Detection of osteoprotegerin (OPG) and its ligand (RANKL) mRNA and protein in femur and tibia of the rat.

abstract：:Vascular endothelial growth factor (VEGF) is an important angiogenic factor in the pituitary gland. The objective of this study was to unveil the VEGF subcellular localisation in different pituitary cell types and to evaluate changes in its expression at different time intervals after oestrogen stimulation. A relevant...

journal_title：Journal of molecular histology

authors： Mukdsi JH,De Paul AL,Gutiérrez S,Roth FD,Aoki A,Torres AI

更新日期：2005-10-01 00:00:00

abstract：:Spinal cord injury frequently results in permanent loss of neurological function. It includes many complex molecular and biochemical mechanisms. G-protein-coupled receptor kinase 6 (GRK6) is an intracellular kinase that regulates the sensitivity of certain G-protein-coupled receptors. Some studies reported GRK2 and GR...

journal_title：Journal of molecular histology

authors： Sun B,Gao Y,Lou D,Wu X,Wei H,Wen H,Deng X,Zhang F

更新日期：2013-06-01 00:00:00

abstract：:Uterine Natural Killer (uNK) cells are the most abundant lymphocyte population recruited in the uteri during murine and human pregnancy. Previous investigation on uNK cells during mouse pregnancy focused more on its accumulation in postimplantation periods, which were believed to play important roles in regulating tro...

journal_title：Journal of molecular histology

authors： Kuang H,Peng H,Xu H,Zhang B,Peng J,Tan Y

更新日期：2010-02-01 00:00:00

abstract：:S100A8 and S100A9 are calcium-binding proteins expressed in myeloid cells and are markers of numerous inflammatory diseases in humans. S100A9 has been associated with dystrophic calcification in human atherosclerosis. Here we demonstrate S100A8 and S100A9 expression in murine and human bone and cartilage cells. Only S...

journal_title：Journal of molecular histology

authors： Zreiqat H,Howlett CR,Gronthos S,Hume D,Geczy CL

更新日期：2007-10-01 00:00:00

abstract：:Despite the efficacy of tamoxifen in preventing disease relapse, a large portion of breast cancer patients show intrinsic or acquired resistance to tamoxifen, leading to treatment failure and unfavorable clinical outcome. MYB proto-oncogene like 2 (MYBL2) is a transcription factor implicated in the initiation and prog...

journal_title：Journal of molecular histology

authors： Li X,Zhang X,Wu CC,Li PP,Fu YM,Xie LH,Sun SS,Zhou YY,Zhu BL

更新日期：2021-02-01 00:00:00

abstract：:Quantitative immunogold procedure was used to study the distribution of molecular components of interendothelial junctions in blood-brain barrier (BBB) microvessels of scrapie infected SJL/J hyperglycemic mice showing obesity and reduced glucose tolerance. Samples of brain (fronto-parietal cerebral cortex and thalamo-...

journal_title：Journal of molecular histology

authors： Vorbrodt AW,Dobrogowska DH,Tarnawski M,Meeker HC,Carp RI

更新日期：2006-01-01 00:00:00

abstract：:Recent studies have shown that chronic endothelial dysfunction can impair multiple aspects of renal physiology and, in turn, contribute to renal fibrosis. Sphingosine 1-phosphate (S1P) has been highlighted as an endothelial barrier-stabilizing mediator. The aim of our study was to investigate the effect of FTY720, an ...

journal_title：Journal of molecular histology

authors： Ni H,Chen J,Pan M,Zhang M,Zhang J,Chen P,Liu B

更新日期：2013-12-01 00:00:00

abstract：:MicroRNAs are small noncoding RNAs involved in various biological processes. We characterized the expression of miR-344-3p during mouse embryonic development. At E9.5-E10.5 and E15.5, in situ hybridization detected strong miR-344-3p signal in the central nervous system, including the cerebral cortex, hindbrain, cerebe...

journal_title：Journal of molecular histology

authors： Liu Q,He H,Zeng T,Huang Z,Fan T,Wu Q

更新日期：2014-08-01 00:00:00

abstract：:Follistatin like-1 (Fstl1) is a secreted glycoprotein and can be up-regulated by TGF-β1. To better study the function of Fstl1 in lung development, we examined Fstl1 expression in the developing lung, in a cell type specific manner, using a tamoxifen inducible Fstl1-reporter mouse strain. Our results show that Fstl1 i...

journal_title：Journal of molecular histology

authors： Liu X,Liu Y,Yang Z,Ning W

更新日期：2018-08-01 00:00:00

abstract：:During human pregnancy the placenta produces a variety of proteins like steroid hormones and their receptors that are responsible for the establishment and ongoing of the feto-placental unit. Inhibins are dimeric glycoproteins, composed of an alpha-subunit and one of two possible beta-subunits (beta (A) or beta (B)). ...

journal_title：Journal of molecular histology

authors： Mylonas I,Schiessl B,Jeschke U,Vogl J,Makrigiannakis A,Kuhn C,Kunze S,Schulze S,Kainer F,Friese K

