Does early weaning shape future endocrine and metabolic disorders? Lessons from animal models.

abstract：:A life-course approach to reduction of risk of non-communicable diseases (NCD) suggests that early-life interventions may be more effective than lifestyle modifications in middle age. Knowledge translation to develop understanding of the Developmental Origins of Health and Disease (DOHaD) within the community offers t...

journal_title：Journal of developmental origins of health and disease

authors： Bay JL,Mora HA,Sloboda DM,Morton SM,Vickers MH,Gluckman PD

更新日期：2012-12-01 00:00:00

abstract：:The evidence underpinning the developmental origins of health and disease (DOHaD) is overwhelming. As the emphasis shifts more towards interventions and the translational strategies for disease prevention, it is important to capitalize on collaboration and knowledge sharing to maximize opportunities for discovery and ...

journal_title：Journal of developmental origins of health and disease

authors： Prescott SL,Allen K,Armstrong K,Collins C,Dickinson H,Gardiner K,Jacka F,Jasoni C,Moore T,Moritz KM,Muhlhausler B,Siero W,Sim K,Nanan R,Saffery R,Singh G,Vickers MH,Craig JM

更新日期：2016-10-01 00:00:00

abstract：:The principles embodied by the Developmental Origins of Health and Disease (DOHaD) view of 'life history' trajectory are increasingly underpinned by biological data arising from molecular-based epigenomic and transcriptomic studies. Although a number of 'omic' platforms are now routinely and widely used in biology and...

journal_title：Journal of developmental origins of health and disease

authors： Pleasants AB,Wake GC,Shorten PR,Hassell-Sweatman CZ,McLean CA,Holbrook JD,Gluckman PD,Sheppard AM

更新日期：2015-02-01 00:00:00

abstract：:Prenatal exposure to persistent organic pollutants (POPs) has been associated with the development of metabolic syndrome-related diseases in offspring. According to epidemiological studies, father's transmission of environmental effects in addition to mother's can influence offspring health. Moreover, maternal prenata...

journal_title：Journal of developmental origins of health and disease

authors： Navarro P,Dalvai M,Charest PL,Herst PM,Lessard M,Marcotte B,Mitchell PL,Leblanc N,Kimmins S,Trasler J,MacFarlane AJ,Marette A,Bailey JL,Jacques H

更新日期：2019-09-16 00:00:00

abstract：:Prenatal glucocorticoids, commonly used in women at risk of preterm delivery, can predispose the newborn to disease in later life. Since male reproductive function is likely to reflect testis development during fetal life, we studied the effects of prenatal glucocorticoids on two key intra-testicular factors that play...

journal_title：Journal of developmental origins of health and disease

authors： Pedrana G,Viotti H,Lombide P,Sanguinetti G,Pino C,Cavestany D,Sloboda DM,Martin GB

更新日期：2016-08-01 00:00:00

abstract：:The developmental origins hypothesis suggests that morbidity and premature mortality arise, in part, from adverse exposures in utero and early in development. Evidence suggests a connection between early nutritional deficits and adult morbidity; however, the effects on mortality have been less well studied and previou...

journal_title：Journal of developmental origins of health and disease

authors： Saxton K,Falconi A,Goldman-Mellor S,Catalano R

更新日期：2013-02-01 00:00:00

abstract：:An estimated 200 million children worldwide fail to meet their development potential due to poverty, poor health and unstimulating environments. Missing developmental milestones has lasting effects on adult human capital. Africa has a large burden of risk factors for poor child development. The objective of this paper...

journal_title：Journal of developmental origins of health and disease

authors： Ford ND,Stein AD

更新日期：2016-04-01 00:00:00

abstract：:Our objective was to investigate associations of body size (birth weight and body mass index (BMI)) and growth in height, body fat (adiposity) and lean mass during childhood and adolescence, with risk markers for diabetes in young South Asian adults. We studied 357 men and women aged 21 years from the Pune Children's ...

journal_title：Journal of developmental origins of health and disease

authors： Kumaran K,Lubree H,Bhat DS,Joshi S,Joglekar C,Yajnik P,Bhave S,Pandit A,Fall CHD,Yajnik CS

更新日期：2020-08-05 00:00:00

abstract：:The early embryo and periconceptional period is a window during which environmental factors may cause permanent change in the pattern and characteristics of development leading to risk of adult onset disease. This has now been demonstrated across small and large animal models and also in the human. Most evidence of pe...

journal_title：Journal of developmental origins of health and disease

authors： Fleming TP,Velazquez MA,Eckert JJ

更新日期：2015-10-01 00:00:00

abstract：:Preterm birth (delivery <37 weeks of gestation) is associated with impaired glomerular capillary growth in neonates; if this persists, it may be a contributing factor in the increased risk of hypertension and chronic kidney disease in people born preterm. Therefore, in this study, we aimed to determine the long-term i...

