KDM3A confers metastasis and chemoresistance in epithelial ovarian cancer.


:The aim of the present study was to investigate the association between KDM3A expression and the clinicopathological parameters of patients with epithelial ovarian cancer (EOC). KDM3A expression was analyzed using immunohistochemistry in EOC tissue microarray containing 90 paired cases of EOC and matched normal control. The expression level of KDM3A protein in EOC tissues was significantly higher than that of adjacent normal control tissues. In addition, positive expression of KDM3A correlated with the metastases. Furthermore, Kaplan-Meier survival analysis showed that a high expression level of KDM3A resulted in a significantly poor prognosis of EOC patients. Knock-down of KDM3A could suppress both the proliferation, migration and invasion in vitro EOC cell lines OV-2008 and ES-2. Additionally, knock-down of KDM3A not only could enhance cellular apoptosis induced by Cisplatin and Paclitaxel, but also induced some pro-apoptotic genes expression. Our data is the first to demonstrate that increased KDM3A expression in EOC is significantly associated with metastases and poor prognosis; and that KDM3A promotes the proliferation, migration and invasion of EOC cells. Knock-down of KDM3A may be an important complement to EOC that is resistant or refractory to chemotherapy.


J Mol Histol





Has Abstract


2016-04-01 00:00:00














  • Correction to: BrdU/EdU dual labeling to determine the cell-cycle dynamics of defined cellular subpopulations.

    abstract::In the original publication of the article, two errors were made in describing the equations for Tc. ...

    journal_title:Journal of molecular histology

    pub_type: 杂志文章,已发布勘误


    authors: Harris L,Zalucki O,Piper M

    更新日期:2018-08-01 00:00:00

  • ITGB1 promotes the chondrogenic differentiation of human adipose-derived mesenchymal stem cells by activating the ERK signaling.

    abstract::Adipose-derived mesenchymal stem cell (ADSC) with a high capacity of chondrogenic differentiation was a promising candidate for cartilage defect treatment. This study's objective is to study the roles of integrin β1 (ITGB1) in regulating ADSC chondrogenic differentiations as well as the underlying mechanisms. The iden...

    journal_title:Journal of molecular histology

    pub_type: 杂志文章


    authors: Luo S,Shi Q,Li W,Wu W,Zha Z

    更新日期:2020-12-01 00:00:00

  • Immunohistochemical detection of sphingosine-1-phosphate receptor 1 in vascular and lymphatic endothelial cells.

    abstract::Sphingosine-1-phosphate receptor 1 (S1P(1)), a receptor for sphingosine-1-phosphate, has been shown to play an important role in the migration, proliferation, and survival of several types of cell including endothelial cells. Given that S1P(1) signaling could serve as a therapeutic target, we evaluate the expression o...

    journal_title:Journal of molecular histology

    pub_type: 杂志文章


    authors: Akiyama T,Sadahira Y,Matsubara K,Mori M,Igarashi Y

    更新日期:2008-10-01 00:00:00

  • Relationship between pancreatic vesicular monoamine transporter 2 (VMAT2) and insulin expression in human pancreas.

    abstract::Vesicular monoamine transporter 2 (VMAT2) is expressed in pancreatic beta cells and has recently been proposed as a target for measurement of beta cell mass in vivo. We questioned, (1) What proportion of beta cells express VMAT2? (2) Is VMAT2 expressed by other pancreatic endocrine or non-endocrine cells? (3) Is the r...

    journal_title:Journal of molecular histology

    pub_type: 杂志文章,多中心研究


    authors: Saisho Y,Harris PE,Butler AE,Galasso R,Gurlo T,Rizza RA,Butler PC

    更新日期:2008-10-01 00:00:00

  • Expression and clinical significance of the HIF-1a/ET-2 signaling pathway during the development and treatment of polycystic ovary syndrome.

    abstract::Polycystic ovary syndrome (PCOS) is a major health problem in reproductive-aged women worldwide, but the precise pathogenesis of PCOS remains unclear. Our previous study revealed that hypoxia-inducible factor (HIF)-1a mediated endothelin (ET)-2 signaling plays an important role in ovulation in rats. Therefore, the pre...

