Abstract:
:Although numerous studies have been conducted to examine the causal factors of childhood obesity, the implications of intrauterine oxidative stress on early postnatal adiposity development remain to be elucidated. The Universiti Sains Malaysia Birth Cohort Study aimed to investigate the effects of prenatal oxidative stress levels on the development of infant adiposity during the first year of life. This study was conducted on the healthy pregnant women aged 19-40 years, from April 2010 to December 2012 in Kelantan, Malaysia. Maternal blood samples were drawn in the second trimester to analyse for oxidative stress markers. Infant anthropometric measurements were taken at birth, 2, 6 and 12 months of age. A total of 153 pregnant women and full-term infants were included in the analysis. Statistical test was conducted by using multiple linear regression. Through the infant first year of life, as maternal DNA damage level in the second trimester increased, infant weights at birth (β=-0.122, P<0.001), 2 months (β=-0.120, P=0013), 6 months (β=-0.209, P=0.003) and 12 months of age (β=-0.241, P=0.006) decreased after adjusting for confounders. Similar results were noted when infant body mass index-for-age Z-scores and triceps skinfold-for-age Z-scores were used as the adiposity indicators. In conclusion, the present study shows a consistent inverse association between maternal DNA damage and infant adiposity during the first year of life. These infants with reduced growth and adiposity in early postnatal life may have a high tendency to experience catch-up growth during childhood, which could be strongly associated with later obesity.
journal_name
J Dev Orig Health Disjournal_title
Journal of developmental origins of health and diseaseauthors
Loy SL,Sirajudeen KN,Hamid Jan JMdoi
10.1017/S204017441300055Xsubject
Has Abstractpub_date
2014-04-01 00:00:00pages
142-51issue
2eissn
2040-1744issn
2040-1752pii
S204017441300055Xjournal_volume
5pub_type
杂志文章abstract::This study aimed to assess the association between maternal-isolated oligohydramnios (IO) and offspring long-term neurological complications. A population-based retrospective cohort study was conducted, including all births at a single tertiary medical center in Israel between the years 1991 and 2014. Multiple pregnan...
journal_title:Journal of developmental origins of health and disease
pub_type: 杂志文章
doi:10.1017/S2040174419000795
更新日期:2020-12-01 00:00:00
abstract::The hypothesis that vitamin content of the diet during gestation alters macronutrient choice, food intake and the expression of serotonin receptors and proopiomelanocortin (POMC) in the hypothalamus of the offspring was investigated. Pregnant Wistar rats (n = 10/group) were fed the AIN-93G diet containing a multivitam...
journal_title:Journal of developmental origins of health and disease
pub_type: 杂志文章
doi:10.1017/S2040174410000565
更新日期:2010-12-01 00:00:00
abstract::Pregnant individuals who overeat are more likely to predispose their fetus to the development of metabolic disorders in adulthood. Physical training is a prevention and treatment interventional strategy that could treat these disorders, since it improves metabolism and body composition. This study assessed the protect...
journal_title:Journal of developmental origins of health and disease
pub_type: 杂志文章
doi:10.1017/S2040174419000503
更新日期:2020-04-01 00:00:00
abstract::Low birth weight and a rapid weight gain in early childhood may lead to an increased risk for developing cardiovascular disease later in life, such as hypertension and dyslipidaemia. In this study, we examined the associations between size at birth, relative weight gain in infancy and childhood with specific cardiovas...
journal_title:Journal of developmental origins of health and disease
pub_type: 杂志文章
doi:10.1017/S2040174415007953
更新日期:2016-04-01 00:00:00
abstract::In this study, diabetes mellitus (DM) was induced in Wistar rats during pregnancy and maintained in the postpartum period (PP) and we evaluated systolic blood pressure (SBP), glomerular filtration rate (GFR) and renal immunohistochemical and morphometric studies from different groups: G1 (non-pregnant control rats), G...
journal_title:Journal of developmental origins of health and disease
pub_type: 杂志文章
doi:10.1017/S2040174417000605
更新日期:2018-02-01 00:00:00
abstract::Intrauterine growth restriction (IUGR) from uteroplacental dysfunction causes impaired nephrogenesis and ultimately hypertension, but it is unknown whether IUGR caused by insufficient space for placental development seen in uterine anomalies and/or multifetal gestation exerts the same effects. Fetal renal development ...
journal_title:Journal of developmental origins of health and disease
pub_type: 杂志文章
doi:10.1017/S2040174413000329
更新日期:2013-10-01 00:00:00
abstract::Overweight/obesity has become a worldwide epidemic, and factors such as a sedentary lifestyle and inadequate eating habits directly contribute to the development of this condition. Studies indicate that rapid weight gain at critical development stages, such as the lactation period, is associated with the development o...
journal_title:Journal of developmental origins of health and disease
pub_type: 杂志文章
doi:10.1017/S2040174419000163
更新日期:2019-12-01 00:00:00
abstract::Bisphenol-A (BPA) is a widely used endocrine-disrupting chemical. Prenatal exposure to BPA is known to affect birth weight, but its impact on the cardiovascular system has not been studied in detail. In this study, we investigated the effects of prenatal BPA treatment and its interaction with postnatal overfeeding on ...
