abstract：:Despite the efficacy of tamoxifen in preventing disease relapse, a large portion of breast cancer patients show intrinsic or acquired resistance to tamoxifen, leading to treatment failure and unfavorable clinical outcome. MYB proto-oncogene like 2 (MYBL2) is a transcription factor implicated in the initiation and prog...

journal_title：Journal of molecular histology

authors： Li X,Zhang X,Wu CC,Li PP,Fu YM,Xie LH,Sun SS,Zhou YY,Zhu BL

更新日期：2021-02-01 00:00:00

abstract：:As one of the most common cancers in female, ovarian cancer (OC) has become a serious public burden now. Mounting researches have indicated long noncoding RNAs (lncRNAs) can affect many biological processes including cancer development. LncRNA LBX2-AS1 was identified to be an oncogene in some cancers, but the role of ...

journal_title：Journal of molecular histology

authors： Gu H,Lin R,Zheng F,Zhang Q

更新日期：2021-02-01 00:00:00

abstract：:Human pluripotent stem cell (hPSC)-derived cardiomyocytes (CMs) hold great promise for the repair of the injured heart, but optimal cell production in a fully chemically defined and cost-effective system is essential for the efficacy and safety of cell transplantation therapies. In this study, we provided a simple and...

journal_title：Journal of molecular histology

authors： Zhang F,Qiu H,Dong X,Wang C,Na J,Zhou J,Wang C

更新日期：2021-02-01 00:00:00

abstract：:Previous studies have shown aberrant expression of ubiquitin-specific protease 14 (USP14) in multiple malignancies, suggesting an important role of USP14 in tumorigenesis. However, the functional role of USP14 in pancreatic ductal adenocarcinoma (PDAC) has never been elucidated. In this study, we found that USP14 was ...

journal_title：Journal of molecular histology

authors： Hang C,Gong C,Fang Y,Chen L,Zhu J

更新日期：2021-01-04 00:00:00

abstract：:Hyperglycemia is associated with impairment of heart function. The current study aimed to investigate the ameliorative effect of polydatin-loaded chitosan nanoparticles (PD-CSNPs), polydatin (PD) and metformin (MET) on diabetic cardiomyopathy in rats. Rats divided into six groups; normal-control, diabetic-control, dia...

journal_title：Journal of molecular histology

authors： Mostafa F,Abdel-Moneim A,Abdul-Hamid M,Galaly SR,Mohamed HM

更新日期：2021-01-03 00:00:00

abstract：:Adipose-derived mesenchymal stem cell (ADSC) with a high capacity of chondrogenic differentiation was a promising candidate for cartilage defect treatment. This study's objective is to study the roles of integrin β1 (ITGB1) in regulating ADSC chondrogenic differentiations as well as the underlying mechanisms. The iden...

journal_title：Journal of molecular histology

authors： Luo S,Shi Q,Li W,Wu W,Zha Z

更新日期：2020-12-01 00:00:00

abstract：:Diabetic nephropathy (DN), a serious complication of hyperglycemia, is one of the most common causes of end-stage renal disease (ESRD). Glomerular podocyte injury is a major mechanism that leads to DN. However, the mechanisms underlying podocyte injury are ambiguous. In this study, we sought to investigate the contrib...

journal_title：Journal of molecular histology

authors： Wang X,Liu Q,Kong D,Long Z,Guo Y,Wang S,Liu R,Hai C

更新日期：2020-10-01 00:00:00

abstract：:The neurovascular structures in the cranial dura mater have been studied with various histological techniques in the past years. In order to obtain a proper approach to reveal the detailed structures, different labeling methods for the cranial vessels and nerve fibers were tested in this study. Firstly, the labeling c...