    journal_title:Journal of molecular histology

    pub_type: 杂志文章


    authors: Wang F,Zhang Z,Wang Z,Xiao K,Wang Q,Su J,Wang Z

    更新日期:2015-04-01 00:00:00

  • Neural-specific expression of miR-344-3p during mouse embryonic development.

    abstract::MicroRNAs are small noncoding RNAs involved in various biological processes. We characterized the expression of miR-344-3p during mouse embryonic development. At E9.5-E10.5 and E15.5, in situ hybridization detected strong miR-344-3p signal in the central nervous system, including the cerebral cortex, hindbrain, cerebe...

    journal_title:Journal of molecular histology

    pub_type: 杂志文章


    authors: Liu Q,He H,Zeng T,Huang Z,Fan T,Wu Q

    更新日期:2014-08-01 00:00:00

  • Localisation of sulphated glycoconjugates during hyaline layer formation in rat molars by ultrastructural cytochemistry.

    abstract::In order to study the presence of sulphated glycoconjugates in the first mineralised layer juxtaposed to the root dentine (the hyaline layer), we have examined the early stages of molar root development by ultrastructural cytochemistry using Cuprolinic Blue combined with enzymatic pretreatment. Upper molars from 10 to...

    journal_title:Journal of molecular histology

    pub_type: 杂志文章


    authors: Tomazela-Herndl SA,Arana-Chavez VE

    更新日期:2004-01-01 00:00:00

  • p63 and p73 expression in extrahepatic bile duct carcinoma and their clinical significance.

    abstract::p53 plays a pivotal role in the prevention of human tumor formation. p73 and p63 are new members of the p53 tumor suppressor family, which are becoming increasingly recognized as important players in human tumorigenesis. However, the roles of these proteins are not well elucidated in extrahepatic bile duct (EBD) carci...

    journal_title:Journal of molecular histology

    pub_type: 杂志文章


    authors: Hong SM,Cho H,Moskaluk CA,Yu E,Zaika AI

    更新日期:2007-06-01 00:00:00

  • Adult neurogenesis and cell cycle regulation in the crustacean olfactory pathway: from glial precursors to differentiated neurons.

    abstract::Adult neurogenesis is a characteristic feature of the olfactory pathways of decapod crustaceans. In crayfish and clawed lobsters, adult-born neurons are the progeny of precursor cells with glial characteristics located in a neurogenic niche on the ventral surface of the brain. The daughters of these precursor cells mi...

    journal_title:Journal of molecular histology

    pub_type: 杂志文章


    authors: Sullivan JM,Sandeman DC,Benton JL,Beltz BS

    更新日期:2007-12-01 00:00:00

  • Ascorbic acid prevents acute myocardial infarction induced by isoproterenol in rats: role of inducible nitric oxide synthase production.

    abstract::The goal of this study was to investigate whether sub-chronic anti-oxidant treatment with ascorbic acid (Vit C) is able to protect the heart against myocardial infarction. The effects of Vit C treatment on the histopatological changes and immunohistochemistry for p53, COX-2 and iNOS were evaluated in rats submitted to...

    journal_title:Journal of molecular histology

    pub_type: 杂志文章


    authors: Ribeiro DA,Buttros JB,Oshima CT,Bergamaschi CT,Campos RR

    更新日期:2009-04-01 00:00:00

  • Isolation of a native osteoblast matrix with a specific affinity for BMP2.

    abstract::During their commitment and differentiation toward the osteoblast lineage, mesenchymal stem cells secrete a unique extracellular matrix (ECM) that contains large quantities of glycosaminoglycans (GAGs). Proteoglycans (PGs) are major structural and functional components of the ECM and are composed of a core protein to ...