journal_title:Journal of developmental origins of health and disease
pub_type: 杂志文章
doi:10.1017/S204017441600057X
更新日期:2017-02-01 00:00:00
abstract::An appropriate foetal cardiovascular (CV) response to reduced substrate supply (e.g. oxygen or other nutrients) is vital for growth and development, and may impact on CV control. The prevailing nutritional environment and associated CV changes may influence subsequent CV responses to challenges during late gestation, ...
journal_title:Journal of developmental origins of health and disease
pub_type: 杂志文章
doi:10.1017/S204017440999016X
更新日期:2010-02-01 00:00:00
abstract::Placental weight is a valuable indicator of its function, predicting both pregnancy outcome and lifelong health. Population-based centile charts of weight-for-gestational-age and parity are useful for identifying extremes of placental weight but fail to consider maternal size. To address this deficit, a multiple regre...
journal_title:Journal of developmental origins of health and disease
pub_type: 杂志文章
doi:10.1017/S2040174419000576
更新日期:2019-10-07 00:00:00
abstract::The hypothesis was that maternal intake of the antioxidant alpha-lipoid acid (ALA), during the developmental period of the hypothalamic orexigenic neurons, causes a permanent beneficial effect in offspring metabolism. Pregnant Wistar rats were fed with standard diet (food) + ALA (0.4% wt/wt) from day 14 of gestation t...
journal_title:Journal of developmental origins of health and disease
pub_type: 杂志文章
doi:10.1017/S2040174420001178
更新日期:2020-12-11 00:00:00
abstract::An estimated 200 million children worldwide fail to meet their development potential due to poverty, poor health and unstimulating environments. Missing developmental milestones has lasting effects on adult human capital. Africa has a large burden of risk factors for poor child development. The objective of this paper...
journal_title:Journal of developmental origins of health and disease
pub_type: 杂志文章
doi:10.1017/S2040174415001427
更新日期:2016-04-01 00:00:00
abstract::Foetal growth restriction impairs skeletal muscle development and adult muscle mitochondrial biogenesis. We hypothesized that key genes involved in muscle development and mitochondrial biogenesis would be altered following uteroplacental insufficiency in rat pups, and improving postnatal nutrition by cross-fostering w...
journal_title:Journal of developmental origins of health and disease
pub_type: 杂志文章
doi:10.1017/S204017441100064X
更新日期:2012-02-01 00:00:00
abstract::Pregnant women, children under 2 and the first thousand days of life have been principal targets for Developmental Origins of Health and Disease interventions. This paradigm has been criticized for laying responsibility for health outcomes on pregnant women and mothers and through the thousand days focus inadvertently...
journal_title:Journal of developmental origins of health and disease
pub_type: 杂志文章
doi:10.1017/S2040174417000629
更新日期:2018-02-01 00:00:00
abstract::Obesity and its complications occur at alarming rates worldwide. Epidemiological data have associated perinatal conditions, such as malnutrition, with the development of some disorders, such as obesity, dyslipidemia, diabetes, and cardiovascular diseases, in childhood and adulthood. Exclusive breastfeeding has been as...
journal_title:Journal of developmental origins of health and disease
pub_type: 杂志文章
doi:10.1017/S2040174420000410
更新日期:2020-10-01 00:00:00
abstract::Donor-conceived neonates have poorer birth outcomes, including low birth weight and preterm delivery that are associated with poorer long-term health in adulthood through the developmental origins of health and disease (DOHaD) theory. The aim of this study was to conduct the first investigation of the adult health out...
journal_title:Journal of developmental origins of health and disease
pub_type: 杂志文章
doi:10.1017/S204017442000080X
更新日期:2020-08-28 00:00:00
abstract::Predisposition to offspring metabolic dysfunction due to poor maternal nutrition differs with the developmental stage at exposure. Post-weaning nutrition also influences offspring phenotype in either adverse or beneficial ways. We studied a well-established rat maternal protein-restriction model to determine whether p...
journal_title:Journal of developmental origins of health and disease
pub_type: 杂志文章
doi:10.1017/S2040174415001051
更新日期:2015-08-01 00:00:00
abstract::Antenatal exposure of the fetus to inflammation may alter postnatal organ development. In our previous work, we demonstrated that the fetal liver is involved in the systemic inflammation associated with chorioamnionitis, leading to metabolic changes. On the basis of these findings, we hypothesized that chorioamnioniti...
journal_title:Journal of developmental origins of health and disease
pub_type: 杂志文章
doi:10.1017/S2040174412000049
更新日期:2012-04-01 00:00:00
abstract::The developmental origins hypothesis suggests that morbidity and premature mortality arise, in part, from adverse exposures in utero and early in development. Evidence suggests a connection between early nutritional deficits and adult morbidity; however, the effects on mortality have been less well studied and previou...
