KDM3A confers metastasis and chemoresistance in epithelial ovarian cancer.


:The aim of the present study was to investigate the association between KDM3A expression and the clinicopathological parameters of patients with epithelial ovarian cancer (EOC). KDM3A expression was analyzed using immunohistochemistry in EOC tissue microarray containing 90 paired cases of EOC and matched normal control. The expression level of KDM3A protein in EOC tissues was significantly higher than that of adjacent normal control tissues. In addition, positive expression of KDM3A correlated with the metastases. Furthermore, Kaplan-Meier survival analysis showed that a high expression level of KDM3A resulted in a significantly poor prognosis of EOC patients. Knock-down of KDM3A could suppress both the proliferation, migration and invasion in vitro EOC cell lines OV-2008 and ES-2. Additionally, knock-down of KDM3A not only could enhance cellular apoptosis induced by Cisplatin and Paclitaxel, but also induced some pro-apoptotic genes expression. Our data is the first to demonstrate that increased KDM3A expression in EOC is significantly associated with metastases and poor prognosis; and that KDM3A promotes the proliferation, migration and invasion of EOC cells. Knock-down of KDM3A may be an important complement to EOC that is resistant or refractory to chemotherapy.


J Mol Histol





Has Abstract


2016-04-01 00:00:00














  • c-Abl mediates angiotensin II-induced apoptosis in podocytes.

    abstract::Angiotensin II (Ang II) has been reported to cause podocyte apoptosis in rats both in vivo and in vitro studies. However, the underlying mechanisms are poorly understood. In the present study, we investigated the role of the nonreceptor tyrosine kinase c-Abl in Ang II-induced podocyte apoptosis. Male Sprague-Dawley ra...

    journal_title:Journal of molecular histology

    pub_type: 杂志文章


    authors: Chen X,Ren Z,Liang W,Zha D,Liu Y,Chen C,Singhal PC,Ding G

    更新日期:2013-10-01 00:00:00

  • The capacity of goat epidermal adult stem cells to reconstruct the damaged ocular surface of total LSCD and activate corneal genetic programs.

    abstract::Epidermal adult stem cells (EpiASCs) have the potential for unlimited proliferation and differentiation, however, the ability of these stem cells to activate corneal genetic programs in response to corneal stroma stimulation needs to be further validated. Herein, a feasible strategy was developed to reconstruct the da...

    journal_title:Journal of molecular histology

    pub_type: 杂志文章


    authors: Zhang P,Ma XY,Huang DT,Yang XY

    更新日期:2020-06-01 00:00:00

  • Endosomal location of dopamine receptors in neuronal cell cytoplasm.

    abstract::Five subtypes of dopamine receptor exist in two subfamilies: two D(1)-like (D(1) and D(5)) and three D(2)-like (D(2), D(3) and D(4)). We produced novel monoclonal antibodies against all three D(2)-like receptors and used them to localize receptors in Ntera-2 (NT-2) cells, the human neuronal precursor cell line. Most o...

    journal_title:Journal of molecular histology

    pub_type: 杂志文章


    authors: Wolstencroft EC,Simic G,thi Man N,Holt I,Lam le T,Buckland PR,Morris GE

    更新日期:2007-08-01 00:00:00

  • Effects of Nel-like molecule-1 and bone morphogenetic protein 2 combination on rat pulp repair.

    abstract::Nel-like molecule-1 (NELL-1) is a novel highly specific growth factor that can induce osteoblast differentiation and bone formation as well as odontoblast differentiation. Recent studies have suggested that NELL-1 can synergistically increase bone formation and regeneration with bone morphogenetic protein 2 (BMP2) and...

    journal_title:Journal of molecular histology

    pub_type: 杂志文章


    authors: Wu J,Wang Q,Han Q,Zhu H,Li M,Fang Y,Wang X

    更新日期:2019-06-01 00:00:00

  • Down-regulation of SETD6 protects podocyte against high glucose and palmitic acid-induced apoptosis, and mitochondrial dysfunction via activating Nrf2-Keap1 signaling pathway in diabetic nephropathy.