journal_title：Journal of developmental origins of health and disease

authors： Sutherland MR,Malik W,Nguyen VB,Tran V,Polglase GR,Black MJ

更新日期：2020-12-10 00:00:00

abstract：:The ability of the aorta to buffer blood flow and provide diastolic perfusion (Windkessel function) is a determinant of cardiovascular health. We have reported cardiac dysfunction indicating downstream vascular abnormalities in young adult baboons who were intrauterine growth restricted (IUGR) at birth as a result of ...

journal_title：Journal of developmental origins of health and disease

authors： Kuo AH,Li J,Li C,Huber HF,Nathanielsz PW,Clarke GD

更新日期：2018-04-01 00:00:00

abstract：:Maternal protein restriction (MPR) during pregnancy impaired the reproduction of male offspring. We investigated, during the first wave of spermatogenesis, whether MPR exerts deleterious effects on germ cell proliferation and differentiation, as well as androgen receptor (AR) protein expression, which was used as a ma...

journal_title：Journal of developmental origins of health and disease

authors： Rodríguez-González GL,Vigueras-Villaseñor RM,Millán S,Moran N,Trejo R,Nathanielsz PW,Larrea F,Zambrano E

更新日期：2012-10-01 00:00:00

abstract：:Pregnant women, children under 2 and the first thousand days of life have been principal targets for Developmental Origins of Health and Disease interventions. This paradigm has been criticized for laying responsibility for health outcomes on pregnant women and mothers and through the thousand days focus inadvertently...

journal_title：Journal of developmental origins of health and disease

authors： Pentecost M,Ross FC,Macnab A

更新日期：2018-02-01 00:00:00

abstract：:As the resident macrophage of the central nervous system, microglia are thought to contribute to Alzheimer's disease (AD) pathology through lack of neuroprotection. The role of immune dysfunction in AD may be due to disruption of regulatory signals for the activation of microglia that may occur early in development. W...

journal_title：Journal of developmental origins of health and disease

authors： vonderEmbse AN,Hu Q,DeWitt JC

更新日期：2017-08-01 00:00:00

abstract：:Childhood obesity rates are higher among Indigenous compared with non-Indigenous Australian children. It has been hypothesized that early-life influences beginning with the intrauterine environment predict the development of obesity in the offspring. The aim of this paper was to assess, in 227 mother-child dyads from ...

journal_title：Journal of developmental origins of health and disease

authors： Pringle KG,Lee YQ,Weatherall L,Keogh L,Diehm C,Roberts CT,Eades S,Brown A,Smith R,Lumbers ER,Brown LJ,Collins CE,Rae KM

更新日期：2019-02-01 00:00:00

abstract：:We sought to examine whether rat maternal food restriction (MFR) affects the expression of steroidogenesis-related genes Cyp19, Cyp17a1, Insl3 and Gdf-9 in the ovaries of offspring from the first (FRG1) and second (FRG2) generations at pre-pubertal age (week 4) and during adulthood (week 8). At week 4, MFR significant...

journal_title：Journal of developmental origins of health and disease

authors： Harrath AH,Alrezaki A,Alwasel SH,Semlali A

更新日期：2019-10-01 00:00:00

abstract：:Renin is essential for renal development and in adult kidneys vitamin D deficiency increases renin gene expression. We aimed to determine whether maternal vitamin D deficiency upregulates fetal renal renin expression, and if this is sustained. We also examined growth and the long-term renal effects in offspring on a n...

journal_title：Journal of developmental origins of health and disease

authors： Boyce AC,Palmer-Aronsten BJ,Kim MY,Gibson KJ

更新日期：2013-10-01 00:00:00

abstract：:The hypothesis was that maternal intake of the antioxidant alpha-lipoid acid (ALA), during the developmental period of the hypothalamic orexigenic neurons, causes a permanent beneficial effect in offspring metabolism. Pregnant Wistar rats were fed with standard diet (food) + ALA (0.4% wt/wt) from day 14 of gestation t...

journal_title：Journal of developmental origins of health and disease

authors： Rabaglino MB,Moreira-Espinoza MJ,Lagares C,Garay MI,Quiroga P,Pasqualini ME,Francini F,Beltramo D

更新日期：2020-12-11 00:00:00

abstract：:Associations between different forms of malnutrition and environmental conditions, including water, sanitation and hygiene (WASH), may contribute towards persistently poor child health, growth and cognitive development. Experiencing poor nutrition in utero or during early childhood is furthermore associated with chron...

journal_title：Journal of developmental origins of health and disease

authors： Momberg DJ,Ngandu BC,Voth-Gaeddert LE,Cardoso Ribeiro K,May J,Norris SA,Said-Mohamed R

更新日期：2021-02-01 00:00:00

abstract：:Extremely premature birth is associated with a permanent disruption of energy metabolism. The underlying mechanisms are poorly understood. The oxidative stress induced by parenteral nutrition (PN) during the first week of life is suspected to reprogram energy metabolism in the liver. Full-term male Hartley guinea pigs...

journal_title：Journal of developmental origins of health and disease

authors： Teixeira V,Guiraut C,Mohamed I,Lavoie JC

更新日期：2020-08-03 00:00:00

abstract：:Overweight/obesity has become a worldwide epidemic, and factors such as a sedentary lifestyle and inadequate eating habits directly contribute to the development of this condition. Studies indicate that rapid weight gain at critical development stages, such as the lactation period, is associated with the development o...

