Abstract：
:The hypothesis was that maternal intake of the antioxidant alpha-lipoid acid (ALA), during the developmental period of the hypothalamic orexigenic neurons, causes a permanent beneficial effect in offspring metabolism. Pregnant Wistar rats were fed with standard diet (food) + ALA (0.4% wt/wt) from day 14 of gestation to day 20 of lactation (n = 4) or food (n = 4). At 3 months of age, male offspring born from ALA-fed rats or controls (CT) were randomly assigned to be fed with food + 10% fructose solution in drinking water (F) or food + tap water (C), resulting in four groups: ALAF, ALAC, CTF, and CTC (n = 5/group). Food intake and body weight (BW) were measured twice a week for 31 days. Metabolites' levels in blood, mRNA expressions of Npy, Agrp (hypothalamus), Fasn, Srebf1, Ppard, and Pparg (liver), and the antioxidant capacity of the liver were determined. Results significance was set at p < 0.05. Average BW gain, daily BW gain, and intraabdominal fat tissue at necropsy were higher in CTF group followed by CTC, ALAF, and ALAC groups. There were no differences between groups in Kcal intake per day. mRNA expressions of hypothalamic and hepatic genes and plasmatic levels of glucose and triglycerides were higher in CTF group followed by ALAF, CTC, and ALAC groups. Fructose intake affected the oxidative capacity of the liver, but this effect was not observed in the ALAF group. In conclusion, maternal ALA intake protected the adult offspring to develop metabolic symptoms associated with high fructose in the drinking water.
journal_name
J Dev Orig Health Disjournal_title
Journal of developmental origins of health and diseaseauthors
Rabaglino MB,Moreira-Espinoza MJ,Lagares C,Garay MI,Quiroga P,Pasqualini ME,Francini F,Beltramo Ddoi
10.1017/S2040174420001178subject
Has Abstractpub_date
2020-12-11 00:00:00pages
1-10eissn
2040-1744issn
2040-1752pii
S2040174420001178pub_type
杂志文章abstract：:The development and life performance of 404 high-producing Holstein dairy cows was studied from birth onwards and during two lactations. The management, environment and parental genetics of the cows were known in detail. Cluster analysis identified four performance 'types': high-yielding (HY) cows and persistently hig...
journal_title：Journal of developmental origins of health and disease
pub_type： 杂志文章
doi：10.1017/S2040174414000361
更新日期：2014-10-01 00:00:00
abstract：:Obesity and its complications occur at alarming rates worldwide. Epidemiological data have associated perinatal conditions, such as malnutrition, with the development of some disorders, such as obesity, dyslipidemia, diabetes, and cardiovascular diseases, in childhood and adulthood. Exclusive breastfeeding has been as...
journal_title：Journal of developmental origins of health and disease
pub_type： 杂志文章
doi：10.1017/S2040174420000410
更新日期：2020-10-01 00:00:00
abstract：:Associations between maternal salivary testosterone at 36 weeks' gestation with birth weight and infant weight gain through 6 months of age were examined in a group of 49 healthy, pregnant women and their offspring. The diurnal decline of maternal testosterone was conserved in late pregnancy, and levels showed signifi...
journal_title：Journal of developmental origins of health and disease
pub_type： 杂志文章
doi：10.1017/S2040174413000135
更新日期：2013-08-01 00:00:00
abstract：:Renin is essential for renal development and in adult kidneys vitamin D deficiency increases renin gene expression. We aimed to determine whether maternal vitamin D deficiency upregulates fetal renal renin expression, and if this is sustained. We also examined growth and the long-term renal effects in offspring on a n...
journal_title：Journal of developmental origins of health and disease
pub_type： 杂志文章
doi：10.1017/S2040174413000342
更新日期：2013-10-01 00:00:00
abstract：:As the resident macrophage of the central nervous system, microglia are thought to contribute to Alzheimer's disease (AD) pathology through lack of neuroprotection. The role of immune dysfunction in AD may be due to disruption of regulatory signals for the activation of microglia that may occur early in development. W...
journal_title：Journal of developmental origins of health and disease
pub_type： 杂志文章
doi：10.1017/S2040174417000277
更新日期：2017-08-01 00:00:00
abstract：:Intrauterine factors important for cognitive development, such as birth weight, chorionicity and umbilical cord characteristics were investigated. A total of 663 twin pairs completed the Wechsler Intelligence Scale for Children-Revised and scores were available for Performance, Verbal and Total Intelligence Quotient (...
journal_title：Journal of developmental origins of health and disease
pub_type： 杂志文章
doi：10.1017/S2040174413000287
更新日期：2013-12-01 00:00:00
abstract：:Adipose tissue (AT) dysfunction links obesity of any cause with cardiometabolic disease, but whether early-life nutritional deficiency can program adipocyte dysfunction independently of obesity is untested. In 3-5-month-old juvenile microswine offspring exposed to isocaloric perinatal maternal protein restriction (MPR...
