Abstract:
:Despite the efficacy of tamoxifen in preventing disease relapse, a large portion of breast cancer patients show intrinsic or acquired resistance to tamoxifen, leading to treatment failure and unfavorable clinical outcome. MYB proto-oncogene like 2 (MYBL2) is a transcription factor implicated in the initiation and progression of various human cancers. However, its role in tamoxifen resistance in breast cancer remained largely unknown. In the present study, by analyzing public transcriptome dataset, we found that MYBL2 is overexpressed in breast cancer and is associated with the poor prognosis of breast cancer patients. By establishing tamoxifen-resistant breast cancer cell lines, we also provided evidence that MYBL2 overexpression contributes to tamoxifen resistance by up-regulating its downstream transcriptional effectors involved in cell proliferation (PLK1, PRC1), survival (BIRC5) and metastasis (HMMR). In contrast, inhibiting those genes via MYBL2 depletion suppresses cancer progression, restores tamoxifen and eventually reduces the risk of disease recurrence. All these findings revealed a critical role of MYBL2 in promoting tamoxifen resistance and exacerbating the progression of breast cancer, which may serve as a novel therapeutic target to overcome drug resistance and improve the prognosis of breast cancer patients.
journal_name
J Mol Histoljournal_title
Journal of molecular histologyauthors
Li X,Zhang X,Wu CC,Li PP,Fu YM,Xie LH,Sun SS,Zhou YY,Zhu BLdoi
10.1007/s10735-020-09920-6subject
Has Abstractpub_date
2021-02-01 00:00:00pages
21-30issue
1eissn
1567-2379issn
1567-2387pii
10.1007/s10735-020-09920-6journal_volume
52pub_type
杂志文章abstract::MicroRNAs are small noncoding RNAs involved in various biological processes. We characterized the expression of miR-344-3p during mouse embryonic development. At E9.5-E10.5 and E15.5, in situ hybridization detected strong miR-344-3p signal in the central nervous system, including the cerebral cortex, hindbrain, cerebe...
journal_title:Journal of molecular histology
pub_type: 杂志文章
doi:10.1007/s10735-013-9555-y
更新日期:2014-08-01 00:00:00
abstract::Human pluripotent stem cell (hPSC)-derived cardiomyocytes (CMs) hold great promise for the repair of the injured heart, but optimal cell production in a fully chemically defined and cost-effective system is essential for the efficacy and safety of cell transplantation therapies. In this study, we provided a simple and...
journal_title:Journal of molecular histology
pub_type: 杂志文章
doi:10.1007/s10735-020-09926-0
更新日期:2021-02-01 00:00:00
abstract::Prostate cancer is the most common cancer in American men and the second leading cause of cancer deaths in this group. Both growth hormone (GH) and the inflammatory cytokine interleukin 6 (IL-6) have been implicated in prostate cancer progression. Studies in other systems have shown that an increase in GH results in a...
journal_title:Journal of molecular histology
pub_type: 杂志文章
doi:10.1007/s10735-006-9027-8
更新日期:2006-01-01 00:00:00
abstract::Angiotensin II (Ang II) has been reported to cause podocyte apoptosis in rats both in vivo and in vitro studies. However, the underlying mechanisms are poorly understood. In the present study, we investigated the role of the nonreceptor tyrosine kinase c-Abl in Ang II-induced podocyte apoptosis. Male Sprague-Dawley ra...
journal_title:Journal of molecular histology
pub_type: 杂志文章
doi:10.1007/s10735-013-9505-8
更新日期:2013-10-01 00:00:00
abstract::Previous findings have shown that P2X-purinoceptor-mediated signaling pathways regulate the release of ACh in the retina. We previously reported the existence of immunoreactivity for P2X1-, P2X2-, P2X4-, and P2X7-purinoceptors in mouse retina and speculated that P2X2 and P2X7-purinoceptors may modulate the activity of...
