Developmental toxicant exposure in a mouse model of Alzheimer's disease induces differential sex-associated microglial activation and increased susceptibility to amyloid accumulation.

abstract：:The ability of the aorta to buffer blood flow and provide diastolic perfusion (Windkessel function) is a determinant of cardiovascular health. We have reported cardiac dysfunction indicating downstream vascular abnormalities in young adult baboons who were intrauterine growth restricted (IUGR) at birth as a result of ...

journal_title：Journal of developmental origins of health and disease

authors： Kuo AH,Li J,Li C,Huber HF,Nathanielsz PW,Clarke GD

更新日期：2018-04-01 00:00:00

abstract：:Predisposition to offspring metabolic dysfunction due to poor maternal nutrition differs with the developmental stage at exposure. Post-weaning nutrition also influences offspring phenotype in either adverse or beneficial ways. We studied a well-established rat maternal protein-restriction model to determine whether p...

journal_title：Journal of developmental origins of health and disease

authors： Bautista CJ,Guzmán C,Rodríguez-González GL,Zambrano E

更新日期：2015-08-01 00:00:00

abstract：:Adverse uterine environments caused by maternal stress (such as bacterial endotoxin) can alter programming of the fetal hypothalamic-pituitary-adrenal axis (HPAA) rendering offspring susceptible to various adulthood diseases. Thus, protection against this type of stress may be critical for ensuring offspring health. T...

journal_title：Journal of developmental origins of health and disease

authors： Fisher RE,Or'Rashid M,Quinton M,AlZahal O,Boermans HJ,McBride BW,Karrow NA

更新日期：2014-06-01 00:00:00

abstract：:A life-course approach to reduction of risk of non-communicable diseases (NCD) suggests that early-life interventions may be more effective than lifestyle modifications in middle age. Knowledge translation to develop understanding of the Developmental Origins of Health and Disease (DOHaD) within the community offers t...

journal_title：Journal of developmental origins of health and disease

authors： Bay JL,Mora HA,Sloboda DM,Morton SM,Vickers MH,Gluckman PD

更新日期：2012-12-01 00:00:00

abstract：:Postnatal and antenatal depression present significant public health concerns. Current opinion on the use of these terms is noted. Previous research findings demonstrate that detrimental effects of untreated maternal depression/anxiety are potentially severe and impact on the whole family; longer-term effects on child...

journal_title：Journal of developmental origins of health and disease

authors： Hall P

更新日期：2012-08-01 00:00:00

abstract：:Prenatal diethylstilbestrol (DES) exposure is associated with increased risk of hormonally mediated cancers and other medical conditions. We evaluated the association between DES and risk of pancreatic cancer and pancreatic disorders, type 2 diabetes, and gallbladder disease, which may be involved with this malignancy...

journal_title：Journal of developmental origins of health and disease

authors： Troisi R,Hyer M,Titus L,Palmer JR,Hatch EE,Huo D,Aagaard KM,Strohsnitter WC,Hoover RN

更新日期：2020-10-28 00:00:00

abstract：:The objectives of this study were to describe the prevalence of cigarette use and water pipe smoking in Jordanian university students and to analyze differences in determinants between cigarette smokers and non-smokers. A cross-sectional questionnaire was administered to a random sample of 400 students (18-24 years, 5...

journal_title：Journal of developmental origins of health and disease

authors： Farajat M,Hoving C,De Vries H

更新日期：2011-06-01 00:00:00

abstract：:Approximately 10% of all babies worldwide are born preterm, and preterm birth is the leading cause of perinatal mortality in developed countries. Although preterm birth is associated with adverse short- and long-term health outcomes, it is not yet clear whether this relationship is causal. Rather, there is evidence th...

journal_title：Journal of developmental origins of health and disease

authors： Harding JE,Derraik JG,Berry MJ,Jaquiery AL,Alsweiler JM,Cormack BE,Bloomfield FH

更新日期：2013-06-01 00:00:00

abstract：:The endocannabinoid system (ECS), modulated by metabolites of linoleic acid (LA), is important in regulating cardiovascular function. In pregnancy, LA is vital for foetal development. We investigated the effects of elevated LA in H9c2 cardiomyoblasts in vitro and of a high linoleic acid (HLA, 6.21%) or low linoleic ac...

journal_title：Journal of developmental origins of health and disease

authors： Sleep SL,Shrestha N,Cuffe JSM,Holland OJ,Headrick JP,McAinch AJ,Hryciw DH

更新日期：2020-12-01 00:00:00

abstract：:This study was undertaken to compare amino acid concentrations in maternal and newborn infants' serum in normal pregnancy and two groups of obese women who were born themselves with normal and small for gestational age (SGA) birth weight. Maternal cholesterol, lipoproteins concentrations and maternal and infants amino...

