Akt plays indispensable roles during the first cell lineage differentiation of mouse.

abstract：:Wnt signaling plays important roles in skeletal development. However, the activation and function of canonical Wnt signaling in joint development remains unclear. We analyzed the lineage identity and developmental changes of the Wnt-responsive cells during synovial joint formation as well as adulthood in the Wnt signa...

journal_title：Journal of molecular histology

authors： Yamagami T,Molotkov A,Zhou CJ

更新日期：2009-08-01 00:00:00

abstract：:Alveolar macrophages (AMs) play a vital role in lung immunity. The recent studies demonstrated that potassium channels were associated with macrophage functions, such as activation, migration and cytokines secretion. However, less is known regarding the expression and function of ERG channels in AMs. Our study showed ...

journal_title：Journal of molecular histology

authors： Dong H,Ji Z,Liu M,Wang Y,Bai X,Wang T,Liu Z,Wu Y,Zhang B,Luo Y,Li Z,Dong M

更新日期：2013-02-01 00:00:00

abstract：:Vascular endothelial growth factor (VEGF) is an important angiogenic factor in the pituitary gland. The objective of this study was to unveil the VEGF subcellular localisation in different pituitary cell types and to evaluate changes in its expression at different time intervals after oestrogen stimulation. A relevant...

journal_title：Journal of molecular histology

authors： Mukdsi JH,De Paul AL,Gutiérrez S,Roth FD,Aoki A,Torres AI

更新日期：2005-10-01 00:00:00

abstract：:Five subtypes of dopamine receptor exist in two subfamilies: two D(1)-like (D(1) and D(5)) and three D(2)-like (D(2), D(3) and D(4)). We produced novel monoclonal antibodies against all three D(2)-like receptors and used them to localize receptors in Ntera-2 (NT-2) cells, the human neuronal precursor cell line. Most o...

journal_title：Journal of molecular histology

authors： Wolstencroft EC,Simic G,thi Man N,Holt I,Lam le T,Buckland PR,Morris GE

更新日期：2007-08-01 00:00:00

abstract：:Previous findings have shown that P2X-purinoceptor-mediated signaling pathways regulate the release of ACh in the retina. We previously reported the existence of immunoreactivity for P2X1-, P2X2-, P2X4-, and P2X7-purinoceptors in mouse retina and speculated that P2X2 and P2X7-purinoceptors may modulate the activity of...

journal_title：Journal of molecular histology

authors： Shigematsu Y,Shimoda Y,Kaneda M

更新日期：2007-08-01 00:00:00

abstract：:Polycystic ovary syndrome (PCOS) is a major health problem in reproductive-aged women worldwide, but the precise pathogenesis of PCOS remains unclear. Our previous study revealed that hypoxia-inducible factor (HIF)-1a mediated endothelin (ET)-2 signaling plays an important role in ovulation in rats. Therefore, the pre...

journal_title：Journal of molecular histology

authors： Wang F,Zhang Z,Wang Z,Xiao K,Wang Q,Su J,Wang Z

更新日期：2015-04-01 00:00:00

abstract：:Stromal cells in the peripheral zone (PZ) of the prostate from older males (PZ-old) could significantly promote Prostate cancer (PCa) growth compared with stromal cells from young males (PZ-young). But the mechanism is still unknown. In the co-culture system with PZ-old cells, Pc3/Du145 cells showed advanced prolifera...

journal_title：Journal of molecular histology

authors： Zou Q,Cui D,Liang S,Xia S,Jing Y,Han B

更新日期：2016-06-01 00:00:00

abstract：:Cyclin G1 plays an essential role in the development of human carcinoma. Here, we characterized the clinical significance of Cyclin G1 and investigated its role in cellular proliferation and apoptosis of epithelial ovarian cancer (EOC). Western blot was used to evaluate the expression of Cyclin G1 in nine fresh EOC ti...

journal_title：Journal of molecular histology

authors： Jiang L,Liu R,Wang Y,Li C,Xi Q,Zhong J,Liu J,Yang S,Wang J,Huang M,Tang C,Fang Z

更新日期：2015-06-01 00:00:00

abstract：:As one of the most common cancers in female, ovarian cancer (OC) has become a serious public burden now. Mounting researches have indicated long noncoding RNAs (lncRNAs) can affect many biological processes including cancer development. LncRNA LBX2-AS1 was identified to be an oncogene in some cancers, but the role of ...

journal_title：Journal of molecular histology

authors： Gu H,Lin R,Zheng F,Zhang Q

更新日期：2021-02-01 00:00:00

abstract：:Selective cyclooxygenase-2 non-steroidal anti-inflammatory drugs are known to inhibit bone repair, especially when long-term administration is required due to chronicle inflammatory diseases. In order to evaluate the action of this drug in bone repair during short-term administration, 48 rats underwent surgical bone d...