    journal_title:Journal of molecular histology

    pub_type: 杂志文章


    authors: Grünert M,Dombrowski C,Sadasivam M,Manton K,Cool SM,Nurcombe V

    更新日期:2007-10-01 00:00:00

  • SLC30A family expression in the pancreatic islets of humans and mice: cellular localization in the β-cells.

    abstract::Zinc is a vital co-factor for insulin metabolism in the pancreatic β-cell, involved in synthesis, maturation, and crystallization. Two families of zinc transporters, namely SLC30A (ZNT) and SLC39A (ZIP) are involved in maintaining cellular zinc homeostasis in mammalian cells. Single nuclear polymorphisms or mutations ...

    journal_title:Journal of molecular histology

    pub_type: 杂志文章


    authors: Cai Y,Kirschke CP,Huang L

    更新日期:2018-04-01 00:00:00

  • Muscarinic acetylcholine receptor-mediated tight junction opening is involved in epiphora in late phase of submandibular gland transplantation.

    abstract::Submandibular gland (SMG) autotransplantation is an effective therapy for treating severe dry eye syndrome. However, epiphora occurs in more than 40% of patients 6 months after operation. We previously found that muscarinic acetylcholine receptor (mAChR) plays a crucial role in regulating SMG secretion partially throu...

    journal_title:Journal of molecular histology

    pub_type: 杂志文章


    authors: Yang NY,Ding C,Li J,Zhang Y,Xiang RL,Wu LL,Yu GY,Cong X

    更新日期:2017-04-01 00:00:00

  • Hormonal regulation of uterine natural killer cells in mouse preimplantation uterus.

    abstract::Uterine Natural Killer (uNK) cells are the most abundant lymphocyte population recruited in the uteri during murine and human pregnancy. Previous investigation on uNK cells during mouse pregnancy focused more on its accumulation in postimplantation periods, which were believed to play important roles in regulating tro...

    journal_title:Journal of molecular histology

    pub_type: 杂志文章


    authors: Kuang H,Peng H,Xu H,Zhang B,Peng J,Tan Y

    更新日期:2010-02-01 00:00:00

  • Temporal and functional changes in glycosaminoglycan expression during osteogenesis.

    abstract::Heparan sulfate proteoglycans (HSPGs) are complex and labile macromolecular moieties on the surfaces of cells that control the activities of a range of extracellular proteins, particularly those driving growth and regeneration. Here, we examine the biosynthesis of heparan sulfate (HS) sugars produced by cultured MC3T3...

    journal_title:Journal of molecular histology

    pub_type: 杂志文章


    authors: Nurcombe V,Goh FJ,Haupt LM,Murali S,Cool SM

    更新日期:2007-10-01 00:00:00

  • Protein expression of the transcriptional regulator MI-ER1 alpha in adult mouse tissues.

    abstract::MI-ER1 is a novel transcriptional regulator that plays a critical role in embryonic development and is differentially expressed in breast carcinoma. The MI-ER1 protein sequence is highly conserved among species, with 95% identity between mouse and humans and 72% between Xenopus and mouse. There are two major protein i...

    journal_title:Journal of molecular histology

    pub_type: 杂志文章


    authors: Thorne LB,McCarthy PL,Paterno GD,Gillespie LL

    更新日期:2008-02-01 00:00:00

  • Quercetin-induced melanogenesis in a reconstituted three-dimensional human epidermal model.

    abstract::Quercetin (3,5,7,3',4'-pentahydroxyflavone) is one of the most abundant natural flavonoids. It is present in various common vegetables and fruits. In this report, we examined the effect of quercetin on melanogenesis using a three-dimensional reconstituted human epidermal culture model, MelanoDerm, which is a new comme...

    journal_title:Journal of molecular histology

    pub_type: 杂志文章


    authors: Takeyama R,Takekoshi S,Nagata H,Osamura RY,Kawana S

    更新日期:2004-02-01 00:00:00

  • The possible role of L-carnitine on the skeletal muscle of ovariectomized rats.