journal_title：Journal of molecular histology

authors： Wang J,Xu D,Cui J,Wang S,She C,Wang H,Wu S,Zhang J,Zhu B,Bai W

更新日期：2020-10-01 00:00:00

abstract：:Chronic stress is regarded as a significant factor in the etiology of the many diseases. Numerous methods have been developed through which the effect of chronic stress is examined. The aim of this study is to demonstrate the new experimental model for analysis of immuno-suppression induced by chronic restraint stress...

journal_title：Journal of molecular histology

authors： Smieško G,Banović P,Gusman V,Simin V,Cimpean AM,Lalošević D

更新日期：2020-08-01 00:00:00

abstract：:Epidermal adult stem cells (EpiASCs) have the potential for unlimited proliferation and differentiation, however, the ability of these stem cells to activate corneal genetic programs in response to corneal stroma stimulation needs to be further validated. Herein, a feasible strategy was developed to reconstruct the da...

journal_title：Journal of molecular histology

authors： Zhang P,Ma XY,Huang DT,Yang XY

更新日期：2020-06-01 00:00:00

abstract：:The natriuretic peptide (NP) system comprises of three ligands, the Atrial Natriuretic Peptide (ANP), Brain Natriuretic peptide (BNP) and C-type Natriuretic peptide (CNP), and three natriuretic peptide receptors, NPRA, NPRB and NPRC. Here we present a comprehensive study of the natriuretic peptide system in healthy mu...

journal_title：Journal of molecular histology

authors： Ahmed A,Gulino A,Amayo S,Arancio W,Florena AM,Belmonte B,Jurjus A,Leone A,Miletich I

更新日期：2020-02-01 00:00:00

abstract：:Microscopy is advancing at a rapid pace, enabling high-speed, high-resolution analyses to be conducted in a wide range of cellular contexts. For example, the capacity to quickly capture high-resolution images from multiple optical sections over multiple channels with confocal microscopy has allowed researchers to gain...

journal_title：Journal of molecular histology

authors： Davila RA,Harkins D,Currey L,Fraser J,Bowles J,Piper M

更新日期：2019-12-01 00:00:00

abstract：:The accurately establishment of the eruptive pathway is of vital importance. The mechanisms governing tooth eruption pathway remain little known. This study is to elucidate the roles of Semaphorin 3A (Sema 3A) in mouse tooth eruptive pathway. C57BL/6 mice (11-13 and 15-17 days after birth) were chosen to observe erupt...

journal_title：Journal of molecular histology

authors： Yu X,Zheng F,Du Y,Tang K,Wang W,Zhang S

更新日期：2019-10-01 00:00:00

abstract：:Odontogenic keratocysts (OKCs) are jaw cystic lesions which are characterized by local invasion and high recurrence rate. The majority of OKCs are exposed to microorganisms and occur along with focal inflammatory infiltrates. Cyst fluids are biological fluids that contain a large content of cytokines and immune globul...

journal_title：Journal of molecular histology

authors： Man QW,Zhong WQ,Zhao YF,Liu B,Zhao Y

更新日期：2019-08-01 00:00:00

abstract：:The first cell lineage differentiation occurs during the development of mouse 8-cell embryo to blastocyst. Akt is a potent kinase whose role during blastocyst formation has not been elucidated. In the present study, immunofluorescence results showed that the Akt protein was specifically localized to the outer cells of...

journal_title：Journal of molecular histology

authors： Xu S,Pang L,Liu Y,Lian X,Mo K,Lv R,Zhu H,Lv C,Lin J,Sun J,Xu L,Wang S

更新日期：2019-08-01 00:00:00

abstract：:The aim of this study was to ascertain whether, like many cell types in cartilaginous tissues if type XI collagen was a pericellular component of annulus fibrosus (AF) cells and chondrocytes. Fine fibrillar networks were visualised which were perlecan, HS (MAb 10E4) and type XI collagen positive. Heparitinase-III pre-...

