Protein expression of the transcriptional regulator MI-ER1 alpha in adult mouse tissues.

abstract：:Tyrosyl-DNA phosphodiesterase 1 (Tdp1) is a DNA repair enzyme that processes blocked 3' ends of DNA breaks. Functional loss of Tdp1 causes spinocerebellar ataxia with axonal neuropathy type 1 (SCAN1). Based on the prominent cytoplasmic expression of Tdp1 in the neurons presumably affected in SCAN1, we hypothesized tha...

journal_title：Journal of molecular histology

authors： Fam HK,Chowdhury MK,Walton C,Choi K,Boerkoel CF,Hendson G

更新日期：2013-08-01 00:00:00

abstract：:The first cell lineage differentiation occurs during the development of mouse 8-cell embryo to blastocyst. Akt is a potent kinase whose role during blastocyst formation has not been elucidated. In the present study, immunofluorescence results showed that the Akt protein was specifically localized to the outer cells of...

journal_title：Journal of molecular histology

authors： Xu S,Pang L,Liu Y,Lian X,Mo K,Lv R,Zhu H,Lv C,Lin J,Sun J,Xu L,Wang S

更新日期：2019-08-01 00:00:00

abstract：:With the marker of Paneth cells-lysozyme, secretory component (SC) immunoreactivity was demonstrated exclusively in Paneth cells of rat small intestine. The other types of epithelial cells (columnar, goblet, endocrine) were negative. On electron microscopic level, many SC-positive colloidal gold particles were found i...

journal_title：Journal of molecular histology

authors： Tang QJ,Tao KZ,Yun-Liu,Sun XJ,Geng MY,Jiang CL

更新日期：2005-06-01 00:00:00

abstract：:The incidence of chronic renal diseases is increasing worldwide, and there is a great need to identify therapies capable of arresting or reducing disease progression. The current treatment of chronic nephropathies is limited to angiotensin-converting enzyme inhibitors and angiotensin receptor blockers, but increasing ...

journal_title：Journal of molecular histology

authors： de Barros EP,Garcia-Pinto AB,Machado PY,dos Santos Pereira MJ,de Carvalho JJ

更新日期：2011-08-01 00:00:00

abstract：:This study aimed to explore whether the altered expression of tumor necrosis factor-alpha (TNF-α), vascular endothelial growth factor (VEGF) and apoptotic changes in mid zone (MZ) and rupture zone (RZ) of fetal membranes (FM) are regulatory mechanisms associated with labor at term. Fifteen FM specimens were collected ...

journal_title：Journal of molecular histology

authors： Elfayomy AK,Almasry SM

更新日期：2014-06-01 00:00:00

abstract：:Chronic stress is regarded as a significant factor in the etiology of the many diseases. Numerous methods have been developed through which the effect of chronic stress is examined. The aim of this study is to demonstrate the new experimental model for analysis of immuno-suppression induced by chronic restraint stress...

journal_title：Journal of molecular histology

authors： Smieško G,Banović P,Gusman V,Simin V,Cimpean AM,Lalošević D

更新日期：2020-08-01 00:00:00

abstract：:DLBCL is the most common lymphoma subtype occurring in older populations as well as in younger HIV infected patients. The current treatment options for DLBCL are effective for most patients yet the relapse rate is high. While many biomarkers for DLBCL exist, they are not in clinical use due to low sensitivity and spec...

journal_title：Journal of molecular histology

authors： Magangane P,Sookhayi R,Govender D,Naidoo R

更新日期：2016-12-01 00:00:00

abstract：:Adipose-derived mesenchymal stem cell (ADSC) with a high capacity of chondrogenic differentiation was a promising candidate for cartilage defect treatment. This study's objective is to study the roles of integrin β1 (ITGB1) in regulating ADSC chondrogenic differentiations as well as the underlying mechanisms. The iden...

journal_title：Journal of molecular histology

authors： Luo S,Shi Q,Li W,Wu W,Zha Z

更新日期：2020-12-01 00:00:00

abstract：:Bone marrow-derived mesenchymal stem cells (BMMSCs) transplantation has shown to be effective in treating chronic kidney disease. However, the effectiveness of this strategy is constrained by low homing and survival rate of transplanted cells in the injured organs. Therefore, developing strategies to improve homing an...

journal_title：Journal of molecular histology

authors： Saberi K,Pasbakhsh P,Omidi A,Borhani-Haghighi M,Nekoonam S,Omidi N,Ghasemi S,Kashani IR

更新日期：2019-04-01 00:00:00

abstract：:Nickel nanoparticles (Ni NPs) have been applied in various fields along with the rapid development of nanotechnology. However, the potential adverse health effects of the Ni NPs are unclear. To investigate the cyto- and genotoxicity and compare the differences between the Ni NPs and the nickel fine particles (Ni FPs),...