    abstract::Diabetic nephropathy (DN), a serious complication of hyperglycemia, is one of the most common causes of end-stage renal disease (ESRD). Glomerular podocyte injury is a major mechanism that leads to DN. However, the mechanisms underlying podocyte injury are ambiguous. In this study, we sought to investigate the contrib...

    journal_title:Journal of molecular histology

    pub_type: 杂志文章


    authors: Wang X,Liu Q,Kong D,Long Z,Guo Y,Wang S,Liu R,Hai C

    更新日期:2020-10-01 00:00:00

  • Relationship between pancreatic vesicular monoamine transporter 2 (VMAT2) and insulin expression in human pancreas.

    abstract::Vesicular monoamine transporter 2 (VMAT2) is expressed in pancreatic beta cells and has recently been proposed as a target for measurement of beta cell mass in vivo. We questioned, (1) What proportion of beta cells express VMAT2? (2) Is VMAT2 expressed by other pancreatic endocrine or non-endocrine cells? (3) Is the r...

    journal_title:Journal of molecular histology

    pub_type: 杂志文章,多中心研究


    authors: Saisho Y,Harris PE,Butler AE,Galasso R,Gurlo T,Rizza RA,Butler PC

    更新日期:2008-10-01 00:00:00

  • Expression of AQP6 and AQP8 in epithelial ovarian tumor.

    abstract::Aquaporins (AQPs), the rapid transition pores for water molecules, play an important role in maintenance of intracellular water balance. Studies showed that AQPs were also involved in occurrence, development, invasion and metastasis of tumors. In this study, we aimed to explore the distribution and expression differen...

    journal_title:Journal of molecular histology

    pub_type: 杂志文章


    authors: Ma J,Zhou C,Yang J,Ding X,Zhu Y,Chen X

    更新日期:2016-04-01 00:00:00

  • Canonical Wnt signaling activity during synovial joint development.

    abstract::Wnt signaling plays important roles in skeletal development. However, the activation and function of canonical Wnt signaling in joint development remains unclear. We analyzed the lineage identity and developmental changes of the Wnt-responsive cells during synovial joint formation as well as adulthood in the Wnt signa...

    journal_title:Journal of molecular histology

    pub_type: 杂志文章


    authors: Yamagami T,Molotkov A,Zhou CJ

    更新日期:2009-08-01 00:00:00

  • Molecular evaluation of chronic restrain stress in mice model of non metastatic fibrosarcoma.

    abstract::Chronic stress is regarded as a significant factor in the etiology of the many diseases. Numerous methods have been developed through which the effect of chronic stress is examined. The aim of this study is to demonstrate the new experimental model for analysis of immuno-suppression induced by chronic restraint stress...

    journal_title:Journal of molecular histology

    pub_type: 杂志文章


    authors: Smieško G,Banović P,Gusman V,Simin V,Cimpean AM,Lalošević D

    更新日期:2020-08-01 00:00:00

  • The effect of CXCL9 on the invasion ability of hepatocellular carcinoma through up-regulation of PREX2.

    abstract::Elevated expression of CXCL9 has been shown to involve in the infiltration of inflammatory cells and liver damage after Hepatitis B virus (HBV) infection. However, whether and by what underlying mechanism does CXCL9 play a role in HBV infection associated hepatocellular carcinoma (HCC) invasion ability remain unclear....

    journal_title:Journal of molecular histology

    pub_type: 杂志文章


    authors: Lan X,Xiao F,Ding Q,Liu J,Liu J,Li J,Zhang J,Tian DA

    更新日期:2014-12-01 00:00:00

  • Temporal and functional changes in glycosaminoglycan expression during osteogenesis.

    abstract::Heparan sulfate proteoglycans (HSPGs) are complex and labile macromolecular moieties on the surfaces of cells that control the activities of a range of extracellular proteins, particularly those driving growth and regeneration. Here, we examine the biosynthesis of heparan sulfate (HS) sugars produced by cultured MC3T3...

