Abstract:
:Microscopy is advancing at a rapid pace, enabling high-speed, high-resolution analyses to be conducted in a wide range of cellular contexts. For example, the capacity to quickly capture high-resolution images from multiple optical sections over multiple channels with confocal microscopy has allowed researchers to gain deeper understanding of tissue morphology via techniques such as three-dimensional rendering, as have more recent advances such as lattice light sheet microscopy and superresolution structured illumination microscopy. With this, though, comes the challenge of storing, curating, analysing and sharing data. While there are ways in which this has been attempted previously, few approaches have provided a central repository in which all of these different aspects of microscopy can be seamlessly integrated. Here, we describe a web-based storage and analysis platform called Microndata, that enables relatively straightforward storage, annotation, tracking, analysis and multi-user access to micrographs. This easy to use tool will simplify and harmonise laboratory work flows, and, importantly, will provide a central storage repository that is readily accessed, even after the researcher responsible for capturing the images has left the laboratory. Microndata is open-source software, available at http://www.microndata.net/.
journal_name
J Mol Histoljournal_title
Journal of molecular histologyauthors
Davila RA,Harkins D,Currey L,Fraser J,Bowles J,Piper Mdoi
10.1007/s10735-019-09850-ysubject
Has Abstractpub_date
2019-12-01 00:00:00pages
573-580issue
6eissn
1567-2379issn
1567-2387pii
10.1007/s10735-019-09850-yjournal_volume
50pub_type
杂志文章abstract::TGF-β1, SNAI1 and MMP-9 are implicated in tumor invasion and metastasis. The purpose of this study was to examine TGF-β1, SNAI1 and MMP-9 expression in papillary thyroid carcinoma (PTC), and to assess association of TGF-β1, SNAI1 and MMP-9 expression with several clinicopathological indicators of PTC. TGF-β1, SNAI1 an...
journal_title:Journal of molecular histology
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abstract::Elevated expression of CXCL9 has been shown to involve in the infiltration of inflammatory cells and liver damage after Hepatitis B virus (HBV) infection. However, whether and by what underlying mechanism does CXCL9 play a role in HBV infection associated hepatocellular carcinoma (HCC) invasion ability remain unclear....
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abstract::The aim of this study was to investigate oxidative DNA damage during 4-nitroquinoline 1-oxide (4NQO)-induced rat tongue carcinogenesis. For this purpose, male Wistar rats were distributed into three groups of 10 animals each and treated with 50 ppm 4NQO solution through their drinking water for 4, 12, and 20 weeks. Te...
journal_title:Journal of molecular histology
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abstract::The aim of the present study was to investigate the association between KDM3A expression and the clinicopathological parameters of patients with epithelial ovarian cancer (EOC). KDM3A expression was analyzed using immunohistochemistry in EOC tissue microarray containing 90 paired cases of EOC and matched normal contro...
journal_title:Journal of molecular histology
pub_type: 撤回出版物,收录出版
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abstract::p21-activated Kinase 6 (PAK6) is a serine/threonine kinase belonging to the p21-activated kinase (PAK) family. PAK kinases are well-known regulators of a wide variety of cellular functions, including regulation of cytoskeleton rearrangement, cell survival, apoptosis and the mitogen-activated protein kinase signaling p...
journal_title:Journal of molecular histology
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doi:10.1007/s10735-011-9324-8
更新日期:2011-06-01 00:00:00
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journal_title:Journal of molecular histology
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doi:10.1007/s10735-013-9553-0
更新日期:2014-06-01 00:00:00
abstract::Multidrug resistance-associated protein 1 (MRP1) belongs to ATP-binding cassette transporters family. The overexpression of MRP1 is predominantly related with the failure of chemo-radiotherapy in various tumors. However, its possible role in hypertrophic scar (HS) is hardly investigated. Here we showed that the mRNA l...
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更新日期:2015-10-01 00:00:00
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journal_title:Journal of molecular histology
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abstract::The cytoplasmic Cu/Zn-superoxide dismutase (SOD1) represents along with catalase and glutathione peroxidase at the first defense line against reactive oxygen species in all aerobic organisms, but little is known about its distribution in developing embryos. In this study, the expression patterns of SOD1 mRNA in mouse ...
journal_title:Journal of molecular histology
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doi:10.1007/s10735-007-9134-1
更新日期:2008-02-01 00:00:00
abstract::The first cell lineage differentiation occurs during the development of mouse 8-cell embryo to blastocyst. Akt is a potent kinase whose role during blastocyst formation has not been elucidated. In the present study, immunofluorescence results showed that the Akt protein was specifically localized to the outer cells of...
journal_title:Journal of molecular histology
pub_type: 杂志文章
doi:10.1007/s10735-019-09833-z
更新日期:2019-08-01 00:00:00
abstract::Computational modelling of whole biological systems from cells to organs is gaining momentum in cell biology and disease studies. This pathway is essential for the derivation of explanatory frameworks that will facilitate the development of a predictive capacity for estimating outcomes or risk associated with particul...
journal_title:Journal of molecular histology
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doi:10.1007/s10735-004-2653-0
更新日期:2004-09-01 00:00:00
abstract::Inpp5f-v3 is a transcriptional variant of Inpp5f (inositol polyphosphate-5-phosphatase F) and locates in distal mouse chromosome 7. It is a paternally expressed imprinted gene in mouse. In this study, we examined the spatiotemporal patterns of Inpp5f-v3 gene during the mouse development. The northern blotting analysis...
