Abstract：
:Alveolar macrophages (AMs) play a vital role in lung immunity. The recent studies demonstrated that potassium channels were associated with macrophage functions, such as activation, migration and cytokines secretion. However, less is known regarding the expression and function of ERG channels in AMs. Our study showed that ERG1 channel expressed in rat alveolar macrophage, and the expression level was increased when AMs were stimulated with LPS. Furthermore, blockade of ERG1 channels with E4031 down-regulated the mature of ERG1 protein, inhibited NF-κB translocation into the nucleus, and reduced LPS-stimulated IL-6 and IL-1β secretion. These results imply that ERG1 channels are functionally expressed in rat alveolar macrophages and play an important role in inflammatory response.
journal_name
J Mol Histoljournal_title
Journal of molecular histologyauthors
Dong H,Ji Z,Liu M,Wang Y,Bai X,Wang T,Liu Z,Wu Y,Zhang B,Luo Y,Li Z,Dong Mdoi
10.1007/s10735-012-9458-3subject
Has Abstractpub_date
2013-02-01 00:00:00pages
117-24issue
1eissn
1567-2379issn
1567-2387journal_volume
44pub_type
杂志文章abstract：:Epidermal adult stem cells (EpiASCs) have the potential for unlimited proliferation and differentiation, however, the ability of these stem cells to activate corneal genetic programs in response to corneal stroma stimulation needs to be further validated. Herein, a feasible strategy was developed to reconstruct the da...
journal_title：Journal of molecular histology
pub_type： 杂志文章
doi：10.1007/s10735-020-09879-4
更新日期：2020-06-01 00:00:00
abstract：:Hyperglycemia is associated with impairment of heart function. The current study aimed to investigate the ameliorative effect of polydatin-loaded chitosan nanoparticles (PD-CSNPs), polydatin (PD) and metformin (MET) on diabetic cardiomyopathy in rats. Rats divided into six groups; normal-control, diabetic-control, dia...
journal_title：Journal of molecular histology
pub_type： 杂志文章
doi：10.1007/s10735-020-09930-4
更新日期：2021-01-03 00:00:00
abstract：:Adipose-derived mesenchymal stem cell (ADSC) with a high capacity of chondrogenic differentiation was a promising candidate for cartilage defect treatment. This study's objective is to study the roles of integrin β1 (ITGB1) in regulating ADSC chondrogenic differentiations as well as the underlying mechanisms. The iden...
journal_title：Journal of molecular histology
pub_type： 杂志文章
doi：10.1007/s10735-020-09918-0
更新日期：2020-12-01 00:00:00
abstract：:In the original publication of the article, two errors were made in describing the equations for Tc. ...
journal_title：Journal of molecular histology
pub_type： 杂志文章,已发布勘误
doi：10.1007/s10735-018-9783-2
更新日期：2018-08-01 00:00:00
abstract：:Dentin is a major component of teeth that protects dental pulp and maintains tooth health. Bone morphogenetic protein (BMP) signaling is required for the formation of dentin. Mice lacking a BMP type I receptor, activin A receptor type 1 (ACVR1), in the neural crest display a deformed mandible. Acvr1 is known to be exp...
journal_title：Journal of molecular histology
pub_type： 杂志文章
doi：10.1007/s10735-018-9806-z
更新日期：2019-02-01 00:00:00
abstract：:Previous studies have shown aberrant expression of ubiquitin-specific protease 14 (USP14) in multiple malignancies, suggesting an important role of USP14 in tumorigenesis. However, the functional role of USP14 in pancreatic ductal adenocarcinoma (PDAC) has never been elucidated. In this study, we found that USP14 was ...
journal_title：Journal of molecular histology
pub_type： 杂志文章
doi：10.1007/s10735-020-09934-0
更新日期：2021-01-04 00:00:00
abstract：:Craniofacial autologous bone grafts offer superior outcomes to long bone grafts in the reconstruction of maxillofacial bone defects, but the mechanism responsible for this superiority has not yet been illustrated clearly. Osteoblasts play vital roles in bone development and regeneration. However, presently, only a few...
journal_title：Journal of molecular histology
pub_type： 杂志文章
doi：10.1007/s10735-019-09810-6
更新日期：2019-04-01 00:00:00
abstract：:The aim of the present study was to investigate the association between KDM3A expression and the clinicopathological parameters of patients with epithelial ovarian cancer (EOC). KDM3A expression was analyzed using immunohistochemistry in EOC tissue microarray containing 90 paired cases of EOC and matched normal contro...
journal_title：Journal of molecular histology
pub_type： 撤回出版物,收录出版
doi：10.1007/s10735-015-9642-3
更新日期：2016-04-01 00:00:00
abstract：:Inpp5f-v3 is a transcriptional variant of Inpp5f (inositol polyphosphate-5-phosphatase F) and locates in distal mouse chromosome 7. It is a paternally expressed imprinted gene in mouse. In this study, we examined the spatiotemporal patterns of Inpp5f-v3 gene during the mouse development. The northern blotting analysis...