journal_title：Journal of developmental origins of health and disease

authors： Tsyvian PB,Bashmakova NV,Kovtun OP,Makarenko LV,Pestryaeva LA

更新日期：2015-08-01 00:00:00

abstract：:Rates of weight gain in infancy and early childhood can influence later neurocognitive, metabolic and cardiovascular health. We studied the relationship of weight gain during infancy and early childhood to intelligence quotient (IQ), blood pressure (BP) and body mass index (BMI) at age 9 in children born with very low...

journal_title：Journal of developmental origins of health and disease

authors： Washburn L,Nixon P,Snively B,Tennyson A,O'Shea TM

更新日期：2010-10-01 00:00:00

abstract：:Prenatal glucocorticoids, commonly used in women at risk of preterm delivery, can predispose the newborn to disease in later life. Since male reproductive function is likely to reflect testis development during fetal life, we studied the effects of prenatal glucocorticoids on two key intra-testicular factors that play...

journal_title：Journal of developmental origins of health and disease

authors： Pedrana G,Viotti H,Lombide P,Sanguinetti G,Pino C,Cavestany D,Sloboda DM,Martin GB

更新日期：2016-08-01 00:00:00

abstract：:Adipose tissue (AT) dysfunction links obesity of any cause with cardiometabolic disease, but whether early-life nutritional deficiency can program adipocyte dysfunction independently of obesity is untested. In 3-5-month-old juvenile microswine offspring exposed to isocaloric perinatal maternal protein restriction (MPR...

journal_title：Journal of developmental origins of health and disease

authors： DuPriest EA,Kupfer P,Lin B,Sekiguchi K,Morgan TK,Saunders KE,Chatkupt TT,Denisenko ON,Purnell JQ,Bagby SP

更新日期：2012-06-01 00:00:00

abstract：:The risk for many chronic diseases appears to be mediated in part by birth weight. Among Aboriginal Canadians, the prevalence of end-stage renal disease and cardiovascular disease risk is disproportionately high, largely because of elevated diabetes prevalence. The relationships between birth weight (and other potenti...

journal_title：Journal of developmental origins of health and disease

authors： Oster RT,Luyckx VA,Toth EL

更新日期：2013-04-01 00:00:00

abstract：:Breast milk constitutes one of the most important sources of postnatal microbes. However, the influence of perinatal factors on the milk microbiome is still poorly understood. The aim of our study was to assess the impact of mode of delivery on the microbiome composition and diversity present in breast milk of healthy...

journal_title：Journal of developmental origins of health and disease

authors： Cabrera-Rubio R,Mira-Pascual L,Mira A,Collado MC

更新日期：2016-02-01 00:00:00

abstract：:Low birth weight and a rapid weight gain in early childhood may lead to an increased risk for developing cardiovascular disease later in life, such as hypertension and dyslipidaemia. In this study, we examined the associations between size at birth, relative weight gain in infancy and childhood with specific cardiovas...

journal_title：Journal of developmental origins of health and disease

authors： Musa MG,Kagura J,Pisa PT,Norris SA

更新日期：2016-04-01 00:00:00

abstract：:Pregnant women, children under 2 and the first thousand days of life have been principal targets for Developmental Origins of Health and Disease interventions. This paradigm has been criticized for laying responsibility for health outcomes on pregnant women and mothers and through the thousand days focus inadvertently...

journal_title：Journal of developmental origins of health and disease

authors： Pentecost M,Ross FC,Macnab A

更新日期：2018-02-01 00:00:00

abstract：:Although numerous studies have been conducted to examine the causal factors of childhood obesity, the implications of intrauterine oxidative stress on early postnatal adiposity development remain to be elucidated. The Universiti Sains Malaysia Birth Cohort Study aimed to investigate the effects of prenatal oxidative s...

journal_title：Journal of developmental origins of health and disease

authors： Loy SL,Sirajudeen KN,Hamid Jan JM

更新日期：2014-04-01 00:00:00

abstract：:The effect of maternal Ramadan-type fasting (RTF) on the outcome of pregnancy, kidney development and nephron number in male rat offspring was investigated in current study. Pregnant rats were given food and water ad libitum during pregnancy (control) or restricted for 16 h per day (RTF). Kidney structure was examined...

journal_title：Journal of developmental origins of health and disease

authors： Mohany M,Ashton N,Harrath AH,Nyengaard JR,Alomar SY,Alwasel S

更新日期：2018-06-01 00:00:00

abstract：:Our objective was to investigate associations of body size (birth weight and body mass index (BMI)) and growth in height, body fat (adiposity) and lean mass during childhood and adolescence, with risk markers for diabetes in young South Asian adults. We studied 357 men and women aged 21 years from the Pune Children's ...

journal_title：Journal of developmental origins of health and disease

authors： Kumaran K,Lubree H,Bhat DS,Joshi S,Joglekar C,Yajnik P,Bhave S,Pandit A,Fall CHD,Yajnik CS

更新日期：2020-08-05 00:00:00

abstract：:Rates of obesity are increasing in women of child bearing age with negative impacts on maternal and offspring health. Emerging evidence suggests in utero origins of respiratory health in offspring of obese mothers but mechanisms are unknown. Changes in maternal cortisol levels are one potential factor as cortisol leve...