journal_title：Journal of developmental origins of health and disease
pub_type： 杂志文章
doi：10.1017/S2040174412000232
更新日期：2012-06-01 00:00:00
abstract：:This study was undertaken to compare amino acid concentrations in maternal and newborn infants' serum in normal pregnancy and two groups of obese women who were born themselves with normal and small for gestational age (SGA) birth weight. Maternal cholesterol, lipoproteins concentrations and maternal and infants amino...
journal_title：Journal of developmental origins of health and disease
pub_type： 杂志文章
doi：10.1017/S2040174415001117
更新日期：2015-08-01 00:00:00
abstract：:Prenatal diethylstilbestrol (DES) exposure is associated with increased risk of hormonally mediated cancers and other medical conditions. We evaluated the association between DES and risk of pancreatic cancer and pancreatic disorders, type 2 diabetes, and gallbladder disease, which may be involved with this malignancy...
journal_title：Journal of developmental origins of health and disease
pub_type： 杂志文章
doi：10.1017/S2040174420000872
更新日期：2020-10-28 00:00:00
abstract：:Preterm birth affects over 12% of all infants born in the US yet the biology of early delivery remains unclear, including whether epigenetic mechanisms are involved. We examined associations of maternal and umbilical cord blood long interspersed nuclear element-1 (LINE-1) DNA methylation with length of gestation and o...
journal_title：Journal of developmental origins of health and disease
pub_type： 杂志文章
doi：10.1017/s2040174412000104
更新日期：2012-06-01 00:00:00
abstract：:The risk for many chronic diseases appears to be mediated in part by birth weight. Among Aboriginal Canadians, the prevalence of end-stage renal disease and cardiovascular disease risk is disproportionately high, largely because of elevated diabetes prevalence. The relationships between birth weight (and other potenti...
journal_title：Journal of developmental origins of health and disease
pub_type： 杂志文章
doi：10.1017/S2040174412000724
更新日期：2013-04-01 00:00:00
abstract：:Adverse uterine environments caused by maternal stress (such as bacterial endotoxin) can alter programming of the fetal hypothalamic-pituitary-adrenal axis (HPAA) rendering offspring susceptible to various adulthood diseases. Thus, protection against this type of stress may be critical for ensuring offspring health. T...
journal_title：Journal of developmental origins of health and disease
pub_type： 杂志文章
doi：10.1017/S2040174414000191
更新日期：2014-06-01 00:00:00
abstract：:Rates of weight gain in infancy and early childhood can influence later neurocognitive, metabolic and cardiovascular health. We studied the relationship of weight gain during infancy and early childhood to intelligence quotient (IQ), blood pressure (BP) and body mass index (BMI) at age 9 in children born with very low...
journal_title：Journal of developmental origins of health and disease
pub_type： 杂志文章
doi：10.1017/S2040174410000401
更新日期：2010-10-01 00:00:00
abstract：:With brown adipose tissue (BAT) becoming a possible therapeutic target to counteract obesity, the prenatal environment could represent a critical window to modify BAT function and browning of white AT. We investigated if levels of uncoupling protein 1 (UCP1) and UCP1-mediated thermogenesis are altered in offspring exp...
journal_title：Journal of developmental origins of health and disease
pub_type： 杂志文章
doi：10.1017/S2040174418000107
更新日期：2018-08-01 00:00:00
abstract：:Our objective was to investigate associations of body size (birth weight and body mass index (BMI)) and growth in height, body fat (adiposity) and lean mass during childhood and adolescence, with risk markers for diabetes in young South Asian adults. We studied 357 men and women aged 21 years from the Pune Children's ...
journal_title：Journal of developmental origins of health and disease
pub_type： 杂志文章
doi：10.1017/S2040174420000707
更新日期：2020-08-05 00:00:00
abstract：:The association between lower birth weight and increased disease risk in adulthood has drawn attention to the physiological processes that shape the gestational environment. We implement genome-wide transcriptional profiling of maternal blood samples to identify subsets of genes and associated transcription control pa...
journal_title：Journal of developmental origins of health and disease
pub_type： 杂志文章
doi：10.1017/S2040174419000175
更新日期：2019-12-01 00:00:00
abstract：:An estimated 200 million children worldwide fail to meet their development potential due to poverty, poor health and unstimulating environments. Missing developmental milestones has lasting effects on adult human capital. Africa has a large burden of risk factors for poor child development. The objective of this paper...
journal_title：Journal of developmental origins of health and disease
pub_type： 杂志文章
doi：10.1017/S2040174415001427
更新日期：2016-04-01 00:00:00
abstract：:Prenatal exposure to persistent organic pollutants (POPs) has been associated with the development of metabolic syndrome-related diseases in offspring. According to epidemiological studies, father's transmission of environmental effects in addition to mother's can influence offspring health. Moreover, maternal prenata...
journal_title：Journal of developmental origins of health and disease
pub_type： 杂志文章
doi：10.1017/S2040174419000497
更新日期：2019-09-16 00:00:00
abstract：:Overweight/obesity has become a worldwide epidemic, and factors such as a sedentary lifestyle and inadequate eating habits directly contribute to the development of this condition. Studies indicate that rapid weight gain at critical development stages, such as the lactation period, is associated with the development o...