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abstract::Uterine Natural Killer (uNK) cells are the most abundant lymphocyte population recruited in the uteri during murine and human pregnancy. Previous investigation on uNK cells during mouse pregnancy focused more on its accumulation in postimplantation periods, which were believed to play important roles in regulating tro...
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更新日期:2010-02-01 00:00:00
abstract::During human pregnancy the placenta produces a variety of proteins like steroid hormones and their receptors that are responsible for the establishment and ongoing of the feto-placental unit. Inhibins are dimeric glycoproteins, composed of an alpha-subunit and one of two possible beta-subunits (beta (A) or beta (B)). ...
journal_title:Journal of molecular histology
pub_type: 杂志文章
doi:10.1007/s10735-006-9029-6
更新日期:2006-01-01 00:00:00
abstract::The natriuretic peptide (NP) system comprises of three ligands, the Atrial Natriuretic Peptide (ANP), Brain Natriuretic peptide (BNP) and C-type Natriuretic peptide (CNP), and three natriuretic peptide receptors, NPRA, NPRB and NPRC. Here we present a comprehensive study of the natriuretic peptide system in healthy mu...
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pub_type: 杂志文章
doi:10.1007/s10735-019-09849-5
更新日期:2020-02-01 00:00:00
abstract::Vesicular monoamine transporter 2 (VMAT2) is expressed in pancreatic beta cells and has recently been proposed as a target for measurement of beta cell mass in vivo. We questioned, (1) What proportion of beta cells express VMAT2? (2) Is VMAT2 expressed by other pancreatic endocrine or non-endocrine cells? (3) Is the r...
journal_title:Journal of molecular histology
pub_type: 杂志文章,多中心研究
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更新日期:2008-10-01 00:00:00
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journal_title:Journal of molecular histology
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abstract::Alveolar macrophages (AMs) play a vital role in lung immunity. The recent studies demonstrated that potassium channels were associated with macrophage functions, such as activation, migration and cytokines secretion. However, less is known regarding the expression and function of ERG channels in AMs. Our study showed ...
journal_title:Journal of molecular histology
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更新日期:2013-02-01 00:00:00
abstract::DLBCL is the most common lymphoma subtype occurring in older populations as well as in younger HIV infected patients. The current treatment options for DLBCL are effective for most patients yet the relapse rate is high. While many biomarkers for DLBCL exist, they are not in clinical use due to low sensitivity and spec...
journal_title:Journal of molecular histology
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更新日期:2016-12-01 00:00:00
abstract::Zinc is a vital co-factor for insulin metabolism in the pancreatic β-cell, involved in synthesis, maturation, and crystallization. Two families of zinc transporters, namely SLC30A (ZNT) and SLC39A (ZIP) are involved in maintaining cellular zinc homeostasis in mammalian cells. Single nuclear polymorphisms or mutations ...
journal_title:Journal of molecular histology
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doi:10.1007/s10735-017-9753-0
更新日期:2018-04-01 00:00:00
abstract::Gekko japonicus undergoes dramatic changes in the caudal spinal cord after tail amputation. The amputation induces cell proliferation in the caudal ependymal tube. We performed hematoxylin and eosin staining at different time points in the regeneration process to investigate the morphological characterization of the r...
journal_title:Journal of molecular histology
pub_type: 杂志文章
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更新日期:2013-06-01 00:00:00
abstract::Estrogens and their receptors are important factors involved in periodontal ligament (PDL) tissue health. As a regulator of estrogen receptors (ER), the proline-, glutamic acid-, and leucine-rich protein 1 (PELP1) may play a role in alveolar bone formation and PDL homeostasis. The aim of the present study was to obser...
journal_title:Journal of molecular histology
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更新日期:2013-06-01 00:00:00
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journal_title:Journal of molecular histology
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更新日期:2018-06-01 00:00:00
abstract::Heparan sulfate proteoglycans (HSPGs) are complex and labile macromolecular moieties on the surfaces of cells that control the activities of a range of extracellular proteins, particularly those driving growth and regeneration. Here, we examine the biosynthesis of heparan sulfate (HS) sugars produced by cultured MC3T3...
journal_title:Journal of molecular histology
pub_type: 杂志文章
doi:10.1007/s10735-007-9123-4
更新日期:2007-10-01 00:00:00
abstract::Selective cyclooxygenase-2 non-steroidal anti-inflammatory drugs are known to inhibit bone repair, especially when long-term administration is required due to chronicle inflammatory diseases. In order to evaluate the action of this drug in bone repair during short-term administration, 48 rats underwent surgical bone d...
journal_title:Journal of molecular histology
pub_type: 杂志文章
doi:10.1007/s10735-008-9176-z
更新日期:2008-08-01 00:00:00