journal_title：Journal of molecular histology

authors： Smith SM,Melrose J

更新日期：2019-06-01 00:00:00

abstract：:Nel-like molecule-1 (NELL-1) is a novel highly specific growth factor that can induce osteoblast differentiation and bone formation as well as odontoblast differentiation. Recent studies have suggested that NELL-1 can synergistically increase bone formation and regeneration with bone morphogenetic protein 2 (BMP2) and...

journal_title：Journal of molecular histology

authors： Wu J,Wang Q,Han Q,Zhu H,Li M,Fang Y,Wang X

更新日期：2019-06-01 00:00:00

abstract：:Bone marrow-derived mesenchymal stem cells (BMMSCs) transplantation has shown to be effective in treating chronic kidney disease. However, the effectiveness of this strategy is constrained by low homing and survival rate of transplanted cells in the injured organs. Therefore, developing strategies to improve homing an...

journal_title：Journal of molecular histology

authors： Saberi K,Pasbakhsh P,Omidi A,Borhani-Haghighi M,Nekoonam S,Omidi N,Ghasemi S,Kashani IR

更新日期：2019-04-01 00:00:00

abstract：:Craniofacial autologous bone grafts offer superior outcomes to long bone grafts in the reconstruction of maxillofacial bone defects, but the mechanism responsible for this superiority has not yet been illustrated clearly. Osteoblasts play vital roles in bone development and regeneration. However, presently, only a few...

journal_title：Journal of molecular histology

authors： Yang X,Jiang J,Zhou L,Wang S,He M,Luo K,Chen Y,Xu X

更新日期：2019-04-01 00:00:00

abstract：:Dentin is a major component of teeth that protects dental pulp and maintains tooth health. Bone morphogenetic protein (BMP) signaling is required for the formation of dentin. Mice lacking a BMP type I receptor, activin A receptor type 1 (ACVR1), in the neural crest display a deformed mandible. Acvr1 is known to be exp...

journal_title：Journal of molecular histology

authors： Zhang X,Shi C,Zhao H,Zhou Y,Hu Y,Yan G,Liu C,Li D,Hao X,Mishina Y,Liu Q,Sun H

更新日期：2019-02-01 00:00:00

abstract：:In the original publication of the article, two errors were made in describing the equations for Tc. ...

journal_title：Journal of molecular histology

authors： Harris L,Zalucki O,Piper M

更新日期：2018-08-01 00:00:00

abstract：:Follistatin like-1 (Fstl1) is a secreted glycoprotein and can be up-regulated by TGF-β1. To better study the function of Fstl1 in lung development, we examined Fstl1 expression in the developing lung, in a cell type specific manner, using a tamoxifen inducible Fstl1-reporter mouse strain. Our results show that Fstl1 i...

journal_title：Journal of molecular histology

authors： Liu X,Liu Y,Yang Z,Ning W

更新日期：2018-08-01 00:00:00

abstract：:Satellite glial cells (SGCs), a peripheral neuroglial cell, surround neurons and form a complete envelope around individual sensory neurons in the trigeminal ganglia (TG), which may be involved in modulating neurons in inflammation. The purpose of this study was to determine the effect of dental injury and inflammatio...

journal_title：Journal of molecular histology

authors： Liu H,Zhao L,Gu W,Liu Q,Gao Z,Zhu X,Wu Z,He H,Huang F,Fan W

更新日期：2018-06-01 00:00:00

abstract：:Zinc is a vital co-factor for insulin metabolism in the pancreatic β-cell, involved in synthesis, maturation, and crystallization. Two families of zinc transporters, namely SLC30A (ZNT) and SLC39A (ZIP) are involved in maintaining cellular zinc homeostasis in mammalian cells. Single nuclear polymorphisms or mutations ...

journal_title：Journal of molecular histology

authors： Cai Y,Kirschke CP,Huang L

更新日期：2018-04-01 00:00:00

abstract：:Some members of aquaporin family (AQP) plays crucial functions in salivary synthesis and secretion. These proteins expression has already been reported during salivary gland formation, however no previous studies in human developing glands have been performed. We evaluated AQP1, 3 and 5 expression through the stages o...