    journal_title:Journal of molecular histology

    pub_type: 杂志文章


    authors: Nurcombe V,Goh FJ,Haupt LM,Murali S,Cool SM

    更新日期:2007-10-01 00:00:00

  • Functional expression of ERG1 potassium channels in rat alveolar macrophages.

    abstract::Alveolar macrophages (AMs) play a vital role in lung immunity. The recent studies demonstrated that potassium channels were associated with macrophage functions, such as activation, migration and cytokines secretion. However, less is known regarding the expression and function of ERG channels in AMs. Our study showed ...

    journal_title:Journal of molecular histology

    pub_type: 杂志文章


    authors: Dong H,Ji Z,Liu M,Wang Y,Bai X,Wang T,Liu Z,Wu Y,Zhang B,Luo Y,Li Z,Dong M

    更新日期:2013-02-01 00:00:00

  • Expression profile and mitochondrial colocalization of Tdp1 in peripheral human tissues.

    abstract::Tyrosyl-DNA phosphodiesterase 1 (Tdp1) is a DNA repair enzyme that processes blocked 3' ends of DNA breaks. Functional loss of Tdp1 causes spinocerebellar ataxia with axonal neuropathy type 1 (SCAN1). Based on the prominent cytoplasmic expression of Tdp1 in the neurons presumably affected in SCAN1, we hypothesized tha...

    journal_title:Journal of molecular histology

    pub_type: 杂志文章


    authors: Fam HK,Chowdhury MK,Walton C,Choi K,Boerkoel CF,Hendson G

    更新日期:2013-08-01 00:00:00

  • Immunogold study of altered expression of some interendothelial junctional molecules in the brain blood microvessels of diabetic scrapie-infected mice.

    abstract::Quantitative immunogold procedure was used to study the distribution of molecular components of interendothelial junctions in blood-brain barrier (BBB) microvessels of scrapie infected SJL/J hyperglycemic mice showing obesity and reduced glucose tolerance. Samples of brain (fronto-parietal cerebral cortex and thalamo-...

    journal_title:Journal of molecular histology

    pub_type: 杂志文章


    authors: Vorbrodt AW,Dobrogowska DH,Tarnawski M,Meeker HC,Carp RI

    更新日期:2006-01-01 00:00:00

  • Correction to: BrdU/EdU dual labeling to determine the cell-cycle dynamics of defined cellular subpopulations.

    abstract::In the original publication of the article, two errors were made in describing the equations for Tc. ...

    journal_title:Journal of molecular histology

    pub_type: 杂志文章,已发布勘误


    authors: Harris L,Zalucki O,Piper M

    更新日期:2018-08-01 00:00:00

  • Expression of cytokeratin 8, vimentin, syndecan-1 and Ki-67 during human tooth development.

    abstract::Spatio-temporal immunolocalizations of cytokeratin 8 (CK8), vimentin, syndecan-1 and Ki-67 were analyzed in ten human incisors and canine tooth germs between the 7th and 20th developmental weeks. CK8 expression was mild to moderate in the epithelial tooth parts, while it shifted from absent or mild in its mesenchymal ...

    journal_title:Journal of molecular histology

    pub_type: 杂志文章


    authors: Kero D,Kalibovic Govorko D,Vukojevic K,Cubela M,Soljic V,Saraga-Babic M

    更新日期:2014-12-01 00:00:00

  • Frozen-section fluorescence microscopy and stereology in the quantification of neuronal death within dorsal root ganglia.

    abstract::Histochemical and morphological research increasingly relies upon quantification of complex biological systems. For such investigations to be meaningful, quantification techniques must meet the seemingly conflicting requirements of being theoretically robust, yet sufficiently practical to facilitate widespread applica...

    journal_title:Journal of molecular histology

    pub_type: 杂志文章


    authors: Hart AM,Terenghi G

    更新日期:2004-08-01 00:00:00

  • SLC30A family expression in the pancreatic islets of humans and mice: cellular localization in the β-cells.

