and disease

authors： Harding JE,Derraik JG,Berry MJ,Jaquiery AL,Alsweiler JM,Cormack BE,Bloomfield FH

更新日期：2013-06-01 00:00:00

abstract：:Preterm birth affects over 12% of all infants born in the US yet the biology of early delivery remains unclear, including whether epigenetic mechanisms are involved. We examined associations of maternal and umbilical cord blood long interspersed nuclear element-1 (LINE-1) DNA methylation with length of gestation and o...

journal_title：Journal of developmental origins of health and disease

authors： Burris HH,Rifas-Shiman SL,Baccarelli A,Tarantini L,Boeke CE,Kleinman K,Litonjua AA,Rich-Edwards JW,Gillman MW

更新日期：2012-06-01 00:00:00

abstract：:The risk for many chronic diseases appears to be mediated in part by birth weight. Among Aboriginal Canadians, the prevalence of end-stage renal disease and cardiovascular disease risk is disproportionately high, largely because of elevated diabetes prevalence. The relationships between birth weight (and other potenti...

journal_title：Journal of developmental origins of health and disease

authors： Oster RT,Luyckx VA,Toth EL

更新日期：2013-04-01 00:00:00

abstract：:The consumption of fructose has increased in children and adolescents and is partially responsible for the high incidence of metabolic diseases. The lifestyle during postnatal development can result in altered metabolic programming, thereby impairing the reproductive system and fertility during adulthood. Therefore, t...

journal_title：Journal of developmental origins of health and disease

authors： Medaglia DSA,Vieira HR,Silveira SDS,Siervo GEML,Marcon MSDS,Mathias PCF,Fernandes GSA

更新日期：2021-01-14 00:00:00

abstract：:The identification of early-life determinants of overweight is crucial to start early prevention. As weight gain accelerates between 2 and 6 years, we studied the association between diet quality in children aged 3 years and the change in BMI and overweight incidence in the following 7 years. From the Dutch GECKO Dren...

journal_title：Journal of developmental origins of health and disease

authors： Vinke PC,Luitjens MHHS,Blijleven KA,Navis G,Kromhout D,Corpeleijn E

更新日期：2020-12-11 00:00:00

abstract：:Hypertension (HTN) remains a common complication after kidney transplantation among paediatric patients. Although low birth weight (LBW) has been implicated as an important risk factor for cardiovascular diseases, its effect on transplantation patients has not yet been addressed. It is essential to determine whether c...

journal_title：Journal of developmental origins of health and disease

authors： Santos LB,Borges LM,Souza LV,Felipe CR,Medina-Pestana JO,Franco MDC

更新日期：2020-02-01 00:00:00

abstract：:Adverse uterine environments caused by maternal stress (such as bacterial endotoxin) can alter programming of the fetal hypothalamic-pituitary-adrenal axis (HPAA) rendering offspring susceptible to various adulthood diseases. Thus, protection against this type of stress may be critical for ensuring offspring health. T...

journal_title：Journal of developmental origins of health and disease

authors： Fisher RE,Or'Rashid M,Quinton M,AlZahal O,Boermans HJ,McBride BW,Karrow NA

更新日期：2014-06-01 00:00:00

abstract：:Overweight/obesity has become a worldwide epidemic, and factors such as a sedentary lifestyle and inadequate eating habits directly contribute to the development of this condition. Studies indicate that rapid weight gain at critical development stages, such as the lactation period, is associated with the development o...

journal_title：Journal of developmental origins of health and disease

authors： Costa VMG,Andreazzi AE,Bolotari M,Lade CG,Guerra MO,Peters VM

更新日期：2019-12-01 00:00:00

abstract：:Although numerous studies have been conducted to examine the causal factors of childhood obesity, the implications of intrauterine oxidative stress on early postnatal adiposity development remain to be elucidated. The Universiti Sains Malaysia Birth Cohort Study aimed to investigate the effects of prenatal oxidative s...

journal_title：Journal of developmental origins of health and disease

authors： Loy SL,Sirajudeen KN,Hamid Jan JM

更新日期：2014-04-01 00:00:00

abstract：:Tobacco smoke has both carcinogenic effects and anti-estrogenic properties and its inconsistent association with breast cancer risk in observational studies may be because of these competing effects across the lifecourse. We conducted a prospective study of prenatal smoke exposure, childhood household smoke exposure, ...

journal_title：Journal of developmental origins of health and disease

authors： Terry MB,Schaefer CA,Flom JD,Wei Y,Tehranifar P,Liao Y,Buka S,Michels KB

更新日期：2011-12-01 00:00:00

abstract：:Obesity and its complications occur at alarming rates worldwide. Epidemiological data have associated perinatal conditions, such as malnutrition, with the development of some disorders, such as obesity, dyslipidemia, diabetes, and cardiovascular diseases, in childhood and adulthood. Exclusive breastfeeding has been as...

journal_title：Journal of developmental origins of health and disease

authors： Souza LL,de Moura EG,Lisboa PC

更新日期：2020-10-01 00:00:00

abstract：:This study was undertaken to compare amino acid concentrations in maternal and newborn infants' serum in normal pregnancy and two groups of obese women who were born themselves with normal and small for gestational age (SGA) birth weight. Maternal cholesterol, lipoproteins concentrations and maternal and infants amino...