journal_title：Journal of molecular histology

authors： Magaye R,Gu Y,Wang Y,Su H,Zhou Q,Mao G,Shi H,Yue X,Zou B,Xu J,Zhao J

更新日期：2016-06-01 00:00:00

abstract：:Craniofacial autologous bone grafts offer superior outcomes to long bone grafts in the reconstruction of maxillofacial bone defects, but the mechanism responsible for this superiority has not yet been illustrated clearly. Osteoblasts play vital roles in bone development and regeneration. However, presently, only a few...

journal_title：Journal of molecular histology

authors： Yang X,Jiang J,Zhou L,Wang S,He M,Luo K,Chen Y,Xu X

更新日期：2019-04-01 00:00:00

abstract：:The distribution of molecular components of interendothelial tight junctions (TJs) was studied in rat blood-brain barrier (BBB) microvessels, using immunogold cytochemistry applied to electron microscopy. Samples of rat brains, both normal (unaffected) and osmotically-affected (1, 5, and 30 min after intracarotid infu...

journal_title：Journal of molecular histology

authors： Dobrogowska DH,Vorbrodt AW

更新日期：2004-06-01 00:00:00

abstract：:Vesicular monoamine transporter 2 (VMAT2) is expressed in pancreatic beta cells and has recently been proposed as a target for measurement of beta cell mass in vivo. We questioned, (1) What proportion of beta cells express VMAT2? (2) Is VMAT2 expressed by other pancreatic endocrine or non-endocrine cells? (3) Is the r...

journal_title：Journal of molecular histology

authors： Saisho Y,Harris PE,Butler AE,Galasso R,Gurlo T,Rizza RA,Butler PC

更新日期：2008-10-01 00:00:00

abstract：:Dentin is a major component of teeth that protects dental pulp and maintains tooth health. Bone morphogenetic protein (BMP) signaling is required for the formation of dentin. Mice lacking a BMP type I receptor, activin A receptor type 1 (ACVR1), in the neural crest display a deformed mandible. Acvr1 is known to be exp...

journal_title：Journal of molecular histology

authors： Zhang X,Shi C,Zhao H,Zhou Y,Hu Y,Yan G,Liu C,Li D,Hao X,Mishina Y,Liu Q,Sun H

更新日期：2019-02-01 00:00:00

abstract：:Epidermal adult stem cells (EpiASCs) have the potential for unlimited proliferation and differentiation, however, the ability of these stem cells to activate corneal genetic programs in response to corneal stroma stimulation needs to be further validated. Herein, a feasible strategy was developed to reconstruct the da...

journal_title：Journal of molecular histology

authors： Zhang P,Ma XY,Huang DT,Yang XY

更新日期：2020-06-01 00:00:00

abstract：:Nel-like molecule-1 (NELL-1) is a novel highly specific growth factor that can induce osteoblast differentiation and bone formation as well as odontoblast differentiation. Recent studies have suggested that NELL-1 can synergistically increase bone formation and regeneration with bone morphogenetic protein 2 (BMP2) and...

journal_title：Journal of molecular histology

authors： Wu J,Wang Q,Han Q,Zhu H,Li M,Fang Y,Wang X

更新日期：2019-06-01 00:00:00

abstract：:Polycystic ovary syndrome (PCOS) is a major health problem in reproductive-aged women worldwide, but the precise pathogenesis of PCOS remains unclear. Our previous study revealed that hypoxia-inducible factor (HIF)-1a mediated endothelin (ET)-2 signaling plays an important role in ovulation in rats. Therefore, the pre...

journal_title：Journal of molecular histology

authors： Wang F,Zhang Z,Wang Z,Xiao K,Wang Q,Su J,Wang Z

更新日期：2015-04-01 00:00:00

abstract：:The members of high-temperature requirement (HtrA) family are evolutionarily conserved serine proteases that combine a trypsin-like protease domain with at least one PDZ interaction domain. HtrA2, a special one, is mainly located in mitochondria and required for maintaining homeostasis. Once released into cytoplasm, H...

journal_title：Journal of molecular histology

authors： Sun H,Li L,Zhou F,Zhu L,Ke K,Tan X,Xu W,Rui Y,Zheng H,Zhou Z,Yang H

更新日期：2013-08-01 00:00:00

abstract：:Cyclin G1 plays an essential role in the development of human carcinoma. Here, we characterized the clinical significance of Cyclin G1 and investigated its role in cellular proliferation and apoptosis of epithelial ovarian cancer (EOC). Western blot was used to evaluate the expression of Cyclin G1 in nine fresh EOC ti...

journal_title：Journal of molecular histology

authors： Jiang L,Liu R,Wang Y,Li C,Xi Q,Zhong J,Liu J,Yang S,Wang J,Huang M,Tang C,Fang Z

更新日期：2015-06-01 00:00:00

abstract：:The natriuretic peptide (NP) system comprises of three ligands, the Atrial Natriuretic Peptide (ANP), Brain Natriuretic peptide (BNP) and C-type Natriuretic peptide (CNP), and three natriuretic peptide receptors, NPRA, NPRB and NPRC. Here we present a comprehensive study of the natriuretic peptide system in healthy mu...