更新日期：2006-01-01 00:00:00

abstract：:Heparan sulfate proteoglycans (HSPGs) are complex and labile macromolecular moieties on the surfaces of cells that control the activities of a range of extracellular proteins, particularly those driving growth and regeneration. Here, we examine the biosynthesis of heparan sulfate (HS) sugars produced by cultured MC3T3...

journal_title：Journal of molecular histology

authors： Nurcombe V,Goh FJ,Haupt LM,Murali S,Cool SM

更新日期：2007-10-01 00:00:00

abstract：:Neutrotrophins are increasingly appreciated as potential modulators of neuronal function in the adult central nervous system (CNS). To describe the neurotrophin environment within the adult CNS, mRNA and protein expression patterns of neurotrophins-3 and -4 and of brain-derived neurotrophin were investigated in adult ...

journal_title：Journal of molecular histology

authors： Riley CP,Cope TC,Buck CR

更新日期：2004-11-01 00:00:00

abstract：:Immunohistochemical and fluorescent in situ hybridization (FISH) assays are useful diagnostic methods for the identification of bacteria on formalin fixed paraffin embedded histological sections. To validate an anti-bacterial antibody or an oligonucleotide probe and to ensure fidelity during subsequent analyses, suita...

journal_title：Journal of molecular histology

authors： Recordati C,Radaelli E,Simpson KW,Scanziani E

更新日期：2008-08-01 00:00:00

abstract：:Nickel nanoparticles (Ni NPs) have been applied in various fields along with the rapid development of nanotechnology. However, the potential adverse health effects of the Ni NPs are unclear. To investigate the cyto- and genotoxicity and compare the differences between the Ni NPs and the nickel fine particles (Ni FPs),...

journal_title：Journal of molecular histology

authors： Magaye R,Gu Y,Wang Y,Su H,Zhou Q,Mao G,Shi H,Yue X,Zou B,Xu J,Zhao J

更新日期：2016-06-01 00:00:00

abstract：:Previous studies have shown aberrant expression of ubiquitin-specific protease 14 (USP14) in multiple malignancies, suggesting an important role of USP14 in tumorigenesis. However, the functional role of USP14 in pancreatic ductal adenocarcinoma (PDAC) has never been elucidated. In this study, we found that USP14 was ...

journal_title：Journal of molecular histology

authors： Hang C,Gong C,Fang Y,Chen L,Zhu J

更新日期：2021-01-04 00:00:00

abstract：:The accurately establishment of the eruptive pathway is of vital importance. The mechanisms governing tooth eruption pathway remain little known. This study is to elucidate the roles of Semaphorin 3A (Sema 3A) in mouse tooth eruptive pathway. C57BL/6 mice (11-13 and 15-17 days after birth) were chosen to observe erupt...

journal_title：Journal of molecular histology

authors： Yu X,Zheng F,Du Y,Tang K,Wang W,Zhang S

更新日期：2019-10-01 00:00:00

abstract：:Sphingosine-1-phosphate receptor 1 (S1P(1)), a receptor for sphingosine-1-phosphate, has been shown to play an important role in the migration, proliferation, and survival of several types of cell including endothelial cells. Given that S1P(1) signaling could serve as a therapeutic target, we evaluate the expression o...

journal_title：Journal of molecular histology

authors： Akiyama T,Sadahira Y,Matsubara K,Mori M,Igarashi Y

更新日期：2008-10-01 00:00:00

abstract：:MT1-MMP and TIMP-2 are well known for their roles in remodelling of extracellular matrix components. However, reports are emerging on the involvement of these molecules in cell kinetics. In the rat incisor tooth, a shortening treatment increases the eruption and cell proliferation rates. However, the role of MT1-MMP a...

journal_title：Journal of molecular histology

authors： Gomes JR,Omar NF,Dos Santos Neves J,Narvaes EA,Novaes PD

更新日期：2010-12-01 00:00:00

abstract：:TGF-β1, SNAI1 and MMP-9 are implicated in tumor invasion and metastasis. The purpose of this study was to examine TGF-β1, SNAI1 and MMP-9 expression in papillary thyroid carcinoma (PTC), and to assess association of TGF-β1, SNAI1 and MMP-9 expression with several clinicopathological indicators of PTC. TGF-β1, SNAI1 an...

journal_title：Journal of molecular histology

authors： Wang N,Jiang R,Yang JY,Tang C,Yang L,Xu M,Jiang QF,Liu ZM

更新日期：2014-08-01 00:00:00

abstract：:Estrogens and their receptors are important factors involved in periodontal ligament (PDL) tissue health. As a regulator of estrogen receptors (ER), the proline-, glutamic acid-, and leucine-rich protein 1 (PELP1) may play a role in alveolar bone formation and PDL homeostasis. The aim of the present study was to obser...