journal_title：Journal of developmental origins of health and disease

authors： Tsyvian PB,Bashmakova NV,Kovtun OP,Makarenko LV,Pestryaeva LA

更新日期：2015-08-01 00:00:00

abstract：:Intrauterine growth restriction (IUGR) from uteroplacental dysfunction causes impaired nephrogenesis and ultimately hypertension, but it is unknown whether IUGR caused by insufficient space for placental development seen in uterine anomalies and/or multifetal gestation exerts the same effects. Fetal renal development ...

journal_title：Journal of developmental origins of health and disease

authors： Meyer-Gesch KM,Sun MY,Koch JM,Ramadoss J,Blohowiak SE,Magness RR,Kling PJ

更新日期：2013-10-01 00:00:00

abstract：:Associations between different forms of malnutrition and environmental conditions, including water, sanitation and hygiene (WASH), may contribute towards persistently poor child health, growth and cognitive development. Experiencing poor nutrition in utero or during early childhood is furthermore associated with chron...

journal_title：Journal of developmental origins of health and disease

authors： Momberg DJ,Ngandu BC,Voth-Gaeddert LE,Cardoso Ribeiro K,May J,Norris SA,Said-Mohamed R

更新日期：2021-02-01 00:00:00

abstract：:The development and life performance of 404 high-producing Holstein dairy cows was studied from birth onwards and during two lactations. The management, environment and parental genetics of the cows were known in detail. Cluster analysis identified four performance 'types': high-yielding (HY) cows and persistently hig...

journal_title：Journal of developmental origins of health and disease

authors： Astiz S,Gonzalez-Bulnes A,Sebastian F,Fargas O,Cano I,Cuesta P

更新日期：2014-10-01 00:00:00

abstract：:The early embryo and periconceptional period is a window during which environmental factors may cause permanent change in the pattern and characteristics of development leading to risk of adult onset disease. This has now been demonstrated across small and large animal models and also in the human. Most evidence of pe...

journal_title：Journal of developmental origins of health and disease

authors： Fleming TP,Velazquez MA,Eckert JJ

更新日期：2015-10-01 00:00:00

abstract：:A developmental approach to public health focuses attention on better nourishing girls and young women, especially those of low socio-economic status, to improve mothers' nutrition and thereby the health of future generations. There have been significant advances in the behavioural sciences that may allow us to unders...

journal_title：Journal of developmental origins of health and disease

authors： Barker M

更新日期：2015-10-01 00:00:00

abstract：:Intrauterine factors important for cognitive development, such as birth weight, chorionicity and umbilical cord characteristics were investigated. A total of 663 twin pairs completed the Wechsler Intelligence Scale for Children-Revised and scores were available for Performance, Verbal and Total Intelligence Quotient (...

journal_title：Journal of developmental origins of health and disease

authors： Antoniou EE,Fowler T,Thiery E,Southwood TR,van Gestel S,Jacobs N,Vlietinck R,van Os J,Rijsdijk FV,Derom C,Zeegers MP

更新日期：2013-12-01 00:00:00

abstract：:Postnatal and antenatal depression present significant public health concerns. Current opinion on the use of these terms is noted. Previous research findings demonstrate that detrimental effects of untreated maternal depression/anxiety are potentially severe and impact on the whole family; longer-term effects on child...

journal_title：Journal of developmental origins of health and disease

authors： Hall P

更新日期：2012-08-01 00:00:00

abstract：:The ability of the aorta to buffer blood flow and provide diastolic perfusion (Windkessel function) is a determinant of cardiovascular health. We have reported cardiac dysfunction indicating downstream vascular abnormalities in young adult baboons who were intrauterine growth restricted (IUGR) at birth as a result of ...

journal_title：Journal of developmental origins of health and disease

authors： Kuo AH,Li J,Li C,Huber HF,Nathanielsz PW,Clarke GD

更新日期：2018-04-01 00:00:00

abstract：:Despite the interest in the relationship of fetal exposures to adult cardiovascular disease, few studies have examined indicators of adult fatty liver disease as an outcome. Previous results are inconsistent, and indicate possible variation by sex. Adult liver enzymes [γ-glutamyl transferase (GGT), alanine transaminas...

journal_title：Journal of developmental origins of health and disease

authors： Harville EW,Chen W,Bazzano L,Oikonen M,Hutri-Kähönen N,Raitakari O

更新日期：2017-04-01 00:00:00

abstract：:An adverse early life environment can increase the risk of metabolic and other disorders later in life. Genetic variation can modify an individual's susceptibility to these environmental challenges. These gene by environment interactions are important, but difficult, to dissect. The nucleus is the primary organelle wh...

journal_title：Journal of developmental origins of health and disease

authors： Jacobson E,Vickers MH,Perry JK,O'Sullivan JM

更新日期：2018-06-01 00:00:00

abstract：:The evolution of birth weight (BW), birth length (BL), and gestational age at delivery (GAD) and their correlation with various maternal sociodemographic variables were studied in Chilean newborns from years 1996 to 2017. A slight decrease in the mean values of these perinatal outcomes was observed; however, their ris...

journal_title：Journal of developmental origins of health and disease

authors： Mardones F,Acuña J

更新日期：2020-12-04 00:00:00