journal_title：Journal of developmental origins of health and disease

authors： de Vries A,Reynolds RM,Seckl JR,van der Wal M,Bonsel GJ,Vrijkotte TG

更新日期：2014-10-01 00:00:00

abstract：:The association between lower birth weight and increased disease risk in adulthood has drawn attention to the physiological processes that shape the gestational environment. We implement genome-wide transcriptional profiling of maternal blood samples to identify subsets of genes and associated transcription control pa...

journal_title：Journal of developmental origins of health and disease

authors： McDade TW,Kuzawa CW,Borja J,Arevalo JMG,Miller G,Cole SW

更新日期：2019-12-01 00:00:00

abstract：:Depression and anxiety in the antenatal period are of public health concern given potential adverse effects for both mother and infant. Both are under-researched in the first trimester of pregnancy, especially in Africa. We examine the prevalence of first trimester antenatal depression and anxiety in a cohort of South...

journal_title：Journal of developmental origins of health and disease

authors： Redinger S,Norris SA,Pearson RM,Richter L,Rochat T

更新日期：2018-02-01 00:00:00

abstract：:Footprints in Time: The Longitudinal Study of Indigenous Children (LSIC) is a national study of 1759 Australian Aboriginal and Torres Strait Islander children living across urban, regional and remote areas of Australia. The study is in its 11th wave of annual data collection, having collected extensive data on topics ...

journal_title：Journal of developmental origins of health and disease

authors： Salmon M,Skelton F,Thurber KA,Bennetts Kneebone L,Gosling J,Lovett R,Walter M

更新日期：2019-02-01 00:00:00

abstract：:Children of parents with major mood and psychotic disorders are at increased risk of psychopathology, including psychotic symptoms. It has been suggested that the risk of psychosis may be more often transmitted from parent to opposite-sex offspring (e.g., from father to daughter) than to same-sex offspring (e.g., from...

journal_title：Journal of developmental origins of health and disease

authors： Aylott A,Zwicker A,MacKenzie LE,Cumby J,Propper L,Abidi S,Bagnell A,Fisher HL,Pavlova B,Alda M,Uher R

更新日期：2019-02-01 00:00:00

abstract：:Maternal undernutrition is known to adversely impact fetal health and development. Insults experienced in utero alter development of the fetus as it adapts to microenvironment stressors, leading to growth restriction and subsequent low birth weight. Infants born small for gestational age have significantly increased r...

journal_title：Journal of developmental origins of health and disease

authors： Schlegel RN,Moritz KM,Paravicini TM

更新日期：2016-10-01 00:00:00

abstract：:Preterm birth affects over 12% of all infants born in the US yet the biology of early delivery remains unclear, including whether epigenetic mechanisms are involved. We examined associations of maternal and umbilical cord blood long interspersed nuclear element-1 (LINE-1) DNA methylation with length of gestation and o...

journal_title：Journal of developmental origins of health and disease

authors： Burris HH,Rifas-Shiman SL,Baccarelli A,Tarantini L,Boeke CE,Kleinman K,Litonjua AA,Rich-Edwards JW,Gillman MW

更新日期：2012-06-01 00:00:00

abstract：:Intrauterine factors important for cognitive development, such as birth weight, chorionicity and umbilical cord characteristics were investigated. A total of 663 twin pairs completed the Wechsler Intelligence Scale for Children-Revised and scores were available for Performance, Verbal and Total Intelligence Quotient (...

journal_title：Journal of developmental origins of health and disease

authors： Antoniou EE,Fowler T,Thiery E,Southwood TR,van Gestel S,Jacobs N,Vlietinck R,van Os J,Rijsdijk FV,Derom C,Zeegers MP

更新日期：2013-12-01 00:00:00

abstract：:With brown adipose tissue (BAT) becoming a possible therapeutic target to counteract obesity, the prenatal environment could represent a critical window to modify BAT function and browning of white AT. We investigated if levels of uncoupling protein 1 (UCP1) and UCP1-mediated thermogenesis are altered in offspring exp...

journal_title：Journal of developmental origins of health and disease

authors： Bytautiene Prewit E,Porter C,La Rosa M,Bhattarai N,Yin H,Gamble P,Kechichian T,Sidossis LS

更新日期：2018-08-01 00:00:00

abstract：:Bisphenol-A (BPA) is a widely used endocrine-disrupting chemical. Prenatal exposure to BPA is known to affect birth weight, but its impact on the cardiovascular system has not been studied in detail. In this study, we investigated the effects of prenatal BPA treatment and its interaction with postnatal overfeeding on ...

journal_title：Journal of developmental origins of health and disease

authors： MohanKumar SM,Rajendran TD,Vyas AK,Hoang V,Asirvatham-Jeyaraj N,Veiga-Lopez A,Olivier NB,Padmanabhan V,MohanKumar PS

更新日期：2017-02-01 00:00:00