journal_title：Journal of developmental origins of health and disease

authors： Costa VMG,Andreazzi AE,Bolotari M,Lade CG,Guerra MO,Peters VM

更新日期：2019-12-01 00:00:00

abstract：:Hypertension (HTN) remains a common complication after kidney transplantation among paediatric patients. Although low birth weight (LBW) has been implicated as an important risk factor for cardiovascular diseases, its effect on transplantation patients has not yet been addressed. It is essential to determine whether c...

journal_title：Journal of developmental origins of health and disease

authors： Santos LB,Borges LM,Souza LV,Felipe CR,Medina-Pestana JO,Franco MDC

更新日期：2020-02-01 00:00:00

abstract：:Foetal growth restriction impairs skeletal muscle development and adult muscle mitochondrial biogenesis. We hypothesized that key genes involved in muscle development and mitochondrial biogenesis would be altered following uteroplacental insufficiency in rat pups, and improving postnatal nutrition by cross-fostering w...

journal_title：Journal of developmental origins of health and disease

authors： Laker RC,Wadley GD,McConell GK,Wlodek ME

更新日期：2012-02-01 00:00:00

abstract：:Intrauterine growth restriction (IUGR) from uteroplacental dysfunction causes impaired nephrogenesis and ultimately hypertension, but it is unknown whether IUGR caused by insufficient space for placental development seen in uterine anomalies and/or multifetal gestation exerts the same effects. Fetal renal development ...

journal_title：Journal of developmental origins of health and disease

authors： Meyer-Gesch KM,Sun MY,Koch JM,Ramadoss J,Blohowiak SE,Magness RR,Kling PJ

更新日期：2013-10-01 00:00:00

abstract：:Here we analyze the outcomes of unlimited access to a low-energy (LE) diet in dams and their offspring. At 3 weeks' gestation, pregnant Wistar rats were divided into two groups: (1) the control group received a normoenergetic diet; and (2) the experimental group received the LE diet. In dams, lactation outcomes, food ...

journal_title：Journal of developmental origins of health and disease

authors： do Nascimento E,de Santana Muniz G,das Graças de Santana Muniz M,de Souza Alexandre L,da Rocha LS,Leandro CG,de Castro RM,Bolaños-Jimenez F

更新日期：2014-02-01 00:00:00

abstract：:Bisphenol-A (BPA) is a widely used endocrine-disrupting chemical. Prenatal exposure to BPA is known to affect birth weight, but its impact on the cardiovascular system has not been studied in detail. In this study, we investigated the effects of prenatal BPA treatment and its interaction with postnatal overfeeding on ...

journal_title：Journal of developmental origins of health and disease

authors： MohanKumar SM,Rajendran TD,Vyas AK,Hoang V,Asirvatham-Jeyaraj N,Veiga-Lopez A,Olivier NB,Padmanabhan V,MohanKumar PS

更新日期：2017-02-01 00:00:00

abstract：:Although abundant evidence exists that adverse events during pregnancy lead to chronic conditions, there is limited information on the impact of acute insults such as sepsis. This study tested the hypothesis that impaired fetal development leads to altered organ responses to a septic insult in both male and female adu...

journal_title：Journal of developmental origins of health and disease

authors： Khazaee R,Vinokurtseva A,McCaig LA,Yamashita C,Hardy DB,Arany E,Veldhuizen RAW

更新日期：2020-12-23 00:00:00

abstract：:Children of parents with major mood and psychotic disorders are at increased risk of psychopathology, including psychotic symptoms. It has been suggested that the risk of psychosis may be more often transmitted from parent to opposite-sex offspring (e.g., from father to daughter) than to same-sex offspring (e.g., from...

journal_title：Journal of developmental origins of health and disease

authors： Aylott A,Zwicker A,MacKenzie LE,Cumby J,Propper L,Abidi S,Bagnell A,Fisher HL,Pavlova B,Alda M,Uher R

更新日期：2019-02-01 00:00:00

abstract：:A developmental approach to public health focuses attention on better nourishing girls and young women, especially those of low socio-economic status, to improve mothers' nutrition and thereby the health of future generations. There have been significant advances in the behavioural sciences that may allow us to unders...

journal_title：Journal of developmental origins of health and disease

authors： Barker M

更新日期：2015-10-01 00:00:00

abstract：:Ilex paraguariensis (yerba mate) has a beneficial effect in the management of obesity. Here, we studied the effects of yerba mate on hypothalamic changes in leptin and insulin signalling, oxidative stress and liver morphology and metabolism in postnatal early overfeeding (EO) Wistar rats. To induce EO, the litter size...

journal_title：Journal of developmental origins of health and disease

authors： Conceição EP,Kaezer AR,Peixoto-Silva N,Felzenszwalb I,de Oliveira E,Moura EG,Lisboa PC

更新日期：2017-02-01 00:00:00