journal_title:Journal of molecular histology
pub_type: 杂志文章
doi:10.1007/s10735-007-9107-4
更新日期:2007-08-01 00:00:00
abstract::Vesicular monoamine transporter 2 (VMAT2) is expressed in pancreatic beta cells and has recently been proposed as a target for measurement of beta cell mass in vivo. We questioned, (1) What proportion of beta cells express VMAT2? (2) Is VMAT2 expressed by other pancreatic endocrine or non-endocrine cells? (3) Is the r...
journal_title:Journal of molecular histology
pub_type: 杂志文章,多中心研究
doi:10.1007/s10735-008-9195-9
更新日期:2008-10-01 00:00:00
abstract::Odontogenic keratocysts (OKCs) are jaw cystic lesions which are characterized by local invasion and high recurrence rate. The majority of OKCs are exposed to microorganisms and occur along with focal inflammatory infiltrates. Cyst fluids are biological fluids that contain a large content of cytokines and immune globul...
journal_title:Journal of molecular histology
pub_type: 杂志文章
doi:10.1007/s10735-019-09829-9
更新日期:2019-08-01 00:00:00
abstract::Heparan sulfate proteoglycans (HSPGs) are complex and labile macromolecular moieties on the surfaces of cells that control the activities of a range of extracellular proteins, particularly those driving growth and regeneration. Here, we examine the biosynthesis of heparan sulfate (HS) sugars produced by cultured MC3T3...
journal_title:Journal of molecular histology
pub_type: 杂志文章
doi:10.1007/s10735-007-9123-4
更新日期:2007-10-01 00:00:00
abstract::The aim of the present study was to investigate the association between KDM3A expression and the clinicopathological parameters of patients with epithelial ovarian cancer (EOC). KDM3A expression was analyzed using immunohistochemistry in EOC tissue microarray containing 90 paired cases of EOC and matched normal contro...
journal_title:Journal of molecular histology
pub_type: 撤回出版物,收录出版
doi:10.1007/s10735-015-9642-3
更新日期:2016-04-01 00:00:00
abstract::Elevated expression of CXCL9 has been shown to involve in the infiltration of inflammatory cells and liver damage after Hepatitis B virus (HBV) infection. However, whether and by what underlying mechanism does CXCL9 play a role in HBV infection associated hepatocellular carcinoma (HCC) invasion ability remain unclear....
journal_title:Journal of molecular histology
pub_type: 杂志文章
doi:10.1007/s10735-014-9593-0
更新日期:2014-12-01 00:00:00
abstract::Under normal homeostasis, melanocyte growth and behaviour is tightly controlled by the surrounding keratinocytes. Keratinocytes regulate melanocyte behaviour through a complex system of paracrine growth factors and cell-cell adhesion molecules. Pathological changes, leading to development of malignant melanoma, upset ...
journal_title:Journal of molecular histology
pub_type: 杂志文章,评审
doi:10.1023/b:hijo.0000032362.35354.bb
更新日期:2004-03-01 00:00:00
abstract::Polycystic ovary syndrome (PCOS) is a major health problem in reproductive-aged women worldwide, but the precise pathogenesis of PCOS remains unclear. Our previous study revealed that hypoxia-inducible factor (HIF)-1a mediated endothelin (ET)-2 signaling plays an important role in ovulation in rats. Therefore, the pre...
journal_title:Journal of molecular histology
pub_type: 杂志文章
doi:10.1007/s10735-015-9609-4
更新日期:2015-04-01 00:00:00
abstract::E3 ubiquitin ligases regulate a variety of biological processes through the ubiquitin-proteasome system, together with ubiquitin activating enzyme E1 and ubiquitin-conjugating enzyme E2. Previous studies have demonstrated that zinc and ring finger 3 (ZNRF3), which belongs to the E3 ubiquitin ligases family is involved...