journal_title：Journal of molecular histology
pub_type： 杂志文章
doi：10.1007/s10735-011-9321-y
更新日期：2011-04-01 00:00:00
abstract：:Polycystic ovary syndrome (PCOS) is a major health problem in reproductive-aged women worldwide, but the precise pathogenesis of PCOS remains unclear. Our previous study revealed that hypoxia-inducible factor (HIF)-1a mediated endothelin (ET)-2 signaling plays an important role in ovulation in rats. Therefore, the pre...
journal_title：Journal of molecular histology
pub_type： 杂志文章
doi：10.1007/s10735-015-9609-4
更新日期：2015-04-01 00:00:00
abstract：:Quercetin (3,5,7,3',4'-pentahydroxyflavone) is one of the most abundant natural flavonoids. It is present in various common vegetables and fruits. In this report, we examined the effect of quercetin on melanogenesis using a three-dimensional reconstituted human epidermal culture model, MelanoDerm, which is a new comme...
journal_title：Journal of molecular histology
pub_type： 杂志文章
doi：10.1023/b:hijo.0000023388.51625.6c
更新日期：2004-02-01 00:00:00
abstract：:The goal of this study was to investigate whether sub-chronic anti-oxidant treatment with ascorbic acid (Vit C) is able to protect the heart against myocardial infarction. The effects of Vit C treatment on the histopatological changes and immunohistochemistry for p53, COX-2 and iNOS were evaluated in rats submitted to...
journal_title：Journal of molecular histology
pub_type： 杂志文章
doi：10.1007/s10735-009-9218-1
更新日期：2009-04-01 00:00:00
abstract：:Pulp regeneration using human dental pulp stem cells (hDPSCs) maintains tooth vitality compared with conventional root canal therapy. Our previous study demonstrated that preameloblast-conditioned medium (PA-CM) from murine apical bud cells induces the odontogenic differentiation of hDPSCs and promoted dentin formatio...
journal_title：Journal of molecular histology
pub_type： 杂志文章
doi：10.1007/s10735-013-9513-8
更新日期：2013-12-01 00:00:00
abstract：:Spinal cord injury frequently results in permanent loss of neurological function. It includes many complex molecular and biochemical mechanisms. G-protein-coupled receptor kinase 6 (GRK6) is an intracellular kinase that regulates the sensitivity of certain G-protein-coupled receptors. Some studies reported GRK2 and GR...
journal_title：Journal of molecular histology
pub_type： 杂志文章
doi：10.1007/s10735-013-9486-7
更新日期：2013-06-01 00:00:00
abstract：:Under normal homeostasis, melanocyte growth and behaviour is tightly controlled by the surrounding keratinocytes. Keratinocytes regulate melanocyte behaviour through a complex system of paracrine growth factors and cell-cell adhesion molecules. Pathological changes, leading to development of malignant melanoma, upset ...
journal_title：Journal of molecular histology
pub_type： 杂志文章,评审
doi：10.1023/b:hijo.0000032362.35354.bb
更新日期：2004-03-01 00:00:00
abstract：:During their commitment and differentiation toward the osteoblast lineage, mesenchymal stem cells secrete a unique extracellular matrix (ECM) that contains large quantities of glycosaminoglycans (GAGs). Proteoglycans (PGs) are major structural and functional components of the ECM and are composed of a core protein to ...
journal_title：Journal of molecular histology
pub_type： 杂志文章
doi：10.1007/s10735-007-9119-0
更新日期：2007-10-01 00:00:00
abstract：:Neutrotrophins are increasingly appreciated as potential modulators of neuronal function in the adult central nervous system (CNS). To describe the neurotrophin environment within the adult CNS, mRNA and protein expression patterns of neurotrophins-3 and -4 and of brain-derived neurotrophin were investigated in adult ...
journal_title：Journal of molecular histology
pub_type： 杂志文章
doi：10.1007/s10735-004-0778-9
更新日期：2004-11-01 00:00:00
abstract：:Tyrosyl-DNA phosphodiesterase 1 (Tdp1) is a DNA repair enzyme that processes blocked 3' ends of DNA breaks. Functional loss of Tdp1 causes spinocerebellar ataxia with axonal neuropathy type 1 (SCAN1). Based on the prominent cytoplasmic expression of Tdp1 in the neurons presumably affected in SCAN1, we hypothesized tha...
journal_title：Journal of molecular histology
pub_type： 杂志文章
doi：10.1007/s10735-013-9496-5
更新日期：2013-08-01 00:00:00
abstract：:Bone marrow-derived mesenchymal stem cells (BMMSCs) transplantation has shown to be effective in treating chronic kidney disease. However, the effectiveness of this strategy is constrained by low homing and survival rate of transplanted cells in the injured organs. Therefore, developing strategies to improve homing an...
journal_title：Journal of molecular histology
pub_type： 杂志文章
doi：10.1007/s10735-019-09812-4
更新日期：2019-04-01 00:00:00
abstract：:Uterine Natural Killer (uNK) cells are the most abundant lymphocyte population recruited in the uteri during murine and human pregnancy. Previous investigation on uNK cells during mouse pregnancy focused more on its accumulation in postimplantation periods, which were believed to play important roles in regulating tro...