journal_title：Journal of molecular histology

authors： Matsumoto MA,De Oliveira A,Ribeiro Junior PD,Nary Filho H,Ribeiro DA

更新日期：2008-08-01 00:00:00

abstract：:Adipose-derived mesenchymal stem cell (ADSC) with a high capacity of chondrogenic differentiation was a promising candidate for cartilage defect treatment. This study's objective is to study the roles of integrin β1 (ITGB1) in regulating ADSC chondrogenic differentiations as well as the underlying mechanisms. The iden...

journal_title：Journal of molecular histology

authors： Luo S,Shi Q,Li W,Wu W,Zha Z

更新日期：2020-12-01 00:00:00

abstract：:The members of high-temperature requirement (HtrA) family are evolutionarily conserved serine proteases that combine a trypsin-like protease domain with at least one PDZ interaction domain. HtrA2, a special one, is mainly located in mitochondria and required for maintaining homeostasis. Once released into cytoplasm, H...

journal_title：Journal of molecular histology

authors： Sun H,Li L,Zhou F,Zhu L,Ke K,Tan X,Xu W,Rui Y,Zheng H,Zhou Z,Yang H

更新日期：2013-08-01 00:00:00

abstract：:MI-ER1 is a novel transcriptional regulator that plays a critical role in embryonic development and is differentially expressed in breast carcinoma. The MI-ER1 protein sequence is highly conserved among species, with 95% identity between mouse and humans and 72% between Xenopus and mouse. There are two major protein i...

journal_title：Journal of molecular histology

authors： Thorne LB,McCarthy PL,Paterno GD,Gillespie LL

更新日期：2008-02-01 00:00:00

abstract：:Nickel nanoparticles (Ni NPs) have been applied in various fields along with the rapid development of nanotechnology. However, the potential adverse health effects of the Ni NPs are unclear. To investigate the cyto- and genotoxicity and compare the differences between the Ni NPs and the nickel fine particles (Ni FPs),...

journal_title：Journal of molecular histology

authors： Magaye R,Gu Y,Wang Y,Su H,Zhou Q,Mao G,Shi H,Yue X,Zou B,Xu J,Zhao J

更新日期：2016-06-01 00:00:00

abstract：:Diabetic nephropathy (DN), a serious complication of hyperglycemia, is one of the most common causes of end-stage renal disease (ESRD). Glomerular podocyte injury is a major mechanism that leads to DN. However, the mechanisms underlying podocyte injury are ambiguous. In this study, we sought to investigate the contrib...

journal_title：Journal of molecular histology

authors： Wang X,Liu Q,Kong D,Long Z,Guo Y,Wang S,Liu R,Hai C

更新日期：2020-10-01 00:00:00

abstract：:Dentin is a major component of teeth that protects dental pulp and maintains tooth health. Bone morphogenetic protein (BMP) signaling is required for the formation of dentin. Mice lacking a BMP type I receptor, activin A receptor type 1 (ACVR1), in the neural crest display a deformed mandible. Acvr1 is known to be exp...

journal_title：Journal of molecular histology

authors： Zhang X,Shi C,Zhao H,Zhou Y,Hu Y,Yan G,Liu C,Li D,Hao X,Mishina Y,Liu Q,Sun H

更新日期：2019-02-01 00:00:00

abstract：:Four and a half LIM domains 2 (FHL2) is a protein of 279 amino acids in length containing four full LIM-domains and a half LIM-domain at the amino terminus. FHL2 is one transcriptional cofactor that can interact with many different proteins, such as AP-1, BRCA1, IGFBP, and integrin, and involved in organ differentiati...

journal_title：Journal of molecular histology

authors： Wang Q,Wang X,Tian X,Tang R,Xu X

更新日期：2016-04-01 00:00:00

abstract：:p21-activated Kinase 6 (PAK6) is a serine/threonine kinase belonging to the p21-activated kinase (PAK) family. PAK kinases are well-known regulators of a wide variety of cellular functions, including regulation of cytoskeleton rearrangement, cell survival, apoptosis and the mitogen-activated protein kinase signaling p...

journal_title：Journal of molecular histology

authors： Zhao W,Yang J,Shi W,Wu X,Shao B,Wu Q,Chen J,Ni L

更新日期：2011-06-01 00:00:00

abstract：:Gekko japonicus undergoes dramatic changes in the caudal spinal cord after tail amputation. The amputation induces cell proliferation in the caudal ependymal tube. We performed hematoxylin and eosin staining at different time points in the regeneration process to investigate the morphological characterization of the r...

journal_title：Journal of molecular histology

authors： Zhou Y,Xu Q,Li D,Zhao L,Wang Y,Liu M,Gu X,Liu Y

更新日期：2013-06-01 00:00:00

abstract：:This study aimed to explore whether the altered expression of tumor necrosis factor-alpha (TNF-α), vascular endothelial growth factor (VEGF) and apoptotic changes in mid zone (MZ) and rupture zone (RZ) of fetal membranes (FM) are regulatory mechanisms associated with labor at term. Fifteen FM specimens were collected ...