journal_title：Journal of molecular histology

authors： de Paula F,Teshima THN,Hsieh R,Souza MM,Coutinho-Camillo CM,Nico MMS,Lourenco SV

更新日期：2017-12-01 00:00:00

abstract：:Submandibular gland (SMG) autotransplantation is an effective therapy for treating severe dry eye syndrome. However, epiphora occurs in more than 40% of patients 6 months after operation. We previously found that muscarinic acetylcholine receptor (mAChR) plays a crucial role in regulating SMG secretion partially throu...

journal_title：Journal of molecular histology

authors： Yang NY,Ding C,Li J,Zhang Y,Xiang RL,Wu LL,Yu GY,Cong X

更新日期：2017-04-01 00:00:00

abstract：:DLBCL is the most common lymphoma subtype occurring in older populations as well as in younger HIV infected patients. The current treatment options for DLBCL are effective for most patients yet the relapse rate is high. While many biomarkers for DLBCL exist, they are not in clinical use due to low sensitivity and spec...

journal_title：Journal of molecular histology

authors： Magangane P,Sookhayi R,Govender D,Naidoo R

更新日期：2016-12-01 00:00:00

abstract：:Stromal cells in the peripheral zone (PZ) of the prostate from older males (PZ-old) could significantly promote Prostate cancer (PCa) growth compared with stromal cells from young males (PZ-young). But the mechanism is still unknown. In the co-culture system with PZ-old cells, Pc3/Du145 cells showed advanced prolifera...

journal_title：Journal of molecular histology

authors： Zou Q,Cui D,Liang S,Xia S,Jing Y,Han B

更新日期：2016-06-01 00:00:00

abstract：:Nickel nanoparticles (Ni NPs) have been applied in various fields along with the rapid development of nanotechnology. However, the potential adverse health effects of the Ni NPs are unclear. To investigate the cyto- and genotoxicity and compare the differences between the Ni NPs and the nickel fine particles (Ni FPs),...

journal_title：Journal of molecular histology

authors： Magaye R,Gu Y,Wang Y,Su H,Zhou Q,Mao G,Shi H,Yue X,Zou B,Xu J,Zhao J

更新日期：2016-06-01 00:00:00

abstract：:Four and a half LIM domains 2 (FHL2) is a protein of 279 amino acids in length containing four full LIM-domains and a half LIM-domain at the amino terminus. FHL2 is one transcriptional cofactor that can interact with many different proteins, such as AP-1, BRCA1, IGFBP, and integrin, and involved in organ differentiati...

journal_title：Journal of molecular histology

authors： Wang Q,Wang X,Tian X,Tang R,Xu X

更新日期：2016-04-01 00:00:00

abstract：:Aquaporins (AQPs), the rapid transition pores for water molecules, play an important role in maintenance of intracellular water balance. Studies showed that AQPs were also involved in occurrence, development, invasion and metastasis of tumors. In this study, we aimed to explore the distribution and expression differen...

journal_title：Journal of molecular histology

authors： Ma J,Zhou C,Yang J,Ding X,Zhu Y,Chen X

更新日期：2016-04-01 00:00:00

abstract：:The aim of the present study was to investigate the association between KDM3A expression and the clinicopathological parameters of patients with epithelial ovarian cancer (EOC). KDM3A expression was analyzed using immunohistochemistry in EOC tissue microarray containing 90 paired cases of EOC and matched normal contro...

journal_title：Journal of molecular histology

authors：

更新日期：2016-04-01 00:00:00

abstract：:Multidrug resistance-associated protein 1 (MRP1) belongs to ATP-binding cassette transporters family. The overexpression of MRP1 is predominantly related with the failure of chemo-radiotherapy in various tumors. However, its possible role in hypertrophic scar (HS) is hardly investigated. Here we showed that the mRNA l...