journal_title:Journal of molecular histology
pub_type: 杂志文章
doi:10.1007/s10735-013-9504-9
更新日期:2013-10-01 00:00:00
abstract::Adipose-derived mesenchymal stem cell (ADSC) with a high capacity of chondrogenic differentiation was a promising candidate for cartilage defect treatment. This study's objective is to study the roles of integrin β1 (ITGB1) in regulating ADSC chondrogenic differentiations as well as the underlying mechanisms. The iden...
journal_title:Journal of molecular histology
pub_type: 杂志文章
doi:10.1007/s10735-020-09918-0
更新日期:2020-12-01 00:00:00
abstract::Submandibular gland (SMG) autotransplantation is an effective therapy for treating severe dry eye syndrome. However, epiphora occurs in more than 40% of patients 6 months after operation. We previously found that muscarinic acetylcholine receptor (mAChR) plays a crucial role in regulating SMG secretion partially throu...
journal_title:Journal of molecular histology
pub_type: 杂志文章
doi:10.1007/s10735-016-9709-9
更新日期:2017-04-01 00:00:00
abstract::Osteoprotegerin (OPG) and the receptor activator of nuclear factor (NF)-kB ligand (RANKL) are key regulators of osteoclastogenesis. The present study had the main aim of showing the localization of OPG and RANKL mRNA and protein in serial sections of the rat femurs and tibiae by immunohistochemistry (IHC) and in situ ...
journal_title:Journal of molecular histology
pub_type: 杂志文章
doi:10.1007/s10735-004-3839-1
更新日期:2005-02-01 00:00:00
abstract::Five subtypes of dopamine receptor exist in two subfamilies: two D(1)-like (D(1) and D(5)) and three D(2)-like (D(2), D(3) and D(4)). We produced novel monoclonal antibodies against all three D(2)-like receptors and used them to localize receptors in Ntera-2 (NT-2) cells, the human neuronal precursor cell line. Most o...
journal_title:Journal of molecular histology
pub_type: 杂志文章
doi:10.1007/s10735-007-9106-5
更新日期:2007-08-01 00:00:00
abstract::Nel-like molecule-1 (NELL-1) is a novel highly specific growth factor that can induce osteoblast differentiation and bone formation as well as odontoblast differentiation. Recent studies have suggested that NELL-1 can synergistically increase bone formation and regeneration with bone morphogenetic protein 2 (BMP2) and...
journal_title:Journal of molecular histology
pub_type: 杂志文章
doi:10.1007/s10735-019-09822-2
更新日期:2019-06-01 00:00:00
abstract::DLBCL is the most common lymphoma subtype occurring in older populations as well as in younger HIV infected patients. The current treatment options for DLBCL are effective for most patients yet the relapse rate is high. While many biomarkers for DLBCL exist, they are not in clinical use due to low sensitivity and spec...
journal_title:Journal of molecular histology
pub_type: 杂志文章
doi:10.1007/s10735-016-9695-y
更新日期:2016-12-01 00:00:00
abstract::Multidrug resistance-associated protein 1 (MRP1) belongs to ATP-binding cassette transporters family. The overexpression of MRP1 is predominantly related with the failure of chemo-radiotherapy in various tumors. However, its possible role in hypertrophic scar (HS) is hardly investigated. Here we showed that the mRNA l...
journal_title:Journal of molecular histology
pub_type: 杂志文章
doi:10.1007/s10735-015-9629-0
更新日期:2015-10-01 00:00:00
abstract::Pulp regeneration using human dental pulp stem cells (hDPSCs) maintains tooth vitality compared with conventional root canal therapy. Our previous study demonstrated that preameloblast-conditioned medium (PA-CM) from murine apical bud cells induces the odontogenic differentiation of hDPSCs and promoted dentin formatio...
journal_title:Journal of molecular histology
pub_type: 杂志文章
doi:10.1007/s10735-013-9513-8
更新日期:2013-12-01 00:00:00
abstract::Stromal cells in the peripheral zone (PZ) of the prostate from older males (PZ-old) could significantly promote Prostate cancer (PCa) growth compared with stromal cells from young males (PZ-young). But the mechanism is still unknown. In the co-culture system with PZ-old cells, Pc3/Du145 cells showed advanced prolifera...