journal_title：Journal of molecular histology

authors： Elfayomy AK,Almasry SM

更新日期：2014-06-01 00:00:00

abstract：:Despite the efficacy of tamoxifen in preventing disease relapse, a large portion of breast cancer patients show intrinsic or acquired resistance to tamoxifen, leading to treatment failure and unfavorable clinical outcome. MYB proto-oncogene like 2 (MYBL2) is a transcription factor implicated in the initiation and prog...

journal_title：Journal of molecular histology

authors： Li X,Zhang X,Wu CC,Li PP,Fu YM,Xie LH,Sun SS,Zhou YY,Zhu BL

更新日期：2021-02-01 00:00:00

abstract：:Microscopy is advancing at a rapid pace, enabling high-speed, high-resolution analyses to be conducted in a wide range of cellular contexts. For example, the capacity to quickly capture high-resolution images from multiple optical sections over multiple channels with confocal microscopy has allowed researchers to gain...

journal_title：Journal of molecular histology

authors： Davila RA,Harkins D,Currey L,Fraser J,Bowles J,Piper M

更新日期：2019-12-01 00:00:00

abstract：:The neurovascular structures in the cranial dura mater have been studied with various histological techniques in the past years. In order to obtain a proper approach to reveal the detailed structures, different labeling methods for the cranial vessels and nerve fibers were tested in this study. Firstly, the labeling c...

journal_title：Journal of molecular histology

authors： Wang J,Xu D,Cui J,Wang S,She C,Wang H,Wu S,Zhang J,Zhu B,Bai W

更新日期：2020-10-01 00:00:00

abstract：:Multidrug resistance-associated protein 1 (MRP1) belongs to ATP-binding cassette transporters family. The overexpression of MRP1 is predominantly related with the failure of chemo-radiotherapy in various tumors. However, its possible role in hypertrophic scar (HS) is hardly investigated. Here we showed that the mRNA l...

journal_title：Journal of molecular histology

authors： Li Y,Yang L,Zheng Z,Shi J,Wu X,Guan H,Jia Y,Tao K,Wang H,Han S,Gao J,Zhao B,Su L,Hu D

更新日期：2015-10-01 00:00:00

abstract：:Vesicular monoamine transporter 2 (VMAT2) is expressed in pancreatic beta cells and has recently been proposed as a target for measurement of beta cell mass in vivo. We questioned, (1) What proportion of beta cells express VMAT2? (2) Is VMAT2 expressed by other pancreatic endocrine or non-endocrine cells? (3) Is the r...

journal_title：Journal of molecular histology

authors： Saisho Y,Harris PE,Butler AE,Galasso R,Gurlo T,Rizza RA,Butler PC

更新日期：2008-10-01 00:00:00

abstract：:Quercetin (3,5,7,3',4'-pentahydroxyflavone) is one of the most abundant natural flavonoids. It is present in various common vegetables and fruits. In this report, we examined the effect of quercetin on melanogenesis using a three-dimensional reconstituted human epidermal culture model, MelanoDerm, which is a new comme...

journal_title：Journal of molecular histology

authors： Takeyama R,Takekoshi S,Nagata H,Osamura RY,Kawana S

更新日期：2004-02-01 00:00:00

abstract：:Computational modelling of whole biological systems from cells to organs is gaining momentum in cell biology and disease studies. This pathway is essential for the derivation of explanatory frameworks that will facilitate the development of a predictive capacity for estimating outcomes or risk associated with particul...

journal_title：Journal of molecular histology

authors： Moore MN,Noble D

更新日期：2004-09-01 00:00:00

abstract：:MT1-MMP and TIMP-2 are well known for their roles in remodelling of extracellular matrix components. However, reports are emerging on the involvement of these molecules in cell kinetics. In the rat incisor tooth, a shortening treatment increases the eruption and cell proliferation rates. However, the role of MT1-MMP a...

journal_title：Journal of molecular histology

authors： Gomes JR,Omar NF,Dos Santos Neves J,Narvaes EA,Novaes PD

更新日期：2010-12-01 00:00:00

abstract：:E3 ubiquitin ligases regulate a variety of biological processes through the ubiquitin-proteasome system, together with ubiquitin activating enzyme E1 and ubiquitin-conjugating enzyme E2. Previous studies have demonstrated that zinc and ring finger 3 (ZNRF3), which belongs to the E3 ubiquitin ligases family is involved...

journal_title：Journal of molecular histology

authors： Zhou Y,Lan J,Wang W,Shi Q,Lan Y,Cheng Z,Guan H

更新日期：2013-10-01 00:00:00

abstract：:The cytoplasmic Cu/Zn-superoxide dismutase (SOD1) represents along with catalase and glutathione peroxidase at the first defense line against reactive oxygen species in all aerobic organisms, but little is known about its distribution in developing embryos. In this study, the expression patterns of SOD1 mRNA in mouse ...

journal_title：Journal of molecular histology

authors： Yon JM,Baek IJ,Lee SR,Jin Y,Kim MR,Nahm SS,Kim JS,Ahn B,Lee BJ,Yun YW,Nam SY

更新日期：2008-02-01 00:00:00