journal_title：Journal of molecular histology

authors： Wang J,Zhu Q,Song S,Dong J,Shi L,Tao R,Ding Y,Hong B

更新日期：2013-06-01 00:00:00

abstract：:Human pluripotent stem cell (hPSC)-derived cardiomyocytes (CMs) hold great promise for the repair of the injured heart, but optimal cell production in a fully chemically defined and cost-effective system is essential for the efficacy and safety of cell transplantation therapies. In this study, we provided a simple and...

journal_title：Journal of molecular histology

authors： Zhang F,Qiu H,Dong X,Wang C,Na J,Zhou J,Wang C

更新日期：2021-02-01 00:00:00

abstract：:Within the reproductive system, oestrogenic stimulation of uterine and pituitary tissue typically causes a proliferative response accompanied by an angiogenic induction of new blood vessels from existing ones, thereby providing nutrients and oxygen to the growing tissue. The pro-oestrogenic pesticide methoxychlor (MXC...

journal_title：Journal of molecular histology

authors： Goldman JM,Murr AS,Buckalew AR,Schmid JE,Abbott BD

更新日期：2004-05-01 00:00:00

abstract：:Soluble epoxide hydrolase (sEH) is a bifunctional enzyme with a C-terminal epoxide hydrolase activity and an N-terminal phosphatase activity. Arachidonic acid epoxides, previously suggested to be involved in apoptosis, oncogenesis and cell proliferation, are generated by cytochrome P450 epoxygenases and are good subst...

journal_title：Journal of molecular histology

authors： Enayetallah AE,French RA,Grant DF

更新日期：2006-05-01 00:00:00

abstract：:The aim of this study was to investigate oxidative DNA damage during 4-nitroquinoline 1-oxide (4NQO)-induced rat tongue carcinogenesis. For this purpose, male Wistar rats were distributed into three groups of 10 animals each and treated with 50 ppm 4NQO solution through their drinking water for 4, 12, and 20 weeks. Te...

journal_title：Journal of molecular histology

authors： Miranda SR,Noguti J,Carvalho JG,Oshima CT,Ribeiro DA

更新日期：2011-04-01 00:00:00

abstract：:This study aimed to explore whether the altered expression of tumor necrosis factor-alpha (TNF-α), vascular endothelial growth factor (VEGF) and apoptotic changes in mid zone (MZ) and rupture zone (RZ) of fetal membranes (FM) are regulatory mechanisms associated with labor at term. Fifteen FM specimens were collected ...

journal_title：Journal of molecular histology

authors： Elfayomy AK,Almasry SM

更新日期：2014-06-01 00:00:00

abstract：:p21-activated Kinase 6 (PAK6) is a serine/threonine kinase belonging to the p21-activated kinase (PAK) family. PAK kinases are well-known regulators of a wide variety of cellular functions, including regulation of cytoskeleton rearrangement, cell survival, apoptosis and the mitogen-activated protein kinase signaling p...

journal_title：Journal of molecular histology

authors： Zhao W,Yang J,Shi W,Wu X,Shao B,Wu Q,Chen J,Ni L

更新日期：2011-06-01 00:00:00

abstract：:Selective cyclooxygenase-2 non-steroidal anti-inflammatory drugs are known to inhibit bone repair, especially when long-term administration is required due to chronicle inflammatory diseases. In order to evaluate the action of this drug in bone repair during short-term administration, 48 rats underwent surgical bone d...

journal_title：Journal of molecular histology

authors： Matsumoto MA,De Oliveira A,Ribeiro Junior PD,Nary Filho H,Ribeiro DA

更新日期：2008-08-01 00:00:00

abstract：:Polycystic ovary syndrome (PCOS) is a major health problem in reproductive-aged women worldwide, but the precise pathogenesis of PCOS remains unclear. Our previous study revealed that hypoxia-inducible factor (HIF)-1a mediated endothelin (ET)-2 signaling plays an important role in ovulation in rats. Therefore, the pre...

journal_title：Journal of molecular histology

authors： Wang F,Zhang Z,Wang Z,Xiao K,Wang Q,Su J,Wang Z

更新日期：2015-04-01 00:00:00

abstract：:The neurovascular structures in the cranial dura mater have been studied with various histological techniques in the past years. In order to obtain a proper approach to reveal the detailed structures, different labeling methods for the cranial vessels and nerve fibers were tested in this study. Firstly, the labeling c...

journal_title：Journal of molecular histology

authors： Wang J,Xu D,Cui J,Wang S,She C,Wang H,Wu S,Zhang J,Zhu B,Bai W

更新日期：2020-10-01 00:00:00

abstract：:The incidence of chronic renal diseases is increasing worldwide, and there is a great need to identify therapies capable of arresting or reducing disease progression. The current treatment of chronic nephropathies is limited to angiotensin-converting enzyme inhibitors and angiotensin receptor blockers, but increasing ...

journal_title：Journal of molecular histology

authors： de Barros EP,Garcia-Pinto AB,Machado PY,dos Santos Pereira MJ,de Carvalho JJ

更新日期：2011-08-01 00:00:00