journal_title：Journal of developmental origins of health and disease
pub_type： 杂志文章
doi：10.1017/S2040174419000163
更新日期：2019-12-01 00:00:00
abstract：:An appropriate foetal cardiovascular (CV) response to reduced substrate supply (e.g. oxygen or other nutrients) is vital for growth and development, and may impact on CV control. The prevailing nutritional environment and associated CV changes may influence subsequent CV responses to challenges during late gestation, ...
journal_title：Journal of developmental origins of health and disease
pub_type： 杂志文章
doi：10.1017/S204017440999016X
更新日期：2010-02-01 00:00:00
abstract：:Extremely premature birth is associated with a permanent disruption of energy metabolism. The underlying mechanisms are poorly understood. The oxidative stress induced by parenteral nutrition (PN) during the first week of life is suspected to reprogram energy metabolism in the liver. Full-term male Hartley guinea pigs...
journal_title：Journal of developmental origins of health and disease
pub_type： 杂志文章
doi：10.1017/S2040174420000719
更新日期：2020-08-03 00:00:00
abstract：:Tobacco smoke has both carcinogenic effects and anti-estrogenic properties and its inconsistent association with breast cancer risk in observational studies may be because of these competing effects across the lifecourse. We conducted a prospective study of prenatal smoke exposure, childhood household smoke exposure, ...
journal_title：Journal of developmental origins of health and disease
pub_type： 杂志文章
doi：10.1017/S2040174411000614
更新日期：2011-12-01 00:00:00
abstract：:Approximately 10% of all babies worldwide are born preterm, and preterm birth is the leading cause of perinatal mortality in developed countries. Although preterm birth is associated with adverse short- and long-term health outcomes, it is not yet clear whether this relationship is causal. Rather, there is evidence th...
journal_title：Journal of developmental origins of health and disease
pub_type： 杂志文章
doi：10.1017/S2040174412000736
更新日期：2013-06-01 00:00:00
abstract：:Preterm birth (delivery <37 weeks of gestation) is associated with impaired glomerular capillary growth in neonates; if this persists, it may be a contributing factor in the increased risk of hypertension and chronic kidney disease in people born preterm. Therefore, in this study, we aimed to determine the long-term i...
journal_title：Journal of developmental origins of health and disease
pub_type： 杂志文章
doi：10.1017/S2040174420001208
更新日期：2020-12-10 00:00:00
abstract：:The identification of early-life determinants of overweight is crucial to start early prevention. As weight gain accelerates between 2 and 6 years, we studied the association between diet quality in children aged 3 years and the change in BMI and overweight incidence in the following 7 years. From the Dutch GECKO Dren...
journal_title：Journal of developmental origins of health and disease
pub_type： 杂志文章
doi：10.1017/S204017442000118X
更新日期：2020-12-11 00:00:00
abstract：:Footprints in Time: The Longitudinal Study of Indigenous Children (LSIC) is a national study of 1759 Australian Aboriginal and Torres Strait Islander children living across urban, regional and remote areas of Australia. The study is in its 11th wave of annual data collection, having collected extensive data on topics ...
journal_title：Journal of developmental origins of health and disease
pub_type： 杂志文章
doi：10.1017/S204017441800017X
更新日期：2019-02-01 00:00:00
abstract：:Hepatitis B and hepatitis C (HBV/HCV) are important global public health concerns. We aimed to evaluate the association between maternal HBV/HCV carrier status and long-term offspring neurological hospitalisations. A population-based cohort analysis compared the risk for long-term childhood neurological hospitalisatio...
journal_title：Journal of developmental origins of health and disease
pub_type： 杂志文章
doi：10.1017/S2040174420001397
更新日期：2021-01-21 00:00:00
abstract：:The principles embodied by the Developmental Origins of Health and Disease (DOHaD) view of 'life history' trajectory are increasingly underpinned by biological data arising from molecular-based epigenomic and transcriptomic studies. Although a number of 'omic' platforms are now routinely and widely used in biology and...
journal_title：Journal of developmental origins of health and disease
pub_type： 杂志文章
doi：10.1017/S2040174414000476
更新日期：2015-02-01 00:00:00
abstract：:Foetal growth restriction impairs skeletal muscle development and adult muscle mitochondrial biogenesis. We hypothesized that key genes involved in muscle development and mitochondrial biogenesis would be altered following uteroplacental insufficiency in rat pups, and improving postnatal nutrition by cross-fostering w...
journal_title：Journal of developmental origins of health and disease
pub_type： 杂志文章
doi：10.1017/S204017441100064X
更新日期：2012-02-01 00:00:00
abstract：:The evolution of birth weight (BW), birth length (BL), and gestational age at delivery (GAD) and their correlation with various maternal sociodemographic variables were studied in Chilean newborns from years 1996 to 2017. A slight decrease in the mean values of these perinatal outcomes was observed; however, their ris...
journal_title：Journal of developmental origins of health and disease
pub_type： 杂志文章
doi：10.1017/S2040174420001117
更新日期：2020-12-04 00:00:00