journal_title：Journal of molecular histology

authors： Li Y,Yang L,Zheng Z,Shi J,Wu X,Guan H,Jia Y,Tao K,Wang H,Han S,Gao J,Zhao B,Su L,Hu D

更新日期：2015-10-01 00:00:00

abstract：:Cyclin G1 plays an essential role in the development of human carcinoma. Here, we characterized the clinical significance of Cyclin G1 and investigated its role in cellular proliferation and apoptosis of epithelial ovarian cancer (EOC). Western blot was used to evaluate the expression of Cyclin G1 in nine fresh EOC ti...

journal_title：Journal of molecular histology

authors： Jiang L,Liu R,Wang Y,Li C,Xi Q,Zhong J,Liu J,Yang S,Wang J,Huang M,Tang C,Fang Z

更新日期：2015-06-01 00:00:00

abstract：:Polycystic ovary syndrome (PCOS) is a major health problem in reproductive-aged women worldwide, but the precise pathogenesis of PCOS remains unclear. Our previous study revealed that hypoxia-inducible factor (HIF)-1a mediated endothelin (ET)-2 signaling plays an important role in ovulation in rats. Therefore, the pre...

journal_title：Journal of molecular histology

authors： Wang F,Zhang Z,Wang Z,Xiao K,Wang Q,Su J,Wang Z

更新日期：2015-04-01 00:00:00

abstract：:Elevated expression of CXCL9 has been shown to involve in the infiltration of inflammatory cells and liver damage after Hepatitis B virus (HBV) infection. However, whether and by what underlying mechanism does CXCL9 play a role in HBV infection associated hepatocellular carcinoma (HCC) invasion ability remain unclear....

journal_title：Journal of molecular histology

authors： Lan X,Xiao F,Ding Q,Liu J,Liu J,Li J,Zhang J,Tian DA

更新日期：2014-12-01 00:00:00

abstract：:Spatio-temporal immunolocalizations of cytokeratin 8 (CK8), vimentin, syndecan-1 and Ki-67 were analyzed in ten human incisors and canine tooth germs between the 7th and 20th developmental weeks. CK8 expression was mild to moderate in the epithelial tooth parts, while it shifted from absent or mild in its mesenchymal ...

journal_title：Journal of molecular histology

authors： Kero D,Kalibovic Govorko D,Vukojevic K,Cubela M,Soljic V,Saraga-Babic M

更新日期：2014-12-01 00:00:00

abstract：:TGF-β1, SNAI1 and MMP-9 are implicated in tumor invasion and metastasis. The purpose of this study was to examine TGF-β1, SNAI1 and MMP-9 expression in papillary thyroid carcinoma (PTC), and to assess association of TGF-β1, SNAI1 and MMP-9 expression with several clinicopathological indicators of PTC. TGF-β1, SNAI1 an...

journal_title：Journal of molecular histology

authors： Wang N,Jiang R,Yang JY,Tang C,Yang L,Xu M,Jiang QF,Liu ZM

更新日期：2014-08-01 00:00:00

abstract：:MicroRNAs are small noncoding RNAs involved in various biological processes. We characterized the expression of miR-344-3p during mouse embryonic development. At E9.5-E10.5 and E15.5, in situ hybridization detected strong miR-344-3p signal in the central nervous system, including the cerebral cortex, hindbrain, cerebe...

journal_title：Journal of molecular histology

authors： Liu Q,He H,Zeng T,Huang Z,Fan T,Wu Q

更新日期：2014-08-01 00:00:00

abstract：:This study aimed to explore whether the altered expression of tumor necrosis factor-alpha (TNF-α), vascular endothelial growth factor (VEGF) and apoptotic changes in mid zone (MZ) and rupture zone (RZ) of fetal membranes (FM) are regulatory mechanisms associated with labor at term. Fifteen FM specimens were collected ...

journal_title：Journal of molecular histology

authors： Elfayomy AK,Almasry SM

更新日期：2014-06-01 00:00:00