journal_title:Journal of molecular histology
pub_type: 杂志文章
doi:10.1007/s10735-016-9679-y
更新日期:2016-06-01 00:00:00
abstract::Diabetic nephropathy (DN), a serious complication of hyperglycemia, is one of the most common causes of end-stage renal disease (ESRD). Glomerular podocyte injury is a major mechanism that leads to DN. However, the mechanisms underlying podocyte injury are ambiguous. In this study, we sought to investigate the contrib...
journal_title:Journal of molecular histology
pub_type: 杂志文章
doi:10.1007/s10735-020-09904-6
更新日期:2020-10-01 00:00:00
abstract::Inpp5f-v3 is a transcriptional variant of Inpp5f (inositol polyphosphate-5-phosphatase F) and locates in distal mouse chromosome 7. It is a paternally expressed imprinted gene in mouse. In this study, we examined the spatiotemporal patterns of Inpp5f-v3 gene during the mouse development. The northern blotting analysis...
journal_title:Journal of molecular histology
pub_type: 杂志文章
doi:10.1007/s10735-011-9321-y
更新日期:2011-04-01 00:00:00
abstract::Some members of aquaporin family (AQP) plays crucial functions in salivary synthesis and secretion. These proteins expression has already been reported during salivary gland formation, however no previous studies in human developing glands have been performed. We evaluated AQP1, 3 and 5 expression through the stages o...
journal_title:Journal of molecular histology
pub_type: 杂志文章
doi:10.1007/s10735-017-9731-6
更新日期:2017-12-01 00:00:00
abstract::Previous studies have shown aberrant expression of ubiquitin-specific protease 14 (USP14) in multiple malignancies, suggesting an important role of USP14 in tumorigenesis. However, the functional role of USP14 in pancreatic ductal adenocarcinoma (PDAC) has never been elucidated. In this study, we found that USP14 was ...
journal_title:Journal of molecular histology
pub_type: 杂志文章
doi:10.1007/s10735-020-09934-0
更新日期:2021-01-04 00:00:00
abstract::The goal of this study was to investigate whether sub-chronic anti-oxidant treatment with ascorbic acid (Vit C) is able to protect the heart against myocardial infarction. The effects of Vit C treatment on the histopatological changes and immunohistochemistry for p53, COX-2 and iNOS were evaluated in rats submitted to...
journal_title:Journal of molecular histology
pub_type: 杂志文章
doi:10.1007/s10735-009-9218-1
更新日期:2009-04-01 00:00:00
abstract::Objective Oligodendroglial tumors with a loss of heterozygosity of 1p (LOH1p) appear to have a better prognosis than oligodendrogliomas without LOH. Previously, we reported glucose uptake in low-grade oligodendroglial tumors to be related to LOH 1p status. Here, we performed an immunohistochemical study of the common ...
journal_title:Journal of molecular histology
pub_type: 杂志文章
doi:10.1007/s10735-008-9191-0
更新日期:2008-10-01 00:00:00
abstract::Cyclin G1 plays an essential role in the development of human carcinoma. Here, we characterized the clinical significance of Cyclin G1 and investigated its role in cellular proliferation and apoptosis of epithelial ovarian cancer (EOC). Western blot was used to evaluate the expression of Cyclin G1 in nine fresh EOC ti...
journal_title:Journal of molecular histology
pub_type: 杂志文章
doi:10.1007/s10735-015-9622-7
更新日期:2015-06-01 00:00:00
abstract::In order to study the presence of sulphated glycoconjugates in the first mineralised layer juxtaposed to the root dentine (the hyaline layer), we have examined the early stages of molar root development by ultrastructural cytochemistry using Cuprolinic Blue combined with enzymatic pretreatment. Upper molars from 10 to...
journal_title:Journal of molecular histology
pub_type: 杂志文章
doi:10.1023/b:hijo.0000021089.75408.7c
更新日期:2004-01-01 00:00:00