    abstract::Zinc is a vital co-factor for insulin metabolism in the pancreatic β-cell, involved in synthesis, maturation, and crystallization. Two families of zinc transporters, namely SLC30A (ZNT) and SLC39A (ZIP) are involved in maintaining cellular zinc homeostasis in mammalian cells. Single nuclear polymorphisms or mutations ...

    journal_title:Journal of molecular histology

    pub_type: 杂志文章


    authors: Cai Y,Kirschke CP,Huang L

    更新日期:2018-04-01 00:00:00

  • Immunocytochemical localization of secretory component in Paneth cell secretory granules-rat Paneth cells participate in acquired immunity.

    abstract::With the marker of Paneth cells-lysozyme, secretory component (SC) immunoreactivity was demonstrated exclusively in Paneth cells of rat small intestine. The other types of epithelial cells (columnar, goblet, endocrine) were negative. On electron microscopic level, many SC-positive colloidal gold particles were found i...

    journal_title:Journal of molecular histology

    pub_type: 杂志文章


    authors: Tang QJ,Tao KZ,Yun-Liu,Sun XJ,Geng MY,Jiang CL

    更新日期:2005-06-01 00:00:00

  • A simple, web-based repository for the management, access and analysis of micrographic images.

    abstract::Microscopy is advancing at a rapid pace, enabling high-speed, high-resolution analyses to be conducted in a wide range of cellular contexts. For example, the capacity to quickly capture high-resolution images from multiple optical sections over multiple channels with confocal microscopy has allowed researchers to gain...

    journal_title:Journal of molecular histology

    pub_type: 杂志文章


    authors: Davila RA,Harkins D,Currey L,Fraser J,Bowles J,Piper M

    更新日期:2019-12-01 00:00:00

  • Neural-specific expression of miR-344-3p during mouse embryonic development.

    abstract::MicroRNAs are small noncoding RNAs involved in various biological processes. We characterized the expression of miR-344-3p during mouse embryonic development. At E9.5-E10.5 and E15.5, in situ hybridization detected strong miR-344-3p signal in the central nervous system, including the cerebral cortex, hindbrain, cerebe...

    journal_title:Journal of molecular histology

    pub_type: 杂志文章


    authors: Liu Q,He H,Zeng T,Huang Z,Fan T,Wu Q

    更新日期:2014-08-01 00:00:00

  • Tissue microarrays as a platform for proteomic investigation.

    abstract::Tissue microarrays have become an essential tool in translational pathology. They are used to confirm results from other experimental platforms, such as expression microarrays, as well as a primary tool to explore the expression profile of proteins by immunohistochemical analysis. Tissue microarrays are routinely used...

    journal_title:Journal of molecular histology

    pub_type: 杂志文章


    authors: Chung JY,Braunschweig T,Tuttle K,Hewitt SM

    更新日期:2007-05-01 00:00:00

  • A new approach for examining the neurovascular structure with phalloidin and calcitonin gene-related peptide in the rat cranial dura mater.

    abstract::The neurovascular structures in the cranial dura mater have been studied with various histological techniques in the past years. In order to obtain a proper approach to reveal the detailed structures, different labeling methods for the cranial vessels and nerve fibers were tested in this study. Firstly, the labeling c...

    journal_title:Journal of molecular histology

    pub_type: 杂志文章


    authors: Wang J,Xu D,Cui J,Wang S,She C,Wang H,Wu S,Zhang J,Zhu B,Bai W

    更新日期:2020-10-01 00:00:00

  • Isolation of a native osteoblast matrix with a specific affinity for BMP2.

    abstract::During their commitment and differentiation toward the osteoblast lineage, mesenchymal stem cells secrete a unique extracellular matrix (ECM) that contains large quantities of glycosaminoglycans (GAGs). Proteoglycans (PGs) are major structural and functional components of the ECM and are composed of a core protein to ...

    journal_title:Journal of molecular histology

    pub_type: 杂志文章


    authors: Grünert M,Dombrowski C,Sadasivam M,Manton K,Cool SM,Nurcombe V

    更新日期:2007-10-01 00:00:00

  • Expression of inhibin/activin subunits alpha (-alpha), beta A (-beta (A)) and beta B (-beta (B)) in placental tissue of normal and intrauterine growth restricted (IUGR) pregnancies.