    abstract::Low muscle strength is observed during the peri-and postmenopausal periods, when the secretion of ovarian hormones is drastically reduced. It is also a predictive of adverse health events as well as incident mobility limitation and disability. The objective of the present study is to study the biochemical and the hist...

    journal_title:Journal of molecular histology

    pub_type: 杂志文章


    authors: Moustafa AM,Boshra V

    更新日期:2011-06-01 00:00:00

  • The effect of CXCL9 on the invasion ability of hepatocellular carcinoma through up-regulation of PREX2.

    abstract::Elevated expression of CXCL9 has been shown to involve in the infiltration of inflammatory cells and liver damage after Hepatitis B virus (HBV) infection. However, whether and by what underlying mechanism does CXCL9 play a role in HBV infection associated hepatocellular carcinoma (HCC) invasion ability remain unclear....

    journal_title:Journal of molecular histology

    pub_type: 杂志文章


    authors: Lan X,Xiao F,Ding Q,Liu J,Liu J,Li J,Zhang J,Tian DA

    更新日期:2014-12-01 00:00:00

  • Osteogenic and angiogenic characterization of mandible and femur osteoblasts.

    abstract::Craniofacial autologous bone grafts offer superior outcomes to long bone grafts in the reconstruction of maxillofacial bone defects, but the mechanism responsible for this superiority has not yet been illustrated clearly. Osteoblasts play vital roles in bone development and regeneration. However, presently, only a few...

    journal_title:Journal of molecular histology

    pub_type: 杂志文章


    authors: Yang X,Jiang J,Zhou L,Wang S,He M,Luo K,Chen Y,Xu X

    更新日期:2019-04-01 00:00:00

  • Oxidative DNA damage is a preliminary step during rat tongue carcinogenesis induced by 4-nitroquinoline 1-oxide.

    abstract::The aim of this study was to investigate oxidative DNA damage during 4-nitroquinoline 1-oxide (4NQO)-induced rat tongue carcinogenesis. For this purpose, male Wistar rats were distributed into three groups of 10 animals each and treated with 50 ppm 4NQO solution through their drinking water for 4, 12, and 20 weeks. Te...

    journal_title:Journal of molecular histology

    pub_type: 杂志文章


    authors: Miranda SR,Noguti J,Carvalho JG,Oshima CT,Ribeiro DA

    更新日期:2011-04-01 00:00:00

  • Methoxychlor-induced alterations in the histological expression of angiogenic factors in pituitary and uterus.

    abstract::Within the reproductive system, oestrogenic stimulation of uterine and pituitary tissue typically causes a proliferative response accompanied by an angiogenic induction of new blood vessels from existing ones, thereby providing nutrients and oxygen to the growing tissue. The pro-oestrogenic pesticide methoxychlor (MXC...

    journal_title:Journal of molecular histology

    pub_type: 杂志文章


    authors: Goldman JM,Murr AS,Buckalew AR,Schmid JE,Abbott BD

    更新日期:2004-05-01 00:00:00

  • Distribution of immunoreactivity for P2X3, P2X5, and P2X6-purinoceptors in mouse retina.

    abstract::Previous findings have shown that P2X-purinoceptor-mediated signaling pathways regulate the release of ACh in the retina. We previously reported the existence of immunoreactivity for P2X1-, P2X2-, P2X4-, and P2X7-purinoceptors in mouse retina and speculated that P2X2 and P2X7-purinoceptors may modulate the activity of...

    journal_title:Journal of molecular histology

    pub_type: 杂志文章


    authors: Shigematsu Y,Shimoda Y,Kaneda M

    更新日期:2007-08-01 00:00:00

  • Distribution of soluble epoxide hydrolase, cytochrome P450 2C8, 2C9 and 2J2 in human malignant neoplasms.

    abstract::Soluble epoxide hydrolase (sEH) is a bifunctional enzyme with a C-terminal epoxide hydrolase activity and an N-terminal phosphatase activity. Arachidonic acid epoxides, previously suggested to be involved in apoptosis, oncogenesis and cell proliferation, are generated by cytochrome P450 epoxygenases and are good subst...