journal_title：Journal of molecular histology
pub_type： 杂志文章
doi：10.1007/s10735-010-9256-8
更新日期：2010-02-01 00:00:00
abstract：:p53 plays a pivotal role in the prevention of human tumor formation. p73 and p63 are new members of the p53 tumor suppressor family, which are becoming increasingly recognized as important players in human tumorigenesis. However, the roles of these proteins are not well elucidated in extrahepatic bile duct (EBD) carci...
journal_title：Journal of molecular histology
pub_type： 杂志文章
doi：10.1007/s10735-007-9084-7
更新日期：2007-06-01 00:00:00
abstract：:Recent studies have shown that chronic endothelial dysfunction can impair multiple aspects of renal physiology and, in turn, contribute to renal fibrosis. Sphingosine 1-phosphate (S1P) has been highlighted as an endothelial barrier-stabilizing mediator. The aim of our study was to investigate the effect of FTY720, an ...
journal_title：Journal of molecular histology
pub_type： 杂志文章
doi：10.1007/s10735-013-9521-8
更新日期：2013-12-01 00:00:00
abstract：:Quantitative immunogold procedure was used to study the distribution of molecular components of interendothelial junctions in blood-brain barrier (BBB) microvessels of scrapie infected SJL/J hyperglycemic mice showing obesity and reduced glucose tolerance. Samples of brain (fronto-parietal cerebral cortex and thalamo-...
journal_title：Journal of molecular histology
pub_type： 杂志文章
doi：10.1007/s10735-006-9026-9
更新日期：2006-01-01 00:00:00
abstract：:The first cell lineage differentiation occurs during the development of mouse 8-cell embryo to blastocyst. Akt is a potent kinase whose role during blastocyst formation has not been elucidated. In the present study, immunofluorescence results showed that the Akt protein was specifically localized to the outer cells of...
journal_title：Journal of molecular histology
pub_type： 杂志文章
doi：10.1007/s10735-019-09833-z
更新日期：2019-08-01 00:00:00
abstract：:The accurately establishment of the eruptive pathway is of vital importance. The mechanisms governing tooth eruption pathway remain little known. This study is to elucidate the roles of Semaphorin 3A (Sema 3A) in mouse tooth eruptive pathway. C57BL/6 mice (11-13 and 15-17 days after birth) were chosen to observe erupt...
journal_title：Journal of molecular histology
pub_type： 杂志文章
doi：10.1007/s10735-019-09838-8
更新日期：2019-10-01 00:00:00
abstract：:Soluble epoxide hydrolase (sEH) is a bifunctional enzyme with a C-terminal epoxide hydrolase activity and an N-terminal phosphatase activity. Arachidonic acid epoxides, previously suggested to be involved in apoptosis, oncogenesis and cell proliferation, are generated by cytochrome P450 epoxygenases and are good subst...
journal_title：Journal of molecular histology
pub_type： 杂志文章
doi：10.1007/s10735-006-9050-9
更新日期：2006-05-01 00:00:00
abstract：:Elevated expression of CXCL9 has been shown to involve in the infiltration of inflammatory cells and liver damage after Hepatitis B virus (HBV) infection. However, whether and by what underlying mechanism does CXCL9 play a role in HBV infection associated hepatocellular carcinoma (HCC) invasion ability remain unclear....
journal_title：Journal of molecular histology
pub_type： 杂志文章
doi：10.1007/s10735-014-9593-0
更新日期：2014-12-01 00:00:00
abstract：:The aim of this study was to investigate oxidative DNA damage during 4-nitroquinoline 1-oxide (4NQO)-induced rat tongue carcinogenesis. For this purpose, male Wistar rats were distributed into three groups of 10 animals each and treated with 50 ppm 4NQO solution through their drinking water for 4, 12, and 20 weeks. Te...
journal_title：Journal of molecular histology
pub_type： 杂志文章
doi：10.1007/s10735-011-9323-9
更新日期：2011-04-01 00:00:00
abstract：:In the last few decades, several growth factors were identified in the testis of various mammalian species. Growth factors are shown to promote cell proliferation, regulate tissue differentiation, and modulate organogenesis. In the present investigation we have studied the localization of EGF and EGFR in the adult bov...
journal_title：Journal of molecular histology
pub_type： 杂志文章
doi：10.1007/s10735-007-9089-2
更新日期：2007-06-01 00:00:00
abstract：:S100A8 and S100A9 are calcium-binding proteins expressed in myeloid cells and are markers of numerous inflammatory diseases in humans. S100A9 has been associated with dystrophic calcification in human atherosclerosis. Here we demonstrate S100A8 and S100A9 expression in murine and human bone and cartilage cells. Only S...
journal_title：Journal of molecular histology
pub_type： 杂志文章
doi：10.1007/s10735-007-9117-2
更新日期：2007-10-01 00:00:00