    abstract::During human pregnancy the placenta produces a variety of proteins like steroid hormones and their receptors that are responsible for the establishment and ongoing of the feto-placental unit. Inhibins are dimeric glycoproteins, composed of an alpha-subunit and one of two possible beta-subunits (beta (A) or beta (B)). ...

    journal_title:Journal of molecular histology

    pub_type: 杂志文章


    authors: Mylonas I,Schiessl B,Jeschke U,Vogl J,Makrigiannakis A,Kuhn C,Kunze S,Schulze S,Kainer F,Friese K

    更新日期:2006-01-01 00:00:00

  • FTY720 prevents progression of renal fibrosis by inhibiting renal microvasculature endothelial dysfunction in a rat model of chronic kidney disease.

    abstract::Recent studies have shown that chronic endothelial dysfunction can impair multiple aspects of renal physiology and, in turn, contribute to renal fibrosis. Sphingosine 1-phosphate (S1P) has been highlighted as an endothelial barrier-stabilizing mediator. The aim of our study was to investigate the effect of FTY720, an ...

    journal_title:Journal of molecular histology

    pub_type: 杂志文章


    authors: Ni H,Chen J,Pan M,Zhang M,Zhang J,Chen P,Liu B

    更新日期:2013-12-01 00:00:00

  • Semaphorin 3A gets involved in the establishment of mouse tooth eruptive pathway.

    abstract::The accurately establishment of the eruptive pathway is of vital importance. The mechanisms governing tooth eruption pathway remain little known. This study is to elucidate the roles of Semaphorin 3A (Sema 3A) in mouse tooth eruptive pathway. C57BL/6 mice (11-13 and 15-17 days after birth) were chosen to observe erupt...

    journal_title:Journal of molecular histology

    pub_type: 杂志文章


    authors: Yu X,Zheng F,Du Y,Tang K,Wang W,Zhang S

    更新日期:2019-10-01 00:00:00

  • Distribution of soluble epoxide hydrolase, cytochrome P450 2C8, 2C9 and 2J2 in human malignant neoplasms.

    abstract::Soluble epoxide hydrolase (sEH) is a bifunctional enzyme with a C-terminal epoxide hydrolase activity and an N-terminal phosphatase activity. Arachidonic acid epoxides, previously suggested to be involved in apoptosis, oncogenesis and cell proliferation, are generated by cytochrome P450 epoxygenases and are good subst...

    journal_title:Journal of molecular histology

    pub_type: 杂志文章


    authors: Enayetallah AE,French RA,Grant DF

    更新日期:2006-05-01 00:00:00

  • CNS neurotrophins are biologically active and expressed by multiple cell types.

    abstract::Neutrotrophins are increasingly appreciated as potential modulators of neuronal function in the adult central nervous system (CNS). To describe the neurotrophin environment within the adult CNS, mRNA and protein expression patterns of neurotrophins-3 and -4 and of brain-derived neurotrophin were investigated in adult ...

    journal_title:Journal of molecular histology

    pub_type: 杂志文章


    authors: Riley CP,Cope TC,Buck CR

    更新日期:2004-11-01 00:00:00

  • ZNRF3 acts as a tumour suppressor by the Wnt signalling pathway in human gastric adenocarcinoma.

    abstract::E3 ubiquitin ligases regulate a variety of biological processes through the ubiquitin-proteasome system, together with ubiquitin activating enzyme E1 and ubiquitin-conjugating enzyme E2. Previous studies have demonstrated that zinc and ring finger 3 (ZNRF3), which belongs to the E3 ubiquitin ligases family is involved...

    journal_title:Journal of molecular histology

    pub_type: 杂志文章


    authors: Zhou Y,Lan J,Wang W,Shi Q,Lan Y,Cheng Z,Guan H

    更新日期:2013-10-01 00:00:00