journal_title：Journal of molecular histology

authors： Ahmed A,Gulino A,Amayo S,Arancio W,Florena AM,Belmonte B,Jurjus A,Leone A,Miletich I

更新日期：2020-02-01 00:00:00

abstract：:Some members of aquaporin family (AQP) plays crucial functions in salivary synthesis and secretion. These proteins expression has already been reported during salivary gland formation, however no previous studies in human developing glands have been performed. We evaluated AQP1, 3 and 5 expression through the stages o...

journal_title：Journal of molecular histology

authors： de Paula F,Teshima THN,Hsieh R,Souza MM,Coutinho-Camillo CM,Nico MMS,Lourenco SV

更新日期：2017-12-01 00:00:00

abstract：:The aim of the present study was to investigate the association between KDM3A expression and the clinicopathological parameters of patients with epithelial ovarian cancer (EOC). KDM3A expression was analyzed using immunohistochemistry in EOC tissue microarray containing 90 paired cases of EOC and matched normal contro...

journal_title：Journal of molecular histology

authors：

更新日期：2016-04-01 00:00:00

abstract：:Zinc is a vital co-factor for insulin metabolism in the pancreatic β-cell, involved in synthesis, maturation, and crystallization. Two families of zinc transporters, namely SLC30A (ZNT) and SLC39A (ZIP) are involved in maintaining cellular zinc homeostasis in mammalian cells. Single nuclear polymorphisms or mutations ...

journal_title：Journal of molecular histology

authors： Cai Y,Kirschke CP,Huang L

更新日期：2018-04-01 00:00:00

abstract：:Quantitative immunogold procedure was used to study the distribution of molecular components of interendothelial junctions in blood-brain barrier (BBB) microvessels of scrapie infected SJL/J hyperglycemic mice showing obesity and reduced glucose tolerance. Samples of brain (fronto-parietal cerebral cortex and thalamo-...

journal_title：Journal of molecular histology

authors： Vorbrodt AW,Dobrogowska DH,Tarnawski M,Meeker HC,Carp RI

更新日期：2006-01-01 00:00:00

abstract：:As one of the most common cancers in female, ovarian cancer (OC) has become a serious public burden now. Mounting researches have indicated long noncoding RNAs (lncRNAs) can affect many biological processes including cancer development. LncRNA LBX2-AS1 was identified to be an oncogene in some cancers, but the role of ...

journal_title：Journal of molecular histology

authors： Gu H,Lin R,Zheng F,Zhang Q

更新日期：2021-02-01 00:00:00

abstract：:Odontogenic keratocysts (OKCs) are jaw cystic lesions which are characterized by local invasion and high recurrence rate. The majority of OKCs are exposed to microorganisms and occur along with focal inflammatory infiltrates. Cyst fluids are biological fluids that contain a large content of cytokines and immune globul...

journal_title：Journal of molecular histology

authors： Man QW,Zhong WQ,Zhao YF,Liu B,Zhao Y

更新日期：2019-08-01 00:00:00

abstract：:Computational modelling of whole biological systems from cells to organs is gaining momentum in cell biology and disease studies. This pathway is essential for the derivation of explanatory frameworks that will facilitate the development of a predictive capacity for estimating outcomes or risk associated with particul...

journal_title：Journal of molecular histology

authors： Moore MN,Noble D

更新日期：2004-09-01 00:00:00

abstract：:Neutrotrophins are increasingly appreciated as potential modulators of neuronal function in the adult central nervous system (CNS). To describe the neurotrophin environment within the adult CNS, mRNA and protein expression patterns of neurotrophins-3 and -4 and of brain-derived neurotrophin were investigated in adult ...

journal_title：Journal of molecular histology

authors： Riley CP,Cope TC,Buck CR

更新日期：2004-11-01 00:00:00

abstract：:Vascular endothelial growth factor (VEGF) is an important angiogenic factor in the pituitary gland. The objective of this study was to unveil the VEGF subcellular localisation in different pituitary cell types and to evaluate changes in its expression at different time intervals after oestrogen stimulation. A relevant...

journal_title：Journal of molecular histology

authors： Mukdsi JH,De Paul AL,Gutiérrez S,Roth FD,Aoki A,Torres AI

更新日期：2005-10-01 00:00:00

abstract：:p21-activated Kinase 6 (PAK6) is a serine/threonine kinase belonging to the p21-activated kinase (PAK) family. PAK kinases are well-known regulators of a wide variety of cellular functions, including regulation of cytoskeleton rearrangement, cell survival, apoptosis and the mitogen-activated protein kinase signaling p...

journal_title：Journal of molecular histology

authors： Zhao W,Yang J,Shi W,Wu X,Shao B,Wu Q,Chen J,Ni L

更新日期：2011-06-01 00:00:00