journal_title:Journal of developmental origins of health and disease
pub_type: 历史文章,杂志文章
doi:10.1017/S2040174412000517
更新日期:2013-02-01 00:00:00
abstract::This study was undertaken to compare amino acid concentrations in maternal and newborn infants' serum in normal pregnancy and two groups of obese women who were born themselves with normal and small for gestational age (SGA) birth weight. Maternal cholesterol, lipoproteins concentrations and maternal and infants amino...
journal_title:Journal of developmental origins of health and disease
pub_type: 杂志文章
doi:10.1017/S2040174415001117
更新日期:2015-08-01 00:00:00
abstract::The identification of early-life determinants of overweight is crucial to start early prevention. As weight gain accelerates between 2 and 6 years, we studied the association between diet quality in children aged 3 years and the change in BMI and overweight incidence in the following 7 years. From the Dutch GECKO Dren...
journal_title:Journal of developmental origins of health and disease
pub_type: 杂志文章
doi:10.1017/S204017442000118X
更新日期:2020-12-11 00:00:00
abstract::Postnatal and antenatal depression present significant public health concerns. Current opinion on the use of these terms is noted. Previous research findings demonstrate that detrimental effects of untreated maternal depression/anxiety are potentially severe and impact on the whole family; longer-term effects on child...
journal_title:Journal of developmental origins of health and disease
pub_type: 杂志文章
doi:10.1017/S2040174412000013
更新日期:2012-08-01 00:00:00
abstract::The Developmental Origins of Health and Disease (DOHaD) framework aims to understand how environmental exposures in early life shape lifecycle health. Our understanding and the ability to prevent poor health outcomes and enrich for resiliency remain limited, in part, because exposure-outcome relationships are complex ...
journal_title:Journal of developmental origins of health and disease
pub_type: 杂志文章
doi:10.1017/S2040174420000689
更新日期:2020-08-04 00:00:00
abstract::The endocannabinoid system (ECS), modulated by metabolites of linoleic acid (LA), is important in regulating cardiovascular function. In pregnancy, LA is vital for foetal development. We investigated the effects of elevated LA in H9c2 cardiomyoblasts in vitro and of a high linoleic acid (HLA, 6.21%) or low linoleic ac...
journal_title:Journal of developmental origins of health and disease
pub_type: 杂志文章
doi:10.1017/S2040174419000813
更新日期:2020-12-01 00:00:00
abstract::As the resident macrophage of the central nervous system, microglia are thought to contribute to Alzheimer's disease (AD) pathology through lack of neuroprotection. The role of immune dysfunction in AD may be due to disruption of regulatory signals for the activation of microglia that may occur early in development. W...
journal_title:Journal of developmental origins of health and disease
pub_type: 杂志文章
doi:10.1017/S2040174417000277
更新日期:2017-08-01 00:00:00
abstract::Early patterns of gut colonization may predispose children to adult disease. Exposures in utero and during delivery are associated with the infant gut microbiome. Although ~35% of women carry group B strep (GBS; Streptococcus agalactiae) during pregnancy, it is unknown if GBS presence influences the infant gut microbi...
journal_title:Journal of developmental origins of health and disease
pub_type: 杂志文章
doi:10.1017/S2040174415001361
更新日期:2016-02-01 00:00:00
abstract::Hypertension (HTN) remains a common complication after kidney transplantation among paediatric patients. Although low birth weight (LBW) has been implicated as an important risk factor for cardiovascular diseases, its effect on transplantation patients has not yet been addressed. It is essential to determine whether c...
journal_title:Journal of developmental origins of health and disease
pub_type: 杂志文章
doi:10.1017/S2040174419000448
更新日期:2020-02-01 00:00:00
abstract::A developmental approach to public health focuses attention on better nourishing girls and young women, especially those of low socio-economic status, to improve mothers' nutrition and thereby the health of future generations. There have been significant advances in the behavioural sciences that may allow us to unders...
journal_title:Journal of developmental origins of health and disease
pub_type: 杂志文章,评审
doi:10.1017/S2040174415001312
更新日期:2015-10-01 00:00:00
abstract::The consumption of fructose has increased in children and adolescents and is partially responsible for the high incidence of metabolic diseases. The lifestyle during postnatal development can result in altered metabolic programming, thereby impairing the reproductive system and fertility during adulthood. Therefore, t...
journal_title:Journal of developmental origins of health and disease
pub_type: 杂志文章
doi:10.1017/S2040174420001385
更新日期:2021-01-14 00:00:00
abstract::The risk for many chronic diseases appears to be mediated in part by birth weight. Among Aboriginal Canadians, the prevalence of end-stage renal disease and cardiovascular disease risk is disproportionately high, largely because of elevated diabetes prevalence. The relationships between birth weight (and other potenti...
journal_title:Journal of developmental origins of health and disease
pub_type: 杂志文章
doi:10.1017/S2040174412000724
更新日期:2013-04-01 00:00:00