    journal_title:Journal of molecular histology

    pub_type: 杂志文章


    authors: Enayetallah AE,French RA,Grant DF

    更新日期:2006-05-01 00:00:00

  • Short-term administration of non-selective and selective COX-2 NSAIDs do not interfere with bone repair in rats.

    abstract::Selective cyclooxygenase-2 non-steroidal anti-inflammatory drugs are known to inhibit bone repair, especially when long-term administration is required due to chronicle inflammatory diseases. In order to evaluate the action of this drug in bone repair during short-term administration, 48 rats underwent surgical bone d...

    journal_title:Journal of molecular histology

    pub_type: 杂志文章


    authors: Matsumoto MA,De Oliveira A,Ribeiro Junior PD,Nary Filho H,Ribeiro DA

    更新日期:2008-08-01 00:00:00

  • Canonical Wnt signaling activity during synovial joint development.

    abstract::Wnt signaling plays important roles in skeletal development. However, the activation and function of canonical Wnt signaling in joint development remains unclear. We analyzed the lineage identity and developmental changes of the Wnt-responsive cells during synovial joint formation as well as adulthood in the Wnt signa...

    journal_title:Journal of molecular histology

    pub_type: 杂志文章


    authors: Yamagami T,Molotkov A,Zhou CJ

    更新日期:2009-08-01 00:00:00

  • The expression of water channel proteins during human salivary gland development: a topographic study of aquaporins 1, 3 and 5.

    abstract::Some members of aquaporin family (AQP) plays crucial functions in salivary synthesis and secretion. These proteins expression has already been reported during salivary gland formation, however no previous studies in human developing glands have been performed. We evaluated AQP1, 3 and 5 expression through the stages o...

    journal_title:Journal of molecular histology

    pub_type: 杂志文章


    authors: de Paula F,Teshima THN,Hsieh R,Souza MM,Coutinho-Camillo CM,Nico MMS,Lourenco SV

    更新日期:2017-12-01 00:00:00

  • Upregulation of p21-activated Kinase 6 in rat brain cortex after traumatic brain injury.

    abstract::p21-activated Kinase 6 (PAK6) is a serine/threonine kinase belonging to the p21-activated kinase (PAK) family. PAK kinases are well-known regulators of a wide variety of cellular functions, including regulation of cytoskeleton rearrangement, cell survival, apoptosis and the mitogen-activated protein kinase signaling p...

    journal_title:Journal of molecular histology

    pub_type: 杂志文章


    authors: Zhao W,Yang J,Shi W,Wu X,Shao B,Wu Q,Chen J,Ni L

    更新日期:2011-06-01 00:00:00

  • Cellular destruction following transmyocardial laser revascularization (TMR).

    abstract::During transmyocardial revascularization, cellular destruction of cardiomyocytes occurs as a result of the high-energy laser. However, the features of myocardial cellular destruction are unclear. The present study was undertaken to examine the structural characteristics of cell death in the myocardium following transm...

    journal_title:Journal of molecular histology

    pub_type: 杂志文章


    authors: Cherian SM,Bobryshev YV,Tran D,Sivaraman A,Lord RS,Cherian KM

    更新日期:2005-05-01 00:00:00

  • Expression of inhibin/activin subunits alpha (-alpha), beta A (-beta (A)) and beta B (-beta (B)) in placental tissue of normal and intrauterine growth restricted (IUGR) pregnancies.

    abstract::During human pregnancy the placenta produces a variety of proteins like steroid hormones and their receptors that are responsible for the establishment and ongoing of the feto-placental unit. Inhibins are dimeric glycoproteins, composed of an alpha-subunit and one of two possible beta-subunits (beta (A) or beta (B)). ...

    journal_title:Journal of molecular histology

    pub_type: 杂志文章


    authors: Mylonas I,Schiessl B,Jeschke U,Vogl J,Makrigiannakis A,Kuhn C,Kunze S,Schulze S,Kainer F,Friese K

    更新日期:2006-01-01 00:00:00